Avirtual wall thicknessmethod is developed to simulate the temperature field of turbine bladeswith thermal barrier coatings(TBCs),to simplify the modeling process and improve the calculation efficiency.The results sho...Avirtual wall thicknessmethod is developed to simulate the temperature field of turbine bladeswith thermal barrier coatings(TBCs),to simplify the modeling process and improve the calculation efficiency.The results show that the virtualwall thickness method can improve themesh quality by 20%,reduce the number ofmeshes by 76.7%and save the calculation time by 35.5%,compared with the traditional real wall thickness method.The average calculation error of the two methods is between 0.21%and 0.93%.Furthermore,the temperature at the blade leading edge is the highest and the average temperature of the blade pressure surface is higher than that of the suction surface under a certain service condition.The blade surface temperature presents a high temperature at both ends and a low temperature in themiddle height when the temperature of incoming gas is uniformand constant.The thermal insulation effect of TBCs is the worst near the air film hole,and the best at the blade leading edge.According to the calculated temperature field of the substrate-coating system,the highest thermal insulation temperature of the TC layer is 172.01 K,and the thermal insulation proportions of TC,TGO and BC are 93.55%,1.54%and 4.91%,respectively.展开更多
In this work,a bright and dark concentric-ring pattern is reported in a dielectric barrier discharge for the first time.The spatiotemporal dynamics of the bright and dark concentric-ring pattern are investigated with ...In this work,a bright and dark concentric-ring pattern is reported in a dielectric barrier discharge for the first time.The spatiotemporal dynamics of the bright and dark concentric-ring pattern are investigated with an intensified charge-coupled device and photomultiplier tubes.The results indicate that the bright and dark concentric-ring pattern is composed of three concentric-ring sublattices.These are bright concentric-ring structures,dark concentric-ring structures and wider concentric-ring structures,respectively.The bright concentric-ring structures and dark concentricring structures are alternately distributed.The bright concentric-ring structures are located at the centre of the wider concentric-ring structures.The wider concentric-ring structures first form from the outer edge and gradually develop to the centre.The essence of all three concentric-ring structures is the individual discharge filaments.The optical emission spectra of different sublattices are acquired and analysed.It is found that the plasma parameters of the three concentricring sublattices are different.Finally,the formation mechanism of the bright and dark concentricring pattern is discussed.展开更多
Barrier walls effectively store water,regulate underground flows,improve exploitable reserves and prevent saltwater intrusion.The effectiveness of the underground barrier wall depends not only on the hydrogeological s...Barrier walls effectively store water,regulate underground flows,improve exploitable reserves and prevent saltwater intrusion.The effectiveness of the underground barrier wall depends not only on the hydrogeological structure,the technical parameters of the wall but also on the layout scheme of the exploitation well system.The results showed that in natural conditions,the ground water level upstream of the barrier wall rose in the presence of a barrier wall.In wells located downstream of high barrier walls,the water level decreased.The amount of underground current flowing into the sea decreased,the annual average value of the whole region decreased was 316 m3/day and night.In presence of a wall,both the water level and the amount of evaporation increased.The average increase in evaporation volume during the calculation period of ten thousand days with walls was 4.114 m3/d.So in presence of a wall,the amount of water that can be exploited increases by the total amount of evaporation plus the decrease in discharge to the sea and is equal to 4,424 m3/d.In the exploitation condition,if the water level in the presence of wall is kept as low as in the absence of wall,the exploitation flow will increase to about 4,400 m3/day and night.From the calculated water level values when there is a wall and without a wall,we can see that if the exploitation flow in presence of a wall and in the absence of wall is the same,the water level drop at the calculated observation wells upstream of the wall will decrease from 0.21 m to 3.97 m.The condition of effective exploitation of the wall depends on the mining scheme.The exploitation scheme is reasonable,the exploitation flow of the wells does not exceed the allowable flow so as not to cause the drying of the aquifer at the location of the well.The upstream area of the wall reflects quite clearly as the Total dissolved solids content in observation wells upstream of the wall at the end of the calculation time is significantly reduced compared to that without the wall,ranging from 69 mg/L to 5,629 mg/L.In the presence of a wall,the water level of observation wells upstream of the wall is higher than that of without a wall from 0.10 m to 0.74 m.展开更多
BACKGROUND Irritable bowel syndrome(IBS)is one of the most frequent and debilitating conditions leading to gastroenterological referrals.However,recommended treatments remain limited,yielding only limited therapeutic ...BACKGROUND Irritable bowel syndrome(IBS)is one of the most frequent and debilitating conditions leading to gastroenterological referrals.However,recommended treatments remain limited,yielding only limited therapeutic gains.Chitin-glucan(CG)is a novel dietary prebiotic classically used in humans at a dosage of 1.5-3.0 g/d and is considered a safe food ingredient by the European Food Safety Authority.To provide an alternative approach to managing patients with IBS,we performed preclinical molecular,cellular,and animal studies to evaluate the role of chitin-glucan in the main pathophysiological mechanisms involved in IBS.AIM To evaluate the roles of CG in visceral analgesia,intestinal inflammation,barrier function,and to develop computational molecular models.METHODS Visceral pain was recorded through colorectal distension(CRD)in a model of long-lasting colon hypersensitivity induced by an intra-rectal administration of TNBS[15 milligrams(mg)/kilogram(kg)]in 33 Sprague-Dawley rats.Intracolonic pressure was regularly assessed during the 9 wk-experiment(weeks 0,3,5,and 7)in animals receiving CG(n=14)at a human equivalent dose(HED)of 1.5 g/d or 3.0 g/d and compared to negative control(tap water,n=11)and positive control(phloroglucinol at 1.5 g/d HED,n=8)groups.The anti-inflammatory effect of CG was evaluated using clinical and histological scores in 30 C57bl6 male mice with colitis induced by dextran sodium sulfate(DSS)administered in their drinking water during 14 d.HT-29 cells under basal conditions and after stimulation with lipopolysaccharide(LPS)were treated with CG to evaluate changes in pathways related to analgesia μ-opioid receptor(MOR),cannabinoid receptor 2(CB2),peroxisome proliferator-activated receptor alpha,inflammation[interleukin(IL)-10,IL-1b,and IL-8]and barrier function[mucin 2-5AC,claudin-2,zonula occludens(ZO)-1,ZO-2]using the real-time PCR method.Molecular modelling of CG,LPS,lipoteichoic acid(LTA),and phospholipomannan(PLM)was developed,and the ability of CG to chelate microbial pathogenic lipids was evaluated by docking and molecular dynamics simulations.Data were expressed as the mean±SEM.RESULTS Daily CG orally-administered to rats or mice was well tolerated without including diarrhea,visceral hypersensitivity,or inflammation,as evaluated at histological and molecular levels.In a model of CRD,CG at a dosage of 3 g/d HED significantly decreased visceral pain perception by 14%after 2 wk of administration(P<0.01)and reduced inflammation intensity by 50%,resulting in complete regeneration of the colonic mucosa in mice with DSS-induced colitis.To better reproduce the characteristics of visceral pain in patients with IBS,we then measured the therapeutic impact of CG in rats with TNBS-induced inflammation to long-lasting visceral hypersensitivity.CG at a dosage of 1.5 g/d HED decreased visceral pain perception by 20%five weeks after colitis induction(P<0.01).When the CG dosage was increased to 3.0 g/d HED,this analgesic effect surpassed that of the spasmolytic agent phloroglucinol,manifesting more rapidly within 3 wk and leading to a 50%inhibition of pain perception(P<0.0001).The underlying molecular mechanisms contributing to these analgesic and anti-inflammatory effects of CG involved,at least in part,a significant induction of MOR,CB2 receptor,and IL-10,as well as a significant decrease in pro-inflammatory cytokines IL-1b and IL-8.CG also significantly upregulated barrier-related genes including muc5AC,claudin-2,and ZO-2.Molecular modelling of CG revealed a new property of the molecule as a chelator of microbial pathogenic lipids,sequestering gram-negative LPS and gram-positive LTA bacterial toxins,as well as PLM in fungi at the lowesr energy conformations.CONCLUSION CG decreased visceral perception and intestinal inflammation through master gene regulation and direct binding of microbial products,suggesting that CG may constitute a new therapeutic strategy for patients with IBS or IBSlike symptoms.展开更多
Spatio-temporal distribution of individual filament in a square superlattice pattern, which consists of large and small spots (filaments), is studied in atmospheric dielectric barrier discharges. The spatial distrib...Spatio-temporal distribution of individual filament in a square superlattice pattern, which consists of large and small spots (filaments), is studied in atmospheric dielectric barrier discharges. The spatial distributions of the two discharges for individual large filament along the direction perpendicular to the electrode are estimated by the distributions of light signals along the electrode. It is found that the discharge at the rising edge of the applied voltage is with a wider column, weaker current, and longer current pulse duration in comparison with that at the falling edge展开更多
The critical lengths of an oscillator based on double-walled carbon nanotubes(DWCNTs)are studied by energy minimization and molecular dynamics simulation.Van der Waals(vdW)potential energy in DWCNTs is shown to be cha...The critical lengths of an oscillator based on double-walled carbon nanotubes(DWCNTs)are studied by energy minimization and molecular dynamics simulation.Van der Waals(vdW)potential energy in DWCNTs is shown to be changed periodically with the lattice matching of the inner and outer tubes by using atomistic models with energy minimization method.If the coincidence length between the inner and outer tubes is long enough,the restoring force cannot drive the DWCNT to slide over the vdW potential barrier to assure the DWCNT acts as an oscillator.The critical coincidence lengths of the oscillators are predicted by a very simple equation and then confirmed with energy minimization method for both the zigzag/zigzag system and the armchair/armchair system.The critical length of the armchair/armchair system is much larger than that of the zigzag/zigzag system.The vdW potential energy fluctuation of the armchair/armchair system is weaker than that of the zigzag/zigzag system.So it is easier to slide over the barrier for the armchair/armchair system.The critical lengths of zigzag/zigzag DWCNTbased oscillator are found increasing along with temperature,by molecular dynamics simulations.展开更多
基金supported by the National Science and Technology Major Project(J2019-IV-0003-0070)the National Natural Science Foundation of China(Grant No.12102320)+1 种基金the Advanced Aviation Power Innovation Workstation Project(HKCX2019-01-003)China Postdoc-toral Science Foundation(2021M692571).
文摘Avirtual wall thicknessmethod is developed to simulate the temperature field of turbine bladeswith thermal barrier coatings(TBCs),to simplify the modeling process and improve the calculation efficiency.The results show that the virtualwall thickness method can improve themesh quality by 20%,reduce the number ofmeshes by 76.7%and save the calculation time by 35.5%,compared with the traditional real wall thickness method.The average calculation error of the two methods is between 0.21%and 0.93%.Furthermore,the temperature at the blade leading edge is the highest and the average temperature of the blade pressure surface is higher than that of the suction surface under a certain service condition.The blade surface temperature presents a high temperature at both ends and a low temperature in themiddle height when the temperature of incoming gas is uniformand constant.The thermal insulation effect of TBCs is the worst near the air film hole,and the best at the blade leading edge.According to the calculated temperature field of the substrate-coating system,the highest thermal insulation temperature of the TC layer is 172.01 K,and the thermal insulation proportions of TC,TGO and BC are 93.55%,1.54%and 4.91%,respectively.
基金supported by National Natural Science Foundation of China(No.12075075)the Natural Science Foundation of Hebei Province,China(Nos.2020201016,A2018201154,A2023201012)Scientific Research and Innovation Team of Hebei University(No.IT2023B03)。
文摘In this work,a bright and dark concentric-ring pattern is reported in a dielectric barrier discharge for the first time.The spatiotemporal dynamics of the bright and dark concentric-ring pattern are investigated with an intensified charge-coupled device and photomultiplier tubes.The results indicate that the bright and dark concentric-ring pattern is composed of three concentric-ring sublattices.These are bright concentric-ring structures,dark concentric-ring structures and wider concentric-ring structures,respectively.The bright concentric-ring structures and dark concentricring structures are alternately distributed.The bright concentric-ring structures are located at the centre of the wider concentric-ring structures.The wider concentric-ring structures first form from the outer edge and gradually develop to the centre.The essence of all three concentric-ring structures is the individual discharge filaments.The optical emission spectra of different sublattices are acquired and analysed.It is found that the plasma parameters of the three concentricring sublattices are different.Finally,the formation mechanism of the bright and dark concentricring pattern is discussed.
文摘Barrier walls effectively store water,regulate underground flows,improve exploitable reserves and prevent saltwater intrusion.The effectiveness of the underground barrier wall depends not only on the hydrogeological structure,the technical parameters of the wall but also on the layout scheme of the exploitation well system.The results showed that in natural conditions,the ground water level upstream of the barrier wall rose in the presence of a barrier wall.In wells located downstream of high barrier walls,the water level decreased.The amount of underground current flowing into the sea decreased,the annual average value of the whole region decreased was 316 m3/day and night.In presence of a wall,both the water level and the amount of evaporation increased.The average increase in evaporation volume during the calculation period of ten thousand days with walls was 4.114 m3/d.So in presence of a wall,the amount of water that can be exploited increases by the total amount of evaporation plus the decrease in discharge to the sea and is equal to 4,424 m3/d.In the exploitation condition,if the water level in the presence of wall is kept as low as in the absence of wall,the exploitation flow will increase to about 4,400 m3/day and night.From the calculated water level values when there is a wall and without a wall,we can see that if the exploitation flow in presence of a wall and in the absence of wall is the same,the water level drop at the calculated observation wells upstream of the wall will decrease from 0.21 m to 3.97 m.The condition of effective exploitation of the wall depends on the mining scheme.The exploitation scheme is reasonable,the exploitation flow of the wells does not exceed the allowable flow so as not to cause the drying of the aquifer at the location of the well.The upstream area of the wall reflects quite clearly as the Total dissolved solids content in observation wells upstream of the wall at the end of the calculation time is significantly reduced compared to that without the wall,ranging from 69 mg/L to 5,629 mg/L.In the presence of a wall,the water level of observation wells upstream of the wall is higher than that of without a wall from 0.10 m to 0.74 m.
基金Supported by the Service Public de Wallonie(SPW-EER,convention 8588,Belgium).
文摘BACKGROUND Irritable bowel syndrome(IBS)is one of the most frequent and debilitating conditions leading to gastroenterological referrals.However,recommended treatments remain limited,yielding only limited therapeutic gains.Chitin-glucan(CG)is a novel dietary prebiotic classically used in humans at a dosage of 1.5-3.0 g/d and is considered a safe food ingredient by the European Food Safety Authority.To provide an alternative approach to managing patients with IBS,we performed preclinical molecular,cellular,and animal studies to evaluate the role of chitin-glucan in the main pathophysiological mechanisms involved in IBS.AIM To evaluate the roles of CG in visceral analgesia,intestinal inflammation,barrier function,and to develop computational molecular models.METHODS Visceral pain was recorded through colorectal distension(CRD)in a model of long-lasting colon hypersensitivity induced by an intra-rectal administration of TNBS[15 milligrams(mg)/kilogram(kg)]in 33 Sprague-Dawley rats.Intracolonic pressure was regularly assessed during the 9 wk-experiment(weeks 0,3,5,and 7)in animals receiving CG(n=14)at a human equivalent dose(HED)of 1.5 g/d or 3.0 g/d and compared to negative control(tap water,n=11)and positive control(phloroglucinol at 1.5 g/d HED,n=8)groups.The anti-inflammatory effect of CG was evaluated using clinical and histological scores in 30 C57bl6 male mice with colitis induced by dextran sodium sulfate(DSS)administered in their drinking water during 14 d.HT-29 cells under basal conditions and after stimulation with lipopolysaccharide(LPS)were treated with CG to evaluate changes in pathways related to analgesia μ-opioid receptor(MOR),cannabinoid receptor 2(CB2),peroxisome proliferator-activated receptor alpha,inflammation[interleukin(IL)-10,IL-1b,and IL-8]and barrier function[mucin 2-5AC,claudin-2,zonula occludens(ZO)-1,ZO-2]using the real-time PCR method.Molecular modelling of CG,LPS,lipoteichoic acid(LTA),and phospholipomannan(PLM)was developed,and the ability of CG to chelate microbial pathogenic lipids was evaluated by docking and molecular dynamics simulations.Data were expressed as the mean±SEM.RESULTS Daily CG orally-administered to rats or mice was well tolerated without including diarrhea,visceral hypersensitivity,or inflammation,as evaluated at histological and molecular levels.In a model of CRD,CG at a dosage of 3 g/d HED significantly decreased visceral pain perception by 14%after 2 wk of administration(P<0.01)and reduced inflammation intensity by 50%,resulting in complete regeneration of the colonic mucosa in mice with DSS-induced colitis.To better reproduce the characteristics of visceral pain in patients with IBS,we then measured the therapeutic impact of CG in rats with TNBS-induced inflammation to long-lasting visceral hypersensitivity.CG at a dosage of 1.5 g/d HED decreased visceral pain perception by 20%five weeks after colitis induction(P<0.01).When the CG dosage was increased to 3.0 g/d HED,this analgesic effect surpassed that of the spasmolytic agent phloroglucinol,manifesting more rapidly within 3 wk and leading to a 50%inhibition of pain perception(P<0.0001).The underlying molecular mechanisms contributing to these analgesic and anti-inflammatory effects of CG involved,at least in part,a significant induction of MOR,CB2 receptor,and IL-10,as well as a significant decrease in pro-inflammatory cytokines IL-1b and IL-8.CG also significantly upregulated barrier-related genes including muc5AC,claudin-2,and ZO-2.Molecular modelling of CG revealed a new property of the molecule as a chelator of microbial pathogenic lipids,sequestering gram-negative LPS and gram-positive LTA bacterial toxins,as well as PLM in fungi at the lowesr energy conformations.CONCLUSION CG decreased visceral perception and intestinal inflammation through master gene regulation and direct binding of microbial products,suggesting that CG may constitute a new therapeutic strategy for patients with IBS or IBSlike symptoms.
基金supported by National Natural Science Foundation of China (No.10775037)Natural Science Foundation of Hebei Province of China (No.A2008000564) Natural Science Foundation of Hebei University 2008Q17, China
文摘Spatio-temporal distribution of individual filament in a square superlattice pattern, which consists of large and small spots (filaments), is studied in atmospheric dielectric barrier discharges. The spatial distributions of the two discharges for individual large filament along the direction perpendicular to the electrode are estimated by the distributions of light signals along the electrode. It is found that the discharge at the rising edge of the applied voltage is with a wider column, weaker current, and longer current pulse duration in comparison with that at the falling edge
基金Supported in part by the National Natural Science Foundation of China(11072108)the Foundation for the Author of National Excellent Doctoral Dissertation of China(201028)+3 种基金the Program for New Century Excellent Talents in University(NCET-11-0832)the Funding of Jiangsu Innovation Program for Graduate Education(CXZZ13-0144)the Funding for Outstanding Doctoral Dissertation in NUAA(BCXJ13-03)the Fundamental Research Funds for the Central Universities of China
文摘The critical lengths of an oscillator based on double-walled carbon nanotubes(DWCNTs)are studied by energy minimization and molecular dynamics simulation.Van der Waals(vdW)potential energy in DWCNTs is shown to be changed periodically with the lattice matching of the inner and outer tubes by using atomistic models with energy minimization method.If the coincidence length between the inner and outer tubes is long enough,the restoring force cannot drive the DWCNT to slide over the vdW potential barrier to assure the DWCNT acts as an oscillator.The critical coincidence lengths of the oscillators are predicted by a very simple equation and then confirmed with energy minimization method for both the zigzag/zigzag system and the armchair/armchair system.The critical length of the armchair/armchair system is much larger than that of the zigzag/zigzag system.The vdW potential energy fluctuation of the armchair/armchair system is weaker than that of the zigzag/zigzag system.So it is easier to slide over the barrier for the armchair/armchair system.The critical lengths of zigzag/zigzag DWCNTbased oscillator are found increasing along with temperature,by molecular dynamics simulations.