AIM: To evaluate the efficacy of topical administration Natamycin, which is produced by China, in an experimental rabbit model of Fusarium solani keratitis, to provide experimental basis for the application of clinica...AIM: To evaluate the efficacy of topical administration Natamycin, which is produced by China, in an experimental rabbit model of Fusarium solani keratitis, to provide experimental basis for the application of clinical safety. · METHODS: Fusarium solani was induced in the right eye of 30 New Zealand rabbits. Forty-eight hours after inoculation, the animals were divided into 3 different treatment groups, 10 rabbit eyes of each group: Group 1 (Natamycin) treated with topical Natamycin, group 2 (Natacyn) treated with topical Natacyn, group 3 (control) treated with topical saline solution. The eyes of each group was examined clinically with slit lamp using ulcer scoring system on day 4, 10, 15, and 21 for status of healing, corneal vascularisation, iritis, hypopyon and macular nebula. The findings were recorded on day 10 and day 21. · RESULTS: Ulcer score on day 10, day 15, day 21: The score of Natamycin group are 1.45±0.16, 1.08±0.11, 0.70±0.40. The score of Natacyn group are 1.35±0.12, 1.10±0.12, 0.65±0.35. the score of control group are 1.30±0.08, 3.63±0.28, 3.80±0.16. Natamycin group and Natacyn group were different from control group(P <0.01). There is no difference between Natamycin group and Natacyn group. Status of healing on day 10 and day 21: The cure rate of the Natamycin group is 90% on day 10, and 100% on day 21. The cure rate of the Natacyn group is 80% on day 10, and 100% on day 21.Natamycin group and Natacyn group were different from control group (P <0.01). There is no difference between Natamycin group and Natacyn group. Corneal vascularisation, iritis, hypopyon and macular nebula on day 10 and day 21: in Natamycin group, the number of the eyes which have Corner vascularisation, iritis, hypopyon and macular nebula are 2,0,0,2. In Natacyn group, the number of the eyes which have Corner vascularisation, iritis, hypopyon and macular nebula are 1,0,0,2. In control group, the number of the eyes which have Corner vascularisation, iritis, hypopyon and macular nebula are 9,9,8,9.Natamycin group and Natacyn group were different from control group (P< 0.01). There is no difference between Natamycin group and Natacyn group. · CONCLUSION: Natamycin was found to be effective in fungal keratitis, similar to Natacyn, and it can stop the corner vascularisation, iritis, hypopyon and macular nebula to happen. Natamyin manufactured in China is effective against fungal keratitis, with esay availability and low toxicity in its use.展开更多
Background:Monitoring the changing pattern of vegetation across diverse landscapes through remote sensing is instrumental in understanding the interactions of human activities and the ecological environment.Land use p...Background:Monitoring the changing pattern of vegetation across diverse landscapes through remote sensing is instrumental in understanding the interactions of human activities and the ecological environment.Land use pattern in the state of Himachal Pradesh in the Indian Western Himalayas has been undergoing rapid modifications due to changing cropping patterns,rising anthropogenic pressure on forests and government policies.We studied land use change in Solan Forest Division of Himachal Pradesh to assess species wise area changes in the forests of the region.Methods:The supervised classification(Maximum likelihood)on two dates of IRS(LISS III)satellite data was performed to assess land use change over the period 1998–2010.Results:Seven land use categories were identified namely,chir pine(Pinus roxburghii)forest,broadleaved forest,bamboo(Dendrocalamus strictus)forest,ban oak(Quercus leucotrichophora)forest,khair(Acacia catechu)forest,culturable blank and cultivation.The area under chir pine,cultivation and khair forests increased by 191 ha(4.55 %),129 ha(13.81 %)and 77 ha(23.40 %),whereas the area under ban oak,broadleaved,culturable blank and bamboo decreased by 181 ha(16.58 %),152 ha(6.30 %),71 ha(2.72 %)and 7 ha(0.47 %),respectively.Conclusions:The study revealed a decrease in the area under forest and culturable blank categories and a simultaneous increase in the area under cultivation primarily due to the large scale introduction of horticultural cash crops in the state.The composition of forests also exhibited some major changes,with an increase in the area of commercially important monoculture plantation species such as pine and khair,and a decline in the area of oak,broadleaved and bamboo which are facing a high anthropogenic pressure in meeting the livelihood demands of forest dependent communities.In time deforestation,forest degradation and ecological imbalances due to the changing forest species composition may inflict irreversible damages upon unstable and fragile mountain zones such as the Indian Himalayas.The associated common property externalities involved at local,regional and global scales,necessitate the monitoring of land use dynamics across forested landscapes in developing future strategies and policies concerning agricultural diversification,natural forest conservation and monoculture tree plantations.展开更多
基金Supported by Major Project of The Ministry of Science and Technology of China (No. 2007BAI26B07)
文摘AIM: To evaluate the efficacy of topical administration Natamycin, which is produced by China, in an experimental rabbit model of Fusarium solani keratitis, to provide experimental basis for the application of clinical safety. · METHODS: Fusarium solani was induced in the right eye of 30 New Zealand rabbits. Forty-eight hours after inoculation, the animals were divided into 3 different treatment groups, 10 rabbit eyes of each group: Group 1 (Natamycin) treated with topical Natamycin, group 2 (Natacyn) treated with topical Natacyn, group 3 (control) treated with topical saline solution. The eyes of each group was examined clinically with slit lamp using ulcer scoring system on day 4, 10, 15, and 21 for status of healing, corneal vascularisation, iritis, hypopyon and macular nebula. The findings were recorded on day 10 and day 21. · RESULTS: Ulcer score on day 10, day 15, day 21: The score of Natamycin group are 1.45±0.16, 1.08±0.11, 0.70±0.40. The score of Natacyn group are 1.35±0.12, 1.10±0.12, 0.65±0.35. the score of control group are 1.30±0.08, 3.63±0.28, 3.80±0.16. Natamycin group and Natacyn group were different from control group(P <0.01). There is no difference between Natamycin group and Natacyn group. Status of healing on day 10 and day 21: The cure rate of the Natamycin group is 90% on day 10, and 100% on day 21. The cure rate of the Natacyn group is 80% on day 10, and 100% on day 21.Natamycin group and Natacyn group were different from control group (P <0.01). There is no difference between Natamycin group and Natacyn group. Corneal vascularisation, iritis, hypopyon and macular nebula on day 10 and day 21: in Natamycin group, the number of the eyes which have Corner vascularisation, iritis, hypopyon and macular nebula are 2,0,0,2. In Natacyn group, the number of the eyes which have Corner vascularisation, iritis, hypopyon and macular nebula are 1,0,0,2. In control group, the number of the eyes which have Corner vascularisation, iritis, hypopyon and macular nebula are 9,9,8,9.Natamycin group and Natacyn group were different from control group (P< 0.01). There is no difference between Natamycin group and Natacyn group. · CONCLUSION: Natamycin was found to be effective in fungal keratitis, similar to Natacyn, and it can stop the corner vascularisation, iritis, hypopyon and macular nebula to happen. Natamyin manufactured in China is effective against fungal keratitis, with esay availability and low toxicity in its use.
文摘Background:Monitoring the changing pattern of vegetation across diverse landscapes through remote sensing is instrumental in understanding the interactions of human activities and the ecological environment.Land use pattern in the state of Himachal Pradesh in the Indian Western Himalayas has been undergoing rapid modifications due to changing cropping patterns,rising anthropogenic pressure on forests and government policies.We studied land use change in Solan Forest Division of Himachal Pradesh to assess species wise area changes in the forests of the region.Methods:The supervised classification(Maximum likelihood)on two dates of IRS(LISS III)satellite data was performed to assess land use change over the period 1998–2010.Results:Seven land use categories were identified namely,chir pine(Pinus roxburghii)forest,broadleaved forest,bamboo(Dendrocalamus strictus)forest,ban oak(Quercus leucotrichophora)forest,khair(Acacia catechu)forest,culturable blank and cultivation.The area under chir pine,cultivation and khair forests increased by 191 ha(4.55 %),129 ha(13.81 %)and 77 ha(23.40 %),whereas the area under ban oak,broadleaved,culturable blank and bamboo decreased by 181 ha(16.58 %),152 ha(6.30 %),71 ha(2.72 %)and 7 ha(0.47 %),respectively.Conclusions:The study revealed a decrease in the area under forest and culturable blank categories and a simultaneous increase in the area under cultivation primarily due to the large scale introduction of horticultural cash crops in the state.The composition of forests also exhibited some major changes,with an increase in the area of commercially important monoculture plantation species such as pine and khair,and a decline in the area of oak,broadleaved and bamboo which are facing a high anthropogenic pressure in meeting the livelihood demands of forest dependent communities.In time deforestation,forest degradation and ecological imbalances due to the changing forest species composition may inflict irreversible damages upon unstable and fragile mountain zones such as the Indian Himalayas.The associated common property externalities involved at local,regional and global scales,necessitate the monitoring of land use dynamics across forested landscapes in developing future strategies and policies concerning agricultural diversification,natural forest conservation and monoculture tree plantations.
