The fast and convenient demultiplex of optical vortex(OV) mode is crucial for its further application. We propose a novel approach that combines classic Young's doublet with an OV source to effectively identify th...The fast and convenient demultiplex of optical vortex(OV) mode is crucial for its further application. We propose a novel approach that combines classic Young's doublet with an OV source to effectively identify the OV mode through the analysis of interference patterns. The interference patterns of the OV source incident on the double slits can be perfectly illustrated by using both the classical double-slit interference method and the Huygens–Fresnel principle. The interference fringes will twist along the negative or positive direction of x axis when topological charge(TC)l>0 or l<0, and the degree of the movement varies with the TC, allowing for a quantitative display of the OV characteristics through the interference patterns. Additionally, we deduce analytically that the zeroth-order interference fringe has a linear relationship with the TC and the vertical position. These findings highlight the ability to identify the OV mode by analyzing the interference patterns produced by Young's doublet.展开更多
We applied adaptive dynamics to double slit interference phenomenon using particle model and obtained partial successful results in our previous report. The patterns qualitatively corresponded well with experiments. S...We applied adaptive dynamics to double slit interference phenomenon using particle model and obtained partial successful results in our previous report. The patterns qualitatively corresponded well with experiments. Several properties such as concave single slit pattern and large influence of slight displacement of the emission position were different from the experimental results. In this study we tried other slit conditions and obtained consistent patterns with experiments. We do not claim that the adaptive dynamics is the principle of quantum mechanics, but the present results support the probability of adaptive dynamics as the candidate of the basis of quantum mechanics. We discuss the advantages of the adaptive dynamical view for foundations of quantum mechanics.展开更多
To accurately predict impact loads can ensure the safe operation of debris flow control projects.The instantaneous impact process is usually considered in the calculation of the debris flow impact force;however,the re...To accurately predict impact loads can ensure the safe operation of debris flow control projects.The instantaneous impact process is usually considered in the calculation of the debris flow impact force;however,the redistribution of an impact load after structural regulation is unclear.In this study we deduced the theoretical calculation of a debris flow impact on a double-row slit dam,and carried out a verification experiment on the debris flow impact.The calculation model considers the influence of the debris flow properties,dam arrangement and pile material.The results show that the impact force of the debris flow is obviously affected by the bulk density.When the bulk density is 21 kg/m^(3),the maximum impact force on the pile dam is 1.15 times that when the bulk density is 15 kg/m^(3),but the time it takes for the debris flow to pass through the dam body is reduced by 60%.The larger the relative pile spacing,the more sufficient the flow space and the lower the maximum impact force.The maximum impact force of relative pile spacing of 0.8 is 12%less than that of elative pile spacing of 0.5.The horizontal distribution of the impact force in the mud depth range is parabolic.The maximum impact force on the centre pier is 1.3 times that of a side pier,and the maximum impact force on the dam body appears at the top of the mud depth range.From the vertical distribution of the impact force,the maximum impact force at the highest mud mark is approximately 70%of that of the bottom.With the increase in the relative pile spacing,the longitudinal maximum impact force distribution first decreases and then increases.展开更多
The Slit family of axon guidance cues act as repulsive molecules for precise axon pathfinding and neuronal migration during nervous system development through interactions with specific Robo receptors.Although we prev...The Slit family of axon guidance cues act as repulsive molecules for precise axon pathfinding and neuronal migration during nervous system development through interactions with specific Robo receptors.Although we previously reported that Slit1–3 and their receptors Robo1 and Robo2 are highly expressed in the adult mouse peripheral nervous system,how this expression changes after injury has not been well studied.Herein,we constructed a peripheral nerve injury mouse model by transecting the right sciatic nerve.At 14 days after injury,quantitative real-time polymerase chain reaction was used to detect mRNA expression of Slit1–3 and Robo1–2 in L4–5 spinal cord and dorsal root ganglia,as well as the sciatic nerve.Immunohistochemical analysis was performed to examine Slit1–3,Robo1–2,neurofilament heavy chain,F4/80,and vimentin in L4–5 spinal cord,L4 dorsal root ganglia,and the sciatic nerve.Co-expression of Slit1–3 and Robo1–2 in L4 dorsal root ganglia was detected by in situ hybridization.In addition,Slit1–3 and Robo1–2 protein expression in L4–5 spinal cord,L4 dorsal root ganglia,and sciatic nerve were detected by western blot assay.The results showed no significant changes of Slit1–3 or Robo1–2 mRNA expression in the spinal cord within 14 days after injury.In the dorsal root ganglion,Slit1–3 and Robo1–2 mRNA expression were initially downregulated within 4 days after injury;however,Robo1–2 mRNA expression returned to the control level,while Slit1–3 mRNA expression remained upregulated during regeneration from 4–14 days after injury.In the sciatic nerve,Slit1–3 and their receptors Robo1–2 were all expressed in the proximal nerve stump;however,Slit1,Slit2,and Robo2 were barely detectable in the nerve bridge and distal nerve stump within 14 days after injury.Slit3 was highly ex-pressed in macrophages surrounding the nerve bridge and slightly downregulated in the distal nerve stump within 14 days after injury.Robo1 was upregulated in vimentin-positive cells and migrating Schwann cells inside the nerve bridge.Robo1 was also upregulated in Schwann cells of the distal nerve stump within 14 days after injury.Our findings indicate that Slit3 is the major ligand expressed in the nerve bridge and distal nerve stump during peripheral nerve regeneration,and Slit3/Robo signaling could play a key role in peripheral nerve repair after injury.This study was approved by Plymouth University Animal Welfare Ethical Review Board (approval No.30/3203) on April 12,2014.展开更多
目的:探讨电针对大鼠坐骨神经损伤后神经导向因子Slit1及其mRNA表达的影响。方法:将72只SD大鼠按随机数字表法分为正常组、模型组和治疗组,每组各24只。建立大鼠右坐骨神经横断后即刻端对端缝合模型。治疗组取"环跳"、"...目的:探讨电针对大鼠坐骨神经损伤后神经导向因子Slit1及其mRNA表达的影响。方法:将72只SD大鼠按随机数字表法分为正常组、模型组和治疗组,每组各24只。建立大鼠右坐骨神经横断后即刻端对端缝合模型。治疗组取"环跳"、"足三里"电针治疗,每日1次,7 d 1个疗程,连续3个疗程。每个疗程结束后以免疫组化法、RT-PCR法分别检测坐骨神经和相应脊髓段(L4-L6)Slit1及其mRNA的表达变化。结果:治疗组Slit1及其mRNA在第1疗程后达到高峰之后逐渐降低,显著高于模型组(P<0.01),且治疗组与模型组始终都显著高于正常组(P<0.01)。结论:电针治疗能明显增强损伤坐骨神经和相应脊髓段(L4-L6)中Slit1及其mRNA的表达,促进周围神经损伤再生修复。展开更多
基金Project supported by the National Key Research and Development Program of China (Grant Nos.2020YFA0710100 and 2023YFA1407100)the National Natural Science Foundation of China (Grant Nos.92050102 and 12374410)+2 种基金the Jiangxi Provincial Natural Science Foundation (Grant No.20224ACB201005)the Fundamental Research Funds for the Central Universities (Grant Nos.20720230102 and 20720220033)China Scholarship Council (Grant No.202206310009)。
文摘The fast and convenient demultiplex of optical vortex(OV) mode is crucial for its further application. We propose a novel approach that combines classic Young's doublet with an OV source to effectively identify the OV mode through the analysis of interference patterns. The interference patterns of the OV source incident on the double slits can be perfectly illustrated by using both the classical double-slit interference method and the Huygens–Fresnel principle. The interference fringes will twist along the negative or positive direction of x axis when topological charge(TC)l>0 or l<0, and the degree of the movement varies with the TC, allowing for a quantitative display of the OV characteristics through the interference patterns. Additionally, we deduce analytically that the zeroth-order interference fringe has a linear relationship with the TC and the vertical position. These findings highlight the ability to identify the OV mode by analyzing the interference patterns produced by Young's doublet.
文摘We applied adaptive dynamics to double slit interference phenomenon using particle model and obtained partial successful results in our previous report. The patterns qualitatively corresponded well with experiments. Several properties such as concave single slit pattern and large influence of slight displacement of the emission position were different from the experimental results. In this study we tried other slit conditions and obtained consistent patterns with experiments. We do not claim that the adaptive dynamics is the principle of quantum mechanics, but the present results support the probability of adaptive dynamics as the candidate of the basis of quantum mechanics. We discuss the advantages of the adaptive dynamical view for foundations of quantum mechanics.
基金funded by the Second Scientific Expedition to Qinghai-Tibet Plateau (Grant No.2019QZKK0902)the National Natural Science Foundation of China (Grant No.42201095)+2 种基金the Natural Science Foundation of Sichuan (Grant No.2022NSFSC1032)the Sichuan Provincial Transportation Science and Technology Project (2021-A-08)the Key science and technology projects of transportation industry (2021-MS4-104)
文摘To accurately predict impact loads can ensure the safe operation of debris flow control projects.The instantaneous impact process is usually considered in the calculation of the debris flow impact force;however,the redistribution of an impact load after structural regulation is unclear.In this study we deduced the theoretical calculation of a debris flow impact on a double-row slit dam,and carried out a verification experiment on the debris flow impact.The calculation model considers the influence of the debris flow properties,dam arrangement and pile material.The results show that the impact force of the debris flow is obviously affected by the bulk density.When the bulk density is 21 kg/m^(3),the maximum impact force on the pile dam is 1.15 times that when the bulk density is 15 kg/m^(3),but the time it takes for the debris flow to pass through the dam body is reduced by 60%.The larger the relative pile spacing,the more sufficient the flow space and the lower the maximum impact force.The maximum impact force of relative pile spacing of 0.8 is 12%less than that of elative pile spacing of 0.5.The horizontal distribution of the impact force in the mud depth range is parabolic.The maximum impact force on the centre pier is 1.3 times that of a side pier,and the maximum impact force on the dam body appears at the top of the mud depth range.From the vertical distribution of the impact force,the maximum impact force at the highest mud mark is approximately 70%of that of the bottom.With the increase in the relative pile spacing,the longitudinal maximum impact force distribution first decreases and then increases.
基金supported by the National Natural Science Foundation of China,No.81371353(to XPD)
文摘The Slit family of axon guidance cues act as repulsive molecules for precise axon pathfinding and neuronal migration during nervous system development through interactions with specific Robo receptors.Although we previously reported that Slit1–3 and their receptors Robo1 and Robo2 are highly expressed in the adult mouse peripheral nervous system,how this expression changes after injury has not been well studied.Herein,we constructed a peripheral nerve injury mouse model by transecting the right sciatic nerve.At 14 days after injury,quantitative real-time polymerase chain reaction was used to detect mRNA expression of Slit1–3 and Robo1–2 in L4–5 spinal cord and dorsal root ganglia,as well as the sciatic nerve.Immunohistochemical analysis was performed to examine Slit1–3,Robo1–2,neurofilament heavy chain,F4/80,and vimentin in L4–5 spinal cord,L4 dorsal root ganglia,and the sciatic nerve.Co-expression of Slit1–3 and Robo1–2 in L4 dorsal root ganglia was detected by in situ hybridization.In addition,Slit1–3 and Robo1–2 protein expression in L4–5 spinal cord,L4 dorsal root ganglia,and sciatic nerve were detected by western blot assay.The results showed no significant changes of Slit1–3 or Robo1–2 mRNA expression in the spinal cord within 14 days after injury.In the dorsal root ganglion,Slit1–3 and Robo1–2 mRNA expression were initially downregulated within 4 days after injury;however,Robo1–2 mRNA expression returned to the control level,while Slit1–3 mRNA expression remained upregulated during regeneration from 4–14 days after injury.In the sciatic nerve,Slit1–3 and their receptors Robo1–2 were all expressed in the proximal nerve stump;however,Slit1,Slit2,and Robo2 were barely detectable in the nerve bridge and distal nerve stump within 14 days after injury.Slit3 was highly ex-pressed in macrophages surrounding the nerve bridge and slightly downregulated in the distal nerve stump within 14 days after injury.Robo1 was upregulated in vimentin-positive cells and migrating Schwann cells inside the nerve bridge.Robo1 was also upregulated in Schwann cells of the distal nerve stump within 14 days after injury.Our findings indicate that Slit3 is the major ligand expressed in the nerve bridge and distal nerve stump during peripheral nerve regeneration,and Slit3/Robo signaling could play a key role in peripheral nerve repair after injury.This study was approved by Plymouth University Animal Welfare Ethical Review Board (approval No.30/3203) on April 12,2014.
文摘目的:探讨电针对大鼠坐骨神经损伤后神经导向因子Slit1及其mRNA表达的影响。方法:将72只SD大鼠按随机数字表法分为正常组、模型组和治疗组,每组各24只。建立大鼠右坐骨神经横断后即刻端对端缝合模型。治疗组取"环跳"、"足三里"电针治疗,每日1次,7 d 1个疗程,连续3个疗程。每个疗程结束后以免疫组化法、RT-PCR法分别检测坐骨神经和相应脊髓段(L4-L6)Slit1及其mRNA的表达变化。结果:治疗组Slit1及其mRNA在第1疗程后达到高峰之后逐渐降低,显著高于模型组(P<0.01),且治疗组与模型组始终都显著高于正常组(P<0.01)。结论:电针治疗能明显增强损伤坐骨神经和相应脊髓段(L4-L6)中Slit1及其mRNA的表达,促进周围神经损伤再生修复。
