Impact of intensive statin therapy on hs-CRP and sCD40L in AMI patients during perioperative period of emergency PCI

Background It＇s an effective treatment to achieve percutaneous coronary intervention （PCI） in acute myocardial infarction （AMI） patients for reperfusion of coronary artery. The PCI treatment can improve the blood supply of coronary artery, make some adverse effects at the same time. Studies have shown that statins have other effects in addition to lipid-lowering, such as anti-inflammatory effects. It can significantly reduce the incidence of coronary heart disease, cardiovascular disease mortality and even all-cause mortality. The aim of this study was to investigate the clinical effects and significance of intensive atorvastatin in AMI patients during perioperative period of PCI. Methods One hundred twelve AMI patients were randomly divided into three groups. The control group （n = 32） was given the routine medicine, and the two therapy groups were administered atorvastatin 80 mg or 40 mg before PCI,and then were administered atorvastati 40 mg q.d or 20 mg q.d after PCI. Levels of high-sensitive C-reactive protein （hs-CRP）, compared after PCI. Results sCD40L, myocardial enzymes and lipid was determined and Compared with the control group, the levels of serum hs-CRP, CD40L in treatment group 1 （n = 40） and treatment 2 group （n = 40） was significant difference between two treatment groups （ atorvastatin in AMI patients during PCI perioperative period i anti-inflammatory, anti-platelets, and stability of plaque and were significantly decreased （P 〈 0.05）, and there P 〈 0.01 ）. Conclusion Intensive treatment of s beneficial, possibly through Mechanisms such as coronary vascular endothelial function.

Levels of circulating follicular helper T cells,T helper 1 cells,and the prognostic significance of soluble form of CD40 ligand on survival in patients with alcoholic cirrhosis

Background:Excessive drinkers(ED)and patients with alcoholic liver disease(ALD)are several times more susceptible to bacterial and viral infections and have a decrease in antibody responses to vaccinations.Follicular helper T(TFH)cells are essential to select B cells in the germinal center and to produce antibodies.TFH cells express both a membrane-associated and a soluble form of CD40 ligand(sCD40L),in which the latter form is released to circulation upon T cell activation.The effect of alcohol on TFH cells has not been studied.Objectives:The goals of this study are to determine the levels of TFH and T helper 1(Th1)cells in ED and those with alcoholic cirrhosis(AC)when compared to healthy controls and to determine the prognostic significance of sCD40L in a cohort of patients with AC.Methods:Controls,ED,and those with AC were enrolled.Baseline demographic,laboratory tests,and peripheral blood mononuclear cells(PBMCs)were isolated and assessed via flow cytometry for TFH cells.In vitro study was performed to determine the ability of PBMCs to secrete interferon(IFN)-ɣupon stimulation.Serum sCD40L was also determined and its prognostic significance was tested in a cohort of AC patients.Results:The levels of circulating TFH(cTFH)cells were significantly lower in peripheral blood of subjects with ED and AC compared to controls(P<0.05).IFN-ɣsecretion from PBMCs upon stimulation was also lower in ED and those with cirrhosis.Serum sCD40L was significantly lower in ED and AC when compared to that in controls(P<0.0005).Its level was an independent predictor of mortality.Conclusions:Patients with AC had significantly lower level of cTFH and sCD40L.The level of sCD40L was an independent predictor of mortality in these patients.