Effects of mesenchymal stem cell on dopaminergic neurons,motor and memory functions in animal models of Parkinson's disease:a systematic review and meta-analysis

Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease itself.Stem cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s disease.Mesenchymal stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of teratogenicity.We performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal model.We searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,2023.The study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control groups.We use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the meta-analysis.Treatment with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational test.Among the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a protective effect on dopaminergic neurons.Subgroup analysis of the amphetamine-induced rotation test showed a significant reduction only in the intracranial-striatum route(SMD[95%CI]=-2.59[-3.25 to-1.94],P=0.0001,I^(2)=74.4%).The memory test showed significant improvement only in the intravenous route(SMD[95%CI]=4.80[1.84 to 7.76],P=0.027,I^(2)=79.6%).Mesenchymal stem cells have been shown to positively impact motor function and memory function and protect dopaminergic neurons in preclinical models of Parkinson’s disease.Further research is required to determine the optimal stem cell types,modifications,transplanted cell numbe rs,and delivery methods for these protocols.

Analysis on Causes of Rural Land Expropriation Disputes Based on Smith's Model

Frequent occurrence of land expropriation disputes in rural areas of China has attracted attention of scholars to study causes. Most existing studies discuss causes from " structure- institution" level. In other words,land expropriation disputes are caused by existing imperfect institutions,regulations,and policies. Such analysis model points institutional causes,but pays little attention to policy implementation process,especially the subjective initiative of parties concerned. This paper described a decade-long land expropriation dispute case in detail.Through description of event and process and survey of reasons of actors,it revealed factors resulting in occurrence and upgrade of dispute,and analyzed factors and their interactions with the aid of Smith Process Model.

A Model of Grand Unified Theory: Suggested Solution for CP-Violation Using Ideas of Phase Paths

This study demonstrates that beyond standard model (BSM) cosmic fundamental interactions—weak, strong, and electromagnetic forces—can be unified through a common basis of representation. This unification allows for the derivation of the fine structure constant with running points of α(t) ≈ 1/(136.9038) at high energy scales, based on electroweak interactions. Through the application of the Ising model, the running point of the elementary charge e at high energy scales is determined, and Coulomb’s law is actually derived from the Yukawa potential. Theoretically, based on S. Weinberg’s electroweak interaction theory, this study unifies the strong and electromagnetic forces by representing them with rYuka, and further advances the reconstruction of the SU(3)C×SU(1)L×U(1)EMframework on the basis of electroweak interaction concepts. In fact, the cosmic fundamental forces can interchange at the mass gap, defined as the Yukawa turning phase at rYuka ≃1.9404 fm, with the SU(3)Diag structural constant fijk on glueballs calculated, estimating a spectrum mass gap of ∆0 > 0.

Evaluating the role of large language models in inflammatory bowel disease patient information

This letter evaluates the article by Gravina et al on ChatGPT’s potential in providing medical information for inflammatory bowel disease patients.While promising,it highlights the need for advanced techniques like reasoning+action and retrieval-augmented generation to improve accuracy and reliability.Emphasizing that simple question and answer testing is insufficient,it calls for more nuanced evaluation methods to truly gauge large language models’capabilities in clinical applications.

Gas–liquid mass transfer and flow phenomena in the Peirce–Smith converter: a water model study

A water model with a geometric similarity ratio of 1：5 was developed to investigate the gas-liquid mass transfer and flow charac- teristics in a Peirce-Smith converter. A gas mixture of CO2 and Ar was injected into a NaOH solution bath. The flow field, volumetric mass transfer coefficient per unit volume （Ak/V; where A is the contact area between phases, V is the volume, and k is the mass transfer coeffi- cient）, and gas utilization ratio （t/） were then measured at different gas flow rates and blow angles. The results showed that the flow field could be divided into five regions, i.e., injection, strong loop, weak loop, splashing, and dead zone. Whereas the Ak/V of the bath increased and then decreased with increasing gas flow rate, and n steadily increased. When the converter was rotated clockwise, both Ak/F and t/increased. However, the flow condition deteriorated when the gas flow rate and blow angle were drastically increased. Therefore, these para- meters must be controlled to optimal conditions. In the proposed model, the optimal gas flow rate and blow angle were 7.5 m3.h-1 and 10°, respectively.

基于抗扰动Smith预估补偿的磨煤机出口风粉温度优化控制

“双碳”背景下,作为高能耗高排放的火电机组,其燃烧性能直接影响发电效率和碳排放量。锅炉燃烧优化控制对运行优化和灵活调峰是有重要意义。电站锅炉磨煤机的出口风粉温度控制面临大延迟、多干扰问题,对燃煤机组安全稳定运行具有重要影响。基于Smith预估控制器,在补偿回路中增设反馈环节,实现了高效抗干扰,提升磨煤机风粉温度控制性能。通过Taylor级数展开和待定系数法求取模型近似转换参数,获得一阶惯性纯滞后模型,进而设计抗扰动型Smith预估补偿控制器。通过与单回路PID控制试验对比,发现Smith预估补偿控制算法可有效补偿控制对象的纯延迟滞后环节,单位阶跃响应超调量降低36.5%,调节时间缩短65.8%。相比经典Smith预估补偿控制算法,抗扰动Smith预估补偿控制算法可提高控制算法的抗扰动性能,并显著改善控制对象的动态特性,单位阶跃响应超调量减小44.7%,调节时间缩短15.7%。同时,实现了扰动最大偏差和收敛时间的降低。最后,在某660 MW超临界一次再热燃煤机组上应用该方法,实现了磨煤机出口风粉温度实际值对设定值的平稳跟踪,进一步验证了该方法的有效性。

多模型调度Smith预估算法的湿化器管路温控方法

医用湿化器的管路温度控制是一个具有滞后性、大惯性且模型参数随流量变化的非线性变结构系统,难以采用单一结构的控制算法来实现高品质的动态性能控制。针对这一难题,提出基于多模型结构调度的Smith预估控制方法,该方法在流量平衡点处采用模型调度的方法进行控制器设计。实验测试证明多模型调度的史密斯预估算法适用于不同设定温度在不同流量模式下的管路温度控制,提升了控制系统的动态性能和鲁棒性。

Solving the Olbers’s Paradox, Explaining the “Red-Shift”, and Challenging the Relativities by “Sun Matters Theory” and “Sun Model of Universe”, an Evolution of the Einstein’s Static Universe Model

Olbers’s paradox, known as the dark night paradox, is an argument in astrophysics that the darkness of the night sky conflicts with the assumption of an infinite and eternal static universe. Big-Bang theory was used to partially explain this paradox, while introducing new problems. Hereby, we propose a better theory, named Sun Matters Theory, to explain this paradox. Moreover, this unique theory supports and extended the Einstein’s static universe model proposed by Albert Einstein in 1917. Further, we proposed our new universe model, “Sun Model of Universe”. Based on the new model and novel theory, we generated innovative field equation by upgrading Einstein’s Field Equation through adding back the cosmological constant, introducing a new variable and modifying the gravitationally-related concepts. According to the Sun Model of Universe, the dark matter and dark energy comprise the so-called “Sun Matters”. The observed phenomenon like the red shift is explained as due to the interaction of ordinary light with Sun Matters leading to its energy and frequency decrease. In Sun Model, our big universe consists of many universes with ordinary matter at the core mixed and surrounded with the Sun Matters. In those universes, the laws of physics may be completely or partially different from that of our ordinary universe with parallel civilizations. The darkness of night can be easily explained as resulting from the interaction of light with the Sun Matters leading to the sharp decrease in the light intensity. Sun Matters also scatter the light from a star, which makes it shining as observed by Hubble. Further, there is a kind of Sun Matters named “Sun Waters”, surrounding every starts. When lights pass by the sun, the Sun Waters deflect the lights to bend the light path. According to the Sun Model, it is the light bent not the space bent that was proposed in the theory of relativities.

Hubble Tension Explanation from This Cosmological Model AΛΩ (Slow Bang Model, SB)

In this article we present a model of Hubble-Lemaître law using the notions of a transmitter (galaxy) and a receiver (MW) coupled to a model of the universe (Slow Bang Model, SB), based on a quantum approach of the evolution of space-time as well as an equation of state that retains all the infinitesimal terms. We find an explanation of the Hubble tension H0. Indeed, we have seen that this constant depends on the transceiver pair which can vary from the lowest observable value, from photons of the CMB (theoretical [km/s/Mpc]) to increasingly higher values depending on the earlier origin of the formation of the observed galaxy or cluster (ETG ~0.3 [Gy], ~74 [km/s/Mpc]). We have produced a theoretical table of the values of the constant according to the possible pairs of transmitter/receiver in the case where these galaxies follow the Hubble flow without large disturbance. The calculated theoretical values of the constant are in the order of magnitude of all values mentioned in past studies. Subsequently, we applied the models to 9 galaxies and COMA cluster and found that the models predict acceptable values of their distances and Hubble constant since these galaxies mainly follow the Hubble flow rather than the effects of a galaxy cluster or a group of clusters. In conclusion, we affirm that this Hubble tension does not really exist and it is rather the understanding of the meaning of this constant that is questioned.

Temperature Control Based on Fuzzy Logic Two-degree-of-freedom Smith Internal Model

According to the characteristics of the large time delay,nonlinearity and the great inertia of temperature control system in biomass pyrolysis reactor,a two-degree-of-freedom Smith internal model controller based on fuzzy control is proposed.Firstly,the mathematical model of the temperature control system is established by using the step response method,and then the two-degree-of-freedom Smith internal model controller is designed,and the good tracking performance and disturbance suppression performance can be obtained by designing the set value tracking controller and interference rejection capability.Secondly,the fuzzy control algorithm is used to realize the on-line tuning of the control parameters of the two-degree-of-freedom Smith internal model algorithm.The simulation results show that,compared with the traditional internal model control,fuzzy internal model PID control and two-degree-of-freedom Smith internal model control,the algorithm proposed in this paper improves the influence of lag time on the control system,realizes the separation control of set point tracking and anti-jamming performance and the self-tuning of control parameters,and improves the control performance of the system.

Analysis of Porter’s Five Forces Competitive Model in China’s Property Rights Trading Market

In recent years,China’s property rights trading market has been extremely competitive,but there are also new contradictions and challenges.This paper aims to analyze the external and internal competitive market of the property rights market through Porter’s five forces competition model,then find out the problems and defects in the development,thereby promoting the better development and progress of China’s property rights trading market.

Exploring the role of N-acetyltransferases in diseases:a focus on N-acetyltransferase 9 in neurodegeneration

Acetyltransferases,required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and disease.Protein acetylation is a common post-translational modification pivotal to basic cellular processes.Close to 80%-90%of proteins are acetylated during translation,which is an irreversible process that affects protein structure,function,life,and localization.In this review,we have discussed the various N-acetyltransferases present in humans,their function,and how they might play a role in diseases.Furthermore,we have focused on N-acetyltransferase 9 and its role in microtubule stability.We have shed light on how N-acetyltransferase 9 and acetylation of proteins can potentially play a role in neurodegenerative diseases.We have specifically discussed the N-acetyltransferase 9-acetylation independent function and regulation of c-Jun N-terminal kinase signaling and microtubule stability during development and neurodegeneration.

Index Design and Comprehensive Evaluation of Germplasm Resources of Fruits Based on Mathematical Model of AHP and FCE:Sterculia nobilis Smith as a Case

The mathematical model of analytic hierarchy process(AHP)-fuzzy comprehensive evaluation(FCE)was applied to comprehensively evaluate the germplasm resources of Sterculia nobilis Smith,and the scientific nature and reliability of the mathematical model was verified by calculating index weights and comprehensive evaluation scores.In this paper,11 indicators were selected to construct a comprehensive evaluation system from four dimensions of yields,resistances,contents of main inclusions in seeds and tree shapes.AHP method was applied to calculate the index weight of each dimension,after passing the consistency test,FCE method was applied to comprehensively evaluate germplasm resources of S.nobilis Smith.The index weights of the yields,resistances,contents of major inclusions in seeds and tree shapes were 0.5518,0.2554,0.1279 and 0.0649,respectively.The yield had the greatest influence on the comprehensive evaluation of germplasm resources of S.nobilis Smith,which was in line with the actual production demand of S.nobilis Smith as a food crop.However,resistances and contents of major inclusions in seeds had limited influence on it,while tree shapes had the least influence on it.After fuzzy comprehensive evaluation,the final evaluation score was 88.00,the corresponding evaluation score was between 4 and 5,and the evaluation results ranged from slight good to good,which indicated that the evaluation weights corresponding to the four dimensions were more scientific and reasonable.In this study,the mathematical model of AHP-FCE was used to establish and evaluate the comprehensive evaluation system of the germplasm resources of S.nobilis Smith.According to the values of index weights and the evaluation results,it showed that the mathematical model was scientific and reliable,and it could provide a new reference method for the comprehensive evaluation of germplasm resources of other fruits.

污染环境中Smith模型的稳定性

针对小容量污染环境中的种群生存问题,考虑了环境毒素浓度和体内毒素浓度受死亡种群的影响,研究了一类外界毒素输入率是常数的污染环境中单种群Smith模型.给出了平衡点存在条件,利用Ruth-Hurwitz准则和复合矩阵理论的分析方法,讨论了平衡点的局部稳定性及全局稳定性.

Rock skeleton models and seismic porosity inversion

By substituting rock skeleton modulus expressions into Gassmann approximate fluid equation, we obtain a seismic porosity inversion equation. However, conventional rock skeleton models and their expressions are quite different from each other, resuling in different seismic porosity inversion equations, potentially leading to difficulties in correctly applying them and evaluating their results. In response to this, a uniform relation with two adjusting parameters suitable for all rock skeleton models is established from an analysis and comparison of various conventional rock skeleton models and their expressions including the Eshelby-Walsh, Pride, Geertsma, Nur, Keys-Xu, and Krief models. By giving the two adjusting parameters specific values, different rock skeleton models with specific physical characteristics can be generated. This allows us to select the most appropriate rock skeleton model based on geological and geophysical conditions, and to develop more wise seismic porosity inversion. As an example of using this method for hydrocarbon prediction and fluid identification, we apply this improved porosity inversion, associated with rock physical data and well log data, to the ZJ basin. Research shows that the existence of an abundant hydrocarbon reservoir is dependent on a moderate porosity range, which means we can use the results of seismic porosity inversion to identify oil reservoirs and dry or water-saturated reservoirs. The seismic inversion results are closely correspond to well log porosity curves in the ZJ area, indicating that the uniform relations and inversion methods proposed in this paper are reliable and effective.

基于模型参考自适应Smith预估器的反馈式AGC厚度控制系统

针对具有纯时间延迟特性的反馈式AGC(automatic gauge control)系统,利用Smith预估器对纯时间延迟具有补偿作用的原理,建立了模型参考自适应Smith预估器反馈式AGC控制系统模型,给出了控制系统结构.推导了自适应调节律和设计算法,结合预估器模型,计算得到轧件出口厚度偏差值的表达式.仿真结果表明,模型参考自适应Smith预估器反馈式AGC系统对铝薄板带材轧制出口厚度偏差控制具有很好的控制效果,解决了反馈式AGC厚度控制由于纯时间延迟特性对控制性能产生很大影响的问题,消除了出口厚度波动现象,响应速度加快,可以满足高精度铝薄板带材轧制生产的控制要求.

NEURAL NETWORK SMITH PREDICTIVE CONTROL FOR TELEROBOTS WITH TIME DELAY

A neural network Smith predictive control strategy is proposed to deal with inpu t and feedback time delays in telerobot systems. The delay time is assumed to b e invariant and unknown. The proposed control structure consists of a slave syst em and a master controller. In the slave system, a recurrent neural network (RNN ) with on-line weight tuning algorithm is employed to approximate the dynamics of the time-delay-free nonlinear plant, which is used to linearize the slave s ystem. The master controller is a Smith predictor for the linearized slave syste m, which provides prediction and maintains the desirable tracking performance. S tability propriety is guaranteed based on the Lyapunov method. A simulation of a two-link robotic manipulator is provided to illustrate the effectiveness of th e proposed control strategy.

基于Smith预估的纯滞后系统的控制

针对具有纯时间滞后的系统,分析了PID算法、Dahlin算法和Smith预估算法的特点,指出只要对Smith预估控制器进行适当的设计,就能等效于Dahlin算法.提出了利用Smith预估器补偿时间滞后,按Dahlin算法原理设计控制器的Dahlin-Smith算法和将Smith预估系统结构变换为内模控制器(IMC)结构,再按内模控制原理进行控制器设计的IMC-Smith算法.在模型匹配和失配情况下进行了仿真研究,结果表明,所提出的新控制算法在系统模型不精确的情况下,具有更好的稳定性和鲁棒性,对于大时间滞后系统是一种比较实用的控制方法.

利用Smiths公式预测有剖宫产史孕妇再次妊娠分娩方式的初步探索

目的:探讨Smiths公式用于有剖宫产(CS)史的孕妇再次妊娠时预测CS风险的意义。方法:对我院63例有CS史并再次妊娠的经产妇利用Smiths公式对不同分娩方式预测其风险系数并探讨Smiths公式的预测值。结果:63例患者中,按公式计算出CS风险预测值<40%的患者阴道试产成功率达100%,CS风险预测值>40%者有37.5%阴道试产失败。结论:利用Smith公式,取40%为临界点,对CS风险预测值>40%的既往有CS史的孕妇行阴道分娩时需慎重。

基于模糊Smith控制的智能阀门定位器

针对工业调节阀中广泛存在的时滞现象,提出一种基于模糊原理的带有Smith预估器的智能阀门定位器控制方法。分析智能阀门定位器的结构和原理,通过设计Smith预估器补偿滞后时间,实现超前响应,克服时滞对系统性能的影响;通过模糊控制与PID控制结合,设计调整模糊规则,实现控制器参数的自整定。两者结合构成模糊Smith方法,提高了系统的动静态性能。模糊内模控制器对克服时滞、提高系统性能有良好的效果,将模糊Smith器与模糊内模控制器及PID控制器进行仿真研究对比。仿真结果表明,模糊Smith控制方法比模糊内模控制方法和传统PID方法更能有效地提高调节阀的快速性,克服时滞,改善系统性能。