Validation of a Marker of Atrial Contraction in the SonR Signal

Introduction: The main component of the endocardial acceleration signal (SonR) is today used for cardiac resynchronization therapy (CRT) optimization. This prospective, single center pilot study focuses on another signal component, SonR4 that may provide further information on the atrial activity. Methods and Results: SonR signal and ECG tracings were recorded simultaneously during a CRT-D optimization procedure in 15 patients (12 men, 68 ± 9.5 years, ischemic heart disease 53%) indicated for CRT. Correlation between SonR4 signal, recorded using SonR and atrial contraction, identified by Echo Doppler was evaluated by Pearson and Student’s t tests under different Atrio-Ventricular (AV) delay programming. From 15 consecutive screened patients, 9 had concomitant analyzable SonR4 and ECG recordings and were included in the study population. The presence of the SonR4 component was systematically correlated to the presence of the A wave. A significant correlation was observed between SonR4 and A wave timings (r = 0.75, p = 0.02) according to different AV delays, with a high reproducibility in SonR4 assessment. Conclusion: A strong correlation between SonR4 and atrial contraction timings was observed, further suggesting that SonR4 is a marker of the atrial contraction. Additional assessments in larger populations are required to confirm these results and build further applications.

大巴山前缘含油气构造条件

文章运用当前地质研究与勘探工作中的重要方法──平衡地质剖面法，对大巴山前缘地区的油气构造条件进行了研究。研究认为，大巴山前缘的构造变形由强到弱（自北东向南西），可分为四个带：①位于城口—高观寺断裂以南、坪坝—雷公坝—乌龙断裂以北的断裂构造带；②位于坪坝—雷公坝—乌龙断裂以南、河口—关庙一渔沙断裂以北的断裂—褶皱带；③位于河口—关庙—渔沙断裂以南、李子垭—沙沱—线以北的褶皱带；④位于李子垭—沙沱—线以南的前锋褶皱—构造复合带。区内滑脱构造、台阶状断层以及断层相关褶皱发育，断层转折褶皱是良好的圈闭构造。平衡剖面的研究，为分析地下一定深度的构造提供了新思路和新方法，结合本区内的生、储、盖组合单元情况，提．出了南门场构造带与马槽坝构造带之间、温泉井构造带与大巴山前缘构造带之间等５个有利的勘探远景区块。

大鼠下丘脑VP神经元及相关核团的生后发育及免疫细胞化学研究

用不同年龄的Ｗｉｓｔａｒ大鼠为实验动物，用免疫细胞化学改良的ＡＢＣ法及常规组织学方法检测了ＶＰ神经元及相关核团的生后发育。结果表明，生后１天，ＳＯＮ，ＰＶＮ，ＣＮ可辩认；生后５～１０天，ＳＣＮ出现；２０～３０天，室管膜由假复层柱状上皮变为单层柱状上皮，相关核团的细胞变大，胞浆增多，大神经元胞体直径达２０～２５μｍ，与６０～９０天的结构相似。免疫细胞化学（ＩＣＣ）显示，生后１天，ＳＯＮ，ＰＶＮ，ＣＮ可见ＶＰ免疫阳性细胞；５～１０天，此阳性细胞胞浆着色加深。２０～３０天，ＶＰ免疫阳性神经元的大小及着色与生后６０～９０天相似，表明ＶＰ免疫阳性神经元生后即出现，２０～３０天此神经元及相关核团的发育状况已接近成年。