Good toilet hygiene can reduce the risk of pathogenic transmission.During flushing,pathogenic bacteria can be spread by the water droplets,especially in the toilet seat.Escherichia coli(E.coli)is one of the frequently...Good toilet hygiene can reduce the risk of pathogenic transmission.During flushing,pathogenic bacteria can be spread by the water droplets,especially in the toilet seat.Escherichia coli(E.coli)is one of the frequently occurring Gram-negative bacterial pathogens found in the toilet seats.In this study,we investigated the potential anti-E.coli activity of some azobenzene compounds.Among them,compound 2,with the heterocyclic nitrogen in both phenyl rings,showed the strongest antibacterial effect on E.coli,with the minimum inhibitory concentration of 80μg/mL and the minimum bactericidal concentration of 320μg/mL.Compound 2 displayed a comparative zone of clearance[(14.50±2.29)mm]to that of ampicillin[(13.17±1.76)mm].The reactive oxygen species(ROS)assay suggested that compound 2 might induce the loss of bacteria via the oxidative stress by eliciting the generation of intracellular ROS.We further examined the potential cytotoxicity of compound 2 to the human skin HaCaT cells.Compound 2-treated skin cells showed a good maintenance of cellular morphology and a clear definition of cell nuclei,with a satisfactory cell viability(ca.90%)at 80μg/mL.Overall,compound 2 would be a possible antibacterial coating agent for the surface sanitizer of the toilet seats to inhibit the growth of E.coli.展开更多
This study reports the synthesis and characterization of quinoline derivatives. The synthesized quinoline compounds were applied to the dyeing treatment of acrylic fabrics. The color fastness to washing and light of q...This study reports the synthesis and characterization of quinoline derivatives. The synthesized quinoline compounds were applied to the dyeing treatment of acrylic fabrics. The color fastness to washing and light of quinoline compound-dyed fabrics was examined. Human skin HaCaT cell line was also used for the skin cytotoxicity evaluation of the quinoline compound-dyed acrylic fabrics.展开更多
基金WONG Wai-Yeung thanks the ITC Guangdong-Hong Kong Technology Cooperation Funding Scheme(TCFS)(No.GHP/038/19GD)and Chengdu University for the financial support.CHUI Chung-Hin from One Health International Limited acknowledges the support of Research Talent Hub Ref.:RtH/016/20,Innovation and Technology Commission,Hong Kong,China.
文摘Good toilet hygiene can reduce the risk of pathogenic transmission.During flushing,pathogenic bacteria can be spread by the water droplets,especially in the toilet seat.Escherichia coli(E.coli)is one of the frequently occurring Gram-negative bacterial pathogens found in the toilet seats.In this study,we investigated the potential anti-E.coli activity of some azobenzene compounds.Among them,compound 2,with the heterocyclic nitrogen in both phenyl rings,showed the strongest antibacterial effect on E.coli,with the minimum inhibitory concentration of 80μg/mL and the minimum bactericidal concentration of 320μg/mL.Compound 2 displayed a comparative zone of clearance[(14.50±2.29)mm]to that of ampicillin[(13.17±1.76)mm].The reactive oxygen species(ROS)assay suggested that compound 2 might induce the loss of bacteria via the oxidative stress by eliciting the generation of intracellular ROS.We further examined the potential cytotoxicity of compound 2 to the human skin HaCaT cells.Compound 2-treated skin cells showed a good maintenance of cellular morphology and a clear definition of cell nuclei,with a satisfactory cell viability(ca.90%)at 80μg/mL.Overall,compound 2 would be a possible antibacterial coating agent for the surface sanitizer of the toilet seats to inhibit the growth of E.coli.
基金supported by the starting fund to C.H. Chui (No. 38-40-116)the National Basic Research Program of China (973 Program) (No. 2013CB834702)+2 种基金the 985 Program and 111 Project from Minzu University of China (Nos. CUN985-07-08 and 111 Project B08044)Areas of Excellence Scheme, University Grants Committee of HKSAR, China (No. AoE/P-03/08)the Science, Technology and Innovation Committee of Shenzhen Municipality (No. JCYJ20120829154440583) for financial support
文摘This study reports the synthesis and characterization of quinoline derivatives. The synthesized quinoline compounds were applied to the dyeing treatment of acrylic fabrics. The color fastness to washing and light of quinoline compound-dyed fabrics was examined. Human skin HaCaT cell line was also used for the skin cytotoxicity evaluation of the quinoline compound-dyed acrylic fabrics.
