The intermolecular clusters of sulfur dioxide with water, SO2（H2O）n （n = 2～5）, are studied by using B3LYP density functional theory and MP2 ab initio methods along with the large basis sets （6-311＋＋G（d,p） an...The intermolecular clusters of sulfur dioxide with water, SO2（H2O）n （n = 2～5）, are studied by using B3LYP density functional theory and MP2 ab initio methods along with the large basis sets （6-311＋＋G（d,p） and aug-cc-pVDZ）. The equilibrium geometries, intermolecular binding energies, and anharmonic frequencies of the clusters are calculated and compared with those of pure water clusters and available experiments. SO2 tends to form cyclic hydrogen-bonded complexes with two or three water molecules. In the larger clusters, however, water molecules begin to retain the structure of pure water clusters and segregate from SO2. Infrared absorption assignments for the small clusters are discussed to resolve a possible incorrect assignment in a recent spectroscopic experiment on the clusters.展开更多
Intractable Still’s disease, namely the intractable systemic juvenile idiopathic arthritis (JIA) is a clinical difficulty of pediatrics, and so far there still lacks any special treatment. In virtue of the markedly a...Intractable Still’s disease, namely the intractable systemic juvenile idiopathic arthritis (JIA) is a clinical difficulty of pediatrics, and so far there still lacks any special treatment. In virtue of the markedly anti-inflammatory and immunosuppres-sive effects of tripterygium glycosides (TG, product of Huangshi Pharmaceutical Factory, 10 mg/展开更多
Background：In small fiber neuropathy （SFN）,thinly myelinated Aδ and unmyelinated C fibers are primarily affected,resulting in sensory and/or autonomic symptoms.Various etiologies have been shown to be associated w...Background：In small fiber neuropathy （SFN）,thinly myelinated Aδ and unmyelinated C fibers are primarily affected,resulting in sensory and/or autonomic symptoms.Various etiologies have been shown to be associated with SFN.This study was aimed to analyze a variety of features in peripheral neuropathy （PN） with small fiber involvement.and to compare disease severity among patients with idiopathic PN,PN associated with impaired glucose tolerance （IGT）,and metabolic syndrome （MS） PN.Methods：Thirty-eight PN patients with small fiber involvement were enrolled from December 20,2013 to May 31,2016.Patients were divided into idiopathic PN,IGT-related PN,and MS-related PN groups.Detailed medical history and small fiber neuropathy were investigated,and symptom inventory questionnaire was conducted,as well as the visual analog scale.Nerve conduction studies and skin biopsies were also performed.The differences among the groups were analyzed using analysis of variance and Kruskal-Wallis test.Results：Eight patients were diagnosed with pure SFN.lntraepidermal nerve fiber density （I ENFD） weakly correlated with motor conduction velocity （MCV） （r =0.372,P =0.025）,and proximal （r =0.383,P =0.021） and distal （r =0.358,P 0.032） compound muscle action potential （CMAP） of the tibial nerve.IENFD also weakly correlated with MCV of the peroneal nerve （r=0.399,P =0.016）.IENFD was shown to be significantly different among all groups （x2 =9.901,P-0.007）.IENFD was significantly decreased （x2 =23.000,P=0.003） in the MS-related PN group compared to the idiopathic PN group.The MCV of the tibial nerve was significantly different among all groups （x2 =8.172,P 〈 0.017）.The proximal （F =4.336,P =0.021） and distal （F =3.262,P =0.049） CMAP of the tibial nerve was also significantly different among all groups.Conclusions：IENFD of patients included in the present study weakly correlated with various electrophysiological parameters.Small and large fibers are more involved in patients with MS-related PN than in patients with idiopathic PN.展开更多
基金supported by the National Natural Science Foundation of China (20528706)the China Postdoctoral Science Foundation (20090450385)
文摘The intermolecular clusters of sulfur dioxide with water, SO2（H2O）n （n = 2～5）, are studied by using B3LYP density functional theory and MP2 ab initio methods along with the large basis sets （6-311＋＋G（d,p） and aug-cc-pVDZ）. The equilibrium geometries, intermolecular binding energies, and anharmonic frequencies of the clusters are calculated and compared with those of pure water clusters and available experiments. SO2 tends to form cyclic hydrogen-bonded complexes with two or three water molecules. In the larger clusters, however, water molecules begin to retain the structure of pure water clusters and segregate from SO2. Infrared absorption assignments for the small clusters are discussed to resolve a possible incorrect assignment in a recent spectroscopic experiment on the clusters.
文摘Intractable Still’s disease, namely the intractable systemic juvenile idiopathic arthritis (JIA) is a clinical difficulty of pediatrics, and so far there still lacks any special treatment. In virtue of the markedly anti-inflammatory and immunosuppres-sive effects of tripterygium glycosides (TG, product of Huangshi Pharmaceutical Factory, 10 mg/
文摘Background：In small fiber neuropathy （SFN）,thinly myelinated Aδ and unmyelinated C fibers are primarily affected,resulting in sensory and/or autonomic symptoms.Various etiologies have been shown to be associated with SFN.This study was aimed to analyze a variety of features in peripheral neuropathy （PN） with small fiber involvement.and to compare disease severity among patients with idiopathic PN,PN associated with impaired glucose tolerance （IGT）,and metabolic syndrome （MS） PN.Methods：Thirty-eight PN patients with small fiber involvement were enrolled from December 20,2013 to May 31,2016.Patients were divided into idiopathic PN,IGT-related PN,and MS-related PN groups.Detailed medical history and small fiber neuropathy were investigated,and symptom inventory questionnaire was conducted,as well as the visual analog scale.Nerve conduction studies and skin biopsies were also performed.The differences among the groups were analyzed using analysis of variance and Kruskal-Wallis test.Results：Eight patients were diagnosed with pure SFN.lntraepidermal nerve fiber density （I ENFD） weakly correlated with motor conduction velocity （MCV） （r =0.372,P =0.025）,and proximal （r =0.383,P =0.021） and distal （r =0.358,P 0.032） compound muscle action potential （CMAP） of the tibial nerve.IENFD also weakly correlated with MCV of the peroneal nerve （r=0.399,P =0.016）.IENFD was shown to be significantly different among all groups （x2 =9.901,P-0.007）.IENFD was significantly decreased （x2 =23.000,P=0.003） in the MS-related PN group compared to the idiopathic PN group.The MCV of the tibial nerve was significantly different among all groups （x2 =8.172,P 〈 0.017）.The proximal （F =4.336,P =0.021） and distal （F =3.262,P =0.049） CMAP of the tibial nerve was also significantly different among all groups.Conclusions：IENFD of patients included in the present study weakly correlated with various electrophysiological parameters.Small and large fibers are more involved in patients with MS-related PN than in patients with idiopathic PN.
