Plasmonic vortices confining orbital angular momentums to surface have aroused wide research interest in the last decade.Recent advances of near-field microscopes have enabled the study on the spatiotemporal dynamics ...Plasmonic vortices confining orbital angular momentums to surface have aroused wide research interest in the last decade.Recent advances of near-field microscopes have enabled the study on the spatiotemporal dynamics of plasmonic vortices,providing a better understanding of optical orbital angular momentums in the evanescent wave regime.However,these works only focused on the objective characterization of plasmonic vortex and have not achieved subjectively tailoring of its spatiotemporal dynamics for specific applications.Herein,it is demonstrated that the plasmonic vortices with the same topological charge can be endowed with distinct spatiotemporal dynamics by simply changing the coupler design.Based on a near-field scanning terahertz microscopy,the surface plasmon fields are directly obtained with ultrahigh spatiotemporal resolution,experimentally exhibiting the generation and evolution divergences during the whole lifetime of plasmonic vortices.The proposed strategy is straightforward and universal,which can be readily applied into visible or infrared frequencies,facilitating the development of plasmonic vortex related researches and applications.展开更多
In this study,we developed an evaluation index system for green total-factor water-use efficiency(GTFWUE)which reflected both economic and green efficiencies of water resource utilization.Then we measured the GTFWUE o...In this study,we developed an evaluation index system for green total-factor water-use efficiency(GTFWUE)which reflected both economic and green efficiencies of water resource utilization.Then we measured the GTFWUE of 30 provinces/municipalities/autonomous regions(hereafter provinces)in China(not including Tibet,Hong Kong,Macao,Taiwan as no data)from 2000 to 2018 using a minimum distance to the strong frontier model that contained an undesirable output.We further analyzed the regional differences and spatial correlations of GTFWUE using these values based on Global and Local Moran’s I statistics,and empirically determined the factors affecting GTFWUE using a spatial econometric model.The evaluation results revealed that the GTFWUE differed substantially between the regions.The provinces with high and low GTFWUE values were located in the coastal and inland areas of China,respectively.The eastern region had a significantly higher GTFWUE than the central and western regions.The GTFWUEs for all three regions(eastern,central,and western regions)decreased slowly from 2000 to 2011(except 2005),remained stable from 2012 to 2016,and rapidly increased in 2017 before decreasing again in 2018.We found significant spatial correlations between the provincial GTFWUEs.The GTFWUE for most provinces belonged to the high-high or low-low cluster region,revealing a significant spatial clustering effect of provincial GTFWUEs.We also found that China’s GTFWUE was highly promoted by economic growth,population size,opening-up level,and urbanization level,and was evidently hindered by water endowment,technological progress,and government influence.However,the water-use structure had little impact on GTFWUE.This study fully demonstrated that the water use mode would be improved,and water resources needed to be used more efficiently and green in China.Moreover,based on the findings of this study,several policy recommendations were proposed from the aspects of cross-regional cooperation,economy,society,and institution.展开更多
Objective:We investigated changes in cortico–subcortical spatiotemporal dynamics to explore the treatment mechanisms oftranscranial alternating current stimulation(tACS)in patientswith Parkinson’s disease(PD).Method...Objective:We investigated changes in cortico–subcortical spatiotemporal dynamics to explore the treatment mechanisms oftranscranial alternating current stimulation(tACS)in patientswith Parkinson’s disease(PD).Methods:Resting-state functional magnetic resonance imaging(rs-fMRI)data were collected from 20 patients with PD and 20 normal controls(NC).Each patient with PD received successivemultidisciplinary intensive rehabilitation treatment and tACStreatment over a one-year interval.Individual functional brain network mapping and co-activation pattern(CAP)analysis were performed to characterize cortico–subcortical dynamics.Results:The same tACS electrode placement stimulated different proportions of functional brain networks across the participants.CAP analysis revealed that the visual network,attentional network,and default mode network co-activated with the thalamus,accumbens,and amygdala,respectively.The pattern characterized by thede-activation of the visual network and the activation of the thalamus showed a significantly low amplitude in the patients with PD than inNCs,and this amplitude increased after tACS treatment.Furthermore,the co-occurrence of cortico–subcortical CAPs was significantly higherin patients with PD than in NCs and decreased after tACS treatment.Conclusions:This study investigated cortico–subcortical spatiotemporaldynamics in patients with PD and further revealed the tACS treatmentmechanism.These findings contribute to understanding cortico–subcortical dynamics and exploring noninvasive neuromodulationtargets of cortico–subcortical circuits in brain diseases,such as PD,Alzheimer’s disease,and depression.展开更多
Obtaining timely and accurate data on the spatiotemporal dynamics of electric power consumption(EPC)is crucial for the effective utilization of electric power in China.The Defense Meteorological Satellite Program’s O...Obtaining timely and accurate data on the spatiotemporal dynamics of electric power consumption(EPC)is crucial for the effective utilization of electric power in China.The Defense Meteorological Satellite Program’s Operational Linescan System(DMSP/OLS)nighttime stable light(NSL)data have good potential for estimating EPC effectively at large scales.However,saturated lighted pixels contained within the NSL data limit the accuracy of EPC estimation.We developed a new method to correct the saturated lighted pixels,using the SPOT VEGETATION(SPOT/VGT)10-day synthesis product(S10)normalized differ-ence vegetation index(NDVI)data and then modeled the spatiotemporal dynamics of EPC in China' Mainland from 2000 to 2008.The results demon-strated the reliability of our approach with an average Rvalue of 0.93(P<0.001)and an average relative error of-28.92%.EPC in China' Mainland showed an average annual growth rate of 13.46% during the study period from 1198.23 billion kWh in 2000 to 3290.51 billion kWh in 2008.EPC in China' Mainland also showed clear regional variation.Northern coastal China and eastern coastal China consumed 37.61%of the total EPC in China' Mainland,with only 25.96% of the population and 6.11% of the area.展开更多
Although the mechanism of neurovascular coupling remains inadequately understood,physiological research has indicated that the dilation of arterioles located within the cerebral cortex column might represent the prima...Although the mechanism of neurovascular coupling remains inadequately understood,physiological research has indicated that the dilation of arterioles located within the cerebral cortex column might represent the primary mechanism of hemodynamic response during neurovascular coupling.This study examined the spatiotemporal pattern of NO diffusion induced by functional stimuli at column spatial resolution.Our modeling makes it possible to explore the responses of mediating factors to functional stimuli from a four-dimensional view,which may lead the way to decoding the mechanism of neurovascular coupling.展开更多
Wet-salted skin,as a special artificial high-salt environment,is rich in protein,fat,collagen and other nutrient substrates,and is a rich resource of halotolerant and halophilic microorganisms.However,knowledge gaps r...Wet-salted skin,as a special artificial high-salt environment,is rich in protein,fat,collagen and other nutrient substrates,and is a rich resource of halotolerant and halophilic microorganisms.However,knowledge gaps regarding the microbial community structure and inter taxa associations of wet-salted skin are large.In this study,the spatiotemporal dynamics and community structure of microorganisms present on wet-salted goatskins were investigated using 16S rRNA gene amplicon sequencing and culturable technique.Alpha diversity analysis based on Sobs,Chao,Ace and Shannon indices revealed that microbial diversity on the wet-salted goatskins exhibited a trend of‘down→up→down→flat’with time.During preservation,genera belonging to the bacteria domain such as Aci-netobacter,Weissella and Streptococcus were slowly dying out,whereas those belonging to halophilic archaea such as Natrialba and Haloterrigena were gradually flourishing.Moreover,to resist high-salt stress,microorganisms on the wet-salted goatskin gradually migrated from the outside to the inside,eventually leading to the microbial diversity inside the skin being the same as or even higher than that on the skin surface.Venn diagram analysis revealed that the strains of some genera,including Psychrobacter,Salimicrobium,Salinicola,Ornithinibacillus,Halomonas,Bacillus and Chromohalobacter,were distributed throughout the interior and exterior of the wet-salted goatskin and existed during various periods.Accordingly,45 protease-producing halophilic or halotolerant microorganisms were isolated and screened from the wet-salted goatskin using the gradient dilution plate method.Importantly,16S rRNA genes of some bacteria exhibited less than 99.5%similarity to valid published species,indicating that they likely are novel spe-cies and have a good potential for application.展开更多
Investigating the spatiotemporal variation of human activity intensity and its determinants is a crucial basis for further revealing the mechanism of human-environment interaction and optimizing the human development ...Investigating the spatiotemporal variation of human activity intensity and its determinants is a crucial basis for further revealing the mechanism of human-environment interaction and optimizing the human development mode.In this study,the human activity intensity on the Qinghai-Tibet Plateau(QTP)from 1990 to 2020 was measured based on the quantitative model of land use data and the actual regional background,and the under-lying natural and socioeconomic determinants were investigated using spatial econometric methods.The results demonstrate that(1)the human activity intensity in QTP has increased by 11.96%,and there are differences in different spatial scales;the areas with high human activity intensity are distributed in the Hehuang Valley where Xining City and its surrounding areas are located,as well as the One-River and Two-River Area where Lhasa City and surrounding areas are located.(2)Human activity intensity has significant positive spatial spillover,suggesting that local changes will cause changes in the same direction in adjacent areas.(3)The human activ-ity intensity in QTP is affected by various determinants.Concerning socioeconomic factors,the economic level has no significant impact on the human activity intensity in QTP,which differs from the general regional law.Both urbanization and traffic conditions have a significant positive effect,and the impact intensity continues to increase.Concerning natural factors,topographic relief has a significant positive effect;the impacts of temper-ature and vegetation coverage have changed from insignificant to a significant positive effect;the impacts of precipitation and river network density have not been verified;there is no linear relationship between altitude and human activity intensity in the entire QTP,while it exists in local regions.Finally,this study proposes three policy implications for the realization of a more harmonious human-environment relationship in QTP.展开更多
Soil fauna can sensitively respond to alterations in soil environment induced by land-use changes.However,little is known about the impact of urban land-use changes on earthworm communities.In this study,three land-us...Soil fauna can sensitively respond to alterations in soil environment induced by land-use changes.However,little is known about the impact of urban land-use changes on earthworm communities.In this study,three land-use types(i.e.,forest,nursery and abandoned lands)were chosen to identify differences in diversity,abundance and biomass of earthworm community in Kunming City.Urban land-use had a pronounced difference in species composition,evenness and diversity of earthworm communities.Forest land had the highest density,biomass and diversity of the earthworm communities.Total abundance was dominated by endogeic species in nursery land(70%)and abandoned land(80%),whereas in the forest land,the earthworm community comprised epigeic,endogeic and anecic species.Temporal changes in earthworm density and biomass were also significantly affected by land-use change.Total density and biomass of earthworms in the forest and nursery lands were highest in September,but highest in the abandoned land in October.The influence of soil physicochemical properties on the earthworm density and biomass also varied with land-use types.Soil temperature significantly affected earthworm density and biomass in the three land-use types.Soil pH was positively correlated with earthworm biomass in the forest land,but negatively associated with earthworm density in the abandoned land.Soil organic matter was positively correlated only with density and biomass of earthworms in the nursery and abandoned lands.Our results suggest that the species composition,abundance and biomass of earthworm communities can be determined by the modification of soil properties associated with urban land-use type.展开更多
Human activities have impacted 77%of the terrestrial ecosystems(excluding Antarctica),and the remaining areas are becoming increasingly endangered.Mapping spatiotemporal dynamics of Human Footprint has been used to ev...Human activities have impacted 77%of the terrestrial ecosystems(excluding Antarctica),and the remaining areas are becoming increasingly endangered.Mapping spatiotemporal dynamics of Human Footprint has been used to evaluate the cumulative interference on terrestrial environments globally.However,fences and hydropower,two widespread and rapidly expanding infrastructures,have not been considered regarding Human Footprint,despite their complicated and extensive effects on ecosystem functioning and species survival.Previous work has proved that fences increase habitat fragmentation,disrupt migratory routes,inadvertently trap and kill wildlife,and hinder genetic exchange.Hydropower construction also caused habitat loss,fragmentation,and degradation.These impacts have received global concern,but fences around the world are difficult to be detected due to the limitations of current cartographic technologies.Furthermore,the effect of hydropower on the terrestrial environment has been underestimated,making the research on this topic at a global scale still in its infancy.Therefore,building an observation network of global fences and hydropower is a necessary step to move forward in the assessment of the impact of human activities on our planet,but also to better provide scientific support for policy-making regarding global biodiversity conservation,the identification of protected areas,and the prioritization of ecological restoration areas.展开更多
Urban heat island(UHI),driving by urbanization,plays an important role in urban sustainability under climate change.However,the quantification of UHI’s response to urbanization is still challenging due to the lack of...Urban heat island(UHI),driving by urbanization,plays an important role in urban sustainability under climate change.However,the quantification of UHI’s response to urbanization is still challenging due to the lack of robust and continuous temperature and urbanization datasets and reliable quantification methods.This study proposed a framework to quantify the response of surface UHI(SUHI)to urban expansion using the annual temperate cycle model.We built a continuous annual SUHI series at the buffer level from 2003 to 2018 in the Jing-Jin-Ji region of China using MODIS land surface temperature and imperviousness derived from Landsat.We then investigated the spatiotemporal dynamic of SUHI under urban expansion and examined the underlying mechanism.Spatially,the largest SUHI interannual variations occurred in suburban areas compared to the urban center and rural areas.Temporally,the increase in SUHI under urban expansion was more significant in daytime compare to nighttime.We found that the seasonal variation of SUHI was largely affected by the seasonal variations of vegetation in rural areas and the interannual variation was mainly attributed to urban expansion in urban areas.Additionally,urban greening led to the decrease in summer daytime SHUI in central urban areas.These findings deepen the understanding of the long-term spatiotemporal dynamic of UHI and the quantitative relationship between UHI and urban expansion,providing a scientific basis for prediction and mitigation of UHI.展开更多
A spatiotemporally dynamic therapy(SDT)is proposed as a powerful therapeutic modality that provides spatially dynamic responses of drug-carriers for adapting to the wound microenvironment.Herein,dynamic chitosan-poly(...A spatiotemporally dynamic therapy(SDT)is proposed as a powerful therapeutic modality that provides spatially dynamic responses of drug-carriers for adapting to the wound microenvironment.Herein,dynamic chitosan-poly(ethylene glycol)(CP)Schiff-base linkages are employed to perform SDT by directly converting a liquid drug Kangfuxin(KFX)into a gel formation.The obtained KFX-CP drug-gel with shape-adaptive property is used to treat a representative oral mucositis(OM)model in a spatiotemporally dynamic manner.The KFX-CP drug-gel creates an instructive microenvironment to regulate signaling biomolecules and endogenous cells behavior,thereby promoting OM healing by the rule of dynamically adjusting shape to fit the irregular OM regions first,and then provides space for tissue regeneration,over KFX potion control and the general hydrogel group of CP hydrogel and KFX-F127.Most interestingly,the regenerated tissue has ordered structure like healthy tissue.Therefore,the SDT provides a new approach for the design of next generation of wound dressing and tissue engineering materials.展开更多
Background The heterogeneity of COVID-19 spread dynamics is determined by complex spatiotemporal transmission patterns at a fine scale,especially in densely populated regions.In this study,we aim to discover such fine...Background The heterogeneity of COVID-19 spread dynamics is determined by complex spatiotemporal transmission patterns at a fine scale,especially in densely populated regions.In this study,we aim to discover such fine-scale transmission patterns via deep learning.Methods We introduce the notion of TransCode to characterize fine-scale spatiotemporal transmission patterns of COVID-19 caused by metapopulation mobility and contact behaviors.First,in Hong Kong,China,we construct the mobility trajectories of confirmed cases using their visiting records.Then we estimate the transmissibility of individual cases in different locations based on their temporal infectiousness distribution.Integrating the spatial and temporal information,we represent the TransCode via spatiotemporal transmission networks.Further,we propose a deep transfer learning model to adapt the TransCode of Hong Kong,China to achieve fine-scale transmission characterization and risk prediction in six densely populated metropolises:New York City,San Francisco,Toronto,London,Berlin,and Tokyo,where fine-scale data are limited.All the data used in this study are publicly available.Results The TransCode of Hong Kong,China derived from the spatial transmission information and temporal infectiousness distribution of individual cases reveals the transmission patterns(e.g.,the imported and exported transmission intensities)at the district and constituency levels during different COVID-19 outbreaks waves.By adapting the TransCode of Hong Kong,China to other data-limited densely populated metropolises,the proposed method outperforms other representative methods by more than 10%in terms of the prediction accuracy of the disease dynamics(i.e.,the trend of case numbers),and the fine-scale spatiotemporal transmission patterns in these metropolises could also be well captured due to some shared intrinsically common patterns of human mobility and contact behaviors at the metapopulation level.Conclusions The fine-scale transmission patterns due to the metapopulation level mobility(e.g.,travel across different districts)and contact behaviors(e.g.,gathering in social-economic centers)are one of the main contributors to the rapid spread of the virus.Characterization of the fine-scale transmission patterns using the TransCode will facilitate the development of tailor-made intervention strategies to effectively contain disease transmission in the targeted regions.展开更多
The Low Earth Orbit(LEO)remote sensing satellite mega-constellation has the characteristics of large quantity and various types which make it have unique superiority in the realization of concurrent multiple tasks.How...The Low Earth Orbit(LEO)remote sensing satellite mega-constellation has the characteristics of large quantity and various types which make it have unique superiority in the realization of concurrent multiple tasks.However,the complexity of resource allocation is increased because of the large number of tasks and satellites.Therefore,the primary problem of implementing concurrent multiple tasks via LEO mega-constellation is to pre-process tasks and observation re-sources.To address the challenge,we propose a pre-processing algorithm for the mega-constellation based on highly Dynamic Spatio-Temporal Grids(DSTG).In the first stage,this paper describes the management model of mega-constellation and the multiple tasks.Then,the coding method of DSTG is proposed,based on which the description of complex mega-constellation observation resources is realized.In the third part,the DSTG algorithm is used to realize the processing of concurrent multiple tasks at multiple levels,such as task space attribute,time attribute and grid task importance evaluation.Finally,the simulation result of the proposed method in the case of constellation has been given to verify the effectiveness of concurrent multi-task pre-processing based on DSTG.The autonomous processing process of task decomposition and task fusion and mapping to grids,and the convenient indexing process of time window are verified.展开更多
Carbon dioxide(CO_(2))emissions from aquatic ecosystems are important components of the global carbon cycle,yet the CO_(2)emissions from coastal reservoirs,especially in developing countries where urbanization and rap...Carbon dioxide(CO_(2))emissions from aquatic ecosystems are important components of the global carbon cycle,yet the CO_(2)emissions from coastal reservoirs,especially in developing countries where urbanization and rapid land use change occur,are still poorly understood.In this study,the spatiotemporal variations in CO_(2)concentrations and fluxes were investigated in Wenwusha Reservoir located in the southeast coast of China.Overall,the mean CO_(2)concentration and flux across the whole reservoir were 41.85±2.03μmol/L and 2.87±0.29 mmol/m2/h,respectively,and the reservoir was a consistent net CO_(2)source over the entire year.The land use types and urbanization levels in the reservoir catchment significantly affected the input of exogenous carbon towater.The mean CO_(2)fluxwasmuch higher from waters adjacent to the urban land(5.05±0.87 mmol/m2/hr)than other land use types.Sites with larger input of exogenous substance via sewage discharge and upstream runoff were often the hotspots of CO_(2)emission in the reservoir.Our results suggested that urbanization process,agricultural activities,and large input of exogenous carbon could result in large spatial heterogeneity of CO_(2)emissions and alter the CO_(2)biogeochemical cycling in coastal reservoirs.Further studies should characterize the diurnal variations,microbial mechanisms,and impact of meteorological conditions on reservoir CO_(2)emissions to expand our understanding of the carbon cycle in aquatic ecosystems.展开更多
Land cover change has presented clear spatial differences in the New Eurasian Continental Bridge Economic Corridor(NECBEC)region in the 21 st century.A spatiotemporal dynamic probability model and a driving force anal...Land cover change has presented clear spatial differences in the New Eurasian Continental Bridge Economic Corridor(NECBEC)region in the 21 st century.A spatiotemporal dynamic probability model and a driving force analysis model of land cover change were developed to analyze explicitly the dynamics and driving forces of land cover change in the NECBEC region.The results show that the areas of grassland,cropland and built-up land increased by 114.57 million ha,8.41 million ha and 3.96 million ha,and the areas of woodland,other land,and water bodies and wetlands decreased by 74.09 million ha,6.26 million ha,and 46.59 million ha in the NECBEC region between 2001 and 2017,respectively.Woodland and other land were mainly transformed to grassland,and grassland was mainly transformed to woodland and cropland.Built-up land had the largest annual rate of increase and 50%of this originated from cropland.Moreover,since the Belt and Road Initiative(BRI)commenced in 2013,there has been a greater change in the dynamics of land cover change,and the gaps in the socio-economic development level have gradually decreased.The index of socio-economic development was the highest in western Europe,and the lowest in northern Central Asia.The impacts of socio-economic development on cropland and built-up land were greater than those for other land cover types.In general,in the context of rapid socio-economic development,the rate of land cover change in the NECBEC has clearly shown an accelerating trend since 2001,especially after the launch of the BRI in 2013.展开更多
基金supported by the National Natural Science Foundation of China(62005193,62135008,62075158,62025504,61935015)the National Science Foundation(2114103)Guangxi Key Laboratory of Optoelectroric Information Processing(GD20202).
文摘Plasmonic vortices confining orbital angular momentums to surface have aroused wide research interest in the last decade.Recent advances of near-field microscopes have enabled the study on the spatiotemporal dynamics of plasmonic vortices,providing a better understanding of optical orbital angular momentums in the evanescent wave regime.However,these works only focused on the objective characterization of plasmonic vortex and have not achieved subjectively tailoring of its spatiotemporal dynamics for specific applications.Herein,it is demonstrated that the plasmonic vortices with the same topological charge can be endowed with distinct spatiotemporal dynamics by simply changing the coupler design.Based on a near-field scanning terahertz microscopy,the surface plasmon fields are directly obtained with ultrahigh spatiotemporal resolution,experimentally exhibiting the generation and evolution divergences during the whole lifetime of plasmonic vortices.The proposed strategy is straightforward and universal,which can be readily applied into visible or infrared frequencies,facilitating the development of plasmonic vortex related researches and applications.
基金Under the auspices of Chinese Ministry of Education Humanities and Social Sciences Project(No.19YJCZH241)Project of Chongqing Social Science Planning Project of China(No.2020QNGL38)+1 种基金Science and Technology Research Program of Chongqing Education Commission of China(No.KJQN201901143)Humanities and Social Sciences Research Program of Chongqing Education Commission of China(No.20SKGH169)。
文摘In this study,we developed an evaluation index system for green total-factor water-use efficiency(GTFWUE)which reflected both economic and green efficiencies of water resource utilization.Then we measured the GTFWUE of 30 provinces/municipalities/autonomous regions(hereafter provinces)in China(not including Tibet,Hong Kong,Macao,Taiwan as no data)from 2000 to 2018 using a minimum distance to the strong frontier model that contained an undesirable output.We further analyzed the regional differences and spatial correlations of GTFWUE using these values based on Global and Local Moran’s I statistics,and empirically determined the factors affecting GTFWUE using a spatial econometric model.The evaluation results revealed that the GTFWUE differed substantially between the regions.The provinces with high and low GTFWUE values were located in the coastal and inland areas of China,respectively.The eastern region had a significantly higher GTFWUE than the central and western regions.The GTFWUEs for all three regions(eastern,central,and western regions)decreased slowly from 2000 to 2011(except 2005),remained stable from 2012 to 2016,and rapidly increased in 2017 before decreasing again in 2018.We found significant spatial correlations between the provincial GTFWUEs.The GTFWUE for most provinces belonged to the high-high or low-low cluster region,revealing a significant spatial clustering effect of provincial GTFWUEs.We also found that China’s GTFWUE was highly promoted by economic growth,population size,opening-up level,and urbanization level,and was evidently hindered by water endowment,technological progress,and government influence.However,the water-use structure had little impact on GTFWUE.This study fully demonstrated that the water use mode would be improved,and water resources needed to be used more efficiently and green in China.Moreover,based on the findings of this study,several policy recommendations were proposed from the aspects of cross-regional cooperation,economy,society,and institution.
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.U20A20191,82071912,12104049,82202291)the Fundamental Research Funds for the Central Universities(Grant No.2021CX11011)the National Key Research and Development Program of China(Grant No.2020YFC2007305).
文摘Objective:We investigated changes in cortico–subcortical spatiotemporal dynamics to explore the treatment mechanisms oftranscranial alternating current stimulation(tACS)in patientswith Parkinson’s disease(PD).Methods:Resting-state functional magnetic resonance imaging(rs-fMRI)data were collected from 20 patients with PD and 20 normal controls(NC).Each patient with PD received successivemultidisciplinary intensive rehabilitation treatment and tACStreatment over a one-year interval.Individual functional brain network mapping and co-activation pattern(CAP)analysis were performed to characterize cortico–subcortical dynamics.Results:The same tACS electrode placement stimulated different proportions of functional brain networks across the participants.CAP analysis revealed that the visual network,attentional network,and default mode network co-activated with the thalamus,accumbens,and amygdala,respectively.The pattern characterized by thede-activation of the visual network and the activation of the thalamus showed a significantly low amplitude in the patients with PD than inNCs,and this amplitude increased after tACS treatment.Furthermore,the co-occurrence of cortico–subcortical CAPs was significantly higherin patients with PD than in NCs and decreased after tACS treatment.Conclusions:This study investigated cortico–subcortical spatiotemporaldynamics in patients with PD and further revealed the tACS treatmentmechanism.These findings contribute to understanding cortico–subcortical dynamics and exploring noninvasive neuromodulationtargets of cortico–subcortical circuits in brain diseases,such as PD,Alzheimer’s disease,and depression.
文摘Obtaining timely and accurate data on the spatiotemporal dynamics of electric power consumption(EPC)is crucial for the effective utilization of electric power in China.The Defense Meteorological Satellite Program’s Operational Linescan System(DMSP/OLS)nighttime stable light(NSL)data have good potential for estimating EPC effectively at large scales.However,saturated lighted pixels contained within the NSL data limit the accuracy of EPC estimation.We developed a new method to correct the saturated lighted pixels,using the SPOT VEGETATION(SPOT/VGT)10-day synthesis product(S10)normalized differ-ence vegetation index(NDVI)data and then modeled the spatiotemporal dynamics of EPC in China' Mainland from 2000 to 2008.The results demon-strated the reliability of our approach with an average Rvalue of 0.93(P<0.001)and an average relative error of-28.92%.EPC in China' Mainland showed an average annual growth rate of 13.46% during the study period from 1198.23 billion kWh in 2000 to 3290.51 billion kWh in 2008.EPC in China' Mainland also showed clear regional variation.Northern coastal China and eastern coastal China consumed 37.61%of the total EPC in China' Mainland,with only 25.96% of the population and 6.11% of the area.
基金supported by the National Natural Science Foundation of China (Grant No. 30770685)
文摘Although the mechanism of neurovascular coupling remains inadequately understood,physiological research has indicated that the dilation of arterioles located within the cerebral cortex column might represent the primary mechanism of hemodynamic response during neurovascular coupling.This study examined the spatiotemporal pattern of NO diffusion induced by functional stimuli at column spatial resolution.Our modeling makes it possible to explore the responses of mediating factors to functional stimuli from a four-dimensional view,which may lead the way to decoding the mechanism of neurovascular coupling.
基金National Key Research and Development Program of China(2017YFB0308401).
文摘Wet-salted skin,as a special artificial high-salt environment,is rich in protein,fat,collagen and other nutrient substrates,and is a rich resource of halotolerant and halophilic microorganisms.However,knowledge gaps regarding the microbial community structure and inter taxa associations of wet-salted skin are large.In this study,the spatiotemporal dynamics and community structure of microorganisms present on wet-salted goatskins were investigated using 16S rRNA gene amplicon sequencing and culturable technique.Alpha diversity analysis based on Sobs,Chao,Ace and Shannon indices revealed that microbial diversity on the wet-salted goatskins exhibited a trend of‘down→up→down→flat’with time.During preservation,genera belonging to the bacteria domain such as Aci-netobacter,Weissella and Streptococcus were slowly dying out,whereas those belonging to halophilic archaea such as Natrialba and Haloterrigena were gradually flourishing.Moreover,to resist high-salt stress,microorganisms on the wet-salted goatskin gradually migrated from the outside to the inside,eventually leading to the microbial diversity inside the skin being the same as or even higher than that on the skin surface.Venn diagram analysis revealed that the strains of some genera,including Psychrobacter,Salimicrobium,Salinicola,Ornithinibacillus,Halomonas,Bacillus and Chromohalobacter,were distributed throughout the interior and exterior of the wet-salted goatskin and existed during various periods.Accordingly,45 protease-producing halophilic or halotolerant microorganisms were isolated and screened from the wet-salted goatskin using the gradient dilution plate method.Importantly,16S rRNA genes of some bacteria exhibited less than 99.5%similarity to valid published species,indicating that they likely are novel spe-cies and have a good potential for application.
基金the National Natural Sci-ence Foundation of China(Grant No.42001139)the Second Ti-betan Plateau Scientific Expedition and Research Program(Grant No.2019QZKK0406)+1 种基金the National Natural Science Foundation of China(Grant No.42230510)the China Postdoctoral Science Foundation(Grant No.2020M670472).
文摘Investigating the spatiotemporal variation of human activity intensity and its determinants is a crucial basis for further revealing the mechanism of human-environment interaction and optimizing the human development mode.In this study,the human activity intensity on the Qinghai-Tibet Plateau(QTP)from 1990 to 2020 was measured based on the quantitative model of land use data and the actual regional background,and the under-lying natural and socioeconomic determinants were investigated using spatial econometric methods.The results demonstrate that(1)the human activity intensity in QTP has increased by 11.96%,and there are differences in different spatial scales;the areas with high human activity intensity are distributed in the Hehuang Valley where Xining City and its surrounding areas are located,as well as the One-River and Two-River Area where Lhasa City and surrounding areas are located.(2)Human activity intensity has significant positive spatial spillover,suggesting that local changes will cause changes in the same direction in adjacent areas.(3)The human activ-ity intensity in QTP is affected by various determinants.Concerning socioeconomic factors,the economic level has no significant impact on the human activity intensity in QTP,which differs from the general regional law.Both urbanization and traffic conditions have a significant positive effect,and the impact intensity continues to increase.Concerning natural factors,topographic relief has a significant positive effect;the impacts of temper-ature and vegetation coverage have changed from insignificant to a significant positive effect;the impacts of precipitation and river network density have not been verified;there is no linear relationship between altitude and human activity intensity in the entire QTP,while it exists in local regions.Finally,this study proposes three policy implications for the realization of a more harmonious human-environment relationship in QTP.
基金supported by the China 948Program of National Forestry Bureau(2015-4-39)the National Science Foundation of China(No.41461052+1 种基金31660191)Yunnan education department project(2017YJS089)
文摘Soil fauna can sensitively respond to alterations in soil environment induced by land-use changes.However,little is known about the impact of urban land-use changes on earthworm communities.In this study,three land-use types(i.e.,forest,nursery and abandoned lands)were chosen to identify differences in diversity,abundance and biomass of earthworm community in Kunming City.Urban land-use had a pronounced difference in species composition,evenness and diversity of earthworm communities.Forest land had the highest density,biomass and diversity of the earthworm communities.Total abundance was dominated by endogeic species in nursery land(70%)and abandoned land(80%),whereas in the forest land,the earthworm community comprised epigeic,endogeic and anecic species.Temporal changes in earthworm density and biomass were also significantly affected by land-use change.Total density and biomass of earthworms in the forest and nursery lands were highest in September,but highest in the abandoned land in October.The influence of soil physicochemical properties on the earthworm density and biomass also varied with land-use types.Soil temperature significantly affected earthworm density and biomass in the three land-use types.Soil pH was positively correlated with earthworm biomass in the forest land,but negatively associated with earthworm density in the abandoned land.Soil organic matter was positively correlated only with density and biomass of earthworms in the nursery and abandoned lands.Our results suggest that the species composition,abundance and biomass of earthworm communities can be determined by the modification of soil properties associated with urban land-use type.
基金the Second Scientific Expedition to the Qinghai-Tibet Plateau(Grant No.2019QZKK0405)the investiga-tion and monitoring project on Rational construction and utilization of grassland fence in China National Park(QHXH-2021-07-19-package 2).
文摘Human activities have impacted 77%of the terrestrial ecosystems(excluding Antarctica),and the remaining areas are becoming increasingly endangered.Mapping spatiotemporal dynamics of Human Footprint has been used to evaluate the cumulative interference on terrestrial environments globally.However,fences and hydropower,two widespread and rapidly expanding infrastructures,have not been considered regarding Human Footprint,despite their complicated and extensive effects on ecosystem functioning and species survival.Previous work has proved that fences increase habitat fragmentation,disrupt migratory routes,inadvertently trap and kill wildlife,and hinder genetic exchange.Hydropower construction also caused habitat loss,fragmentation,and degradation.These impacts have received global concern,but fences around the world are difficult to be detected due to the limitations of current cartographic technologies.Furthermore,the effect of hydropower on the terrestrial environment has been underestimated,making the research on this topic at a global scale still in its infancy.Therefore,building an observation network of global fences and hydropower is a necessary step to move forward in the assessment of the impact of human activities on our planet,but also to better provide scientific support for policy-making regarding global biodiversity conservation,the identification of protected areas,and the prioritization of ecological restoration areas.
基金supported by the National Science Foundation(CBET-1803920)。
文摘Urban heat island(UHI),driving by urbanization,plays an important role in urban sustainability under climate change.However,the quantification of UHI’s response to urbanization is still challenging due to the lack of robust and continuous temperature and urbanization datasets and reliable quantification methods.This study proposed a framework to quantify the response of surface UHI(SUHI)to urban expansion using the annual temperate cycle model.We built a continuous annual SUHI series at the buffer level from 2003 to 2018 in the Jing-Jin-Ji region of China using MODIS land surface temperature and imperviousness derived from Landsat.We then investigated the spatiotemporal dynamic of SUHI under urban expansion and examined the underlying mechanism.Spatially,the largest SUHI interannual variations occurred in suburban areas compared to the urban center and rural areas.Temporally,the increase in SUHI under urban expansion was more significant in daytime compare to nighttime.We found that the seasonal variation of SUHI was largely affected by the seasonal variations of vegetation in rural areas and the interannual variation was mainly attributed to urban expansion in urban areas.Additionally,urban greening led to the decrease in summer daytime SHUI in central urban areas.These findings deepen the understanding of the long-term spatiotemporal dynamic of UHI and the quantitative relationship between UHI and urban expansion,providing a scientific basis for prediction and mitigation of UHI.
基金supported by Key Program of Beijing Natural Science Foundation(Z200025)National Natural Science Foundation of China(52003161)+3 种基金National Mega-project for Innovative Drugs(2019ZX09721001-007-002)Shenzhen Science and Technology Project(JCYJ20180507183842516)Fundamental Research Funds for the Central Universities(BHYC1705B,PYBZ1709)Research Projects on Biomedical Transformation of China-Japan Friendship Hospital(PYBZ1806).
文摘A spatiotemporally dynamic therapy(SDT)is proposed as a powerful therapeutic modality that provides spatially dynamic responses of drug-carriers for adapting to the wound microenvironment.Herein,dynamic chitosan-poly(ethylene glycol)(CP)Schiff-base linkages are employed to perform SDT by directly converting a liquid drug Kangfuxin(KFX)into a gel formation.The obtained KFX-CP drug-gel with shape-adaptive property is used to treat a representative oral mucositis(OM)model in a spatiotemporally dynamic manner.The KFX-CP drug-gel creates an instructive microenvironment to regulate signaling biomolecules and endogenous cells behavior,thereby promoting OM healing by the rule of dynamically adjusting shape to fit the irregular OM regions first,and then provides space for tissue regeneration,over KFX potion control and the general hydrogel group of CP hydrogel and KFX-F127.Most interestingly,the regenerated tissue has ordered structure like healthy tissue.Therefore,the SDT provides a new approach for the design of next generation of wound dressing and tissue engineering materials.
基金the Ministry of Science and Technology of the People’s Republic of China(2021ZD0112501,2021ZD0112502)the Research Grants Council of Hong Kong SAR(RGC/HKBU12201318,RGC/HKBU12201619,RGC/HKBU12202220)the Guangdong Basic and Applied Basic Research Foundation(2022A1515010124).
文摘Background The heterogeneity of COVID-19 spread dynamics is determined by complex spatiotemporal transmission patterns at a fine scale,especially in densely populated regions.In this study,we aim to discover such fine-scale transmission patterns via deep learning.Methods We introduce the notion of TransCode to characterize fine-scale spatiotemporal transmission patterns of COVID-19 caused by metapopulation mobility and contact behaviors.First,in Hong Kong,China,we construct the mobility trajectories of confirmed cases using their visiting records.Then we estimate the transmissibility of individual cases in different locations based on their temporal infectiousness distribution.Integrating the spatial and temporal information,we represent the TransCode via spatiotemporal transmission networks.Further,we propose a deep transfer learning model to adapt the TransCode of Hong Kong,China to achieve fine-scale transmission characterization and risk prediction in six densely populated metropolises:New York City,San Francisco,Toronto,London,Berlin,and Tokyo,where fine-scale data are limited.All the data used in this study are publicly available.Results The TransCode of Hong Kong,China derived from the spatial transmission information and temporal infectiousness distribution of individual cases reveals the transmission patterns(e.g.,the imported and exported transmission intensities)at the district and constituency levels during different COVID-19 outbreaks waves.By adapting the TransCode of Hong Kong,China to other data-limited densely populated metropolises,the proposed method outperforms other representative methods by more than 10%in terms of the prediction accuracy of the disease dynamics(i.e.,the trend of case numbers),and the fine-scale spatiotemporal transmission patterns in these metropolises could also be well captured due to some shared intrinsically common patterns of human mobility and contact behaviors at the metapopulation level.Conclusions The fine-scale transmission patterns due to the metapopulation level mobility(e.g.,travel across different districts)and contact behaviors(e.g.,gathering in social-economic centers)are one of the main contributors to the rapid spread of the virus.Characterization of the fine-scale transmission patterns using the TransCode will facilitate the development of tailor-made intervention strategies to effectively contain disease transmission in the targeted regions.
基金supported by the National Natural Science Foundation of China(Nos.62003115 and 11972130)the Shenzhen Science and Technology Program,China(JCYJ20220818102207015)the Heilongjiang Touyan Team Program,China。
文摘The Low Earth Orbit(LEO)remote sensing satellite mega-constellation has the characteristics of large quantity and various types which make it have unique superiority in the realization of concurrent multiple tasks.However,the complexity of resource allocation is increased because of the large number of tasks and satellites.Therefore,the primary problem of implementing concurrent multiple tasks via LEO mega-constellation is to pre-process tasks and observation re-sources.To address the challenge,we propose a pre-processing algorithm for the mega-constellation based on highly Dynamic Spatio-Temporal Grids(DSTG).In the first stage,this paper describes the management model of mega-constellation and the multiple tasks.Then,the coding method of DSTG is proposed,based on which the description of complex mega-constellation observation resources is realized.In the third part,the DSTG algorithm is used to realize the processing of concurrent multiple tasks at multiple levels,such as task space attribute,time attribute and grid task importance evaluation.Finally,the simulation result of the proposed method in the case of constellation has been given to verify the effectiveness of concurrent multi-task pre-processing based on DSTG.The autonomous processing process of task decomposition and task fusion and mapping to grids,and the convenient indexing process of time window are verified.
基金supported by the National Science Foundation of China(Nos.41801070,41671088)the National Science Foundation of Fujian Province(No.2020J01136)+2 种基金2020 Innovation Training Programme Project for Fujian Normal University Student’s(No.cxxl-2020270)the Research Grants Council of the Hong Kong Special Administrative Region,China(Nos.CUHK458913,14302014,14305515)the CUHK Direct Grant(No.SS15481),Open Research Fund Program of Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control(No.KHK1806),a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)and the Minjiang Scholar Programme.
文摘Carbon dioxide(CO_(2))emissions from aquatic ecosystems are important components of the global carbon cycle,yet the CO_(2)emissions from coastal reservoirs,especially in developing countries where urbanization and rapid land use change occur,are still poorly understood.In this study,the spatiotemporal variations in CO_(2)concentrations and fluxes were investigated in Wenwusha Reservoir located in the southeast coast of China.Overall,the mean CO_(2)concentration and flux across the whole reservoir were 41.85±2.03μmol/L and 2.87±0.29 mmol/m2/h,respectively,and the reservoir was a consistent net CO_(2)source over the entire year.The land use types and urbanization levels in the reservoir catchment significantly affected the input of exogenous carbon towater.The mean CO_(2)fluxwasmuch higher from waters adjacent to the urban land(5.05±0.87 mmol/m2/hr)than other land use types.Sites with larger input of exogenous substance via sewage discharge and upstream runoff were often the hotspots of CO_(2)emission in the reservoir.Our results suggested that urbanization process,agricultural activities,and large input of exogenous carbon could result in large spatial heterogeneity of CO_(2)emissions and alter the CO_(2)biogeochemical cycling in coastal reservoirs.Further studies should characterize the diurnal variations,microbial mechanisms,and impact of meteorological conditions on reservoir CO_(2)emissions to expand our understanding of the carbon cycle in aquatic ecosystems.
基金National Key R&D Program of China,No.2017YFA0603702,No.2018YFC0507202National Natural Science Foundation of China,No.41971358,No.41930647,No.41977066+1 种基金Strategic Priority Research Program(A)of the Chinese Academy of Sciences,No.XDA20030203Innovation Project of LREIS,No.O88RA600YA。
文摘Land cover change has presented clear spatial differences in the New Eurasian Continental Bridge Economic Corridor(NECBEC)region in the 21 st century.A spatiotemporal dynamic probability model and a driving force analysis model of land cover change were developed to analyze explicitly the dynamics and driving forces of land cover change in the NECBEC region.The results show that the areas of grassland,cropland and built-up land increased by 114.57 million ha,8.41 million ha and 3.96 million ha,and the areas of woodland,other land,and water bodies and wetlands decreased by 74.09 million ha,6.26 million ha,and 46.59 million ha in the NECBEC region between 2001 and 2017,respectively.Woodland and other land were mainly transformed to grassland,and grassland was mainly transformed to woodland and cropland.Built-up land had the largest annual rate of increase and 50%of this originated from cropland.Moreover,since the Belt and Road Initiative(BRI)commenced in 2013,there has been a greater change in the dynamics of land cover change,and the gaps in the socio-economic development level have gradually decreased.The index of socio-economic development was the highest in western Europe,and the lowest in northern Central Asia.The impacts of socio-economic development on cropland and built-up land were greater than those for other land cover types.In general,in the context of rapid socio-economic development,the rate of land cover change in the NECBEC has clearly shown an accelerating trend since 2001,especially after the launch of the BRI in 2013.