Structure Based Library Approach to Photosynthesis Inhibitors:The Solid Phase Synthesis of Hydro-Uracils and Thiouracils

A general method for the solid phase synthesis of hydro-uracils and thiouracils is described. Resino ester 2 reacts with various primary amines to give secondary amines 3, which are converted to the resino ureas (thioureas) 4 by treatment with isocyanates (isothiocyanates). Preparation of the hydro-uracils and thiouracils 5 is achieved by acidic cyclization-cleavage from the resin. The synthesis is designed to be amenable for structure based library approach to photosystem II D1 protein inhibitors.

低能氮离子注入固态尿嘧啶的初步研究

对 ２５ ｋｅ Ｖ 氮离子束辐照尿嘧啶引起其分子结构的变化进行了研究。通过紫外光谱的分析，得到了离子注入后尿嘧啶的残余紫外吸收曲线。傅里叶红外光谱仪的分析，说明尿嘧啶受到了一定程度的损伤。茚三酮反应的测定证明了辐射后的样品中出现了新的化学基团——氨基。

低能离子注入对固态尿嘧啶损伤的初步研究

对２５ｋｅＶ氮、氩离子束辐照尿嘧啶（ｕｒａｃｉｌ）引起其分子结构的变化分别进行了研究，通过紫外光谱的分析，得到了离子注入后尿嘧啶的残余紫外吸收曲线，富里叶红外光谱仪的分析，说明尿嘧啶受到了一定程度的损伤；茚三酮反应的测定证明了氮、氩离子辐照后的样品中均产生了新的化学基团氨基。