Bone tissue engineering is the main method for repairing large segment bone defects.In this study,a layer of bioactive MgO nanoparticles was wrapped on the surface of spherical Zn powders,which allowed the MgO nanopar...Bone tissue engineering is the main method for repairing large segment bone defects.In this study,a layer of bioactive MgO nanoparticles was wrapped on the surface of spherical Zn powders,which allowed the MgO nanoparticles to be incorporated into 3D-printed Zn matrix and improved the biodegradation and biocompatibility of the Zn matrix.The results showed that porous pure Zn scaffolds and Zn/MgO scaffolds with skeletal-gyroid(G)model structure were successfully prepared by selective laser melting(SLM).The average porosity of two porous scaffolds was 59.3 and 60.0%,respectively.The pores were uniformly distributed with an average pore size of 558.6-569.3μm.MgO nanoparticles regulated the corrosion rate of scaffolds,resulting in a more uniform corrosion degradation behavior of the Zn/MgO scaffolds in simulated body fluid solution.The degradation ratio of Zn/MgO composite scaffolds in vivo was increased compared to pure Zn scaffolds,reaching 15.6%at 12 weeks.The yield strength(10.8±2.4 MPa)of the Zn/MgO composite scaffold was comparable to that of cancellous bone,and the antimicrobial rate were higher than 99%.The Zn/MgO composite scaffolds could better guide bone tissue regeneration in rat cranial bone repair experiments(completely filling the scaffolds at 12 weeks).Therefore,porous Zn/MgO scaffolds with G-model structure prepared with SLM are a promising biodegradable bone tissue engineering scaffold.展开更多
基金support for this work from the National Natural Science Foundation of China (Nos.52171241 and 52373251).
文摘Bone tissue engineering is the main method for repairing large segment bone defects.In this study,a layer of bioactive MgO nanoparticles was wrapped on the surface of spherical Zn powders,which allowed the MgO nanoparticles to be incorporated into 3D-printed Zn matrix and improved the biodegradation and biocompatibility of the Zn matrix.The results showed that porous pure Zn scaffolds and Zn/MgO scaffolds with skeletal-gyroid(G)model structure were successfully prepared by selective laser melting(SLM).The average porosity of two porous scaffolds was 59.3 and 60.0%,respectively.The pores were uniformly distributed with an average pore size of 558.6-569.3μm.MgO nanoparticles regulated the corrosion rate of scaffolds,resulting in a more uniform corrosion degradation behavior of the Zn/MgO scaffolds in simulated body fluid solution.The degradation ratio of Zn/MgO composite scaffolds in vivo was increased compared to pure Zn scaffolds,reaching 15.6%at 12 weeks.The yield strength(10.8±2.4 MPa)of the Zn/MgO composite scaffold was comparable to that of cancellous bone,and the antimicrobial rate were higher than 99%.The Zn/MgO composite scaffolds could better guide bone tissue regeneration in rat cranial bone repair experiments(completely filling the scaffolds at 12 weeks).Therefore,porous Zn/MgO scaffolds with G-model structure prepared with SLM are a promising biodegradable bone tissue engineering scaffold.
