Impact of interstitial cells of Cajal on slow wave and gallbladder contractility in a guinea pig model of acute cholecystitis

BACKGROUND Impaired interstitial cells of Cajal(ICCs)are central to the pathophysiology of acute cholecystitis(AC).Common bile duct ligation is a common model of AC,producing acute inflammatory changes and decrease in gallbladder contractility.AIM To investigate the origin of slow wave(SW)in the gallbladder and the effect of ICCs on gallbladder contractions during the process of AC.METHODS Methylene blue(MB)with light was used to establish selective impaired ICCs gallbladder tissue.Gallbladder motility was assessed using the frequency of SW and gallbladder muscle contractility in vitro in normal control(NC),AC12h,AC24h,and AC48h groups of guinea pigs.Hematoxylin and eosin and Massonstained gallbladder tissues were scored for inflammatory changes.ICCs pathological changes alterations were estimated using immunohistochemistry and transmission electron microscopy.The alterations of c-Kit,α-SMA,cholecystokinin A receptor(CCKAR),and connexin 43(CX43)were assessed using Western blot.RESULTS Impaired ICCs muscle strips resulted in the decrease in gallbladder SW frequency and contractility.The frequency of SW and gallbladder contractility were significantly lower in the AC12h group.Compared with the NC group,the density and ultrastructure of ICCs were remarkably impaired in the AC groups,especially in the AC12h group.The protein expression levels of c-Kit were significantly decreased in the AC12h group,while CCKAR and CX43 protein expression levels were significantly decreased in the AC48h group.CONCLUSION Loss ICCs could lead to a decrease in gallbladder SW frequency and contractility.The density and ultrastructure of ICCs were clearly impaired in the early stage of AC,while CCKAR and CX43 were significantly reduced at end stage.

Serum neuronal pentraxin 2 is related to cognitive dysfunction and electroencephalogram slow wave/fast wave frequency ratio in epilepsy

BACKGROUND Cognitive dysfunction in epileptic patients is a high-incidence complication.Its mechanism is related to nervous system damage during seizures,but there is no effective diagnostic biomarker.Neuronal pentraxin 2(NPTX2)is thought to play a vital role in neurotransmission and the maintenance of synaptic plasticity.This study explored how serum NPTX2 and electroencephalogram(EEG)slow wave/fast wave frequency ratio relate to cognitive dysfunction in patients with epilepsy.AIM To determine if serum NPTX2 could serve as a potential biomarker for diagnosing cognitive impairment in epilepsy patients.METHODS The participants of this study,conducted from January 2020 to December 2021,comprised 74 epilepsy patients with normal cognitive function(normal group),37 epilepsy patients with cognitive dysfunction[epilepsy patients with cognitive dysfunction(ECD)group]and 30 healthy people(control group).The minimental state examination(MMSE)scale was used to evaluate cognitive function.We determined serum NPTX2 levels using an enzyme-linked immunosorbent kit and calculated the signal value of EEG regions according to the EEG recording.Pearson correlation coefficient was used to analyze the correlation between serum NPTX2 and the MMSE score.RESULTS The serum NPTX2 level in the control group,normal group and ECD group were 240.00±35.06 pg/mL,235.80±38.01 pg/mL and 193.80±42.72 pg/mL,respectively.The MMSE score was lowest in the ECD group among the three,while no significant difference was observed between the control and normal groups.In epilepsy patients with cognitive dysfunction,NPTX2 level had a positive correlation with the MMSE score(r=0.367,P=0.0253)and a negative correlation with epilepsy duration(r=−0.443,P=0.0061)and the EEG slow wave/fast wave frequency ratio value in the temporal region(r=−0.339,P=0.039).CONCLUSION Serum NPTX2 was found to be related to cognitive dysfunction and the EEG slow wave/fast wave frequency ratio in patients with epilepsy.It is thus a potential biomarker for the diagnosis of cognitive impairment in patients with epilepsy.

Comparative research on three types of coaxial slow wave structures

This paper studies three types of coaxial slow wave structures （SWSs）： （1） with ripples on both the inner and outer conductors; （2） with ripples on the outer conductor and smooth on the inner one; and （3） with ripples on the inner conductor and smooth on the outer one. The frequencies, coupling impedances, time growth rates and beam-wave interaction efficiencies of the three types of coaxial SWSs are obtained by theoretical analysis. Moreover, the relativistic Ccrenkov generators （RCGs） with the three types of coaxial SWSs are simulated with a fully electromagnetic particle- in-cell code, and the results verify the theoretical analysis. It is proved that the RCG with double-rippled coaxial SWS has the highest conversion efficiency and the shortest starting time.

The Self-Consistent Nonlinear Theory of Charged Particle Beam Acceleration by Slowed Circularly Polarized Electromagnetic Waves

The relativistic interaction of charged particle beams with a circularly polarized electromagnetic wave propagating along a uniform guiding magnetic field in the tunneling of a dielectric medium is analyzed. The acceleration mechanism and a self-consistent nonlinear theory are presented for the interaction of relativistic charged particle beams with electromagnetic waves. Numerical results show that the beam particle can be efficiently accelerated in the interaction process.

Clinical application and research progress of extracellular slow wave recording in the gastrointestinal tract

The physiological function of the gastrointestinal(GI)tract is based on the slow wave generated and transmitted by the interstitial cells of Cajal.Extracellular myoelectric recording techniques are often used to record the characteristics and propagation of slow wave and analyze the models of slow wave transmission under physiological and pathological conditions to further explore the mechanism of GI dysfunction.This article reviews the application and research progress of electromyography,bioelectromagnetic technology,and high-resolution mapping in animal and clinical experiments,summarizes the clinical application of GI electrical stimulation therapy,and reviews the electrophysiological research in the biliary system.

Acoustic-electromagnetic slow waves in a periodical defective piezoelectric slab

Coupled slow waves, slow acoustic waves, and electromagnetic waves are simultaneously achieved based on a piezoelectric material, in which a line defect is created within a honeycomb lattice array of cylindrical holes etched in a LiNbO3slab. Finite element simulations in frequency domain and time domain demonstrate that a highly localized slow mode is obtained in the defect. Owing to the piezoelectricity of LiNbO3, acoustic and electromagnetic waves are coupled with each other and transmit along the line defect. Therefore, in addition to a slow acoustic wave, an electromagnetic wave with a group velocity even lower than conventional acoustic waves is achieved.

A Comparative Study of Dispersion Characteristics Determination of a Trapezoidally Corrugated Slow Wave Structure Using Different Techniques

The linear dispersion relation of a trapezoidally corrugated slow wave structure （TCSWS） is analyzed and presented. The size parameters of the TCSWS are chosen in such a way that they operate in the x-band frequency range. The dispersion relation is solved by utilizing the Rayleigh-Fourier method by expressing the radial function in terms of the Fourier series. A highly accurate synthetic technique is also applied to determine the complete dispersion characteristics from experimentally measured resonances （cold test）. Periodic structures resonate at specific frequencies when the terminals are shorted numerical calculation, synthetic technique and cold appropriately. The dispersion characteristics obtained from test are compared, and an excellent agreement is achieved.

Frequency Tunability and Slow-Wave Characteristics of a High-Efficiency Ridged MILO

A high-efficiency ridged magnetically insulated transmission line oscillator (RMILO) is proposed and investigated theoretically and numerically in this paper. In the RMILO, ridge-disk vanes are introduced to enhance the power efficiency. Theoretical investigation shows that the ridge-disk can enhance the coupling impedance of the slow-wave structure (SWS), and so enhance the power efficiency. Moreover, the ridge has a weak influence on frequency, so, it influences little on the tunability of the MILO. In simulation, when the applied voltage is increased to 807 kV, the RMILO can get the 3 dB tunable frequency range with 7.6 - 13.9 GHz and the 3 dB tuning bandwidth with 58.6% which has an increase of 27.6% compared with the conventional MILO. So, the tuning performance of the RMILO is more superior. Besides, the RMILO gets the maximum output power of 7.1 GW, the corresponding power efficiency is 22.6% and the frequency is 1.400 GHz. Furthermore, when the applied voltage is increased to 807 kV, high-power microwave with a power of 13.5 GW, frequency of 1.400 GHz, and ef?ciency of 24.5% is generated, which has an increase of 20.2% compared with the conventional MILO. The simulation results con?rm the ones predicted by theoretical analysis.

Electroencephalogram findings in 10 patients with post-stroke epilepsy:A retrospective study

BACKGROUND Post-stroke epilepsy is a common and easily overlooked complication of acute cerebrovascular disease.Long-term seizures can seriously affect the prognosis and quality of life of patients.Electroencephalogram(EEG)is the simplest way to diagnose epilepsy,and plays an important role in predicting seizures and guiding medication.AIM To explore the EEG characteristics of patients with post-stroke epilepsy and improve the detection rate of inter-seizure epileptiform discharges.METHODS From January 2017 to June 2020,10 patients with post-stroke epilepsy in our hospital were included.The clinical,imaging,and EEG characteristics were collected.The stroke location,seizure type,and ictal and interictal EEG manifestations of the patients with post-stroke epilepsy were then retrospectively analyzed.RESULTS In all 10 patients,epileptiform waves occurred in the side opposite to the stroke lesion during the interictal stage;these manifested as sharp wave,sharp-wave complex,or spike discharges in the anterior head lead of the side opposite to the lesion.CONCLUSION In EEG,epileptiform waves can occur in the side opposite to the stroke lesion in patients with post-stroke epilepsy.

A staggered double vane circuit for a W-band traveling-wave tube amplifier

Based on the combination of a staggered double vane slow wave structure （SWS） and round electron beam, a 200-W W-band traveling-wave tube （TWT） amplifier is studied in this paper. The main advantages of round beam operation over the sheet beam is that the round beam can be formed more easily and the focus requirement can be dramatically reduced. It operates in the fundamental mode at the first spatial harmonic. The geometric parameters are optimized and a transition structure for the slow wave circuit is designed which can well match the signal that enters into and goes out from the tube. Then a TWT model is established and the particle-in-cell （PIC） simulation results show that the tube can provide over 200-W output power in a frequency range of 88 GHz-103 GHz with a maximum power of 289 W at 95 GHz, on the assumption that the input power is 0.1 W and the beam power is 5.155 kW. The corresponding conversion efficiency and gain at 95 GHz are expected to be 5.6% and 34.6 dB, respectively. Such amplifiers can potentially be used in high power microwave-power-modules （MPM） and for other portable applications.

Analysis on Motion and Cable Dynamic Tension for An ALT-Tanker System

A two-degree freedom model for an ALT-tanker system is established corresponding to the pitch of the ALT and the surge of the tanker.Tension in the mooring cable between the ALT and the tanker is represented by an unsymmetrical,piecewise-nonlinear function.Wave load on the tower is evaluated by use of the Morison equation.The first order wave load acting on the tanker is calculated by the linear diffraction theory based on the 2-D Helmholtz equation,and the near field approach of Pinkster is used to evaluate the second order drift force.The dynamic equation of motion is established based on the principle of D＇lembert.Dynamic response and cable tension of a mooring system composed of an 88.4 m ALT and a 100000 t grade tanker are calculated.The influence of wave frequency,wave excitation amplitude,wind and current force on ALT-tanker motion and cable tension is discussed.

1.03THz折叠波导慢波结构及电子光学系统研究

太赫兹真空电子器件成为未来主要的发展方向,本文对1.03 THz折叠波导慢波结构及电子光学系统进行了研究,分析了不同电子注通道形状对于折叠波导特性的影响,包括色散特性、耦合阻抗、衰减特性、功率、增益等,并且利用OPERA 3D软件设计了电子光学系统。仿真结果表明,在中心1.03 THz频率处,与矩形电子注通道折叠波导慢波结构相比,圆形电子注通道的结构色散曲线更为平缓,耦合阻抗提升6.9%,损耗降低6.8%;在10 GHz带宽内功率提升47.4%,增益提升1.2 dB,互作用长度缩短12.3%。在工作电压为17.4 kV时,阴极发射电流大于3 mA,电子注半径为0.012 mm,在均匀区永磁聚焦系统中可稳定传输。

矩形栅慢波系统的高频特性分析

对于矩形栅这一经典的慢波结构,采用场匹配法来分析其慢波特性,进而得到其耦合阻抗。其中对槽区内的场处理,保留其高次项,表示为一无限本征驻波之和的形式。然后通过数值实例具体分析了矩形栅的两种典型结构:浅槽栅和深槽栅。当增大槽深后,色散增强,系统通带变窄,同时耦合阻抗有明显增大,工作点移向前向波区,适合用在放大器的慢波结构上。

曲折圆形槽波导慢波系统的高频特性

对曲折圆形槽波导新型慢波系统的高频特性进行了研究,通过理论分析和数值计算,得到了它的色散曲线和耦合阻抗表达式,并分析了结构参数变化对色散特性和耦合阻抗的影响。研究表明:当周期变小时色散减弱,耦合阻抗增加;而增大直波导长度时色散变弱,但同时耦合阻抗也会下降。因此较小的周期有利于改善曲折圆形槽波导慢波电路的高频特性。鉴于这种电路的耦合阻抗较低,可以适当地减小直波导长度来提高耦合阻抗。曲折槽波导结合了曲折波导散热能力强、色散特性好、容易加工和槽波导单模工作、低损耗、大尺寸等优点,在毫米波及亚毫米波段的行波管中具有较好的发展前景。

矩形栅慢波系统的理论与实验研究

为了克服单模近似法在分析矩形栅慢波系统高频特性时的局限性,采用了一种新的方法,即在表示槽区内的场时,保留其高次项,表为一无限本征驻波之和的形式,利用场匹配法得到其色散特性,进而求得耦合阻抗。然后针对矩形栅慢波系统进行了数值计算,并分析了金属栅的几何尺寸对系统高频特性的影响,以作为器件设计的参考。设计出3cm、8mm波段的矩形栅高频结构模型,进行实验测量,得到的实验值与理论值符合良好。

波在磁化周期等离子体中的传播特性

电磁波与等离子体之间存在极为丰富的相互作用现象,对电磁波的传播构成重大影响。该文研究了在磁场指导下,对电磁波在密度周期变化的磁化等离子体中的传播特性,进行了理论分析并导出色散方程,通过数值计算分析了等离子体密度变化分别对电磁波传播特性的影响。计算结果表明密度n1变化对左、右旋波的截止频率影响不大,而n0的变化对左旋波的截止频率影响大,对右旋波的通带宽度影响大。并发现密度周期变化磁化等离子体构成一周期慢波系统,在该系统中明显出现慢波,这可能对注波互作用产生重大影响。

大功率太赫兹返波管的数值模拟研究

为了提升传统超高频小功率返波管的工作频率和输出功率,提出了一种过模表面波太赫兹返波管的紧凑结构.其中,慢波系统是在一段过模圆柱波导内壁沿圆周方向平行挖去若干个均匀环形槽构成的,相邻槽间距固定不变.该结构较之传统的单模结构能有效地降低管内电场强度、避免场击穿,提高系统在太赫兹频段的功率容量.采用数值模拟的方法对该慢波系统的结构参数进行了筛选,最终选取波导内半径为2 mm、槽深为0.2 mm、槽宽为0.6 mm、单周期长度为1 mm,共采用17个周期.利用2.5维粒子模拟程序对系统进行了热测实验,在电子注电压为550 kV、电子注电流为350 A的条件下,模拟得到了14.4 MW的峰值功率输出,其能量转换效率达到7.5%,振荡频率高于0.14 THz,时域波形及频谱特性良好.

新型反绕双螺旋线慢波系统的分析与设计

基于降低工艺难度的目的,提出了一种新型反绕双螺旋线慢波系统,该系统的正绕反绕螺旋线半径不等。利用3维电磁软件CST MWS仿真分析了结构参数对色散和耦合阻抗的影响。结果表明:耦合阻抗在螺旋带内半径较大时没有明显下降;减小螺旋带宽度有利于降低相速度和提高耦合阻抗;在一定范围内,相速度随螺距的减小而增大。在此基础上,结合工程要求设计了8 mm波段行波管的新型反绕双螺旋线慢波系统,耦合阻抗达到21Ω,工作电压约为20 kV,同时由于电子通道半径较大,降低了对电子光学系统的要求;纵向翼片加载的引进较为有效地展宽了带宽。

脉冲空间行波管的研制

脉冲空间行波管主要用于环境卫星、微波遥感卫星、海洋卫星等军民用卫星系统,本文主要介绍了中国科学院电子学研究所脉冲空间行波管的研制进展,包括栅控电子枪、双渐变慢波系统、高匹配性能输能结构、多级降压收集极的设计方案、样管测试结果及环境试验情况等。