A novel difluorocarbene promoted single-atom skeletal editing of 2H-indazoles is demonstrated herein.Ethyl bromodifluoroacetate was severed as the difluorocarbene source in the current protocol,facilitating the cleava...A novel difluorocarbene promoted single-atom skeletal editing of 2H-indazoles is demonstrated herein.Ethyl bromodifluoroacetate was severed as the difluorocarbene source in the current protocol,facilitating the cleavage of the N-N bond via carbon atom insertion.This metal-free ring expansion reaction enables the late-stage diversification of indazole skeletons,assembling a diverse array of functionalized quinazolin-4(3H)-ones in decent yields with excellent functional group compatibility.展开更多
Nitrenes,as neutral monovalent nitrogen-centered molecular species,can insert into various bond or remove nitrogen atoms from amines.Nitrene assisted single-atom skeletal editing,discovered decades ago,provides an eff...Nitrenes,as neutral monovalent nitrogen-centered molecular species,can insert into various bond or remove nitrogen atoms from amines.Nitrene assisted single-atom skeletal editing,discovered decades ago,provides an efficient approach for the precise alteration of cyclic skeletons.In this review,we briefly summarize early studies on skeletal editing of cyclic frameworks involving nitrene species,and introduce several recent important advances systematically.展开更多
基金supported by the National Natural Science Foundation of China(21931013,22271105)the Natural Science Foundation of Fujian Province(2022J02009)+1 种基金the Science and Technology Research Project of Education Department of Hubei Province(B2021133)the Hubei Key Laboratory of Pollutant Analysis&Reuse Technology(PA190109)
文摘A novel difluorocarbene promoted single-atom skeletal editing of 2H-indazoles is demonstrated herein.Ethyl bromodifluoroacetate was severed as the difluorocarbene source in the current protocol,facilitating the cleavage of the N-N bond via carbon atom insertion.This metal-free ring expansion reaction enables the late-stage diversification of indazole skeletons,assembling a diverse array of functionalized quinazolin-4(3H)-ones in decent yields with excellent functional group compatibility.
基金financial support from the National Key R&D Programof China(2022YFA1503703toB.T.and 2021YFF0701604 to B.T.)National Natural Science Foundation of China(22231004 to B.T.,22371113 to Y.-B.W.,22271135 to S.-H.X.)+1 种基金Guangdong Innovative Program(2019BT02Y335 to B.T.)Shenzhen Science and Technology Program(JCYJ20220818100604009 to Y.-B.W.,JCYJ20210324105005015 to S.-H.X.,JCYJ20210324104212035 to Y.-B.W.and KQTD20210811090112004 to B.T.).
文摘Nitrenes,as neutral monovalent nitrogen-centered molecular species,can insert into various bond or remove nitrogen atoms from amines.Nitrene assisted single-atom skeletal editing,discovered decades ago,provides an efficient approach for the precise alteration of cyclic skeletons.In this review,we briefly summarize early studies on skeletal editing of cyclic frameworks involving nitrene species,and introduce several recent important advances systematically.
