Exercise-with-melatonin therapy has complementary and synergistic effects on spinal cord injury and Alzheimer's disease,but its effect on stroke is still poorly understood.In this study,we established a rat model ...Exercise-with-melatonin therapy has complementary and synergistic effects on spinal cord injury and Alzheimer's disease,but its effect on stroke is still poorly understood.In this study,we established a rat model of ischemic stroke by occluding the middle cerebral artery for 60 minutes.We treated the rats with exercise and melatonin therapy for 7 consecutive days.Results showed that exercise-with-melatonin therapy significantly prolonged sleep duration in the model rats,increased delta power values,and regularized delta power rhythm.Additionally,exercise-with-melatonin therapy improved coordination,endurance,and grip strength,as well as learning and memory abilities.At the same time,it led to higher hippocampal CA1 neuron activity and postsynaptic density thickness and lower expression of glutamate receptor 2 than did exercise or melatonin therapy alone.These findings suggest that exercise-withmelatonin therapy can alleviate sleep disorder and motor dysfunction by increasing glutamate receptor 2 protein expression and regulating hippocampal CA1 synaptic plasticity.展开更多
The association between sleep-disordered breathing(SDB) and cardiovascular risk has been the focus of attention in recent years.Sleep disorders are emerging risk factors for cardiovascular disease and have been relate...The association between sleep-disordered breathing(SDB) and cardiovascular risk has been the focus of attention in recent years.Sleep disorders are emerging risk factors for cardiovascular disease and have been related to the whole spectrum of stroke,including transient ischemic attack,ischemic cerebral infarction and intracerebral haemorrhage.It has been shown that lacunar stroke or lacunar infarctions affecting the internal capsule or the protuberance are associated with a higher frequency of SDB.Acute stroke patients with associated SDB have a worse prognosis and a higher mortality as compared to patients with first-ever stroke without SDB.Preliminary studies provide evidence of the usefulness of treatment with continuous positive airway pressure when SDB is present in stroke patients.展开更多
目的分析2013—2023年缺血性卒中和睡眠相关性研究的现状及研究热点。方法在Web of Science核心合集中检索2013年1月1日—2023年12月31日缺血性卒中和睡眠相关性研究的文献。使用RStudio的bibliometrix软件包和VOSviewer软件对该领域研...目的分析2013—2023年缺血性卒中和睡眠相关性研究的现状及研究热点。方法在Web of Science核心合集中检索2013年1月1日—2023年12月31日缺血性卒中和睡眠相关性研究的文献。使用RStudio的bibliometrix软件包和VOSviewer软件对该领域研究的发文量、国家/地区、机构、作者、期刊、文献引用、关键词和研究热点进行分析,并进行可视化呈现。结果共检索到798篇文献。以通信作者分析,中国发文199篇,居全球首位,且与多个国家建立了合作关系。美国发文196篇,位列第2。发文量最多的机构是加拿大多伦多大学,共34篇。发文量前10位的作者中5位来自美国密歇根大学,相互合作较密切,其中美国学者Devin L Brown发表文章数量为28篇,被引频次236次,发文量和被引频次均居首位。发文量最多的期刊是Sleep Medicine(74篇),发表文章被引频次最高的期刊是Stroke(3542次)。关键词可视化分析发现卒中与睡眠呼吸暂停出现频次最高。在卒中与睡眠相关性研究领域,研究主题分析提示失眠、抑郁作为基础课题对该领域发展非常重要,卒中预防、功能结局、脑血流主题研究需要努力开发。结论越来越多的研究聚焦于缺血性卒中和睡眠之间的关联性,中国和美国在该领域发表文献较多,睡眠呼吸障碍是主要研究热点。未来在卒中和睡眠领域可探索失眠、抑郁、卒中预防、功能结局、脑血流等主题。展开更多
基金supported by China Rehabilitation Research Center,No.2021zx-03the Special Fund for Joint Training of Doctoral Students between the University of Health and Rehabilitation Sciences and China Rehabilitation Research Center,No.2020 kfdx-008(both to TZ)。
文摘Exercise-with-melatonin therapy has complementary and synergistic effects on spinal cord injury and Alzheimer's disease,but its effect on stroke is still poorly understood.In this study,we established a rat model of ischemic stroke by occluding the middle cerebral artery for 60 minutes.We treated the rats with exercise and melatonin therapy for 7 consecutive days.Results showed that exercise-with-melatonin therapy significantly prolonged sleep duration in the model rats,increased delta power values,and regularized delta power rhythm.Additionally,exercise-with-melatonin therapy improved coordination,endurance,and grip strength,as well as learning and memory abilities.At the same time,it led to higher hippocampal CA1 neuron activity and postsynaptic density thickness and lower expression of glutamate receptor 2 than did exercise or melatonin therapy alone.These findings suggest that exercise-withmelatonin therapy can alleviate sleep disorder and motor dysfunction by increasing glutamate receptor 2 protein expression and regulating hippocampal CA1 synaptic plasticity.
文摘The association between sleep-disordered breathing(SDB) and cardiovascular risk has been the focus of attention in recent years.Sleep disorders are emerging risk factors for cardiovascular disease and have been related to the whole spectrum of stroke,including transient ischemic attack,ischemic cerebral infarction and intracerebral haemorrhage.It has been shown that lacunar stroke or lacunar infarctions affecting the internal capsule or the protuberance are associated with a higher frequency of SDB.Acute stroke patients with associated SDB have a worse prognosis and a higher mortality as compared to patients with first-ever stroke without SDB.Preliminary studies provide evidence of the usefulness of treatment with continuous positive airway pressure when SDB is present in stroke patients.
文摘目的分析2013—2023年缺血性卒中和睡眠相关性研究的现状及研究热点。方法在Web of Science核心合集中检索2013年1月1日—2023年12月31日缺血性卒中和睡眠相关性研究的文献。使用RStudio的bibliometrix软件包和VOSviewer软件对该领域研究的发文量、国家/地区、机构、作者、期刊、文献引用、关键词和研究热点进行分析,并进行可视化呈现。结果共检索到798篇文献。以通信作者分析,中国发文199篇,居全球首位,且与多个国家建立了合作关系。美国发文196篇,位列第2。发文量最多的机构是加拿大多伦多大学,共34篇。发文量前10位的作者中5位来自美国密歇根大学,相互合作较密切,其中美国学者Devin L Brown发表文章数量为28篇,被引频次236次,发文量和被引频次均居首位。发文量最多的期刊是Sleep Medicine(74篇),发表文章被引频次最高的期刊是Stroke(3542次)。关键词可视化分析发现卒中与睡眠呼吸暂停出现频次最高。在卒中与睡眠相关性研究领域,研究主题分析提示失眠、抑郁作为基础课题对该领域发展非常重要,卒中预防、功能结局、脑血流主题研究需要努力开发。结论越来越多的研究聚焦于缺血性卒中和睡眠之间的关联性,中国和美国在该领域发表文献较多,睡眠呼吸障碍是主要研究热点。未来在卒中和睡眠领域可探索失眠、抑郁、卒中预防、功能结局、脑血流等主题。
