Myeloid sarcoma as a differential diagnosis of small bowel obstruction

We are presenting the case of a 42-year-old ?male patient, who was hospitalized due to an acute small bowel obstruction caused by a tissue mass of the mesentery. The patient reported that he had a history of a testicular tumour. For therapy of intestinal obstruction as well as for diagnostic reasons we decided to perform ?an explorative laparotomy. On histopathological examination the immunohistological staining was positive for myeloperoxidase (MPO) and KP-1 (CD68). Staining was slightly positive for Bcl-2, CD117, CD34, but negative for CD3, CD4, CD5, CD8, CD20, CD30, CD79, Bcl-6 and S-100. This leads to the diagnosis of a myeloid sarcoma. After recovery from surgery and chemotherapy, allogenic bone marrow transplantation was performed. Most intestinal obstructions are caused by postoperative adhesions or hernias and only in rare cases caused by a myeloid sarcoma.

Huge peripheral primitive neuroectodermal tumor of the small bowel mesentery at nonage:A case report and review of the literature

Extraskeletal Ewing's sarcoma/peripheral primitive neuroectodermal tumor(E-EWS/pP NET) is a rare aggressive malignant small round cell tumor. In this report, we present the case of a 15-year-old boy who suffered from acute abdominal pain accompanied by hematemesis and melena, and was eventually diagnosed with E-EWS/p PNET. To date, there have been only five reported cases of E-EWS/pP NET of the small bowel including the patient in this report. To the best of our knowledge, this is the first documentation of a pP NET of the small bowel mesentery at nonage. All these have made this report rare and significant.

Fibroblastic reticular cell sarcoma of the small intestine:a very rare case report and clinicopathological diagnosis

A 54-year-old man was admitted for the evaluation of fever and abodominal pain. Radiological and endoscopic examination revealed a lung nodule and multiple small intestine uclers. Clinical diagnosis such as tuberculosis and Crohn's disease had been proposed. He developed intestine perforation after small bowel endoscopic procedure. During emergent surgery the involved intestinal segments were resected and a pathological diagnosis of fibroblastic histiocytic sarcoma(FBRC) was made. The patient died in the sixth month after the operation. The management of this cases highlighted the drawback of pattern recognition as the most commonly used clinical reasoning method, and the importance of histological investigation.

以CD56^+小肠粒细胞肉瘤为首发表现的急性单核细胞白血病1例并文献复习

目的探讨粒细胞肉瘤的发病机制、诊治与转归。方法分析1例以CD56+小肠粒细胞肉瘤为首发表现的急性单核细胞白血病患者的临床病理特征及实验室检查结果,并复习相关文献。结果收治1例男性患者,39岁。小肠系膜切除物免疫组化检测示:粒细胞肉瘤,CD56阳性;骨髓细胞学检查示:急性单核细胞白血病,诊断为急性单核细胞白血病伴小肠粒细胞肉瘤。经IA方案诱导化疗后疾病达完全缓解,继续IA方案巩固化疗,拟行异基因造血干细胞移植。结论以小肠粒细胞肉瘤为首发表现的急性白血病较为少见。粒细胞肉瘤的预后差,CD56抗原阳性提示预后不良,经诱导化疗获疾病缓解的患者应尽快行异基因造血干细胞移植以期达到长期生存。

Peripheral Primary Neuroectodermal Tumour of the Ileum: A Case Report and Review of the Literature

Background: Ewing’s Sarcoma (ES)/peripheral Primitive Neuroectodermal Tumor (pPNET) is a rare aggressive malignant small round cell tumour. Most of them arise in bony sites, and they represent the second commonest primary osseous malignancy in adolescence and young adults. The localization of the small bowel is very rare, to our knowledge only 35 cases of ES/pPNET of the small bowel have been reported in the literature. Case Presentation: We report a case of pPNET of the ileum in a 26-year-old female, presented abdominal pain with a transit disorder. The clinical examination was unremarkable. The histological and immunohistochemical study confirmed the diagnosis of peripheral primary neuroectodermal tumours. The patient was treated by tumor resection followed by adjuvant chemotherapy. The evolution was good, without recurrence with a follow-up of 12 months. Conclusion: PNET of the ileum is very rare. We report this case to enrich the database of this rare clinical entity and to improve the management of patients with PNET of the ileum.