Projection of precipitation extremes over South Asia from CMIP6 GCMs

Extreme precipitation events are one of the most dangerous hydrometeorological disasters,often resulting in significant human and socio-economic losses worldwide.It is therefore important to use current global climate models to project future changes in precipitation extremes.The present study aims to assess the future changes in precipitation extremes over South Asia from the Coupled Model Intercomparison Project Phase 6(CMIP6)Global Climate Models(GCMs).The results were derived using the modified Mann-Kendall test,Sen's slope estimator,student's t-test,and probability density function approach.Eight extreme precipitation indices were assessed,including wet days(RR1mm),heavy precipitation days(RR10mm),very heavy precipitation days(RR20mm),severe precipitation days(RR50mm),consecutive wet days(CWD),consecutive dry days(CDD),maximum 5-day precipitation amount(RX5day),and simple daily intensity index(SDII).The future changes were estimated in two time periods for the 21^(st) century(i.e.,near future(NF;2021-2060)and far future(FF;2061-2100))under two Shared Socioeconomic Pathway(SSP)scenarios(SSP2-4.5 and SSP5-8.5).The results suggest increases in the frequency and intensity of extreme precipitation indices under the SSP5-8.5 scenario towards the end of the 21^(st) century(2061-2100).Moreover,from the results of multimodel ensemble means(MMEMs),extreme precipitation indices of RR1mm,RR10mm,RR20mm,CWD,and SDII demonstrate remarkable increases in the FF period under the SSP5-8.5 scenario.The spatial distribution of extreme precipitation indices shows intensification over the eastern part of South Asia compared to the western part.The probability density function of extreme precipitation indices suggests a frequent(intense)occurrence of precipitation extremes in the FF period under the SSP5-8.5 scenario,with values up to 35.00 d for RR1mm and 25.00-35.00 d for CWD.The potential impacts of heavy precipitation can pose serious challenges to the study area regarding flooding,soil erosion,water resource management,food security,and agriculture development.

Incidence, Mortality, and Epidemiology of Leukemia in South Asia: An Ecological Study

Background: Nowadays cancer is a buzzword in every corner of the world. Back a few decades, cancer was not that much known to the people of South Asia let alone known of Leukemia. Many countries in the South Asian region are designated as developing countries. Hence, the deficiency of diagnosis system, treatment, management, and lack of knowledge about leukemia in this region are major problems. Therefore, the incidence rate, mortality rate, and several deaths are increasing day by day. Methods: This cross-sectional study is aimed to investigate the incidence and mortality of leukemia in South Asian Countries for the year 2020 by acquiring data from the global cancer project (GLOBOCAN2020) accessible at https://gco.iarc.fr. Results: In South Asia, 1,733,573 cancer cases were documented in 2020 where 62,163 cases were leukemia related. The highest incidence rate was reported in Pakistan (4.3 in 1,000,000) and Sri Lanka (4.1 in 1,000,000) and the lowest in Bangladesh (1.8 in 1,000,000) and Nepal (2.0 in 1,000,000). On the other hand, 1,124,875 death had been reported in 2020, where 45,707 (4.1%) death was associated with leukemia. Pakistan (3.4 in 1,000,000) and Maldives (3.1 in 1,000,000) had the highest death and lowest in Bangladesh (1.4 in 1,000,000) and Nepal (1.5 in 1,000,000). Adults aged from 60 - 85 years old have the highest rate of incidence and mortality rate in all countries except Nepal. Conclusions: Leukemia is one of the major concerning cancer of all ages people in South Asia, the situation and related risk factors information can be helpful to reduce death through proper treatment.

Views of South Asian Physicians on Climate Related Health Effects: A Multinational Cross-Sectional Pilot Study

Background: South Asian populations are vulnerable to poor health outcomes associated with climate due to the region’s complex topography, poverty, lack of education, and population density. Physicians, being highly trusted members of society, can help mitigate climate change effects in their countries. Objectives: The present study assessed perceptions of physicians from four South Asian countries (Bangladesh, Bhutan, India, and Pakistan). We hypothesized that physicians from these countries will be aware and knowledgeable about health effects of climate change. Methods: We conducted a cross-sectional online survey of physicians between March and July 2022. Data of 201 physicians was analyzed using the Kruskal-Wallis test and Dunn’s post hoc method. Results: Physicians from four South Asian countries were attuned to the health risks associated with climate change. A majority of physicians (86.6%) believed that climate change would make health conditions in their countries more severe or frequent (Bangladesh 83.3%;Bhutan 70%;India 91% and Pakistan 90.8%). The most common health effect related to climate change was illnesses related to reduced outdoor air quality (54.3%). Common barriers to discuss climate change with patients from all four countries were physicians’ lack of knowledge (strongly agree, 13.8%;agree 47.7%) in how to approach the issue with patients, lack of time (strongly agree, 12%;agree, 48%) and their perception that patients were not interested in knowing about climate change (strongly agree, 8.6%;agree, 42.6%). More than half (56.2%) of the physicians reported no training (Bangladesh, 51.7%;Bhutan, 80%;India, 44.6%;Pakistan, 63.1%) and approximately 30% reported less than 20 hours of training (Bangladesh, 28.3%;Bhutan, 15.0%;India, 39.3%;Pakistan, 27.7%) in climate-change-related health effects. Conclusion: While additional large-scale research is needed to understand the trends observed in our pilot study, our findings identify the need to introduce interventions to improve physicians’ knowledge of the health impacts of climate crisis.

Seasonal Variation and Heat Preference of the South Asia High

By use of the NCEP/ NCAR reanalysis data, the seasonal variation of the South Asia high (SAH) is analyzed. The influences of temporal and spatial variations of the middle and upper level atmospheric temperatures, the visible heat sources, and the diabatic heating rates in the whole atmospheric column on the seasonal variation of the SAH are discussed. Results show that the SAH has two seasonal balancing modes, one of which is the land high in summer and the other the ocean high in winter. The land high itself can be divided into two patterns as well, that is the Tibetan high and the Iranian high. Heating fields have important impacts on the seasonal variation of the SAH. The SAH is a warm high and its center has the property of heat preference, usually locating over or moving to an area with relatively larger heating rates. The annual cycle of the SAH is mainly controlled by the seasonal process of the latent and sensible heating in South Asia. Strong shortwave radiative heating in the north at high latitudes and over the Tibetan Plateau also has an effects on the northward movement and maintenance of the SAH. The cooling effect of infrared radiation is an important cause in weakening the SAH.

The Impact of the Tropical Indian Ocean on South Asian High in Boreal Summer

The tropical Indian Ocean （TIO） is warmer than normal during the summer when or after the El Nio decays. The present study investigates the impact of TIO SST on the South Asian High （SAH） in summer. When the TIO is warmer, the SAH strengthens and its center shifts southward. It is found that the variations in the SAH cannot be accounted for by the precipitation anomaly. A possible mechanism is proposed to explain the connection between the TIO and SAH： warmer SST in the TIO changes the equivalent potential temperature （EPT） in the atmospheric boundary layer （ABL）, alters the temperature profile of the moist atmosphere, warms the troposphere, which produces significant positive height anomaly over South Asia and modifies the SAH. An atmospheric general circulation model, ECHAM5, which has a reasonable prediction skill in the TIO and South Asia, was selected to test the effects of TIO SST on the SAH. The experiment with idealized heating over the TIO reproduced the response of the SAH to TIO warming. The results suggest that the TIO-induced EPT change in the ABL can account for the variations in the SAH.

Analysis of the Simulated Climatic Characters of the South Asia High with a Flexible Coupled Ocean-Atmosphere GCM

The ability of a climate model to reproduce the climatic characters of the South Asia High （SAH） is assessed by analyzing the 110-yr output of a Flexible Coupled GCM, version 0 （FGCM-0）. Comparing the results of FGCM-0 with the NCEP/NCAR reanalysis data, the major findings show that FGCM-0 has better results in simulation of the geopotential height field at 100 hPa, and reproduces fairly the main atmospheric circulation centers. However, there are still some differences in the simulated results compared with the reanalysis data. The coupled model also successfully reproduces the mean seasonal variation of the SAH, that is, it moves from the Pacific Ocean to the Asian continent, remaining over the Tibetan Plateau from winter to summer, and then withdraws from the Tibetan Plateau to the Pacific Ocean from summer to winter. However, such observed relationships between the SAH positions and the summer precipitation patterns cannot be fairly reproduced in the FGCM-0.

COMPARISONS OF THE WEST PACIFIC SUBTROPICAL HIGH AND THE SOUTH ASIA HIGH BETWEEN NCEP/NCAR AND ECMWF REANALYSIS DATASETS

Comparisons of the west Pacific subtropical high with the South Asia High are made using the NCEP/NCAR and ECMWF 500 hPa and 100 hPa monthly boreal geopotential height fields for the period 1961-2000. Discrepancies are found for the time prior to 1980. The west Pacific subtropical high in the NCEP/NCAR data is less intense than in ECMWF data before 1980. The range and strength of the west Pacific subtropical high variation described by the NCEP/NCAR data are larger than those depicted by ECMWF data. The same situation appears in the 100-hPa geopotential field. These discoveries suggest that the interdecadal variation of the two systems as shown by the NCEP/NCAR data may not be true. Besides, the South Asia High center in the NCEP/NCAR data is obviously stronger than in the ECMWF data during the periods 1969, 1979-1991 and 1992-1995. Furthermore, the range is larger from 1992 to 1995.

Observed Diurnal Cycle of Summer Precipitation over South Asia and East Asia Based on CMORPH and TRMM Satellite Data

The characteristics of the summer precipitation diurnal cycle over South Asia and East Asia during 2001–13 are investigated based on the high spatiotemporal resolution estimates of the CPC(Climate Prediction Center) Morphing(CMORPH) technique. The results show that summer precipitation over South Asia and East Asia possesses a remarkable diurnal cycle, with obvious regional differences. Over the coastal areas, plateau, and high mountains, summer precipitation peaks in the late afternoon; while over low altitude areas, such as valleys, basins, and inshore seas, it peaks during midnight to early morning. In addition to these general features consistent with previous studies, the high resolution CMORPH technique can depict finer regional details, such as the less coherent phase pattern over a few regions. Besides, through comparative analysis of the diurnal cycle strength and precipitation fields, the authors find that for humid areas the summer precipitation diurnal cycle is especially significant over Southeast China, the Sichuan Basin, Hainan Province, Taiwan Province, the Philippines, and Indonesia. And it is relatively weak over the south of Northeast China, central East China, Yunnan Province, the central Indian Peninsula, and most oceanic areas. Comparisons between two satellite datasets—those of the CMORPH and Tropical Rainfall Measuring Mission(TRMM) 3B42 products—are also presented. For summer precipitation and the main diurnal cycle features, the results from both products agree over most regions, except a few areas, e.g., the Tibetan Plateau.

SSR Analysis on Diversity of AA Genome Oryza Species in the Southeast and South Asia

To investigate genetic diversities among the AA genome Oryza species in the Southeast and South Asia, a total of 428 accessions of the AA genome Oryza species were genotyped using 36 simple sequence repeats (SSR) markers distributed throughout the rice genome. All of the 36 SSR markers generated polymorphic bands, revealing 100% polymorphism. The number of alleles per locus ranged from 3 to 17 with the mean of 8.6. The Nei's genetic diversity index (He) ranged from 0.337 at RM455 to 0.865 at RM169 with an average value of 0.650. The genetic diversity of the AA genome Oryza species in the Southeast Asia was obviously higher than that in the South Asia. Among the detected Oryza species in the South and Southeast Asia, O. rufipogon showed the highest genetic diversity. Meanwhile, a higher genetic differentiation (Fst) was found among the detected Oryza species in the Southeast Asia than in the South Asia. The Fst value between O. nivara and O. sativa was the highest. The results from the number of specific alleles, specific loci, and allele frequency confirmed the greater genetic variation among the detected species. In addition, the specific allele in RM161 displayed higher frequency (0.193), suggesting its important function in identifying Oryza species of AA genome.

IMPACTS OF MONTHLY ANOMALIES OF INTRASEASONAL OSCILLATION OVER SOUTH CHINA SEA AND SOUTH ASIA ON THE ACTIVITY OF SUMMER MONSOON AND RAINFALL IN EASTERN CHINA

The impact of strong(weak) intraseasonal oscillation(ISO) over South China Sea(SCS) and South Asia(SA)in summer on the SCS and SA summer monsoon and the summer rainfall in Eastern China are studied by using the NCEP-NCAR analysis data and the rainfall data of 160 stations in China from 1961 to 2010.It is found that the impacts are significantly different in different months of summer.The study shows that in June and July cyclonic(anticyclonic) atmospheric circulation over SCS and SA corresponds to strong(weak) ISO over SCS.In August,however,strong(weak) ISO over SCS still corresponds to cyclonic(anticyclonic) atmospheric circulation over SA.In June and August cyclonic(anticyclonic) atmospheric circulation over South Asia corresponds to strong(weak) ISO over SA while a strong(weak) ISO corresponds to anticyclonic(cyclonic) atmospheric circulation over SA in July.Besides,in June the strong(weak) ISO over SA corresponds to cyclonic(anticyclonic) atmospheric circulation over SCS,while in July and August the atmospheric circulation is in the same phase regardless of whether the ISO over SA is strong or weak.The impacts of the strong(weak)ISO over SCS on the rainfall of eastern China are similar in June and July,which favors less(more) rainfall in Yangtze-Huaihe Rivers basin but sufficient(deficient) rainfall in the south of Yangtze River.However,the impacts are not so apparent in August.In South Asia,the strong(weak) ISO in July results in less(more)rainfall in the south of Yangtze River but sufficient(deficient) rainfall in Yangtze-Huaihe Rivers basin.The influence on the rainfall in eastern China in June and August is not as significant as in July.

ON THE RELATIONSHIP BETWEEN 100-hPa SOUTH ASIA HIGH AND MEI-YU IN JIANGSU PROVINCE

By analyzing the change of an index for the characteristics of South Asia High and variations of upper-air troughs in 2002–2005,we studied the impact of South Asia high on the beginning and ending of the Mei-yu(i.e.sustained rain corresponding to the ripening season of plum)in Jiangsu province.Statistic verification is conducted on the relationships between the index and the Mei-yu season in 1991–2005 to examine the impacts of the SAH characteristics index on a rain intensity index of Mei-yu and regional distribution of a characteristics index for different annual patterns of Mei-yu.Historical composite is performed of the 100-hPa circulation field for these patterns using the 100-hPa geopotential height of Northern Hemisphere from 2002 to 2005 and 45-year NCEP reanalysis to study the difference in the circulation for different patterns of Mei-yu.Diagnostic and statistic conclusions,which share much in common,have been obtained as follows.(1)The characteristics preceding to and the advancement/retreat of SAH and the movement of westerly troughs are the factors that influence the onset time of the Mei-yu season;after the Mei-yu onset,the progression/withdrawal of SAH and how farther east it extends are determining how long the Mei-yu lasts and when it ends.(2)During the Mei-yu,the general 100-hPa circulation situation and average characteristics of the SAH are well corresponding to the characteristics of the season and annual patterns of Mei-yu.In addition,the averages of the SAH ridgeline and east-extending index for June,July and the Mei-yu season have some implications to the forecast of the index of Mei-yu intensity.These conclusions can be served as powerful means in determining the starting/ending dates, duration and annual pattern of the Mei-yu season.

Public health preparedness and responses to the coronavirus disease 2019(COVID-19)pandemic in South Asia:a situation and policy analysis

Like rest of the world,the South Asian region is facing enormous challenges with the coronavirus disease 2019(COVID-19)pandemic.The socio-economic context of the eight South Asian countries is averse to any longterm lockdown program,but the region still observed stringent lockdown close to two months.This paper analyzed major measures in public health preparedness and responses in those countries in the pandemic.The research was based on a situation analysis to discuss appropriate plan for epidemic preparedness,strategies for prevention and control measures,and adequate response management mechanism.Based on the data from March 21 to June 26,2020,it appeared lockdown program along with other control measures were not as effective to arrest the exponential growth of fortnightly COVID-19 cases in Afghanistan,Bangladesh,India,Nepal and Pakistan.However,Bhutan,Maldives and Sri Lanka have been successfully limiting the spread of the disease.The in-depth analysis of prevention and control measures espoused densely populated context of South Asia needs community-led intervention strategy,such as case containment,in order to reverse the growing trend,and adopt the policy of mitigation instead of suppression to formulate COVID-19 action plan.On the other hand,mechanism for response management encompassed a four-tier approach of governance to weave community-led local bodies with state,national and international governance actors for enhancing the countries’emergency operation system.It is concluded resource-crunch countries in South Asia are unable to cope with the disproportionate demand of capital and skilled health care workforce at the time of the pandemic.Hence,response management needs an approach of governance maximization instead of resource maximization.The epidemiologic management of population coupled with suitable public health prevention and control measures may be a more appropriate strategy to strike a balance between economy and population health during the time of pandemic.

Relation among Summer Rainfall in South Shandong and High Pressure in South Asia and Atmospheric Circulation

[Objective] The aim was to study the relation among summer rainfall in south Shandong and high pressure in South Asia and atmospheric circulation.[Method] Taking the precipitation in south Shandong along the Yellow River and Huaihe River,using the NCEP/NCAR data and summer rainfall data in south Shandong in summer from 1961 to 2005,the characteristics of high pressure in South Asia and atmospheric circulation in drought year and flood year in summer in south Shandong Province were expounded.The mechanism of 100 hPa pressure in South Asian influencing precipitation in south Shandong Province was discussed.The interaction of different equipment,different altitude and different system of atmosphere circulation in low and high layer was expounded.[Results] The first mode of EOF decomposition of precipitation in summer in south Shandong Province explained above 63% variances and reflected universal form of precipitation.The difference of central position of the central position of height field of high pressure in South Asia in drought and flood year was small.But the wind field center was inconsistent.As the area of SAH was smaller and its eastern ridge line stretched to the Western Pacific between the middle of south Shandong and Changjiang Estuary,flood summer occurred when there was an unusual cyclone lied in the east of 90° E and south of Lake Baikal.The area of SAH was larger and its eastern ridge line stretching to the Western Pacific over Changjiang Estuary,drought summer occurred,when there was an unusual anticyclone lied in the east of 90° E and south of Lake Baikal.SAH and summer rainfall also had close relationship with Tele-connection Patterns over the Eurasia continent and EAP Tele-connection.When the height anomaly was in '+-+' form in the north of the Caspian Sea,around Lake Baikal and Kamchatka,and when the height anomaly in East Asia-West Pacific area was in '-+' form from low altitude to high altitude,there was much precipitation in summer;and conversely,it was drought in summer in south Shandong.[Conclusion] It provided the oretical basis for summer rainfall in south Shandong.

FURTHER RESEARCH ON MECHANISM OF TBO IN SOUTH ASIAN MONSOON REGION

The results of this study prove that there is significant troposphere biennial oscillation(TBO) in the South Asian climate, especially with the Indian summer monsoon rainfall. In order to explore the mechanism of TBO in the South Asian region, we defined a unified South Asian monsoon index to depict South Asian summer monsoon(SASM) and South Asian winter monsoon(SAWM) and the transition features between SASM and SAWM. Through further analysis, the connection between the abnormity of SASM and SAWM was discovered. Normally, a strong SAWM is beneficial for a weak SASM later, while a weak SAWM favors a strong SASM. Meanwhile, a strong SASM is favorable for a weak SAWM and a weak SAWM always happens after a weak SASM. Such results suggest the evolution of the South Asian monsoon, which may be an important mechanism to excite TBO in South Asia.

Impact of global financial crunch on financially innovative microfinance institutions in South Asia

The wave of global financial crises(2008-2009)caused a surge in the capital flows of developed countries particularly,between developed and developing countries.The crunch hit all financial sectors with unanticipated severity.The study evaluates the role of a country’s political practices in moderating the impact of global financial crunch on microfinance performance.Using the fixed effect panel regression method on the dataset comprising of 95 MFIs operating in South Asia from 2003 to 2012,we determine that microfinance operational capability shares a positive relationship with the institutional attributes of a country and our output reveals that impact of country’s political practices is pervasive on the financial output of MFIs,liable to different levels of implementation.The findings further reveals that MFIs situated in countries having vigorous political practices are less severely affected by the economic crunch.

Diversifying on the Ark:multiple new endemic lineages of dwarf geckos from the Western Ghats provide insights into the systematics and biogeography of South Asian Cnemaspis(Reptilia:Squamata)

The highly speciose gekkonid genus Cnemaspis Strauch,1887 is polyphyletic,with three distantly related and geographically isolated clades from Africa,South Asia(SA),and Southeast Asia.At present,there are 85 known species within SA Cnemaspis,although the number continues to increase rapidly with focused surveys and rigorous taxonomic work.Recent studies have provided valuable insights into the diversity and evolutionary history of SA Cnemaspis;however,most of these studies lack sufficient sampling in the Western Ghats(WG),where the genus has its greatest diversity.We addressed this research gap by conducting extensive sampling across the WG and re-examining museum specimens,thus providing a systematic account of various extant Cnemaspis species along with their distribution and natural history.We described 12 new species and a southern WG endemic clade of SA Cnemaspis.Ten of the newly described species are endemic to the forests of the southern WG.We also identified 10 well-supported subclades that can be separated across morphological,geographic,and phylogenetic axes.A time-calibrated phylogeny and ancestral area reconstructions confirmed the Paleocene origin of SA Cnemaspis in the WG and provide insights into its evolutionary history and biogeography.The discovery of multiple endemic and deeply divergent lineages further highlights the evolutionary significance of the WG for lizards.

ANALYSIS OF EFFECT OF ENVIRONMENTAL POTENTIAL VORTICITY LOCATED AT SOUTH EDGE OF SOUTH ASIA HIGH ON INTENSIFICATION OF TROPICAL CYCLONES

The NCEP 1°×1°reanalysis of June-to-September dataset between 2002 to 2009 is used in this study to conduct statistical analysis of the relationship between the environmental potential vorticity(PV)on 150 hPa located at the south edge of South Asia High(SAH)and TCs making landfall.The results show that 23 of the TCs are affected by the PV on 150 hPa located at the south edge of SAH between 2002 to2009,and three TCs'center pressure decline after the high-value environmental PV moves to the center of the TCs.These three TCs are Senlaku(0216),Bilis(0604)and Linfa(0903).Through diagnostic analysis from the viewpoint of isolines,we determined the relationship between the intensification of these TCs and the PV anomaly at high levels;the isentropic surface is close to the high level’s PV anomaly under the influence of the 150-hPa PV anomaly,leading to the decline of isentropic surfaces on both sides of the PV anomaly.Then the warm core of the middle and high levels of the TC strengthens and PV increases at the middle level,and both of them are beneficial to the reinforcement of the cyclonic vorticity in the low level.As a result,the center pressure of the TC declines.According to Wu’s theory of Slantwise Vorticity Development(SVD),the incline of the isentropic surfaces leads to the development of vertical vorticity,contributing to the vertical motion and the release of the latent heat.Then the warm core of the TC strengthens and the TC strengthens,too.Otherwise,piecewise PV inversion also shows that the high-level PV influences the mid-level more than the low level.

ANALYSIS ON EFFECT OF SOUTH ASIA HIGH ON MID-SUMMER EXTREME DROUGHT AND FLOOD IN SICHUAN-CHONGQING REGION

NCEP/NCAR data are utilized to analyze an extreme flood year(1998) and an extreme dry year(2006) in the Sichuan-Chongqing region(SCR) and the results are as follows. The positive divergence of South Asia High(SAH) is stronger in the flood year; the position of the ridge line of SAH is southward compared with the annual average; Western Pacific Subtropical High(WPSH) extends westward and its ridge line is southward. In the drought year, the positive divergence of SAH is weaker, its ridge line is northward, and the position of WPSH is also northward. As shown in the dynamics, in drought(flood) years, negative(positive) vorticity advection in the upper atmosphere can cause the atmosphere to ascend(descend), and anomalous circulation of SAH displays divergence(convergence), and anomalous circulation of the lower atmosphere shows convergence(divergence). Thermal structure of the atmosphere shows that there is warm(cold) temperature advection in the lower atmosphere, and the vertical distribution of diabetic heating causes SAH's local circulation to display convergence(divergence) and affects vertical motion of the lower atmosphere circulation eventually. To some extent, the two extreme years in the SCR is closely related to the vertical motion of atmosphere circulation and the variation of such vertical motion is caused by differences of interactions between SAH and lower atmosphere circulations.

Anti-cancer potential of South Asian plants

Phyto-chemicals are increasingly being used in the treatment of cancer because of their availability,potential anti-cancer activity with less adverse effects when compared with chemotherapy.The variation of climate and geography in South Asian countries provides a nursing environment for the growth of versatile plant species,that are repeatedly drawing attention of the scientific community.In this review,we have focused on the anti-cancer potential of thirty plants,which are commonly found in Bangladesh,India,Nepal,Pakistan and Sri Lanka,with their mechanisms of action.In particular,we have discussed the bio-active components that display anti-cancer activity,which have been identified in these plants.This review may help researchers to profile plants with known anti-cancer effect of this region and further investigations of anti-cancer agents in medicinal plants from South Asia.

South Asian medicinal plants and chronic kidney disease

Chronic kidney disease remains as one of the serious health issues in South Asia.The paucity of effective pharmacotherapy targeting the management of chronic kidney disease has led to a search for alternative pharmacologic therapies.The traditional knowledge of medicinal plants plays a key role in the discovery of novel nephroprotective agents.This review aims to present the use of such South Asian ethnomedicinal plants that have sufficient therapeutic potency for the management of kidney diseases.Medicinal plants are rich sources of bioactive compounds that have been reported to exert nephroprotective mechanisms,such as antioxidant,anti-inflammation,diuretic,and immunomodulation.Many South Asian medicinal plants have been detailed in traditional medicinal pharmacopoeias for the management of kidney-related diseases.Some have shown promising effects to address nephropathy in animal models and in vitro research.This information can be beneficial in the development of novel pharmaceutical agents targeting the management of kidney diseases and improvement of quality of life for chronic kidney disease patients by fulfilling the requirements for disease management unmet by modern allopathic medicine.