In this study, a scintillation detector was developed to measure the space proton effective dose for astronauts based on the proton effective dose conversion coefficients provided by International Commission on Radiol...In this study, a scintillation detector was developed to measure the space proton effective dose for astronauts based on the proton effective dose conversion coefficients provided by International Commission on Radiological Protection Report No. 116. In the Monte Carlo N-Particle Transport Code X(version 2.6.0) simulation process, by modulating the depth and solid angle of truncated conical holes in an iron shell from lower-energy protons to higher-energy protons, the energy deposited in the scintillator by isotropic protons was nearly proportional to the corresponding effective dose, with a maximum relative deviation of 13.28% at thirteen energy points in the energy range of 10–400 MeV. Therefore, the detector can monitor proton effective dose indirectly in real time by measuring the deposited energy. We calibrated the photoelectric conversion efficiency of the detector at the cobalt source, tested the response of the detector in the energy range of 30–100 MeV in unidirectional proton field, and validated the simulation with the experimental results.展开更多
The distinctions between locality and non-locality as well as causality and excess correlation may be related to coupling between increments of space-time or to the total space-time within the universe as a unit. The ...The distinctions between locality and non-locality as well as causality and excess correlation may be related to coupling between increments of space-time or to the total space-time within the universe as a unit. The most likely candidates for the latter are the proton and the electron when related by Minkowski’s space-time. When two velocities: light in a vacuum for locality and the “entanglement” velocity based upon parameters that define the universe for non-locality, are considered the two times required to produce identities for the -v<sup>2</sup>t<sup>2</sup> components are frequencies whose energies approximate the neutral hydrogen line (primarily associated with shifts in electron spin direction) and the mass equivalence of a proton. The values for the additional three spatial dimensions required to produce a solution whose square root is not imaginary and greater than zero are within the domains of the surface areas of the human cerebrum. Detailed calculations converge to show that the proportions of energy that represent the electron’s Compton energy and the proton’s mass equivalent may be central to the condition of excess correlation within the cerebral volume. Proton channels within the neuronal cell plasma membranes whose pH-dependent specific currents produce the required magnetic field strengths could be the physical substrates by which excess correlations between brain activities of human subjects separated by non-local distances might occur. If protons are considered as the basic Eddington (number) units of the universe then Mach’s principle that any component of the universe is determined by all of its components may be testable empirically.展开更多
目的探讨酰胺质子转移加权成像(amide proton transfer weighted imaging,APTw)的影像组学术前预测宫颈癌淋巴血管间隙侵犯(lymphovascular space invasion,LVSI)的价值。材料与方法回顾性分析经手术病理证实的宫颈癌患者病例及影像资...目的探讨酰胺质子转移加权成像(amide proton transfer weighted imaging,APTw)的影像组学术前预测宫颈癌淋巴血管间隙侵犯(lymphovascular space invasion,LVSI)的价值。材料与方法回顾性分析经手术病理证实的宫颈癌患者病例及影像资料66例。所有患者均行盆腔3.0 T MRI检查,包括轴位T2WI、矢状位T2WI、动态对比增强磁共振成像(dynamic contrast enhanced magnetic resonance imaging,DCE-MRI)和3D-APTw序列扫描。在APTw-T2WI融合图像上对肿瘤实质区域进行感兴趣区(region of interest,ROI)勾画并记录APT值。在APT重建图像上进行肿瘤病灶分割并提取影像组学特征。采用组内相关系数(intra-class correlation coefficient,ICC)选取观察者内和观察者间复测信度好的影像组学特征(ICC>0.900)。采用递归特征消除法(recursive feature elimination,RFE)及最小绝对收缩和选择算子(least absolute shrinkage and selection operator,LASSO)算法进行特征降维和筛选。基于logistic回归分类器构建临床模型、APTw影像组学模型和联合组学模型。采用受试者工作特征(receiver operating characteristic,ROC)曲线和决策曲线分析(decision curve analysis,DCA)评估模型的诊断效能和临床价值,采用DeLong检验比较不同模型的预测效能。结果在训练集中,APTw影像组学模型预测宫颈癌LVSI的效能高于临床模型(AUC=0.826 vs.0.675),差异有统计学意义(DeLong检验P<0.05)。联合组学模型在训练集和测试集中的AUC值分别为0.838和0.825。DeLong检验结果显示,联合组学模型在训练集中术前评估LVSI的效能显著高于临床模型和APTw影像组学模型(P均<0.05)。决策曲线显示APTw影像组学模型和联合组学模型在训练集和测试集中均具有较高的临床价值。结论基于APTw的影像组学模型在术前预测宫颈癌LVSI方面具有较高的潜力,联合临床因素能进一步提高预测效能,有望为宫颈癌患者的个体化治疗和预后评估提供重要的支持。展开更多
太阳质子事件通量的预测对航天器的抗辐射加固设计和宇航员的出舱活动具有重要意义。针对1年以下的中短期航天任务,对太阳活跃年和太阳平静年分别统计了太阳质子事件和大于10 Me V质子事件通量的发生概率,分析得到太阳质子事件通量分布...太阳质子事件通量的预测对航天器的抗辐射加固设计和宇航员的出舱活动具有重要意义。针对1年以下的中短期航天任务,对太阳活跃年和太阳平静年分别统计了太阳质子事件和大于10 Me V质子事件通量的发生概率,分析得到太阳质子事件通量分布基本符合对数正态分布。在此基础上,计算出了一定置信度下1年以下不同航天任务期内的质子事件通量分布,为执行中短期航天任务提供了太阳质子事件通量预测的依据。展开更多
基金supported by the National Natural Science Foundation of China(No.11305127)the State Key Lab of Intense Pulsed Radiation Simulation and Effect Basic Research Foundation(No.SKLIPR1216)
文摘In this study, a scintillation detector was developed to measure the space proton effective dose for astronauts based on the proton effective dose conversion coefficients provided by International Commission on Radiological Protection Report No. 116. In the Monte Carlo N-Particle Transport Code X(version 2.6.0) simulation process, by modulating the depth and solid angle of truncated conical holes in an iron shell from lower-energy protons to higher-energy protons, the energy deposited in the scintillator by isotropic protons was nearly proportional to the corresponding effective dose, with a maximum relative deviation of 13.28% at thirteen energy points in the energy range of 10–400 MeV. Therefore, the detector can monitor proton effective dose indirectly in real time by measuring the deposited energy. We calibrated the photoelectric conversion efficiency of the detector at the cobalt source, tested the response of the detector in the energy range of 30–100 MeV in unidirectional proton field, and validated the simulation with the experimental results.
文摘The distinctions between locality and non-locality as well as causality and excess correlation may be related to coupling between increments of space-time or to the total space-time within the universe as a unit. The most likely candidates for the latter are the proton and the electron when related by Minkowski’s space-time. When two velocities: light in a vacuum for locality and the “entanglement” velocity based upon parameters that define the universe for non-locality, are considered the two times required to produce identities for the -v<sup>2</sup>t<sup>2</sup> components are frequencies whose energies approximate the neutral hydrogen line (primarily associated with shifts in electron spin direction) and the mass equivalence of a proton. The values for the additional three spatial dimensions required to produce a solution whose square root is not imaginary and greater than zero are within the domains of the surface areas of the human cerebrum. Detailed calculations converge to show that the proportions of energy that represent the electron’s Compton energy and the proton’s mass equivalent may be central to the condition of excess correlation within the cerebral volume. Proton channels within the neuronal cell plasma membranes whose pH-dependent specific currents produce the required magnetic field strengths could be the physical substrates by which excess correlations between brain activities of human subjects separated by non-local distances might occur. If protons are considered as the basic Eddington (number) units of the universe then Mach’s principle that any component of the universe is determined by all of its components may be testable empirically.
文摘目的探讨酰胺质子转移加权成像(amide proton transfer weighted imaging,APTw)的影像组学术前预测宫颈癌淋巴血管间隙侵犯(lymphovascular space invasion,LVSI)的价值。材料与方法回顾性分析经手术病理证实的宫颈癌患者病例及影像资料66例。所有患者均行盆腔3.0 T MRI检查,包括轴位T2WI、矢状位T2WI、动态对比增强磁共振成像(dynamic contrast enhanced magnetic resonance imaging,DCE-MRI)和3D-APTw序列扫描。在APTw-T2WI融合图像上对肿瘤实质区域进行感兴趣区(region of interest,ROI)勾画并记录APT值。在APT重建图像上进行肿瘤病灶分割并提取影像组学特征。采用组内相关系数(intra-class correlation coefficient,ICC)选取观察者内和观察者间复测信度好的影像组学特征(ICC>0.900)。采用递归特征消除法(recursive feature elimination,RFE)及最小绝对收缩和选择算子(least absolute shrinkage and selection operator,LASSO)算法进行特征降维和筛选。基于logistic回归分类器构建临床模型、APTw影像组学模型和联合组学模型。采用受试者工作特征(receiver operating characteristic,ROC)曲线和决策曲线分析(decision curve analysis,DCA)评估模型的诊断效能和临床价值,采用DeLong检验比较不同模型的预测效能。结果在训练集中,APTw影像组学模型预测宫颈癌LVSI的效能高于临床模型(AUC=0.826 vs.0.675),差异有统计学意义(DeLong检验P<0.05)。联合组学模型在训练集和测试集中的AUC值分别为0.838和0.825。DeLong检验结果显示,联合组学模型在训练集中术前评估LVSI的效能显著高于临床模型和APTw影像组学模型(P均<0.05)。决策曲线显示APTw影像组学模型和联合组学模型在训练集和测试集中均具有较高的临床价值。结论基于APTw的影像组学模型在术前预测宫颈癌LVSI方面具有较高的潜力,联合临床因素能进一步提高预测效能,有望为宫颈癌患者的个体化治疗和预后评估提供重要的支持。
基金Fundamental Research Program of Shenzhen(SZWD2021007,JCYJ20200109105606426)National Natural Science Foundation of China(92050203)Science and Technology on Plasma Physics Laboratory。
文摘太阳质子事件通量的预测对航天器的抗辐射加固设计和宇航员的出舱活动具有重要意义。针对1年以下的中短期航天任务,对太阳活跃年和太阳平静年分别统计了太阳质子事件和大于10 Me V质子事件通量的发生概率,分析得到太阳质子事件通量分布基本符合对数正态分布。在此基础上,计算出了一定置信度下1年以下不同航天任务期内的质子事件通量分布,为执行中短期航天任务提供了太阳质子事件通量预测的依据。
