The Yangtze River basin(YRB)experienced a record-breaking mei-yu season in June‒July 2020.This unique long-lasting extreme event and its origin have attracted considerable attention.Previous studies have suggested tha...The Yangtze River basin(YRB)experienced a record-breaking mei-yu season in June‒July 2020.This unique long-lasting extreme event and its origin have attracted considerable attention.Previous studies have suggested that the Indian Ocean(IO)SST forcing and soil moisture anomaly over the Indochina Peninsula(ICP)were responsible for this unexpected event.However,the relative contributions of IO SST and ICP soil moisture to the 2020 mei-yu rainfall event,especially their linkage with atmospheric circulation changes,remain unclear.By using observations and numerical simulations,this study examines the synergistic impacts of IO SST and ICP soil moisture on the extreme mei-yu in 2020.Results show that the prolonged dry soil moisture led to a warmer surface over the ICP in May under strong IO SST backgrounds.The intensification of the warm condition further magnified the land thermal effects,which in turn facilitated the westward extension of the western North Pacific subtropical high(WNPSH)in June‒July.The intensified WNPSH amplified the water vapor convergence and ascending motion over the YRB,thereby contributing to the 2020 mei-yu.In contrast,the land thermal anomalies diminish during normal IO SST backgrounds due to the limited persistence of soil moisture.The roles of IO SST and ICP soil moisture are verified and quantified using the Community Earth System Model.Their synergistic impacts yield a notable 32%increase in YRB precipitation.Our findings provide evidence for the combined influences of IO SST forcing and ICP soil moisture variability on the occurrence of the 2020 super mei-yu.展开更多
Sea surface temperature(SST)is one of the important parameters of global ocean and climate research,which can be retrieved by satellite infrared and passive microwave remote sensing instruments.While satellite infrare...Sea surface temperature(SST)is one of the important parameters of global ocean and climate research,which can be retrieved by satellite infrared and passive microwave remote sensing instruments.While satellite infrared SST offers high spatial resolution,it is limited by cloud cover.On the other hand,passive microwave SST provides all-weather observation but suffers from poor spatial resolution and susceptibility to environmental factors such as rainfall,coastal effects,and high wind speeds.To achieve high-precision,comprehensive,and high-resolution SST data,it is essential to fuse infrared and microwave SST measurements.In this study,data from the Fengyun-3D(FY-3D)medium resolution spectral imager II(MERSI-II)SST and microwave imager(MWRI)SST were fused.Firstly,the accuracy of both MERSIII SST and MWRI SST was verified,and the latter was bilinearly interpolated to match the 5km resolution grid of MERSI SST.After pretreatment and quality control of MERSI SST and MWRI SST,a Piece-Wise Regression method was employed to correct biases in MWRI SST.Subsequently,SST data were selected based on spatial resolution and accuracy within a 3-day window of the analysis date.Finally,an optimal interpolation method was applied to fuse the FY-3D MERSI-II SST and MWRI SST.The results demonstrated a significant improvement in spatial coverage compared to MERSI-II SST and MWRI SST.Furthermore,the fusion SST retained true spatial distribution details and exhibited an accuracy of–0.12±0.74℃compared to OSTIA SST.This study has improved the accuracy of FY satellite fusion SST products in China.展开更多
Somatostatin,a naturally produced neuroprotective peptide,depresses excitatory neurotransmission and exerts anti-proliferative and anti-inflammatory effects on the retina.In this review,we summarize the progress of so...Somatostatin,a naturally produced neuroprotective peptide,depresses excitatory neurotransmission and exerts anti-proliferative and anti-inflammatory effects on the retina.In this review,we summarize the progress of somatostatin treatment of diabetic retinopathy through analysis of relevant studies published from February 2019 to February 2023 extracted from the PubMed and Google Scholar databases.Insufficient neuroprotection,which occurs as a consequence of declined expression or dysregulation of retinal somatostatin in the very early stages of diabetic retinopathy,triggers retinal neurovascular unit impairment and microvascular damage.Somatostatin replacement is a promising treatment for retinal neurodegeneration in diabetic retinopathy.Numerous pre-clinical and clinical trials of somatostatin analog treatment for early diabetic retinopathy have been initiated.In one such trial(EUROCONDOR),topical administration of somatostatin was found to exert neuroprotective effects in patients with pre-existing retinal neurodysfunction,but had no impact on the onset of diabetic retinopathy.Overall,we concluded that somatostatin restoration may be especially beneficial for the growing population of patients with early-stage retinopathy.In order to achieve early prevention of diabetic retinopathy initiation,and thereby salvage visual function before the appearance of moderate non-proliferative diabetic retinopathy,several issues need to be addressed.These include the needs to:a)update and standardize the retinal screening scheme to incorporate the detection of early neurodegeneration,b)identify patient subgroups who would benefit from somatostatin analog supplementation,c)elucidate the interactions of somatostatin,particularly exogenously-delivered somatostatin analogs,with other retinal peptides in the context of hyperglycemia,and d)design safe,feasible,low cost,and effective administration routes.展开更多
BACKGROUND Severe acute pancreatitis(SAP),a condition with rapid onset,critical condition and unsatisfactory prognosis,poses a certain threat to human health,warranting optimization of relevant treatment plans to impr...BACKGROUND Severe acute pancreatitis(SAP),a condition with rapid onset,critical condition and unsatisfactory prognosis,poses a certain threat to human health,warranting optimization of relevant treatment plans to improve treatment efficacy.AIM To evaluate the efficacy and safety of computerized tomography-guided the-rapeutic percutaneous puncture catheter drainage(CT-TPPCD)combined with somatostatin(SS)in the treatment of SAP.METHODS Forty-two SAP patients admitted to The Second Affiliated Hospital of Fujian Medical University from June 2020 to June 2023 were selected.On the basis of routine treatment,20 patients received SS therapy(control group)and 22 patients were given CT-TPPCD plus SS intervention(research group).The efficacy,safety(pancreatic fistula,intra-abdominal hemorrhage,sepsis,and organ dysfunction syndrome),abdominal bloating and pain relief time,bowel recovery time,hospital stay,inflammatory indicators(C-reactive protein,interleukin-6,and pro-calcitonin),and Acute Physiology and Chronic Health Evaluation(APACHE)II score of both groups were evaluated for comparison.RESULTS Compared with the control group,the research group had a markedly higher total effective rate,faster abdominal bloating and pain relief and bowel recovery,INTRODUCTION Pancreatitis,an inflammatory disease occurring in the pancreatic tissue,is classified as either acute or chronic and is associated with high morbidity and mortality,imposing a socioeconomic burden[1,2].The pathogenesis of this disease involves early protease activation,activation of nuclear factor kappa-B-related inflammatory reactions,and infiltration of immune cells[3].Severe acute pancreatitis(SAP)is a serious condition involving systemic injury and subsequent possible organ failure,accounting for 20%of all acute pancreatitis cases[4].SAP is also characterized by rapid onset,critical illness and unsatisfactory prognosis and is correlated with serious adverse events such as systemic inflammatory response syn-drome and acute lung injury,threatening the health of patients[5,6].Therefore,timely and effective therapeutic inter-ventions are of great significance for improving patient prognosis and ensuring therapeutic effects.Somatostatin(SS),a peptide hormone that can be secreted by endocrine cells and the central nervous system,is in-volved in the regulatory mechanism of glucagon and insulin synthesis in the pancreas[7].It has complex and pleiotropic effects on the gastrointestinal tract,which can inhibit the release of gastrointestinal hormones and negatively modulate the exocrine function of the stomach,pancreas and bile,while exerting a certain influence on the absorption of the di-gestive system[8,9].SS has shown certain clinical effectiveness when applied to SAP patients and can regulate the severity of SAP and immune inflammatory responses,and this regulation is related to its influence on leukocyte apoptosis and adhesion[10,11].Computerized tomography-guided therapeutic percutaneous puncture catheter drainage(CT-TPPCD)is a surgical procedure to collect lesion fluid and pus samples from necrotic lesions and perform puncture and drainage by means of CT image examination and precise positioning[12].In the research of Liu et al[13],CT-TPPCD applied to pa-tients undergoing pancreatic surgery contributes to not only good curative effects but also a low surgical risk.Baudin et al[14]also reported that CT-TPPCD has a clinical success rate of 64.6%in patients with acute infectious necrotizing pan-creatitis,with nonfatal surgery-related complications found in only two cases,suggesting that this procedure is clinically effective and safe in the treatment of the disease.In light of the limited studies on the efficacy and safety of SS plus CT-TPPCD in SAP treatment,this study performed a relevant analysis to improve clinical outcomes in SAP patients.展开更多
本文基于卫星遥感的观测海表面温度(Sea Surface Temperature,SST)数据和自然资源部第一海洋研究所全球0.1°分辨率海浪-潮流-环流耦合数值预报模式(The surface wave-tide-circulation coupled ocean model developed by First Ins...本文基于卫星遥感的观测海表面温度(Sea Surface Temperature,SST)数据和自然资源部第一海洋研究所全球0.1°分辨率海浪-潮流-环流耦合数值预报模式(The surface wave-tide-circulation coupled ocean model developed by First Institute of Oceanography,MNR,China,FIO-COM)的预报结果,采用线性回归模型和长短期记忆神经网络(Long Short-Term Memory,LSTM)对SST预报结果进行误差校正。利用2016—2021年的数据开展了一系列对比试验,线性回归模型基于局部线性的假设实现对下一时刻误差的预报,LSTM利用2016—2020年共56个月的历史偏差数据训练模型,使用2021年的数据进行检验。结果表明,线性回归模型和LSTM神经网络都可以改善预报结果,LSTM神经网络相对于线性回归模型的效果更好,SST误差降低70%左右;与线性回归模型相比,经LSTM校正后的各点的偏差的概率密度分布集中在0附近。LSTM方法在统计意义上优于线性拟合且结果更稳定,可进一步推广到海洋数值预报多要素偏差校正。展开更多
基金supported by the National Key R&D Program of China(Grant No.2022YFF0801603).
文摘The Yangtze River basin(YRB)experienced a record-breaking mei-yu season in June‒July 2020.This unique long-lasting extreme event and its origin have attracted considerable attention.Previous studies have suggested that the Indian Ocean(IO)SST forcing and soil moisture anomaly over the Indochina Peninsula(ICP)were responsible for this unexpected event.However,the relative contributions of IO SST and ICP soil moisture to the 2020 mei-yu rainfall event,especially their linkage with atmospheric circulation changes,remain unclear.By using observations and numerical simulations,this study examines the synergistic impacts of IO SST and ICP soil moisture on the extreme mei-yu in 2020.Results show that the prolonged dry soil moisture led to a warmer surface over the ICP in May under strong IO SST backgrounds.The intensification of the warm condition further magnified the land thermal effects,which in turn facilitated the westward extension of the western North Pacific subtropical high(WNPSH)in June‒July.The intensified WNPSH amplified the water vapor convergence and ascending motion over the YRB,thereby contributing to the 2020 mei-yu.In contrast,the land thermal anomalies diminish during normal IO SST backgrounds due to the limited persistence of soil moisture.The roles of IO SST and ICP soil moisture are verified and quantified using the Community Earth System Model.Their synergistic impacts yield a notable 32%increase in YRB precipitation.Our findings provide evidence for the combined influences of IO SST forcing and ICP soil moisture variability on the occurrence of the 2020 super mei-yu.
文摘Sea surface temperature(SST)is one of the important parameters of global ocean and climate research,which can be retrieved by satellite infrared and passive microwave remote sensing instruments.While satellite infrared SST offers high spatial resolution,it is limited by cloud cover.On the other hand,passive microwave SST provides all-weather observation but suffers from poor spatial resolution and susceptibility to environmental factors such as rainfall,coastal effects,and high wind speeds.To achieve high-precision,comprehensive,and high-resolution SST data,it is essential to fuse infrared and microwave SST measurements.In this study,data from the Fengyun-3D(FY-3D)medium resolution spectral imager II(MERSI-II)SST and microwave imager(MWRI)SST were fused.Firstly,the accuracy of both MERSIII SST and MWRI SST was verified,and the latter was bilinearly interpolated to match the 5km resolution grid of MERSI SST.After pretreatment and quality control of MERSI SST and MWRI SST,a Piece-Wise Regression method was employed to correct biases in MWRI SST.Subsequently,SST data were selected based on spatial resolution and accuracy within a 3-day window of the analysis date.Finally,an optimal interpolation method was applied to fuse the FY-3D MERSI-II SST and MWRI SST.The results demonstrated a significant improvement in spatial coverage compared to MERSI-II SST and MWRI SST.Furthermore,the fusion SST retained true spatial distribution details and exhibited an accuracy of–0.12±0.74℃compared to OSTIA SST.This study has improved the accuracy of FY satellite fusion SST products in China.
基金supported by the Natural Science Foundation of Chongqing of China,Nos.cstc2020jcyj-msxmX0698(to YF),cstc2021jcyjbshX0147(to KO)a grant from Chongqing Jiangjin District Bureau of Science and Technology,No.Y2022017(to YF).
文摘Somatostatin,a naturally produced neuroprotective peptide,depresses excitatory neurotransmission and exerts anti-proliferative and anti-inflammatory effects on the retina.In this review,we summarize the progress of somatostatin treatment of diabetic retinopathy through analysis of relevant studies published from February 2019 to February 2023 extracted from the PubMed and Google Scholar databases.Insufficient neuroprotection,which occurs as a consequence of declined expression or dysregulation of retinal somatostatin in the very early stages of diabetic retinopathy,triggers retinal neurovascular unit impairment and microvascular damage.Somatostatin replacement is a promising treatment for retinal neurodegeneration in diabetic retinopathy.Numerous pre-clinical and clinical trials of somatostatin analog treatment for early diabetic retinopathy have been initiated.In one such trial(EUROCONDOR),topical administration of somatostatin was found to exert neuroprotective effects in patients with pre-existing retinal neurodysfunction,but had no impact on the onset of diabetic retinopathy.Overall,we concluded that somatostatin restoration may be especially beneficial for the growing population of patients with early-stage retinopathy.In order to achieve early prevention of diabetic retinopathy initiation,and thereby salvage visual function before the appearance of moderate non-proliferative diabetic retinopathy,several issues need to be addressed.These include the needs to:a)update and standardize the retinal screening scheme to incorporate the detection of early neurodegeneration,b)identify patient subgroups who would benefit from somatostatin analog supplementation,c)elucidate the interactions of somatostatin,particularly exogenously-delivered somatostatin analogs,with other retinal peptides in the context of hyperglycemia,and d)design safe,feasible,low cost,and effective administration routes.
基金Supported by 2022 Fujian Medical University Qihang Fund General Project Plan,No.2022QH1120。
文摘BACKGROUND Severe acute pancreatitis(SAP),a condition with rapid onset,critical condition and unsatisfactory prognosis,poses a certain threat to human health,warranting optimization of relevant treatment plans to improve treatment efficacy.AIM To evaluate the efficacy and safety of computerized tomography-guided the-rapeutic percutaneous puncture catheter drainage(CT-TPPCD)combined with somatostatin(SS)in the treatment of SAP.METHODS Forty-two SAP patients admitted to The Second Affiliated Hospital of Fujian Medical University from June 2020 to June 2023 were selected.On the basis of routine treatment,20 patients received SS therapy(control group)and 22 patients were given CT-TPPCD plus SS intervention(research group).The efficacy,safety(pancreatic fistula,intra-abdominal hemorrhage,sepsis,and organ dysfunction syndrome),abdominal bloating and pain relief time,bowel recovery time,hospital stay,inflammatory indicators(C-reactive protein,interleukin-6,and pro-calcitonin),and Acute Physiology and Chronic Health Evaluation(APACHE)II score of both groups were evaluated for comparison.RESULTS Compared with the control group,the research group had a markedly higher total effective rate,faster abdominal bloating and pain relief and bowel recovery,INTRODUCTION Pancreatitis,an inflammatory disease occurring in the pancreatic tissue,is classified as either acute or chronic and is associated with high morbidity and mortality,imposing a socioeconomic burden[1,2].The pathogenesis of this disease involves early protease activation,activation of nuclear factor kappa-B-related inflammatory reactions,and infiltration of immune cells[3].Severe acute pancreatitis(SAP)is a serious condition involving systemic injury and subsequent possible organ failure,accounting for 20%of all acute pancreatitis cases[4].SAP is also characterized by rapid onset,critical illness and unsatisfactory prognosis and is correlated with serious adverse events such as systemic inflammatory response syn-drome and acute lung injury,threatening the health of patients[5,6].Therefore,timely and effective therapeutic inter-ventions are of great significance for improving patient prognosis and ensuring therapeutic effects.Somatostatin(SS),a peptide hormone that can be secreted by endocrine cells and the central nervous system,is in-volved in the regulatory mechanism of glucagon and insulin synthesis in the pancreas[7].It has complex and pleiotropic effects on the gastrointestinal tract,which can inhibit the release of gastrointestinal hormones and negatively modulate the exocrine function of the stomach,pancreas and bile,while exerting a certain influence on the absorption of the di-gestive system[8,9].SS has shown certain clinical effectiveness when applied to SAP patients and can regulate the severity of SAP and immune inflammatory responses,and this regulation is related to its influence on leukocyte apoptosis and adhesion[10,11].Computerized tomography-guided therapeutic percutaneous puncture catheter drainage(CT-TPPCD)is a surgical procedure to collect lesion fluid and pus samples from necrotic lesions and perform puncture and drainage by means of CT image examination and precise positioning[12].In the research of Liu et al[13],CT-TPPCD applied to pa-tients undergoing pancreatic surgery contributes to not only good curative effects but also a low surgical risk.Baudin et al[14]also reported that CT-TPPCD has a clinical success rate of 64.6%in patients with acute infectious necrotizing pan-creatitis,with nonfatal surgery-related complications found in only two cases,suggesting that this procedure is clinically effective and safe in the treatment of the disease.In light of the limited studies on the efficacy and safety of SS plus CT-TPPCD in SAP treatment,this study performed a relevant analysis to improve clinical outcomes in SAP patients.
基金funded by the National Natural Science Foundation of China[grant number 42105063]the Youth Training Project of the Key Laboratory for Meteorological Disaster Monitoring and Early Warning and Risk Management of Characteristic Agriculture in Arid Regions[project number CAMT-202302]a funded project of Hengyang Normal University[project number 2022QD11].
文摘本文基于卫星遥感的观测海表面温度(Sea Surface Temperature,SST)数据和自然资源部第一海洋研究所全球0.1°分辨率海浪-潮流-环流耦合数值预报模式(The surface wave-tide-circulation coupled ocean model developed by First Institute of Oceanography,MNR,China,FIO-COM)的预报结果,采用线性回归模型和长短期记忆神经网络(Long Short-Term Memory,LSTM)对SST预报结果进行误差校正。利用2016—2021年的数据开展了一系列对比试验,线性回归模型基于局部线性的假设实现对下一时刻误差的预报,LSTM利用2016—2020年共56个月的历史偏差数据训练模型,使用2021年的数据进行检验。结果表明,线性回归模型和LSTM神经网络都可以改善预报结果,LSTM神经网络相对于线性回归模型的效果更好,SST误差降低70%左右;与线性回归模型相比,经LSTM校正后的各点的偏差的概率密度分布集中在0附近。LSTM方法在统计意义上优于线性拟合且结果更稳定,可进一步推广到海洋数值预报多要素偏差校正。
