Spatio-Temporal Dynamics of Land Use Units in the Kadzel Sub-Catchment Basin in Diffa, Niger

Environmental degradation linked to land occupation and use, such as climate change and anthropogenic activities, has led to the modification of the landscape units of the Kadzel sub-watershed. The objective of this study is to analyze the dynamics of land use units in the Kadzel area in Diffa between 1992 and 2022 and to propose a future scenario for sustainable environmental management. The approach used relies on remote sensing and geographic information systems to analyze the dynamics of land use units. Additionally, the Markov Cellular Automata (CA) model was used to predict future land use. The land cover maps were produced from a supervised classification by maximum likelihood based on the true and false color compositions of bands 4/3/2 (TM5), 3/2/1 (ETM+) and 7/5/4 (8 OLI). Ten occupation classes were discriminated. Between 1992 and 2022, there was a decrease in the areas of irrigated crops (4.91% and 2.88%), of shrubby tree steppes (14.31% and 9.48%), field-fallow complexes (22.23% and 10.52%), and degraded areas. Grassy steppes (25.76% and 13.32%). However, this reduction has been beneficial for wastelands, urban areas and bodies of water. Based on predictive modeling, it is predicted that by 2052, urban areas, fallow field complexes and bare soils will constitute the main types of housing units. The regressive trend in natural resources appears to continue into the future with current land use practices.

Spatio-temporal dynamics of vegetation in Jungar Banner of China during 2000–2017

It is known that the exploitation of opencast coal mines has seriously damaged the environments in the semi-arid areas.Vegetation status can reliably reflect the ecological degeneration and restoration in the opencast mining areas in the semi-arid areas.Long-time series MODIS NDVI data are widely used to simulate the vegetation cover to reflect the disturbance and restoration of local ecosystems.In this study, both qualitative(linear regression method and coefficient of variation(CoV)) and quantitative(spatial buffer analysis, and change amplitude and the rate of change in the average NDVI) analyses were conducted to analyze the spatio-temporal dynamics of vegetation during 2000–2017 in Jungar Banner of Inner Mongolia Autonomous Region, China, at the large(Jungar Banner and three mine groups) and small(three types of functional areas: opencast coal mining excavation areas, reclamation areas and natural areas) scales.The results show that the rates of change in the average NDVI in the reclamation areas(20%–60%) and opencast coal mining excavation areas(10%–20%) were considerably higher than that in the natural areas(<7%).The vegetation in the reclamation areas experienced a trend of increase(3–5 a after reclamation)-decrease(the sixth year of reclamation)-stability.The vegetation in Jungar Banner has a spatial heterogeneity under the influences of mining and reclamation activities.The ratio of vegetation improvement area to vegetation degradation area in the west, southwest and east mine groups during 2000–2017 was 8:1, 20:1 and 33:1, respectively.The regions with the high CoV of NDVI above 0.45 were mainly distributed around the opencast coal mining excavation areas, and the regions with the CoV of NDVI above 0.25 were mostly located in areas with low(28.8%) and medium-low(10.2%) vegetation cover.The average disturbance distances of mining activities on vegetation in the three mine groups(west, southwest and east) were 800, 800 and 1000 m, respectively.The greater the scale of mining, the farther the disturbance distances of mining activities on vegetation.We conclude that vegetation reclamation will certainly compensate for the negative impacts of opencast coal mining activities on vegetation.Sufficient attention should be paid to the proportional allocation of plant species(herbs and shrubs) in the reclamation areas, and the restored vegetation in these areas needs to be protected for more than 6 a.Then, as the repair time increased, the vegetation condition of the reclamation areas would exceed that of the natural areas.

Spatio-temporal Dynamics of Urbanization in China Using DMSP/OLS Nighttime Light Data from 1992–2013

Understanding the dynamics of urbanization is essential to the sustainable development of cities. Meanwhile the analysis of urban development can also provide scientifically and effective information for decision-making. With the long-term Defense Meteorological Satellite Program’s Operational Linescan System(DMSP/OLS) nighttime light images, a pixel level assessment of urbanization of China from 1992 to 2013 was conducted in this study, and the spatio-temporal dynamics and future trends of urban development were fully detected. The results showed that the urbanization and urban dynamics of China experienced drastic fluctuations from 1992 to 2013, especially for those in the coastal and metropolitan areas. From a regional perspective, it was found that the urban dynamics and increasing trends in North Coast China, East Coast China and South Coast China were much more stable and significant than that in other regions. Moreover, with the sustainability estimating of nighttime light dynamics, the regional agglomeration trends of urban regions were also detected. The light intensity in nearly 50% of lighted pixels may continuously decrease in the future, indicating a severe situation of urbanization within these regions. In this study, The results revealed in this study can provided a new insight in long time urbanization detecting and is thus beneficial to the better understanding of trends and dynamics of urban development.

Fusing multi-source data to map spatio-temporal dynamics of winter rape on the Jianghan Plain and Dongting Lake Plain, China

Mapping crop distribution with remote sensing data is of great importance for agricultural production, food security and agricultural sustainability. Winter rape is an important oil crop, which plays an important role in the cooking oil market of China. The Jianghan Plain and Dongting Lake Plain (JPDLP) are major agricultural production areas in China. Essential changes in winter rape distribution have taken place in this area during the 21st century. However, the pattern of these changes remains unknown. In this study, the spatial and temporal dynamics of winter rape from 2000 to 2017 on the JPDLP were analyzed. An artificial neural network (ANN)-based classification method was proposed to map fractional winter rape distribution by fusing moderate resolution imaging spectrometer (MODIS) data and high-resolution imagery. The results are as follows:(1) The total winter rape acreages on the JPDLP dropped significantly, especially on the Jianghan Plain with a decline of about 45% during 2000 and 2017.(2) The winter rape abundance keeps changing with about 20–30% croplands changing their abundance drastically in every two consecutive observation years.(3) The winter rape has obvious regional differentiation for the trend of its change at the county level, and the decreasing trend was observed more strongly in the traditionally dominant agricultural counties.

Analysis of Spatio-Temporal Dynamics of Land Use in the Bouba Ndjidda National Park and Its Adjacent Zone (North Cameroun)

We evaluated the dynamics of land use in the Bouba Ndjidda National Park (BNNP) and adjacent areas, in northern Cameroon. Using a maximum likelihood supervised classification of satellite images from 1990 to 2016, coupled with field and a socio-economic survey, we performed a robust land-use classification. Between 1990 and 2016, the area included eight classes of land use, with the largest in 1990 being the woody savannah (42.9%) followed by the gallery forest (20.2%) and the clear forest (16.3%). Between 1990 and 1999, the gallery forest lost 64.8% of its area mostly to the benefit of woody savannahs. Between 1999 and 2016, the largest loss of area was that of the clear forest, which decreased generally by 43.2% in favor of woody savannah. Rates of increase of crop field areas were 59.6% and 78.8% respectively for the periods of 1990 to 1999 and 1999 to 2016 to the detriment of woody savannahs. We attribute the changes in land use observed mainly to the increasing human population and associated agriculture, overgrazing, fuelwood harvesting and bush fires. The exploitation of non-timber forest products and climatic factors may also have changed the vegetation cover. We recommend the implementation of farming techniques with low impact on the environment such as agroforestry.

Role of permafrost in resilience of social-ecological system and its spatio-temporal dynamics in the source regions of Yangtze and Yellow Rivers

Permafrost is one of the key components of terrestrial ecosystem in cold regions. In the context of climate change, few studies have investigated resilience of social ecological system(SER) from the perspective of permafrost that restricts the hydrothermal condition of alpine grassland ecosystem. In this paper, based on the structural dynamics, we developed the numerical model for the SER in the permafrost regions of the source of Yangtze and Yellow Rivers, analyzed the spatial-temporal characteristics and sensitivity of the SER, and estimated the effect of permafrost change on the SER. The results indicate that: 1) the SER has an increasing trend, especially after 1997, which is the joint effect of precipitation, temperature, NPP and ecological conservation projects; 2) the SER shows the spatial feature of high in southeast and low in northwest,which is consistent with the variation trends of high southeast and low northwest for the precipitation, temperature and NPP, and low southeast and high northwest for the altitude; 3) the high sensitive regions of SER to the permafrost change have gradually transited from the island distribution to zonal and planar distribution since 1980, moreover, the sensitive degree has gradually reduced; relatively, the sensitivity has high value in the north and south, and low value in the south and east; 4) the thickness of permafrost active layer shows a highly negative correlation with the SER. The contribution rate of permafrost change to the SER is-4.3%, that is, once the thickness of permafrost active layer increases 1 unit, the SER would decrease 0.04 units.

Spatio-temporal Dynamic Simulation of Urban Land Use in Karst Areas Based on CLUE-S Model——A Case Study of Dahua Yao Nationality Autonomous County in Guangxi Zhuang Autonomous Region

This article uses TM images in 1999 and 2006 in Dahua County,selects the driving factors having great impact on urban land use change,and conducts data processing using GIS software.It then uses CLUE-S model to simulate land use change pattern in 2006,and uses land use map in 2006 to test the simulation results.The results show that the simulation achieves good effect,indicating that we can use CLUE-S model to simulate the future urban land use change in karst areas,to provide scientific decision-making support for sustainable development of land use.

Three-dimensional imaging of spatio-temporal dynamics of small blood capillary network in the cortex based on optical coherence tomography:A review

Optical coherence tomography angiography(OCTA)has emerged as an advanced in vivo im-aging modality,which is widely used for the clinic ophthalmology and neuroscience research in the rodent brain cortex among others.Based on the high numerical aperture(NA)probing lens and the motion-corrected algorithms,a high-resolution imaging technique called OCT micro-angiography is applied to resolve the small blood capillary vessels ranging from 5μm to 10μm in diameter.As OCT-based techniques are recently evolving further from the structural imaging of capillaries toward spatio-temporal dynamic imaging of blood flow in capillaries,here we present a review on the latest techniques for the dynamic flow imaging.Studies on capillary blood flow using these techniques will help us better understand the roles of capillary blood flow for normal functioning of the brain as well as how it malfunctions in diseases.

Comparison of the spatio-temporal dynamics of vegetation between the Changbai Mountains of eastern Eurasia and the Appalachian Mountains of eastern North America

The Changbai Mountains and the Appalachian Mountains have similar spatial contexts.The elevation,latitude,and moisture gradients of both mountain ranges offer regional insight for investigating the vegetation dynamics in eastern Eurasia and eastern North America.We determined and compared the spatial patterns and temporal trends in the normalized difference vegetation index(NDVI)in the Changbai Mountains and the Appalachian Mountains using time series data from the Global Inventory Modeling and Mapping Studies 3^(rd) generation dataset from 1982 to 2013.The spatial pattern of NDVI in the Changbai Mountains exhibited fragmentation,whereas NDVI in the Appalachian Mountains decreased from south to north.The vegetation dynamics in the Changbai Mountains had an insignificant trend at the regional scale,whereas the dynamics in the Appalachian Mountains had a significant increasing trend.NDVI increased in 55% of the area of the Changbai Mountains and in 95% of the area of the Appalachian Mountains.The peak NDVI occurred one month later in the Changbai Mountains than in the Appalachian Mountains.The results revealed a significant increase in NDVI in autumn in both mountain ranges.The climatic trend in the Changbai Mountains included warming and decreased precipitation,and whereas that in the Appalachian Mountains included significant warming and increased precipitation.Positive and negative correlations existed between NDVI and temperature and precipitation,respectively,in both mountain ranges.Particularly,the spring temperature and NDVI exhibited a significant positive correlation in both mountain ranges.The results of this study suggest that human actives caused the differences in the spatial patterns of NDVI and that various characteristics of climate change and intensity of human actives dominated the differences in the NDVI trends between the Changbai Mountains and the Appalachian Mountains.Additionally,the vegetation dynamics of both mountain ranges were not identical to those in previous broader-scale studies.

Spatio-Temporal Dynamics and Structure Preserving Algorithm for Computer Virus Model

The present work is related to the numerical investigation of the spatio-temporal susceptible-latent-breaking out-recovered(SLBR)epidemic model.It describes the computer virus dynamics with vertical transmission via the internet.In these types of dynamics models,the absolute values of the state variables are the fundamental requirement that must be fulfilled by the numerical design.By taking into account this key property,the positivity preserving algorithm is designed to solve the underlying SLBR system.Since,the state variables associated with the phenomenon,represent the computer nodes,so they must take in absolute.Moreover,the continuous system(SLBR)acquires two steady states i.e.,the virus-free state and the virus existence state.The stability of the numerical design,at the equilibrium points,portrays an exceptional aspect about the propagation of the virus.The designed discretization algorithm sustains the stability of both the steady states.The computer simulations also endorse that the proposed discretization algorithm retains all the traits of the continuous SLBR model with spatial content.The stability and consistency of the proposed algorithm are verified,mathematically.All the facts are also ascertained by numerical simulations.

Dynamic Multi-Graph Spatio-Temporal Graph Traffic Flow Prediction in Bangkok:An Application of a Continuous Convolutional Neural Network

The ability to accurately predict urban traffic flows is crucial for optimising city operations.Consequently,various methods for forecasting urban traffic have been developed,focusing on analysing historical data to understand complex mobility patterns.Deep learning techniques,such as graph neural networks(GNNs),are popular for their ability to capture spatio-temporal dependencies.However,these models often become overly complex due to the large number of hyper-parameters involved.In this study,we introduce Dynamic Multi-Graph Spatial-Temporal Graph Neural Ordinary Differential Equation Networks(DMST-GNODE),a framework based on ordinary differential equations(ODEs)that autonomously discovers effective spatial-temporal graph neural network(STGNN)architectures for traffic prediction tasks.The comparative analysis of DMST-GNODE and baseline models indicates that DMST-GNODE model demonstrates superior performance across multiple datasets,consistently achieving the lowest Root Mean Square Error(RMSE)and Mean Absolute Error(MAE)values,alongside the highest accuracy.On the BKK(Bangkok)dataset,it outperformed other models with an RMSE of 3.3165 and an accuracy of 0.9367 for a 20-min interval,maintaining this trend across 40 and 60 min.Similarly,on the PeMS08 dataset,DMST-GNODE achieved the best performance with an RMSE of 19.4863 and an accuracy of 0.9377 at 20 min,demonstrating its effectiveness over longer periods.The Los_Loop dataset results further emphasise this model’s advantage,with an RMSE of 3.3422 and an accuracy of 0.7643 at 20 min,consistently maintaining superiority across all time intervals.These numerical highlights indicate that DMST-GNODE not only outperforms baseline models but also achieves higher accuracy and lower errors across different time intervals and datasets.

Dynamic adaptive spatio-temporal graph network for COVID-19 forecasting

Appropriately characterising the mixed space-time relations of the contagion process caused by hybrid space and time factors remains the primary challenge in COVID-19 forecasting.However,in previous deep learning models for epidemic forecasting,spatial and temporal variations are captured separately.A unified model is developed to cover all spatio-temporal relations.However,this measure is insufficient for modelling the complex spatio-temporal relations of infectious disease transmission.A dynamic adaptive spatio-temporal graph network(DASTGN)is proposed based on attention mechanisms to improve prediction accuracy.In DASTGN,complex spatio-temporal relations are depicted by adaptively fusing the mixed space-time effects and dynamic space-time dependency structure.This dual-scale model considers the time-specific,space-specific,and direct effects of the propagation process at the fine-grained level.Furthermore,the model characterises impacts from various space-time neighbour blocks under time-varying interventions at the coarse-grained level.The performance comparisons on the three COVID-19 datasets reveal that DASTGN achieves state-of-the-art results with a maximum improvement of 17.092%in the root mean-square error and 11.563%in the mean absolute error.Experimental results indicate that the mechanisms of designing DASTGN can effectively detect some spreading characteristics of COVID-19.The spatio-temporal weight matrices learned in each proposed module reveal diffusion patterns in various scenarios.In conclusion,DASTGN has successfully captured the dynamic spatio-temporal variations of COVID-19,and considering multiple dynamic space-time relationships is essential in epidemic forecasting.

Spatio-temporal breather dynamics in microcomb soliton crystals

Solitons,the distinct balance between nonlinearity and dispersion,provide a route toward ultrafast electromagnetic pulse shaping,high-harmonic generation,real-time image processing,and RF photonic communications.Here we uniquely explore and observe the spatio-temporal breather dynamics of optical soliton crystals in frequency microcombs,examining spatial breathers,chaos transitions,and dynamical deterministic switching–in nonlinear measurements and theory.To understand the breather solitons,we describe their dynamical routes and two example transitional maps of the ensemble spatial breathers,with and without chaos initiation.We elucidate the physical mechanisms of the breather dynamics in the soliton crystal microcombs,in the interaction plane limit cycles and in the domain-wall understanding with parity symmetry breaking from third-order dispersion.We present maps of the accessible nonlinear regions,the breather frequency dependences on third-order dispersion and avoided-mode crossing strengths,and the transition between the collective breather spatio-temporal states.Our range of measurements matches well with our first-principles theory and nonlinear modeling.To image these soliton ensembles and their breathers,we further constructed panoramic temporal imaging for simultaneous fast-and slow-axis two-dimensional mapping of the breathers.In the phasedifferential sampling,we present two-dimensional evolution maps of soliton crystal breathers,including with defects,in both stable breathers and breathers with drift.Our fundamental studies contribute to the understanding of nonlinear dynamics in soliton crystal complexes,their spatio-temporal dependences,and their stability-existence zones.

Multidimensional measurement of poverty and its spatio-temporal dynamics in China from the perspective of development geography

Exploring the spatio-temporal dynamics of poverty is important for research on sustainable poverty reduction in China. Based on the perspective of development geography, this paper proposes a panel vector autoregressive(PVAR) model that combines the human development approach with the global indicator framework for Sustainable Development Goals(SDGs) to identify the poverty-causing and the poverty-reducing factors in China. The aim is to measure the multidimensional poverty index(MPI) of China’s provinces from 2007 to 2017, and use the exploratory spatio-temporal data analysis(ESTDA) method to reveal the characteristics of the spatio-temporal dynamics of multidimensional poverty. The results show the following:(1) The poverty-causing factors in China include the high social gross dependency ratio and crop-to-disaster ratio, and the poverty-reducing factors include the high per capita GDP, per capita social security expenditure, per capita public health expenditure, number of hospitals per 10,000 people, rate of participation in the new rural cooperative medical scheme, vegetation coverage, per capita education expenditure, number of universities, per capita research and development(R&D) expenditure, and funding per capita for cultural undertakings.(2) From 2007 to 2017, provincial income poverty(IP), health poverty(HP), cultural poverty(CP), and multidimensional poverty have been significantly reduced in China, and the overall national poverty has dropped by 5.67% annually. there is a differentiation in poverty along different dimensions in certain provinces.(3) During the study period, the local spatial pattern of multidimensional poverty between provinces showed strong spatial dynamics, and a trend of increase from the eastern to the central and western regions was noted. The MPI among provinces exhibited a strong spatial dependence over time to form a pattern of decrease from northwestern and northeastern China to the surrounding areas.(4) The spatio-temporal networks of multidimensional poverty in adjacent provinces were mainly negatively correlated, with only Shaanxi and Henan, Shaanxi and Ningxia, Qinghai and Gansu, Hubei and Anhui, Sichuan and Guizhou, and Hainan and Guangdong forming spatially strong cooperative poverty reduction relationships. These results have important reference value for the implementation of China’s poverty alleviation strategy.

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

A Rapid Adaptation Approach for Dynamic Air‑Writing Recognition Using Wearable Wristbands with Self‑Supervised Contrastive Learning

Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily activities.Unlike existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple scenarios.It features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance output.Through wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist movements.Remarkably,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various tasks.The system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and letters.The proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific training.Its utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication.

Efficient and Stable Perovskite Solar Cells and Modules Enabled by Tailoring Additive Distribution According to the Film Growth Dynamics

Gas quenching and vacuum quenching process are widely applied to accelerate solvent volatilization to induce nucleation of perovskites in blade-coating method.In this work,we found these two pre-crystallization processes lead to different order of crystallization dynamics within the perovskite thin film,resulting in the differences of additive distribution.We then tailor-designed an additive molecule named 1,3-bis(4-methoxyphenyl)thiourea to obtain films with fewer defects and holes at the buried interface,and prepared perovskite solar cells with a certified efficiency of 23.75%.Furthermore,this work also demonstrates an efficiency of 20.18%for the large-area perovskite solar module(PSM)with an aperture area of 60.84 cm^(2).The PSM possesses remarkable continuous operation stability for maximum power point tracking of T_(90)>1000 h in ambient air.

Stability Prediction in Smart Grid Using PSO Optimized XGBoost Algorithm with Dynamic Inertia Weight Updation

Prediction of stability in SG(Smart Grid)is essential in maintaining consistency and reliability of power supply in grid infrastructure.Analyzing the fluctuations in power generation and consumption patterns of smart cities assists in effectively managing continuous power supply in the grid.It also possesses a better impact on averting overloading and permitting effective energy storage.Even though many traditional techniques have predicted the consumption rate for preserving stability,enhancement is required in prediction measures with minimized loss.To overcome the complications in existing studies,this paper intends to predict stability from the smart grid stability prediction dataset using machine learning algorithms.To accomplish this,pre-processing is performed initially to handle missing values since it develops biased models when missing values are mishandled and performs feature scaling to normalize independent data features.Then,the pre-processed data are taken for training and testing.Following that,the regression process is performed using Modified PSO(Particle Swarm Optimization)optimized XGBoost Technique with dynamic inertia weight update,which analyses variables like gamma(G),reaction time(tau1–tau4),and power balance(p1–p4)for providing effective future stability in SG.Since PSO attains optimal solution by adjusting position through dynamic inertial weights,it is integrated with XGBoost due to its scalability and faster computational speed characteristics.The hyperparameters of XGBoost are fine-tuned in the training process for achieving promising outcomes on prediction.Regression results are measured through evaluation metrics such as MSE(Mean Square Error)of 0.011312781,MAE(Mean Absolute Error)of 0.008596322,and RMSE(Root Mean Square Error)of 0.010636156 and MAPE(Mean Absolute Percentage Error)value of 0.0052 which determine the efficacy of the system.

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface receptors.Mutations inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-Secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as well.However,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-secretase.In this review,we focus on recent studies of structural dynamic mechanisms ofγ-secretase.Different mechanisms,including the“Fit-Stay-Trim,”“Sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics simulations.While an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental findings.The approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-secretase.In addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is discussed.Finally,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations of theγ-secretase-substrate complexes.Comprehensive understanding of the functional mechanisms ofγ-secretase will greatly facilitate the rational design of effective drug molecules for treating familial Alzheimer’s disease and perhaps Alzheimer’s disease in general.

Dynamic Interaction Analysis of Coupled Axial-Torsional-Lateral Mechanical Vibrations in Rotary Drilling Systems

Maintaining the integrity and longevity of structures is essential in many industries,such as aerospace,nuclear,and petroleum.To achieve the cost-effectiveness of large-scale systems in petroleum drilling,a strong emphasis on structural durability and monitoring is required.This study focuses on the mechanical vibrations that occur in rotary drilling systems,which have a substantial impact on the structural integrity of drilling equipment.The study specifically investigates axial,torsional,and lateral vibrations,which might lead to negative consequences such as bit-bounce,chaotic whirling,and high-frequency stick-slip.These events not only hinder the efficiency of drilling but also lead to exhaustion and harm to the system’s components since they are difficult to be detected and controlled in real time.The study investigates the dynamic interactions of these vibrations,specifically in their high-frequency modes,usingfield data obtained from measurement while drilling.Thefindings have demonstrated the effect of strong coupling between the high-frequency modes of these vibrations on drilling sys-tem performance.The obtained results highlight the importance of considering the interconnected impacts of these vibrations when designing and implementing robust control systems.Therefore,integrating these compo-nents can increase the durability of drill bits and drill strings,as well as improve the ability to monitor and detect damage.Moreover,by exploiting thesefindings,the assessment of structural resilience in rotary drilling systems can be enhanced.Furthermore,the study demonstrates the capacity of structural health monitoring to improve the quality,dependability,and efficiency of rotary drilling systems in the petroleum industry.