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采用ROC曲线分析东南亚缺失型α珠蛋白合成障碍性贫血的血液学指标 被引量:7
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作者 喻晶 郑金花 +2 位作者 张银汉 刘晓翌 刘小平 《现代检验医学杂志》 CAS 2011年第5期58-61,共4页
目的 探讨东南亚缺失型α珠蛋白合成障碍性贫血(俗称α地中海贫血)的临床血液学指标,找出最适合其筛查的红细胞平均体积(MCV)、红细胞脆性(EF)及血红蛋白A2(HbA2)的截断值(cutoff),提高检测东南亚缺失型α地中海贫血(简称地... 目的 探讨东南亚缺失型α珠蛋白合成障碍性贫血(俗称α地中海贫血)的临床血液学指标,找出最适合其筛查的红细胞平均体积(MCV)、红细胞脆性(EF)及血红蛋白A2(HbA2)的截断值(cutoff),提高检测东南亚缺失型α地中海贫血(简称地贫)的灵敏度和特异度.方法 对经基因确诊的162例东南亚缺失型α地贫(--SEA/αα)患者和143例正常者进行MCV,红细胞脆性试验和Hb电泳测定;采用ROC曲线分析得到最佳的MCV,EF及HbA2的cutoff值;采用平行及系列联合检测法分析cutoff值的灵敏度和特异度.结果 地贫组与正常组的MCV,EF和HbA2分别为68.14±5.95 fl和85.99±8.76 fl,(50.13±15.87)%和(81.51±12.63)%,(1.93±0.49)%和(2.55±0.62)%,地贫组的三项指标均明显降低,差异具有统计学显著性意义(t值分别为14.51,17.60,9.16,P〈0.001).以基因诊断的结果为金标准,MCV,EF和HbA2三指标ROC曲线下面积分别为0.927,0.922和0.827;其最佳cutoff值分别为74fl,70%和2.05%;其诊断--SEA/αα地贫的灵敏度分别为92.01%,90.12%和74.69%,特异度分别为89.51%,82.52%和80.42%.与单项MCV检测相比,采用平行联合检测法筛查--SEA/αα可明显提高诊断的灵敏度(χ2值=5.03,P〈0.05);系列联合检测法可明显提高诊断的特异度(χ2值=4.86,P〈0.05).结论 采用ROC曲线分析得到的最佳MCV,EF及HbA2的cutoff值,对筛查--SEA/αα具有较好的诊断价值,平行联合检测法可提高诊断的灵敏度,系列联合检测法可提高诊断的特异度. 展开更多
关键词 ROC曲线 红细胞平均体积(MCV) 红细胞脆性(EF) 血红蛋白A2(HbA2) 东南亚缺失型α珠蛋白合成障碍性贫血(--SEA/αα) 联合检测
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The EU-Vietnam Relations Through Promoting European Studies in Vietnam
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作者 Pham Quang Minh 《International Relations and Diplomacy》 2014年第3期151-158,共8页
The Vietnam-Europe relations can be traced back to four centuries ago when the first European missionary arrived in the country. However, this relationship has gone a long history with up and down events, partly becau... The Vietnam-Europe relations can be traced back to four centuries ago when the first European missionary arrived in the country. However, this relationship has gone a long history with up and down events, partly because of the misunderstanding and lack of information that influenced much on their cooperation. The main objective of the paper is to analyze the development of European Studies in Vietnam from historical perspective using the first hand information collected in Vietnam, and argued that in order to promote the European Union (EU)-Vietnam relations, European studies must be a priority in policy agenda of both sides. The paper concluded that European studies should be seen as an efficient measure to attract more and more students, and through which to promote image and understanding among people, and believed that there will be no doubt about the future of the EU-Vietnam relationship. 展开更多
关键词 area studies European studies European Union (EU)-Vietnam relations EU-Association of southeastasian Nations (ASEAN) cooperation
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