Objective: We aimed to study the relationship between clinical effect and surgical methods of inner thigh primary soft tissue sarcomas. Methods: Wide or radical resection were performed in 45 cases of soft tissue sarc...Objective: We aimed to study the relationship between clinical effect and surgical methods of inner thigh primary soft tissue sarcomas. Methods: Wide or radical resection were performed in 45 cases of soft tissue sarcomas, including 20 cases of postoperative recurrence after radiation therapy, 7 cases of first treatment. Thirty-six cases received 4–6 cycles of postoperative chemotherapy. Results: Thirty-eight of 45 cases were followed up for 1–5 years, with 5 case of recurrence and 6 cases of distant metastasis. Conclusion: The inner thigh primary soft tissue sarcoma can be effectively treated with wide or radical resection.展开更多
Standard treatment for soft tissue sarcoma,based on complete surgical resection with or without adjuvant radiotherapy and chemotherapy,has not substantially changed during the last several decades.Nevertheless,recent ...Standard treatment for soft tissue sarcoma,based on complete surgical resection with or without adjuvant radiotherapy and chemotherapy,has not substantially changed during the last several decades.Nevertheless,recent advances have contributed to considerable improvement in the management of these patients;for example,new magnetic resonance imaging sequences such as diffusionweighted imaging and magnetic resonance imaging radiomics can better assess tumor extension and even estimate its grade.Detection of circulating genetic material(liquid biopsy)and next-generation sequencing are powerful techniques for genetic analysis,which will increase our understanding of the underlying molecular mechanisms and may reveal potential therapeutic targets.The role of chemotherapy in non-metastatic disease is still controversial,and there is a need to identify patients who really benefit from this treatment.Novel chemotherapeutic regimens have entered clinical praxis and can change the outcome of patients with metastatic disease.Advances in radiotherapy have helped decrease local adverse effects and sustain good local control of the disease.The following report provides an updated view of the diagnosis,treatment,and future perspectives on the management of patients with soft tissue sarcomas.展开更多
We accepted 66 cases with soft tissue sarcoma of abdomen testified by the Pathologists. The ratio of male to female was 1.5 to 1, but the aged-groups in female were more. The male incidences increased as the ages did....We accepted 66 cases with soft tissue sarcoma of abdomen testified by the Pathologists. The ratio of male to female was 1.5 to 1, but the aged-groups in female were more. The male incidences increased as the ages did. The mean age was 46.79 ±17. 04. The neoplasms arises more often in the abdominal wall below 30 years old, and it does mainly in the abdominal viscera and in the retroperitoneum over 30 years old. Fibrosarcoma Protuberance was the main type in the abdominal wall,and leiomyosarcoma was the main type in the abdominal viscera, and in the retroperitoneum, the most was liposarcoma, the following was leiomyosarcoma. Among the soft tissue sarcoma of the abdomen. the most was in retroperitoneum, and the following was in abdominal viscera. Therefore, it was difficult to diagnose early. The keys to the question were B-mode ultrasonic examining,computed tomography (CT) scanning and magnetic resonance imaging (MRI). Surgery was the primary therapeutic modality. The resectability was the major prognostic factor Radiotherapy and chemotherapy indicated a clear beneficial effect on soft tissue sarcoma of the abdomen and they can slightly decrease the recurrences and the metastases, but they had no obvious influence on the survival. In 5-year survival, the lesion of abdomen was the best, and those both of abdominal viscera and of retroperitoneum were the bad. To increase the 5-year survival, what counts are early diagnosis and the resectability.展开更多
Soft tissue sarcoma are rare tumors arising mostly from embryonic mesoderm, that can affect almost any part of the human body, including the gastrointestinal tract. The prognosis associated with soft tissue sarcoma is...Soft tissue sarcoma are rare tumors arising mostly from embryonic mesoderm, that can affect almost any part of the human body, including the gastrointestinal tract. The prognosis associated with soft tissue sarcoma is still poor, mainly because of the low efficacy of traditional approaches based on surgery and chemotherapy. As a result of genetic and molecular analysis, several new target therapies have been developed, leading to a significant improvement in the survival of patients affected by advanced disease. In this review we aim to explore the therapeutic potential and benefit of target therapy in the management of gastrointestinal soft tissue sarcoma and the possible complications or pitfalls of such an approach.展开更多
文摘Objective: We aimed to study the relationship between clinical effect and surgical methods of inner thigh primary soft tissue sarcomas. Methods: Wide or radical resection were performed in 45 cases of soft tissue sarcomas, including 20 cases of postoperative recurrence after radiation therapy, 7 cases of first treatment. Thirty-six cases received 4–6 cycles of postoperative chemotherapy. Results: Thirty-eight of 45 cases were followed up for 1–5 years, with 5 case of recurrence and 6 cases of distant metastasis. Conclusion: The inner thigh primary soft tissue sarcoma can be effectively treated with wide or radical resection.
文摘Standard treatment for soft tissue sarcoma,based on complete surgical resection with or without adjuvant radiotherapy and chemotherapy,has not substantially changed during the last several decades.Nevertheless,recent advances have contributed to considerable improvement in the management of these patients;for example,new magnetic resonance imaging sequences such as diffusionweighted imaging and magnetic resonance imaging radiomics can better assess tumor extension and even estimate its grade.Detection of circulating genetic material(liquid biopsy)and next-generation sequencing are powerful techniques for genetic analysis,which will increase our understanding of the underlying molecular mechanisms and may reveal potential therapeutic targets.The role of chemotherapy in non-metastatic disease is still controversial,and there is a need to identify patients who really benefit from this treatment.Novel chemotherapeutic regimens have entered clinical praxis and can change the outcome of patients with metastatic disease.Advances in radiotherapy have helped decrease local adverse effects and sustain good local control of the disease.The following report provides an updated view of the diagnosis,treatment,and future perspectives on the management of patients with soft tissue sarcomas.
文摘We accepted 66 cases with soft tissue sarcoma of abdomen testified by the Pathologists. The ratio of male to female was 1.5 to 1, but the aged-groups in female were more. The male incidences increased as the ages did. The mean age was 46.79 ±17. 04. The neoplasms arises more often in the abdominal wall below 30 years old, and it does mainly in the abdominal viscera and in the retroperitoneum over 30 years old. Fibrosarcoma Protuberance was the main type in the abdominal wall,and leiomyosarcoma was the main type in the abdominal viscera, and in the retroperitoneum, the most was liposarcoma, the following was leiomyosarcoma. Among the soft tissue sarcoma of the abdomen. the most was in retroperitoneum, and the following was in abdominal viscera. Therefore, it was difficult to diagnose early. The keys to the question were B-mode ultrasonic examining,computed tomography (CT) scanning and magnetic resonance imaging (MRI). Surgery was the primary therapeutic modality. The resectability was the major prognostic factor Radiotherapy and chemotherapy indicated a clear beneficial effect on soft tissue sarcoma of the abdomen and they can slightly decrease the recurrences and the metastases, but they had no obvious influence on the survival. In 5-year survival, the lesion of abdomen was the best, and those both of abdominal viscera and of retroperitoneum were the bad. To increase the 5-year survival, what counts are early diagnosis and the resectability.
文摘Soft tissue sarcoma are rare tumors arising mostly from embryonic mesoderm, that can affect almost any part of the human body, including the gastrointestinal tract. The prognosis associated with soft tissue sarcoma is still poor, mainly because of the low efficacy of traditional approaches based on surgery and chemotherapy. As a result of genetic and molecular analysis, several new target therapies have been developed, leading to a significant improvement in the survival of patients affected by advanced disease. In this review we aim to explore the therapeutic potential and benefit of target therapy in the management of gastrointestinal soft tissue sarcoma and the possible complications or pitfalls of such an approach.
