Supporting Skin Structure and Its Barrier Functions with Evidence-Based Skin Care Ingredients

The epidermis, and in particular its outermost layer, the stratum corneum, contributes much of the barrier function of the skin and is a readily visible representation of skin health. Maintaining the health of the skin barrier has arguably become more important than ever in the modern world, in which a large majority of people are exposed to environmental insults. These external factors can damage the integrity of the skin barrier and prematurely age the skin. Therefore, it has become increasingly important to maintain and protect the stratum corneum. Here, we briefly review the complex, multilayered structure of the skin and relate it to clinically translatable function, with an emphasis on the stratum corneum. In the context of epidermal structure and function, the formulation and clinical data for Phelityl® Reviving Cream will be reviewed. Phelityl Reviving Cream was shown to be associated with improvements in both immediate- and long-term parameters, including a significant positive effect on the skin barrier and immediate and long-lasting hydration.

Interspecific differences and ecological correlations between scale number and skin structure in freshwater fishes

Fish skin is mainly composed of the epidermis,dermis,and its derivative scales.There is a wide diversity in scale number in fishes,but the diversity of skin structure lacks systematic histological comparison.This research aimed to improve our understanding of the functional relationship between the scale number and the skin structure in freshwater fishes and to determine which ecological factors affect the scale number and skin structure.First,we presented a method to quantify skin structure in fish and histologically quantified the skin structure of 54 freshwater fishes.Second,we collected the scale number and habitat information of 509 Cyprinidae fishes in China and explored which ecological factors were related to their scale number.Third,common carp and scaleless carp were used as models to study the effects of scale loss on swimming.We found a strong negative correlation between scale thickness and scale number.The main factor affecting the skin structure of fishes was the species’water column position,and the skin of benthic fishes was the most well-developed(thicker skin layers(dermis,epidermis)or more/larger goblet cells and club cells).The scale number was related to two factors,namely,temperature and water column position,and cold,benthic and pelagic adaptation may have contributed to increased scale numbers.Only in benthic fishes,the more well-developed their skin,the more scales.In common carp,scale loss did not affect its swimming performance.In summary,we suggest that there is a rich diversity of skin structure in freshwater fishes,and the scales of fish with well-developed skin tend to degenerate(greater number/smaller size/thinner,or even disappear),but the skin of fish with degenerated scales is not necessarily well developed.

Research on stretching flame correction technology of aluminum alloy ship frame skin welding structure

At present,conventional flame correction has shortcomings such as random heating route and low efficiency.The welding seam of the aluminum alloy ship frame skin structure is concentrated and the frame restraint is large.It is difficult to control and eliminate the local convex deformation after welding.In order to improve the conventional orthopedic technology and improve the orthopedic efficiency,the pre-elastic deformation technology is proposed.Using the method of combining numerical simulation and experiment,the orthopedic effect of conventional and pre-elastic orthopedic technology is studied,and the influence of pre-deformation variables and heating path on deformation control of the frame skin structure after welding is simulated.The simulation results show that the technical key to the control of convex deformation lies in the control of the pre-elastic deformation and the setting of the heating route.The experimental verification results show that the pre-elastic deformation technology has a better control effect than conventional orthopedics,can significantly improve the orthopedic efficiency,and provides a new method for deformation control in the shipbuilding industry.

Control effect of structured skin care plan of integrated Chinese and Western medicine in elderly patients with incontinence-associated dermatitis

Objective:The objective of this study is to explore the clinical effects of structured skin care plan of integrated Chinese and Western medicine in intervening elderly patients with incontinence-associated dermatitis(IAD).Materials and Methods:Totally,66 elderly patients with IAD were randomly divided into the experiment group(32 cases)and control group(34 cases).The control group was given routine nursing care,while the experiment group was given a structured skin care plan.The observational course was 2 weeks.The treatment efficiency and healing time were compared between the two groups.Results:After 2-week intervention,the total effective rate of the experiment group was higher than that of the control group(97.1%vs.78.1%,X^(2)=3.913,P=0.048).The skin assessment tool score of the experiment group was lower than that of the control group(0.56±1.58 vs.1.75±2.46,Z=−−2.401,P=0.016).The healing time of the experiment group was shorter than that of the control group(7.29±4.76 days vs.10.69±6.36 days,Z=−2.280,P=0.026).Conclusion:The structured skin care plan of integrated Chinese and Western medicine showed a good effect in elderly IAD patients,and provided a reference for clinical treatment and care of elderly patients with IAD.

RESEARCH ON NURBS SKINNING SURFACE VIA COMPLEX CURVES

In order to design the production with complex external shapes, a newmethod is put forward using non-uniform rational B-spline(NURBS)curves to unifythe description of complex curves composed of several segments with different degrees,and then these complex curves are used to construct NURBS skinning surface. Somekinds of skills are used to dispose the knot of NURBS curves and surfaces for practicalproblems. Finally, the method is verified by several complex examples.

Relationship between Dermal Structural Changes on Ultrasonographic Images and Skin Viscoelasticity in Overweight and Obese Japanese Males

It has been reported that overweight Japanese males have poorly organised dermis and their skin may be fragile to external forces because of decreased dermal echogenicity. However, it is unknown whether the changes in the dermal structure actually affect the dermal function. The objective of this study was to clarify the relationship between dermal structural parameters and dermal functional parameters in overweight and obese Japanese males. A cross-sectional, observational study was conducted on Japanese male volunteers. Two ultrasound scanners, a 20-MHz Dermascan C® and an 18-MHz MylabTM five® were used to evaluate dermal structure. Echogenicity of the lower dermis and dermal thickness of the participants’ abdomens and thighs were measured. A Cutometer® MPA580 was used to evaluate skin viscoelasticity, skin deformation (R0) and elasticity (R2, R7). The correlation between dermal structural parameters and skin viscoelasticity were validated using Pearson’s correlation coefficient or Spearman’s correlation coefficient by rank test. A total of 79 male volunteers were recruited of which 43 were control subjects with BMI <25 (age, 22 - 63 years), 25 were overweight subjects with BMI ≥ 25 to <30 (age, 23 - 64 years) and the 11 obese subjects had a BMI ≥ 30 (age, 26 - 47 years). There was no correlation between dermal structural parameters and skin viscoelasticity in the abdomens or thighs of all 79 participants. On the other hand, in the 36 overweight and obese participants, thigh dermal echogenicity was significantly and negatively correlated with R0 (r = -0.456, p < 0.01) and dermal thickness in the abdomen was significantly and positively correlated with R0 (r = 0.464, p < 0.01). The dermal functional parameter was significantly correlated with dermal structural parameters in overweight and obese males;in other words, a decrease in dermal function may be caused by structural changes in the dermis during obesity.

Topology optimization of support structure of telescope skin based on bit-matrix representation NSGA-II

Non-dominated sorting genetic algorithm II（NSGA-II）with multiple constraints handling is employed for multi-objective optimization of the topological structure of telescope skin,in which a bit-matrix is used as the representation of a chromosome,and genetic algorithm（GA）operators are introduced based on the matrix.Objectives including mass,in-plane performance,and out-of-plane load-bearing ability of the individuals are obtained by fnite element analysis（FEA）using ANSYS,and the matrix-based optimization algorithm is realized in MATLAB by handling multiple constraints such as structural connectivity and in-plane strain requirements.Feasible confgurations of the support structure are achieved.The results confrm that the matrix-based NSGA-II with multiple constraints handling provides an effective method for two-dimensional multi-objective topology optimization.

Lightweight Design of Spaceborne CFRP Rigid Antenna Reflector

In order to overcome the shortcoming of space-borne rigid antenna reflector made of carbon fiber reinforced plastic(CFRP)skins with aluminum honeycomb sandwich(SAHS)structure,a new type of full CFRP skin plus rib(SPR)structure ring-focused parabolic surface antenna reflector with the size of 2.5 m×1.9 m is designed.Under the condition that the original caliber,surface type,and interface remain unchanged,the main influence factors are designed and controlled.First,from the perspective of high stiffness,lightweight,and easy to form,a finite element simulation software is used to analyze and optimize the layout of the rib,the cross-sectional shape of the rib,the size of the rib,and the matching of the size and the coefficients of thermal expansion(CTEs)of the rib and the skin.Second,two structures are prepared by the autoclave molding process.Third,the weight and the surface precision root mean square(RMS)value are measured.The results show that the fundamental frequency of the SPR structure is 142.2 Hz,which is 3.5 Hz higher;the number of the new structural parts is reduced by 40%,and the forming process is greatly simplified.The total weight of the new structure is 11.9 kg,lighter 42.5%,indicating that the weight loss is obvious.The RMS value is 0.15 mm,which is slightly lower 0.01 mm but satisfies the accuracy requirement not greater than 0.3 mm.It is proved that the SPR structure reflector is a superior structure of the lightweight spaceborne antenna reflector.

In-plane corrugated cosine honeycomb for 1D morphing skin and its application on variable camber wing

A novel 0-Poisson＇s ratio cosine honeycomb support structure of flexible skin is proposed. Mechanical model of the structure is analyzed with the energy method, finite element method （FEM） and experiments have been performed to validate the theoretical model. The in-plane characteristics of the cosine honeycomb are compared with accordion honeycomb through analytical models and experiments. Finally, the application of the cosine honeycomb on a variable camber wing is studied. Studies show that mechanical model agrees well with results of FEM and experiments. The transverse non-dimensional elastic modulus of the cosine honeycomb increases （decreases） when the wavelength or the wall width increases （decreases）, or when the amplitude decreases （increases）. Compared with accordion honeycomb, the transverse non-dimensional elastic modulus of the cosine honeycomb is smaller, which means the driving force is smaller and the power consumption is less during deformation. In addition, the cosine honeycomb can satisfy the deform- ing requirements of the variable camber wing.