Correlation of serum HMGB1 and sTLT-1 contents with oxidative stress response and endothelial injury in patients with ischemic stroke

Objective: To study the correlation of serum HMGB1 and sTLT-1 contents with oxidative stress response and endothelial injury in patients with ischemic stroke. Methods: The patients who were diagnosed with ischemic stroke in Zhouzhi County People's Hospital between February 2015 and March 2017 were selected as the stroke group of the study, and healthy subjects who received physical examination during the same period were selected as the control group of the study. Serum was collected to determine the contents of HMGB1, sTLT-1, oxidative stress reaction molecules and endothelial injury molecules. Results: Serum HMGB1, sTLT-1, vWF, vWF-cp, sTM, ET-1, D-D, 8-OHdG, LPO and NOS contents of stroke group were significantly higher than those of control group while T-SOD and GSH-Px contents were significantly lower than those of control group;serum T-SOD and GSH-Px contents of stroke patients with high HMBG-1 content were significantly lower than those of stroke patients with low HMBG-1 content while 8-OHdG, LPO and NOS contents were significantly higher than those of stroke patients with low HMBG-1 content;serum vWF, vWF-cp, sTM, ET-1 and D-D contents of stroke patients with high sTLT-1 content were significantly higher than those of stroke patients with low sTLT-1 content. Conclusion: The abnormally elevated HMGB1 and sTLT-1 in serum of patients with ischemic stroke can induce oxidative stress response and aggravate endothelial injury.

血清hs-cTnT、sTLT-1水平与急性心肌梗死患者PCI术后发生心血管不良事件的相关性

目的探讨血清高敏心肌肌钙蛋白(hs-cTnT)、可溶性髓样细胞触发受体样转录因子-1(sTLT-1)水平与急性心肌梗死(AMI)患者经皮冠状动脉介入(PCI)术后发生心血管不良事件的相关性。方法抽取2017年1月至2020年1月于大同市第五人民医院行PCI术治疗的发生心血管不良事件的AMI患者53例纳入发生组,另抽取同期行PCI术治疗的未发生心血管不良事件的AMI患者53例纳入未发生组。比较两组患者的心率、手术时间、血清hs-cTnT及sTLT-1水平。分析PCI术后心血管不良事件发生与血清hs-cTnT、sTLT-1水平之间的关系,采用受试者工作特征曲线(ROC)下面积(AUC)评价血清hs-cTnT、sTLT-1水平对心血管不良事件的预测价值。结果未发生组血清hs-cTnT[(2.14±0.75)ng/ml]、sTLT-1[(551.26±68.38)pg/ml]均低于发生组[(3.67±0.85)ng/ml,(607.24±65.31)pg/ml],差异有统计学意义(P<0.05)。Logistic回归分析结果显示,血清hs-cTnT、sTLT-1水平高表达可能是诱发心血管不良事件的影响因素(OR>1,P<0.05)。绘制ROC,结果显示,血清hs-cTnT、sTLT-1水平预测心血管不良事件发生的AUC均>0.7,均有一定预测价值,当各指标取最佳阈值取值时,可获得最佳预测价值。结论血清hs-cTnT、sTLT-1水平升高与AMI患者PCI术后的心血管不良事件的发生密切相关,可能参与心血管不良事件的发生与发展,且两者均对PCI术后发生心血管不良事件具有预测价值。