Objective To investigate the protective effects of sound conditioning against subsequent high -level noise trauma in rats.Method Rats were exposed to a 4 kHz octave band noise at 95 dB SPL for 10 hours,then to a traum...Objective To investigate the protective effects of sound conditioning against subsequent high -level noise trauma in rats.Method Rats were exposed to a 4 kHz octave band noise at 95 dB SPL for 10 hours,then to a traumatic exposure dose(105 dB SPL for 13 hours) delivered 12h later.Control animals were exposured to the traumatic dose only.ABR thresholds were obtained before and after noise exposure.Result Animals that had been sound conditioned demonstrated less ABR threshold shift compared to those that had not.Conclusion Moderate level sound exposure appears to have a toughening effect on the rat cochlea(or'conditioning') leading to decreased hearing loss from subsequent traumatic exposure.展开更多
文摘Objective To investigate the protective effects of sound conditioning against subsequent high -level noise trauma in rats.Method Rats were exposed to a 4 kHz octave band noise at 95 dB SPL for 10 hours,then to a traumatic exposure dose(105 dB SPL for 13 hours) delivered 12h later.Control animals were exposured to the traumatic dose only.ABR thresholds were obtained before and after noise exposure.Result Animals that had been sound conditioned demonstrated less ABR threshold shift compared to those that had not.Conclusion Moderate level sound exposure appears to have a toughening effect on the rat cochlea(or'conditioning') leading to decreased hearing loss from subsequent traumatic exposure.
