Modelling the Dynamical State of the Projected Primary and Secondary Intra-Solution-Particle Movement System of Efavirenz In-Vivo

This work seeks to describe intra-solution particle movement system. It makes use of data obtained from simulations of patients on efavirenz. A system of ordinary differential equations is used to model movement state at some particular concentration. The movement states’ description is found for the primary and secondary level. The primary system is found to be predominantly an unstable system while the secondary system is stable. This is derived from the state of dynamic eigenvalues associated with the system. The saturated solution-particle is projected to be stable both for the primary potential and secondary state. A volume conserving linear system has been suggested to describe the dynamical state of movement of a solution particle.

Mssbauer Effect in Ultrafine Particles with Fe-C Solid Solution,γ-Fe and Fe_3C Phases

Ultrafine particles prepared by evaporating pure Fe in CH4 atmosphere using arc-dischargeheating method, were found to consist of Fe-C solid solution, γ-Fe and Fe3C phases. EfFect of annealing temperature on phase transformation and hyperfine interactions has been investigated by Mossbauer spectroscopy, X-ray diffraction (XRD), differential thermal analysis and thermogravimetry (DTA-TG), transmission electron microscopy (TEM), oxygen determination and vibrating sample magnetometer (VSM) measurements. It was observed that phase transformation of γ-Fe to α-Fe occurs during annealing in vacuum. The mechanism causing the change of hyperfine interactions with annealing temperature differs for Fe-C solution and interstitial compounds. DifFerence of hyperfine interactions of Fe-C solid solution in the starting sample and its annealed samples is ascribed to the improvement of activation of interstitial carbon atoms. Stress-relieving in structure of annealed Fe3C particle can result in a weak influence on hyperfine interactions. Parameters fitted to the Mossbauer spectra show the existence of superparamagnetism in all the samples. Absorbed and combined oxygen on particle surface of the starting sample were determined.

High-gradient magnetic field-controlled migration of solutes and particles and their effects on solidification microstructure：A review

We present a review of the principal developments in the evolution and synergism of solute and particle migration in a liquid melt in high-gradient magnetic fields and we also describe their effects on the solidification microstructure of alloys.Diverse areas relevant to various aspects of theory and applications of high-gradient magnetic field-controlled migration of solutes and particles are surveyed. They include introduction, high-gradient magnetic field effects, migration behavior of solute and particles in high-gradient magnetic fields, microstructure evolution induced by high-gradient magnetic fieldcontrolled migrations of solute and particles, and properties of materials modified by high-gradient magnetic field-tailored microstructure. Selected examples of binary and multiphase alloy systems are presented and examined, with the main focus on the correlation between the high-gradient magnetic field-modified migration and the related solidification microstructure evolution. Particular attention is given to the mechanisms responsible for the microstructure evolution induced by highgradient magnetic fields.

Improved particle swarm optimization based on particles' explorative capability enhancement

Accelerating the convergence speed and avoiding the local optimal solution are two main goals of particle swarm optimization（PSO）. The very basic PSO model and some variants of PSO do not consider the enhancement of the explorative capability of each particle. Thus these methods have a slow convergence speed and may trap into a local optimal solution. To enhance the explorative capability of particles, a scheme called explorative capability enhancement in PSO（ECE-PSO） is proposed by introducing some virtual particles in random directions with random amplitude. The linearly decreasing method related to the maximum iteration and the nonlinearly decreasing method related to the fitness value of the globally best particle are employed to produce virtual particles. The above two methods are thoroughly compared with four representative advanced PSO variants on eight unimodal and multimodal benchmark problems. Experimental results indicate that the convergence speed and solution quality of ECE-PSO outperform the state-of-the-art PSO variants.

Effect of Thermal Buoyancy on Fluid Flow and Inclusion Motion in Tundish without Flow Control Devices——Part II :Inclusion Motion

Following up the fluid flow simulation in a 60 t tundish, the trajectories of inclusions in the 60 t tundish without flow control are simulated by considering the force balance between the drag force and the inertial buoyancy force. The Stochastic model yields more accurate inclusion motion than the non-Stochastic model due to including the effect of the turbulent fluctuation. The average residence time of inclusions decreases with increasing size. The thermal buoyancy favors inclusions removal especially the small inclusions. Using solute transport like the dye injection in water model and copper addition in the real steel tundish cannot accurately study the motion of the inclusions. In the simulation, more than 68% inclusions bigger than 10μm are removed to the top, and less than 32% enters the mold. The thermal buoyancy has little effect on the fraction of inclusions moved to the top of the inlet zone, and it mainly favors the removal of inclusions smaller than 100μm to the top surface of the outlet zone. For inclusions bigger than 100μm, the effect of thermal buoyancy on their motion can be ignored compared to the inertial buoyancy effect.

Influence of solute cloud and precipitates on spatiotemporal characteristics of Portevin-Le Chatelier effect in A2024 aluminum alloys

In this paper, solute concentration and precipitate content in A2024 aluminum alloy are adjusted by solution treatment （ST） at different temperatures and tensile experiments on these treated specimens are carried out. It is found that the temperature of solution treatment （ST temperature） has a remarkable influence on the amplitude of the serrated flow and the propagation characteristics of shear bands. These results are due to the effects of solute atoms and precipitates on dynamic strain aging （DSA）. When ST temperature is higher than 300 ℃, solute concentration is relatively high and solute cloud is a key factor of DSA. When ST temperature is lower than 300 ℃, precipitate content is relatively high and the mechanism of DSA is determined by precipitates.