Distance decay of place attachment and perceived authenticity of mountain tourism destinations in China

Place attachment has been a research focus in the fields of park and recreation management.Place attachment plays an important role in promoting sustainable development of parks and mountain tourism destination,however,there are limited studies that identified the spatial patterns of place attachment,especially in the context of mountain tourism destinations in China.Also,the geospatial spectrum of visitors is usually broad,examining the multivariate relationships among spatial proximity,perceived authenticity,and place attachment are essential for mountain tourism destinations to promote destination image and strengthen emotional bonding with targeted visitor groups.In this study,we selected an iconic and highly visited park,Jiuzhai Valley National Park in China,as our study site and conducted an on-site visitor survey to collect 557 samples.Study uses factor analysis and the structure equation model to analyze the relationship among spatial proximity,perceived authenticity,and place attachment.Results validate the two-dimension structure of place attachment and perceived authenticity.Study findings suggest that spatial proximity has significant impacts on existential authenticity and place identity,but has no significant impacts on place dependence.Perceived authenticity has a positive impact on place attachment.Study results advance the theories of place attachment and provide effective strategies to enhance emotional attachment between visitors and mountain tourism destinations.

Mechanisms and impacts of chromosomal translocations in cancers

Chromosomal aberrations have been associated with cancer development since their discovery more than a hundred years ago.Chromosomal translocations,a type of particular structural changes involving heterologous chromosomes,have made a critical impact on diagnosis,prognosis and treatment of cancers.For example,the discovery of translocation between chromosomes 9 and 22 and the subsequent success of targeting the fusion product BCR-ABL transformed the therapy for chronic myelogenous leukemia.In the past few decades,tremendous progress has been achieved towards elucidating the mechanism causing chromosomal translocations.This review focuses on the basic mechanisms underlying the generation of chromosomal translocations.In particular,the contribution of frequency of DNA double strand breaks and spatial proximity of translocating loci is discussed.