Mid-term outcomes of microfragmented adipose tissue plus arthroscopic surgery for knee osteoarthritis:A randomized,activecontrol,multicenter clinical trial

BACKGROUND Osteoarthritis(OA)is the most prevalent form of degenerative whole-joint disease.Before the final option of knee replacement,arthroscopic surgery was the most widely used joint-preserving surgical treatment.Emerging regenerative therapies,such as those involving platelet-rich plasma,mesenchymal stem cells,and microfragmented adipose tissue(MFAT),have been pushed to the forefront of treatment to prevent the progression of OA.Currently,MFAT has been successfully applied to treat different types of orthopedic diseases.AIM To assess the efficacy and safety of MFAT with arthroscopic surgery in patients with knee OA(KOA).METHODS A randomized,multicenter study was conducted between June 2017 and November 2022 in 10 hospitals in Zhejiang,China.Overall,302 patients diagnosed with KOA(Kellgren-Lawrence grades 2-3)were randomized to the MFAT group(n=151,were administered MFAT following arthroscopic surgery),or the control group(n=151,were administered hyaluronic acid following arthroscopic surgery).The study outcomes were changes in the Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)score,the visual analog scale(VAS)score,the Lequesne index score,the Whole-Organ Magnetic Resonance Imaging Score(WORMS),and safety over a 24-mo period from baseline.RESULTS The changes in the WOMAC score(including the three subscale scores),VAS pain score,and Lequesne index score at the 24-mo mark were significantly different in the MFAT and control groups,as well as when comparing values at the posttreatment visit and those at baseline(P<0.001).The MFAT group consistently demonstrated significant decreases in the WOMAC pain scores and VAS scores at all follow-ups compared to the control group(P<0.05).Furthermore,the WOMAC stiffness score,WOMAC function score,and Lequesne index score differed significantly between the groups at 12 and 24 mo(P<0.05).However,no signicant between-group differences were observed in the WORMS at 24 mo(P=0.367).No serious adverse events occurred in both groups.CONCLUSION The MFAT injection combined with arthroscopic surgery treatment group showed better mid-term clinical outcomes compared to the control group,suggesting its efficacy as a therapeutic approach for patients with KOA.

Application of Tranexamic Acid in Shoulder Arthroscopic Surgery:A Randomised Controlled Trial

Objective To explore the optimal administration route of tranexamic acid(TXA)in shoulder arthroscopic surgery.Methods Patients undergoing arthroscopic rotator cuff repair were randomly divided into four groups:control group(without TXA treatment),intravenous group(TXA was intravenously administered 10 minutes before surgery),irrigation group(TXA was added to the irrigation fluid during subacromial decompression and acromioplasty),and intravenous plus irrigation group(TXA was applied both intravenously and via intra-articular irrigation).The primary outcome was visual clarity assessed with visual analog scale(VAS)score,and the secondary outcomes included irrigation fluid consumption and time to subacromial decompression and acromioplasty procedure.Results There were 134 patients enrolled in the study,including 33 in the control group,35 in the intravenous group,32 in the irrigation group,and 34 in the intravenous plus irrigation group.The median and interquartile range of VAS scores for the intravenous,irrigation,and intravenous plus irrigation groups were 2.70(2.50,2.86)(Z=-3.677,P=0.002),2.67(2.50,2.77)(Z=-3.058,P<0.001),and 2.91(2.75,3.00)(Z=-6.634,P<0.001),respectively,significantly higher than that of the control group[2.44(2.37,2.53)].Moreover,the control group consumed more irrigation fluid than the intravenous group,irrigation group,and intravenous plus irrigation group(all P<0.05).The intravenous plus irrigation group consumed less irrigation fluid than either the intravenous group or the irrigation group(both P<0.001).There was no difference in subacromial decompression and acromioplasty operative time among the four groups.Conclusion TXA applied both topically and systematically can improve intraoperative visual clarity,and the combined application is more effective.

Cataract surgery in aged patients:phacoemul-sification or small-incision extracapsular cataract surgery

AIM: To evaluate the effects and safety of phacoemulsification (Phaco) or small-incision extracapsular cataract surgery (SICS) and intraocular lens (IOL) implantation for aged patients. METHODS: Totally 137 aged patients (149 eyes) underwent cataract operation in the case of stable systemic condition, the blood pressure less than 160/95mmHg, blood glucose less than 8mmol/L, and under the help of electrocardiogram surveillance by anesthesiologists during the operation. 106 aged patients (114 eyes) underwent Phaco while 31 aged patients (35 eyes) underwent SICS. The postoperative visual acuity, corneal endothelial cell loss, surgery time and major complications were observed and analyzed retrospectively. RESULTS: The best-corrected visual acuity (BCVA) of >= 0.6 was achieved in 135 eyes (92.6%) at 1 month postoperatively (chi(2)=259.730, P<0.001). For aged patients, both Phaco and SICS could significantly improve visual acuity with no significant difference (chi(2)=4.535, P > 0.05). Postoperative corneal endothelial cell loss was 18.6%, in PHACO group, the rate was 18.5%; in SICS group, the rate was 19.0%, the difference of which was no significant (chi(2)=0.102, P>0.05). The surgery time was different in two groups. No severe complications occurred. CONCLUSION: Both Phaco and SICS combined with IOL implantation for aged patients are effective and safe. Before surgery, detailed physical examination should be performed. When the systemic condition is stable, cataract surgery for aged patients is safe.

Analgesic effects of low -dose trama dol after arthroscopic knee surgery

Objective To investigate analgesic effect of i ntra -articular low -dose tramadol a fter arthroscopic knee surgery.Methods60patients undergoing arthroscopic k nee surgery under lumbar anesthesia were randomly divided into intra -ar ticular injection of tramadol(TJ group),mulscle injection of tramadol(TM)and saline control group.Vision analog scoring was conducted under exte nsion of knee joint 8h and24h after drugs administration.Follow -up was done to observe unwanted e ffects 48h after surgery.Results Score of TJ group was significantly lower than those of other groups(P <0.05).No unwanted effects were found.Conclusion Intra -articular tramadol in low -dose could relieve operative pain.

Visual outcome of manual small-incision cataract surgery:comparison of modified Blumenthal and Ruit techniques

AIM:To compare the efficacy and visual results of the modified Blumenthal and Ruit techniques for manual small-incision cataract surgery(MSICS).· METHODS:This was a prospective,non-randomized comparison of 129 patients with senile cataracts scheduled to undergo routine cataract surgery via either a superior scleral tunnel incision,i.e.,the Blumenthal technique(group 1,n = 64) or a temporal scleral tunnel incision,i.e.,the Ruit technique(group 2,n =65).MSICS and intraocular lens implantation were performed through an unsutured 6.5-to 7.0-mm scleral tunnel incision.Uncorrected and corrected visual acuity,intraoperative and postoperative complications,and surgically induced astigmatism calculated by simple subtraction were compared.Patients were examined at 1 day,1 week,1 month,and 3 months after surgery.· RESULTS:Both groups achieved good visual outcome with minor complications.Three months after surgery,the corrected visual acuity was 0.73 in the Blumenthal group and 0.69 in the Ruit group(P =0.29).The average(SD) postoperative astigmatism was 0.87(0.62) diopter(D) for the Blumenthal group and 0.86(0.62) D for the Ruit group.The mean(SD) surgically induced astigmatism was 0.55(0.45) D and 0.50(0.44) D for the Blumenthal and Ruit groups,respectively(P =0.52).Common complications were minimal hyphema and corneal edema.There was no statistically significant difference in the complication rate between the groups(P >0.05).· CONCLUSION:In MSICS,both the Blumenthal and Ruit techniques achieved good visual outcomes,with low complication rates.

Arthroscopic surgery for synovial chondroma of the subacromial bursa with non-traumatic shoulder subluxation complications:Two case reports

BACKGROUND Synovial chondromatosis is a disease originating from the synovium and characterized by the presence of metaplastic cartilaginous nodules in synovial cavities.The exact prevalence of synovial chondromatosis remains unknown,and the involvement of the shoulder joint is very rare.Synovial chondromatosis accompanied by subluxation of the humeral head without a history of trauma is rarely encountered,and to our knowledge,no published reports describe this condition.CASE SUMMARY We present two cases of synovial chondromatosis in the shoulder joint,accompanied by subluxation of the humeral head,in two arthroscopically managed adult patients.We performed arthroscopic labrum fixation and removal of the loose body from the shoulder joint.To identify primary and secondary categories,pathological analysis was arranged.Clinical and radiographic evaluations at the 1-mo follow-up were satisfactory.CONCLUSION The biomechanical function of the shoulder joint requires attention,especially following the detection of loose bodies,as observed with synovial chondroma occurring in rare sites.Arthroscopic management is successful in patients with synovial chondromatosis combined with shoulder subluxation.

Incidence and risk factors for vitreous loss in residents performing manual small-incision cataract surgery

AIM: To assess the incidence of vitreous loss and associated risk factors in residents performing manual small-incision cataract surgery(MSICS). METHODS: The present retrospective record review study was performed on 490 patients who underwent MSICS performed between November 2018 and December 2019 by 7 third-year postgraduate residents. The study group comprised of patients having intraoperative vitreous prolapse. All the surgeries were performed under supervision of a trained assistant. RESULTS: The mean age of the participants at the time of surgery was 68.42±2.05 y. Of the 490 patients, 250 patients were male, and 240 patients were female(P=0.23). A total of 215(43.9%) eyes had mature white cataract, 185(37.8%) eyes had brown cataract, and 90(18.3%) eyes had immature senile cataract. The incidence of intraoperative vitreous loss among residents was 2%(10/490). Vitreous loss occurred during hydrodissection [1/10(10%)], nucleus delivery [3/10(30%)], irrigation and aspiration [5/10(50%)], and intraocular lens insertion [1/10(10%)]. Multivariate stepwise Logistic regression analysis confirmed immature senile cataract [odds ratio(OR)=3.99;P=0.02], irrigation and aspiration of cortical material(OR=3.07;P=0.03), and anterior capsular extension(OR=3.22, P=0.03) as independent risk factors for vitreous loss. CONCLUSION: Immature senile cataract, irrigation and aspiration of cortical material, and anterior capsular extension are independent risk factors for vitreous loss. Our findings may serve as a guide for future trainers or residents learning MSICS.

Arthroscopic approach to the posterior compartment of the knee using a posterior transseptal portal

Arthroscopic surgery of the posterior compartment ofthe knee is difficult when only two anterior portals are used for access because of the inaccessibility of the back of the knee. Since its introduction, the posterior transseptal portal has been widely employed to access lesions in the posterior compartment. However, special care should be taken to avoid neurovascular injuries around the posteromedial, posterolateral, and transseptal portals. Most importantly, popliteal vessel injury should be avoided when creating and using the transseptal portal during surgery. Purpose of the present study is to describe how to avoid the neurovascular injuries during establishing the posterior three portals and to introduce our safer technique to create the transseptal portal. To date, we have performed arthroscopic surgeries via the transseptal portal in the posterior compartments of 161 knees and have not encountered nerve or vascular injury. In our procedure, the posterior septum is perforated with a 1.5-3.0-mm Kirschner wire that is protected by a sheath inserted from the posterolateral portal and monitored from the posteromedial portal to avoid popliteal vessel injury.

Effects of different positions on rehabilitation after rotator cuff repair under shoulder arthroscopy

Objective Shoulder arthroscopic rotator cuff tear repair is currently the main treatment for full-thickness rotator cuff tears,and postoperative rehabilitation training is essential.However,pain and limitation of activity during the rehabilitation process will lead to poor results.Hence,identifying rehabilitation approaches is crucial.This study aimed to compare patient's rehabilitation outcomes and experience between rehabilitation in the supine position and in the standing position.Methods This prospective study included patients diagnosed with full-thickness rotator cuff tears who underwent shoulder arthroscopic double-row rivet repair at Sir Run Run Shaw Hospital,Zhejiang University School of Medicine from March 2019 to September 2021.The patients were randomly assigned to the standing rehabilitation exercise group(group A)and the supine rehabilitation exercise group(group B).All patients were followed up for 6 months to record and compare the visual analog scale(VAS)scores,shoulder range of motion,and rehabilitation compliance.Results Altogether,86 patients participated in the study,of whom 79 patients completed the 6-month follow-up.Groups A and B had 39 and 40 patients,respectively.Before operation,the VAS score,forward flexion and extension angle,and abduction angle were comparable between groups A and B.After operation,the patients in groups A and B all experienced a significant improvement in the VAS score,forward flexion and extension angle,and abduction angle(p<0.05).In addition,patients in group B had better VAS score(4.58±0.87 vs.5.21±1.13,p=0.0068;2.15±0.66 vs.2.51±0.51,p=0.0078;0.78±0.86 vs.1.33±0.81,p=0.0015),forward flexion and extension angle(109.30±2.87°vs.102.33±3.74°,p=0.0001;109.53±3.39°vs.104.18±2.76°,p=0.0001;125.22±6.05°vs.117.59±2.27°,p=0.0001),and abduction angle(91.78±2.77°vs.82.92±2.12°,p=0.0001;91.62±2.78°vs.82.82±1.45°,p=0.0001;109.48±3.37°vs.100.10±2.94°,p=0.0001)at 2 wk,6 wk and 6 m postoperatively.Conclusion After 6 months of follow-up,the patients who performed rehabilitation exercises in the supine position achieved better rehabilitation outcomes than those who performed rehabilitation exercises while standing.

不同性别对日间关节镜手术患者瑞马唑仑使用剂量及术后恢复质量的影响

目的 探讨性别对日间关节镜手术患者瑞马唑仑使用剂量以及术后24 h恢复质量(QoR)的影响。方法 选择预约在日间手术中心进行关节镜半月板修复术的患者50例,按照性别分为两组,其中男25例(M组),女25例(F组)。本研究主要观察两组在麻醉诱导失去意识和术中维持瑞马唑仑剂量的区别,以及采用QoR-15量表、阿森斯失眠(AIS)量表观察性别对术后睡眠和24 h恢复质量的影响。结果M组患者失去意识时瑞马唑仑剂量为0.14(0.13,0.15) mg/kg,麻醉维持剂量为0.80(0.60,0.96)mg/(kg·h);F组患者失去意识时瑞马唑仑剂量为0.14(0.12,0.16) mg/kg,麻醉维持剂量为0.90(0.79,1.12)mg/(kg·h),两组患者失去意识与麻醉维持的瑞马唑仑剂量差异均无统计学意义(P> 0.05)。两组对术后第1天睡眠的AIS总分影响差异无统计学意义(P> 0.05),但女性患者较男性患者更易发生低血压和PONV,术后比期望中更早醒及QoR-15总分、生理舒适度分数降低,差异有统计学意义(P <0.05)。结论 性别对日间关节镜患者瑞马唑仑麻醉诱导剂量及麻醉维持剂量影响较小,但女性患者术后睡眠清醒时间更早,男性患者术后24 h恢复质量较高。

透明质酸钠关节腔内注射联合关节镜手术治疗水平撕裂型半月板损伤的效果

目的分析透明质酸钠关节腔内注射联合关节镜手术治疗水平撕裂型半月板损伤的效果。方法选择2020年1月至2021年12月南京市溧水区人民医院收治的72例水平撕裂型半月板损伤患者,按照随机数字表法将其分为对照组(36例)与研究组(36例)。对照组接受关节镜手术治疗,研究组在对照组的基础上采用透明质酸钠关节腔内注射,持续治疗5周。比较两组治疗前后膝关节Lysholm评分、国际膝关节评分委员会(IKDC)评分;比较两组临床疗效;比较两组治疗前后膝关节活动度;比较两组治疗前后血清白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平;记录两组治疗过程中并发症的发生情况。结果治疗后,两组Lysholm评分、IKDC评分、膝关节活动度高于治疗前,且研究组高于对照组(P<0.05)。研究组临床疗效优于对照组(P<0.05)。治疗后两组IL-1β、TNF-α水平低于治疗前,且研究组低于对照组(P<0.05)。两组并发症总发生率比较,差异无统计学意义(P>0.05)。结论透明质酸钠关节腔内注射联合关节镜手术治疗水平撕裂型半月板损伤效果显著,可减轻炎症反应,改善膝关节活动度与膝关节功能,且安全性良好。

全肩关节镜和关节镜辅助小切口手术治疗肩袖损伤的对比研究

目的探讨应用全肩关节镜手术与关节镜辅助下小切口手术治疗肩袖损伤的疗效差异及对术后关节功能的影响。方法选取2020年1月~2022年12月收治的肩袖损伤并接受手术治疗的患者93例,随机分A组和B组,A组47例、B组46例。A组接受关节镜辅助下小切口手术,B组接受全肩关节镜手术。比较两组手术失血量、手术用时、住院用时、视觉模拟疼痛评分(VAS)、美国加州大学肩关节功能评分(UCLA)及整体疗效差异。结果术前两组VAS评分、UCLA评分比较,差异无统计学意义(P>0.05),术后1月、3月、6月B组各时间点VAS评分均低于A组(P<0.05),B组UCLA评分均高于A组(P<0.05);B组手术失血量、住院时间少于A组,手术用时高于A组(P<0.05);两组治疗总优良率比较,差异无统计学意义(P>0.05)。结论两种手术整体疗效相近;关节镜下小切口手术创伤性低,手术用时短;全肩关节镜手术失血量少、住院用时短,且术后疼痛与关节功能恢复效率更高。

手术沙滩椅体位摆置标准作业程序的建立及应用

目的研究手术沙滩椅体位(beach chair position,BCP)摆置标准作业程序(standard operation procedure,SOP)的建立及应用。方法采用方便抽样的方法,选取2020年10—12月厦门大学附属第一医院收治的16例肩关节镜手术患者为对照组,以对等原则选取2021年1—3月收治的16例患者为观察组。对照组按常规手术体位摆置;观察组按BCP摆置SOP实施摆置。比较2组摆置时间、团队协作熟悉度及医生满意度,并就对手术BCP摆置SOP进行评价。结果观察组手术体位摆置时间为(471.81±52.41)s,短于对照组的(719.13±66.94)s(P<0.05);观察组手术医生的满意度高于对照组,手术团队协作熟悉度评分高于对照组,差异有统计学意义(P<0.05)。2组麻醉医生满意度比较,差异无统计学意义(P>0.05)。团队成员对手术BCP摆置SOP评价认可度均较高。结论手术BCP摆置SOP的建立及应用使手术体位护理规范化、标准化、同质化,有效提高手术室护理质量和工作效率。

温针灸联合关节镜微创手术治疗膝骨关节炎的临床研究

目的:探讨温针灸联合关节镜微创手术治疗膝骨关节炎(knee osteoarthritis,KOA)的临床效果。方法:选取2022年1—10月马鞍山市人民医院收治的60例膝骨关节炎患者为研究对象,根据治疗方式分为两组,其中治疗组30例,应用温针灸联合关节镜微创手术治疗,对照组30例,应用单纯关节镜微创手术治疗。对比两组Lequesne疗效、Lysholm膝关节评分、美国西安大略和麦克马斯特大学骨关节炎指数(Western Ontario and McMaster University osteoarthritis index,WOMAC)功能评分。结果:治疗后,治疗组患者总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗前,两组Lysholm膝关节功能评分比较,差异无统计学意义(P>0.05);治疗后3个月、6个月,治疗组Lysholm膝关节功能评分显著高于对照组,差异有统计学意义(P<0.05)。治疗前,两组WOMAC评分比较,差异无统计学意义(P>0.05);治疗后3个月、6个月,治疗组WOMAC评分显著低于对照组,差异有统计学意义(P<0.05)。结论:温针灸联合关节镜微创手术治疗KOA较单纯关节镜微创手术效果更好。

脑电双频指数监测下腋路臂丛神经阻滞复合全身麻醉在肩关节镜手术中的应用效果

目的:探究脑电双频指数(BIS)监测下腋路臂丛神经阻滞复合全身麻醉在肩关节镜手术中的应用效果。方法:选择2020年1月—2023年1月在宁夏医科大学总医院、吴忠市人民医院进行肩关节镜手术的患者86例,应用随机数字表法将其分为对照组(采用BIS监测下锁骨上入路臂丛神经阻滞复合全身麻醉)及观察组(采用BIS监测下腋路臂丛神经阻滞复合全身麻醉),各43例。对比两组不同时刻[麻醉前(T_(0))、气管插管即刻(T_(1))、切皮时(T_(2))、拔管时(T_(3))]心率(HR)、平均动脉压(MAP)、BIS值;对比两组麻醉苏醒后及术后2、12 h疼痛评分[视觉模拟评分法(VAS)]、肌力评分;对比两组术中舒芬太尼用量;对比两组不良反应发生率。结果:T_(0)时,两组HR、MAP比较,差异均无统计学意义(P>0.05);T_(1)、T_(2)、T_(3)时,观察组HR、MAP均低于对照组,差异均有统计学意义(P<0.05);T_(0)、T_(1)、T_(2)时,两组BIS比较,差异均无统计学意义(P>0.05);观察组T_(3)时BIS高于对照组,差异有统计学意义(P<0.05)。观察组麻醉苏醒后及术后6、12 h的VAS评分均低于对照组,肌力评分均高于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计意义(P>0.05)。结论:BIS监测下腋路臂丛神经阻滞复合全身麻醉在肩关节镜手术中的麻醉效果显著,可稳定血流动力学,患者术后疼痛程度较轻,对肌力影响较小,安全性较高。

针对性康复护理对肩袖损伤行关节镜手术患者术后肩关节功能恢复及护理满意度的影响

目的 分析针对性康复护理对肩袖损伤行关节镜手术患者术后肩关节功能恢复及护理满意度的影响。方法 选取2020年6月至2023年6月于厦门大学附属中山医院接受关节镜手术治疗的肩袖损伤患者100例,根据随机数字表法分为两组,对照组(50例)采取常规护理方法,观察组(50例)在此基础上施以针对性康复护理干预,对比两组的肩关节功能(欧美肩关节评分系统C-M)、生活质量(SF-36)、并发症发生率及护理满意度。结果 术后5个月时,观察组的C-M评分、SF-36评分均较对照组高(P <0.05);观察组并发症发生率较对照组更低(4.00%vs. 16.00%,P <0.05);观察组护理满意度较对照组更高(98.00%vs. 82.00%,P <0.05)。结论 将针对性康复护理用于肩袖损伤行关节镜手术患者,能使其肩关节功能得到更好恢复,减少并发症发生,提高生活质量与护理满意度。

术后早期被动运动结合个性化延伸护理在行关节镜下肩袖修复术患者中的应用

目的探析术后早期被动运动结合个性化延伸护理在行关节镜下肩袖修复术患者中的应用价值。方法抽取2021年9~12月在滨州医学院附属医院行关节镜下肩袖修复术的100例患者为观察对象,采取随机数字表法将符合标准的患者分为对照组和观察组,均为50例。对照组实施常规护理,观察组实施术后早期被动运动结合个性化延伸护理。比较2组的肩关节活动度、肩关节功能以及并发症发生率。结果术后3个月及术后6个月,2组的体侧外旋角度和主动前屈角度均较术后当日增大,肩关节功能评价量表中的5个项目评分均较术后当日升高(P均<0.05),且观察组均较同一时期的对照组更优(P均<0.05)。2组间感染、关节肿胀等并发症的总发生率相比,观察组较对照组更低(P<0.05)。结论术后早期被动运动结合个性化延伸护理对行关节镜下肩袖修复术患者术后并发症的减少、肩关节活动度的改善以及肩关节功能的提升均可产生积极影响。

关节镜肩袖修补术后关节僵硬的发病机制及中西医治疗进展

肩袖(RC)损伤是临床常见的肩关节疾病,并且随着人们年龄增长,其发生率也不断上升。针对保守治疗效果不佳的患者,临床常采取具有创伤小、恢复快等优势的肩关节镜下肩袖修补(ARCR)术,但术后常出现的并发症关节僵硬直接影响手术治疗效果,甚至导致手术失败。作者通过搜索相关文献,探讨ARCR术后关节僵硬的相关发病机制及目前临床常用的治疗方法 ,以期为改善术后关节僵硬提供新思路。

不同体位对膝关节镜手术患者蛛网膜下腔阻滞罗哌卡因ED50的影响

目的研究不同体位对膝关节镜手术患者蛛网膜下腔阻滞罗哌卡因半数有效剂量(ED50)的影响。方法选取90例需要进行择期单侧膝关节镜手术的患者,年龄18~64岁,ASA分级为I或Ⅱ级,体质量指数(BMI)为18~24 kg/m^(2),根据不同的体位,这些患者被分为三组,分别是头高脚低0°组、10°组和20°组。试验采用序贯法,每组第1例患者均获得蛛网膜下腔注射0.75%罗哌卡因11.25 mg,接下来根据前1例患者蛛网膜下腔阻滞是否有效,决定下一位患者的剂量是否减少或增加0.75 mg。使用概率单位回归分析法,计算罗哌卡因在不同体位下的蛛网膜下腔阻滞ED50。结果三组的ED50分别为:0°组为11.625 mg(95%CI:11.259~11.991 mg);10°组为11.325 mg(95%CI:10.968~11.669 mg);20°组为9.373 mg(95%CI:8.963~9.765 mg)。与0°组比较,10°组和20°组运动阻滞恢复时间缩短,20°组ED50降低、最高感觉阻滞平面下降、运动阻滞起效时间延长(P<0.05);与10°组比较,20°组ED50降低、运动阻滞恢复时间缩短(P<0.05)。三组术中低血压和恶心呕吐发生率比较差异无统计学意义(P>0.05)。结论膝关节镜手术患者在保持头高脚低0°、10°、20°体位时,蛛网膜下腔阻滞罗哌卡因的ED50分别为11.625 mg、11.325 mg和9.373 mg。通过头高脚低20°的姿势可以降低蛛网膜下腔阻滞的罗哌卡因ED50。