Jetting-based bioprinting:process,dispense physics,and applications

Jetting-based bioprinting facilitates contactless drop-on-demand deposition of subnanoliter droplets at well-defined positions to control the spatial arrangement of cells,growth factors,drugs,and biomaterials in a highly automated layer-by-layer fabrication approach.Due to its immense versatility,jetting-based bioprinting has been used for various applications,including tissue engineering and regenerative medicine,wound healing,and drug development.A lack of in-depth understanding exists in the processes that occur during jetting-based bioprinting.This review paper will comprehensively discuss the physical considerations for bioinks and printing conditions used in jetting-based bioprinting.We first present an overview of different jetting-based bioprinting techniques such as inkjet bioprinting,laser-induced forward transfer bioprinting,electrohydrodynamic jet bioprinting,acoustic bioprinting and microvalve bioprinting.Next,we provide an in-depth discussion of various considerations for bioink formulation relating to cell deposition,print chamber design,droplet formation and droplet impact.Finally,we highlight recent accomplishments in jetting-based bioprinting.We present the advantages and challenges of each method,discuss considerations relating to cell viability and protein stability,and conclude by providing insights into future directions of jetting-based bioprinting.

A novel encoding mechanism for particle physics

This study proposes a novel particle encoding mechanism that seamlessly incorporates the quantum properties of particles,with a specific emphasis on constituent quarks.The primary objective of this mechanism is to facilitate the digital registration and identification of a wide range of particle information.Its design ensures easy integration with different event generators and digital simulations commonly used in high-energy experiments.Moreover,this innovative framework can be easily expanded to encode complex multi-quark states comprising up to nine valence quarks and accommodating an angular momentum of up to 99/2.This versatility and scalability make it a valuable tool.

Exploring device physics of perovskite solar cell via machine learning with limited samples

Perovskite solar cells(PsCs)have developed tremendously over the past decade.However,the key factors influencing the power conversion efficiency(PCE)of PSCs remain incompletely understood,due to the complexity and coupling of these structural and compositional parameters.In this research,we demon-strate an effective approach to optimize PSCs performance via machine learning(ML).To address chal-lenges posed by limited samples,we propose a feature mask(FM)method,which augments training samples through feature transformation rather than synthetic data.Using this approach,squeeze-and-excitation residual network(SEResNet)model achieves an accuracy with a root-mean-square-error(RMSE)of 0.833%and a Pearson's correlation coefficient(r)of 0.980.Furthermore,we employ the permu-tation importance(PI)algorithm to investigate key features for PCE.Subsequently,we predict PCE through high-throughput screenings,in which we study the relationship between PCE and chemical com-positions.After that,we conduct experiments to validate the consistency between predicted results by ML and experimental results.In this work,ML demonstrates the capability to predict device performance,extract key parameters from complex systems,and accelerate the transition from laboratory findings to commercialapplications.

Ultrafast photoemission electron microscopy:A multidimensional probe of nonequilibrium physics

Exploring the realms of physics that extend beyond thermal equilibrium has emerged as a crucial branch of condensed matter physics research.It aims to unravel the intricate processes involving the excitations,interactions,and annihilations of quasi-and many-body particles,and ultimately to achieve the manipulation and engineering of exotic non-equilibrium quantum phases on the ultrasmall and ultrafast spatiotemporal scales.Given the inherent complexities arising from many-body dynamics,it therefore seeks a technique that has efficient and diverse detection degrees of freedom to study the underlying physics.By combining high-power femtosecond lasers with real-or momentum-space photoemission electron microscopy(PEEM),imaging excited state phenomena from multiple perspectives,including time,real space,energy,momentum,and spin,can be conveniently achieved,making it a unique technique in studying physics out of equilibrium.In this context,we overview the working principle and technical advances of the PEEM apparatus and the related laser systems,and survey key excited-state phenomena probed through this surface-sensitive methodology,including the ultrafast dynamics of electrons,excitons,plasmons,spins,etc.,in materials ranging from bulk and nano-structured metals and semiconductors to low-dimensional quantum materials.Through this review,one can further envision that time-resolved PEEM will open new avenues for investigating a variety of classical and quantum phenomena in a multidimensional parameter space,offering unprecedented and comprehensive insights into important questions in the field of condensed matter physics.

Physics-based seismic analysis of ancient wood structure:fault-to-structure simulation

Based on the domain reduction method,this study employs an SEM-FEM hybrid workflow which integrates the advantages of the spectral element method(SEM)for flexible and highly efficient simulation of seismic wave propagation in a three-dimensional(3D)regional-scale geophysics model and the finite element method(FEM)for fine simulation of structural response including soil-structure interaction,and performs a physics-based simulation from initial fault rupture on an ancient wood structure.After verification of the hybrid workflow,a large-scale model of an ancient wood structure in the Beijing area,The Tower of Buddhist Incense,is established and its responses under the 1665 Tongxian earthquake and the 1730 Yiheyuan earthquake are simulated.The results from the simulated ground motion and seismic response of the wood structure under the two earthquakes demonstrate that this hybrid workflow can be employed to efficiently provide insight into the relationships between geophysical parameters and the structural response,and is of great significance toward accurate input for seismic simulation of structures under specific site and fault conditions.

基于Interactive Physics的物理习题教学--以2023年高考全国乙卷25题和湖北卷15题为例

在传统高中物理教学中,多过程碰撞的物理过程很难在板书上展现出来,成为教学的一大难点。基于Interactive Physics仿真功能,以2023年高考全国乙卷25题和湖北卷15题为例,将多过程碰撞的物理过程可视化,直观展现物理模型,帮助学生理解题目的复杂情境,有效缩短学习时间,提高教学质量和教学效率,实现最优化的教学目标。

Tensile Shock Physics in Compressible Thermoviscoelastic Solid Medium

This paper addresses tensile shock physics in thermoviscoelastic (TVE) solids without memory. The mathematical model is derived using conservation and balance laws (CBL) of classical continuum mechanics (CCM), incorporating the contravariant second Piola-Kirchhoff stress tensor, the covariant Green’s strain tensor, and its rates up to order n. This mathematical model permits the study of finite deformation and finite strain compressible deformation physics with an ordered rate dissipation mechanism. Constitutive theories are derived using conjugate pairs in entropy inequality and the representation theorem. The resulting mathematical model is both thermodynamically and mathematically consistent and has closure. The solution of the initial value problems (IVPs) describing evolutions is obtained using a variationally consistent space-time coupled finite element method, derived using space-time residual functional in which the local approximations are in hpk higher-order scalar product spaces. This permits accurate description problem physics over the discretization and also permits precise a posteriori computation of the space-time residual functional, an accurate measure of the accuracy of the computed solution. Model problem studies are presented to demonstrate tensile shock formation, propagation, reflection, and interaction. A unique feature of this research is that tensile shocks can only exist in solid matter, as their existence requires a medium to be elastic (presence of strain), which is only possible in a solid medium. In tensile shock physics, a decrease in the density of the medium caused by tensile waves leads to shock formation ahead of the wave. In contrast, in compressive shocks, an increase in density and the corresponding compressive waves result in the formation of compression shocks behind of the wave. Although these are two similar phenomena, they are inherently different in nature. To our knowledge, this work has not been reported in the published literature.

Design and Research of an Intelligent Learning System for University Physics

In order to break through the limitations of traditional teaching,realize the integration of online and offline teaching,and optimize the intelligent learning experience of university physics,this paper proposes the design of an intelligent learning system for university physics based on cloud computing platforms,and applies this system to teaching environment of university physics.It successfully integrates emerging technologies such as cloud computing,machine learning,and situational awareness,integrates learning context awareness,intelligent recording and broadcasting,resource sharing,learning performance prediction,and content planning and recommendation,and comprehensively improves the quality of university physics teaching.It can optimize the teaching process and deepen intelligent teaching reform,aiming at providing references for the teaching practice of university physics.

Reform and Practice of University Physics Experimental Teaching Based on OBE Concept

Aiming at the problems of unclear teaching objectives,obsolete content,and single method in the experimental teaching of university physics at our university,we have implemented a series of reform initiatives.It mainly includes clarifying the student-centered teaching objectives,optimizing the experimental content,innovating the teaching methods,improving the assessment and evaluation system,and improving the experimental conditions[1,2].After the implementation of the reform,the learning effectiveness of students has been significantly improved,the teaching level of teachers has been significantly enhanced,the curriculum system has been optimized,the efficiency of teaching management has been enhanced,and social recognition has been strengthened.Practice shows that the teaching reform based on the outcome-based education concept effectively improves the quality of university physics experimental teaching and lays the foundation for cultivating innovative talents.

Integration of Ideological and Political Education in College Physics Courses Under the Reform of Smart Teaching

The development of the times has prompted China to enhance the quality of education and the value of talent.As guides for students,teachers should conscientiously implement ideological and political education,create college physics courses that are more in line with modern talent cultivation,eliminate the fixed and singular nature of traditional teaching,and find the integration points of ideological and political education.Teachers need to use the textbook itself,the expansion of resources in smart classrooms,and current technological progress to implement ideological and political education in order to cultivate more high-quality and high-level comprehensive talents for society.

COMSOL Multiphysics在物理化学教学中的应用

将计算仿真融入大学化学专业课程的讲授是帮助学生具体化抽象概念、提升教学质量的新思路。本文介绍了多场物理仿真软件COMSOL Multiphysics的基本原理和操作,并结合大学物理化学课程的教学内容,总结说明了该软件在相平衡、化学平衡以及化学动力学等章节中的应用实例。由学生反馈可知,计算模拟软件在课堂教学中的可视化的演示,增强了学生对所学知识的理解和掌握,提高了学生的学习热情和思考深度。

The Longmen Cloud Physics Field Experiment Base, China Meteorological Administration

Aiming at the needs of mechanism analysis of rainstorms and development of numerical prediction models in south China, the Guangzhou Institute of Tropical and Marine Meteorology of China Meteorological Administration and the Chinese Academy of Meteorological Sciences jointly set up the Longmen Cloud Physics Field Experiment Base,China Meteorological Administration. This paper introduces the instruments and field experiments of this base, provides an overview of the recent advances in retrieval algorithms of microphysical parameters, improved understanding of microphysical characteristics, as well as the formation mechanisms and numerical prediction of heavy rainfalls in south China based on the field experiments dataset.

基于Vernier Video Physics软件的物理实验探究——以“探究平抛运动的特点”为例

智能手机的飞速发展和智能手机APP的不断更新对当今社会的各个方面都产生了深远的影响。与此同时,智能手机APP也逐渐被引入课堂教学中,为学生提供了自主学习的机会,也使物理实验教学模式发生了巨大的改变,成了广大教育者关注的热点。利用Vernier Video Physics软件和Vernier Graphical Analysis软件,再结合平抛运动实验仪,对小钢球的运动轨迹进行逐帧追踪定位,得到小钢球做平抛运动的y-x图像、x-t图像、y-t图像和v_(y)-t图像,再对图像进行相应函数拟合,经过数据分析,得到小钢球做平抛运动在水平方向和竖直方向的运动特点。利用智能手机APP辅助高中物理实验教学可以激发学生的学习兴趣,帮助学生理解物理概念和规律,使学生积极主动地参与到实验中来,培养他们的动手能力,提升他们的实验素养。

Rock physics and seismic reflectivity parameterization and amplitude variation with offsets inversion in terms of total organic carbon indicator

Total organic carbon (TOC) prediction with elastic parameter inversions has been widely used in the identification and evaluation of source rocks. However, the elastic parameters used to predict TOC are not only determined by TOC but also depend on the other physical properties of source rocks. Besides, the TOC prediction with the elastic parameters inversion is an indirect method based on the statistical relationship obtained from well logs and experiment data. Therefore, we propose a rock physics model and define a TOC indicator mainly affected by TOC to predict TOC directly. The proposed rock physics model makes the equivalent elastic moduli of source rocks parameterized by the TOC indicator. Combining the equivalent elastic moduli of source rocks and Gray’s approximation leads to a novel linearized approximation of the P-wave reflection coefficient incorporating the TOC indicator. Model examples illustrate that the novel reflectivity approximation well agrees with the exact Zoeppritz equation until incident angles reach 40°. Convoluting the novel P-wave reflection approximation with seismic wavelets as the forward solver, an AVO inversion method based on the Bayesian theory is proposed to invert the TOC indicator with seismic data. The synthetic examples and field tests validate the feasibility and stability of the proposed AVO inversion approach. Using the inversion results of the TOC indicator, TOC is directly and accurately estimated in the target area.

Petrophysical parameters inversion for heavy oil reservoir based on a laboratory-calibrated frequency-variant rock-physics model

Heavy oil has high density and viscosity, and exhibits viscoelasticity. Gassmann's theory is not suitable for materials saturated with viscoelastic fluids. Directly applying such model leads to unreliable results for seismic inversion of heavy oil reservoir. To describe the viscoelastic behavior of heavy oil, we modeled the elastic properties of heavy oil with varying viscosity and frequency using the Cole-Cole-Maxwell (CCM) model. Then, we used a CCoherent Potential Approximation (CPA) instead of the Gassmann equations to account for the fluid effect, by extending the single-phase fluid condition to two-phase fluid (heavy oil and water) condition, so that partial saturation of heavy oil can be considered. This rock physics model establishes the relationship between the elastic modulus of reservoir rock and viscosity, frequency and saturation. The viscosity of the heavy oil and the elastic moduli and porosity of typical reservoir rock samples were measured in laboratory, which were used for calibration of the rock physics model. The well-calibrated frequency-variant CPA model was applied to the prediction of the P- and S-wave velocities in the seismic frequency range (1–100 Hz) and the inversion of petrophysical parameters for a heavy oil reservoir. The pre-stack inversion results of elastic parameters are improved compared with those results using the CPA model in the sonic logging frequency (∼10 kHz), or conventional rock physics model such as the Xu-Payne model. In addition, the inversion of the porosity of the reservoir was conducted with the simulated annealing method, and the result fits reasonably well with the logging curve and depicts the location of the heavy oil reservoir on the time slice. The application of the laboratory-calibrated CPA model provides better results with the velocity dispersion correction, suggesting the important role of accurate frequency dependent rock physics models in the seismic prediction of heavy oil reservoirs.

2024 Adult Compendium of Physical Activities:A third update of the energy costs of human activities

Background:The Compendium of Physical Activities was published in 1993 to improve the comparability of energy expenditure values assigned to self-reported physical activity(PA)across studies.The original version was updated in 2000,and again in 2011,and has been widely used to support PA research,practice,and public health guidelines.Methods:This 2024 update was tailored for adults 19-59 years of age by removing data from those≥60 years.Using a systematic review and supplementary searches,we identified new activities and their associated measured metabolic equivalent(MET)values(using indirect calorimetry)published since 2011.We replaced estimated METs with measured values when possible.Results:We screened 32,173 abstracts and 1507 full-text papers and extracted 2356 PA energy expenditure values from 701 papers.We added303 new PAs and adjusted 176 existing MET values and descriptions to reflect the addition of new data and removal of METs for older adults.We added a Major Heading(Video Games).The 2024 Adult Compendium includes 1114 PAs(912 with measured and 202 with estimated values)across 22 Major Headings.Conclusion:This comprehensive update and refinement led to the creation of The 2024 Adult Compendium,which has utility across research,public health,education,and healthcare domains,as well as in the development of consumer health technologies.The new website with the complete lists of PAs and supporting resources is available at https://pacompendium.com.

Association between physical activity and risk of gastroesophageal reflux disease:A systematic review and meta-analysis

Background:Lifestyle plays an important role in preventing and managing gastroesophageal reflux disease(GERD).In response to the conflicting results in previous studies,we performed a systematic review and meta-analysis to investigate this association.Methods:Relevant studies published until January 2023 were retrieved from 6 databases,and the prevalence of symptomatic gastroesophageal reflux(GER)or GERD was determined from the original studies.A random effects model was employed to meta-analyze the association by computing the pooled relative risk(RR)with 95%confidence intervals(95%CIs).Furthermore,subgroup and dose-response analyses were performed to explore subgroup differences and the association between cumulative physical activity(PA)time and GERD.Results:This meta-analysis included 33 studies comprising 242,850 participants.A significant negative association was observed between PA and the prevalence of symptomatic GER(RR=0.74,95%CI:0.66-0.83;p<0.01)or GERD(RR=0.80,95%CI:0.76-0.84;p<0.01),suggesting that engaging in PA might confer a protective benefit against GERD.Subgroup analyses consistently indicated the presence of this association across nearly all subgroups,particularly among the older individuals(RR_(<40 years):RR_(≥40 years)=0.85:0.69,p<0.01)and smokers(RR_(smoker):RR_(non-smoker)=0.67:0.82,p=0.03).Furthermore,a dose-response analysis revealed that individuals who engaged in 150 min of PA per week had a 72.09%lower risk of developing GERD.Conclusion:Maintaining high levels of PA decreased the risk of GERD,particularly among older adults and smokers.Meeting the recommended PA level of 150 min per week may significantly decrease the prevalence of GERD.

Physical Literacy的本土化:概念厘定、实践反思及应对

Physical Literacy(简称PL)是身体活动与健康促进领域的重要理念,也是新时代学校体育的开拓点之一。长期以来,学界对PL的认知存在争议或模糊不清,导致其在实践中出现了一定的迟滞和偏差,故对相关认知加以厘定与反思具有重要意义。研究认为:(1)从形式逻辑来看,我国学者构建的PL概念在内涵与外延上存在争议或误用。内涵方面,“素养”作为属概念规定了PL的内在特性;“体育素养”的转译窄化了PL的内涵,而译为“身体素养”更能体现PL的身体本源性;作为面向全民的基础生活素养,PL并非核心素养在体育学科的具体化,不宜将其与体育学科核心素养相等同。外延方面,部分PL的外延体系存在偷换“Physical”概念、子素养客体化、子素养相容等问题。(2)在本土实践中,对PL的评价被横向割裂,且纵向衔接不畅;PL的发展情境囿于学校,家庭、社区等校外情境应用不足。针对以上问题,该研究建议未来既要构建横纵贯通的评价体系,也要注意营造多样化的发展情境。

Alexa,let's train now!——A systematic review and classification approach to digital and home-based physical training interventions aiming to support healthy cognitive aging

Background:There is mounting evidence that regular physical activity is an important prerequisite for healthy cognitive aging.Consequently,the finding that almost one-third of the adult population does not reach the recommended level of regular physical activity calls for further public health actions.In this context,digital and home-based physical training interventions might be a promising alternative to center-based intervention programs.Thus,this systematic review aimed to summarize the current state of the literature on the effects of digital and home-based physical training interventions on adult cognitive performance.Methods:In this pre-registered systematic review(PROSPERO;ID:CRD42022320031),5 electronic databases(PubMed,Web of Science,Psyclnfo,SPORTDiscus,and Cochrane Library)were searched by 2 independent researchers(FH and PT)to identify eligible studies investigating the effects of digital and home-based physical training interventions on cognitive performance in adults.The systematic literature search yielded 8258 records(extra17 records from other sources),of which 27 controlled trials were considered relevant.Two reviewers(FH and PT)independently extracted data and assessed the risk of bias using a modified version of the Tool for the assEssment of Study qualiTy and reporting in EXercise(TESTEX scale).Results:Of the 27 reviewed studies,15 reported positive effects on cognitive and motor-cognitive outcomes(i.e.,performance improvements in measures of executive functions,working memory,and choice stepping reaction test),and a considerable heterogeneity concerning study-related,population-related,and intervention-related characteristics was noticed.A more detailed analysis suggests that,in particular,interventions using online classes and technology-based exercise devices(i.e.,step-based exergames)can improve cognitive performance in healthy older adults.Approximately one-half of the reviewed studies were rated as having a high risk of bias with respect to completion adherence(≤85%)and monitoring of the level of regular physical activity in the control group.Conclusion:The current state of evidence concerning the effectiveness of digital and home-based physical training interventions is mixed overall,though there is limited evidence that specific types of digital and home-based physical training interventions(e.g.,online classes and step-based exergames)can be an effective strategy for improving cognitive performance in older adults.However,due to the limited number of available studies,future high-quality studies are needed to buttress this assumption empirically and to allow for more solid and nuanced conclusions.

Association of accelerometer-measured sleep duration and different intensities of physical activity with incident type 2 diabetes in a population-based cohort study

Purpose:The aim of the current study was to investigate the association of accelerometer-measured sleep duration and different intensities of physical activity(PA)with the risk of incident type 2 diabetes in a population-based prospective cohort study.Methods:Altogether,88,000 participants(mean age=62.2±7.9 years,mean±SD)were included from the UK Biobank.Sleep duration(short:<6 h/day;normal:6-8 h/day;long:>8 h/day)and PA of different intensities were measured using a wrist-won accelerometer over a 7-day period between 2013 and 2015.PA was classified according to the median or World Health Organization-recommendation:total volume of PA(high,low),moderate-to-vigorous PA(MVPA)(recommended,not recommended),and light-intensity PA(high,low).Incidence of type 2diabetes was ascertained using hospital records or death registries.Results:During a median follow-up of 7.0 years,1615 incident type 2 diabetes cases were documented.Compared with normal sleep duration,short(hazard ratio(HR)=1.21,95%confidence interval(95%CI):1.03-1.41)but not long sleep duration(HR=1.01,95%CI:0.89-1.15)was associated with excessive type 2 diabetes risk.This increased risk among short sleepers seems to be protected against by PA.Compared with normal sleepers with high or recommended PA,short sleepers with low volume of PA(HR=1.81,95%CI:1.46-2.25),not recommended(below the World Health Organization-recommended level of)MVPA(HR=1.92,95%CI:1.55-2.36),or low light-intensity PA(HR=1.49,95%CI:1.13-1.90)had a higher risk of type 2 diabetes,while short sleepers with a high volume of PA(HR=1.14,95%CI:0.88-1.49),recommended MVPA(HR=1.02,95%CI:0.71-1.48),or high light-intensity PA(HR=1.14,95%CI:0.92-1.41)did not.Conclusion:Accelerometer-measured short but not long sleep duration was associated with a higher risk of incident type 2 diabetes.A higher level of PA,regardless of intensity,potentially ameliorates this excessive risk.