Focusing on the effect specificity of meridian points along the running course of meridian,by taking the treatment of post-stroke depression(PSD)with the acupoints of the governor vessel as an example,the correlation ...Focusing on the effect specificity of meridian points along the running course of meridian,by taking the treatment of post-stroke depression(PSD)with the acupoints of the governor vessel as an example,the correlation between meridian points and disease was explored.The specific regulatory effect of governor vessel,Baihui(百会GV20)and Shenting(神庭GV24)in physiology and pathology in PSD and the material basis of the specificity effect were analyzed.Finally,the specific relationship between the acupoints of the governor vessel and PSD was explained.展开更多
Objective:To explore whether or not the changes in body surface resistance at yuan-source points of three yin meridians of foot can specifically responds the onset of primary dysmenorrhea(PD) in females of menstrual p...Objective:To explore whether or not the changes in body surface resistance at yuan-source points of three yin meridians of foot can specifically responds the onset of primary dysmenorrhea(PD) in females of menstrual period and the before and after,so as to provide the evidence for acupoint selection in clinic.Methods:A total of 90 cases of PD were recruited in a PD group and 90 healthy female undergraduates were recruited in a normal group.The yuan-source of points of three yin meridians of foot were selected,i.e.Taibai(太白SP3),Taichong(太冲LR3) and Taixi(太溪KI3).The acupoints for control were Xuehai(血海SP10),the non-special acupoint,Xuanzhong(悬钟GB39),the acupoint not on the relevant meridian,as well as a non-meridian point.Successively,before menstruation,on Day 1 during menstruation and on Day 3 after menstruation,the body surface resistance at the above-mentioned test sites was detected in the participants of two groups each day.The resistance imbalance degree(RID) of the bilateral acupoints was taken as the outcome indicator.The observation lasted one menstrual cycle.Results:(1) Intra-group comparison:at LR3,the RID was lower on Day 1 during menstruation than that before menstruation significantly in the normal group(P ≤0.05).There was no significant change in RID at the same time points,but RID on Day 3 after menstruation was lower significantly than that before menstruation in the PD group(P ≤0.05).At SP3,KI3,SP10,GB39 and sham acupoint,there were no significant differences in RID among different time points within the same group(all P> 0.05).(2) Intergroup comparison:there were no significant differences in RID among different time points at the same point.(all P> 0.05).Conclusion:RID at yuan-source points of three yin meridians of foot cannot specifically respond to PD.However,at LR3,before and after menstruation,RID changes are different between PD patients and healthy female undergraduates,which needs a further study in the future.展开更多
目的采用基于核磁共振(1H nuclear magnetic resonance,NMR)的代谢组学方法分别观察针刺阳明经穴与他经穴位对健康男性血浆代谢产物的影响,运用模式识别方法分析阳明经穴是否具有共性,与他经穴位是否具有差异性。方法将60例健康青年男...目的采用基于核磁共振(1H nuclear magnetic resonance,NMR)的代谢组学方法分别观察针刺阳明经穴与他经穴位对健康男性血浆代谢产物的影响,运用模式识别方法分析阳明经穴是否具有共性,与他经穴位是否具有差异性。方法将60例健康青年男性随机分为足三里组、梁门组、巨髎组、阳陵泉组、委中组和空白对照组,每组10例。分别针刺相应穴位,连续针刺5 d,抽取所有受试者的空腹静脉血,采用1H NMR检测血浆代谢物,运用主成分分析和正交偏最小二乘判别分析等模式识别方法分析所得数据。结果 1H-NMR和模式识别相结合的代谢组学方法能较好地区分出足三里组、阳陵泉组、委中组,但对足三里组、梁门组和巨髎组的区分并不明显。针刺阳明经穴位主要影响血浆中的小分子代谢物,与能量代谢通路密切相关;针刺阳陵泉主要影响血浆代谢物中的大分子物质,与脂代谢、脂转运密切相关;针刺委中对血浆代谢物影响不大。结论研究结果提示,阳明经穴具有一定的共性,与阳陵泉、委中均不同;基于NMR和模式识别的代谢组学技术为从代谢角度区分阳明经穴和他经穴位提供了实验证据,有可能成为研究经穴特异性的新的有用工具。展开更多
基金Supported by National Natural Science Foundation of China:81804161,Natural Science Foundation of Jiangsu Province:BK20171070
文摘Focusing on the effect specificity of meridian points along the running course of meridian,by taking the treatment of post-stroke depression(PSD)with the acupoints of the governor vessel as an example,the correlation between meridian points and disease was explored.The specific regulatory effect of governor vessel,Baihui(百会GV20)and Shenting(神庭GV24)in physiology and pathology in PSD and the material basis of the specificity effect were analyzed.Finally,the specific relationship between the acupoints of the governor vessel and PSD was explained.
基金Supported by National Natural Science Foundation of China:81573884,81973755,81603542Excellent Innovation Team Construction Project of Hebei University of Chinese Medicine:JTZ2020008。
文摘Objective:To explore whether or not the changes in body surface resistance at yuan-source points of three yin meridians of foot can specifically responds the onset of primary dysmenorrhea(PD) in females of menstrual period and the before and after,so as to provide the evidence for acupoint selection in clinic.Methods:A total of 90 cases of PD were recruited in a PD group and 90 healthy female undergraduates were recruited in a normal group.The yuan-source of points of three yin meridians of foot were selected,i.e.Taibai(太白SP3),Taichong(太冲LR3) and Taixi(太溪KI3).The acupoints for control were Xuehai(血海SP10),the non-special acupoint,Xuanzhong(悬钟GB39),the acupoint not on the relevant meridian,as well as a non-meridian point.Successively,before menstruation,on Day 1 during menstruation and on Day 3 after menstruation,the body surface resistance at the above-mentioned test sites was detected in the participants of two groups each day.The resistance imbalance degree(RID) of the bilateral acupoints was taken as the outcome indicator.The observation lasted one menstrual cycle.Results:(1) Intra-group comparison:at LR3,the RID was lower on Day 1 during menstruation than that before menstruation significantly in the normal group(P ≤0.05).There was no significant change in RID at the same time points,but RID on Day 3 after menstruation was lower significantly than that before menstruation in the PD group(P ≤0.05).At SP3,KI3,SP10,GB39 and sham acupoint,there were no significant differences in RID among different time points within the same group(all P> 0.05).(2) Intergroup comparison:there were no significant differences in RID among different time points at the same point.(all P> 0.05).Conclusion:RID at yuan-source points of three yin meridians of foot cannot specifically respond to PD.However,at LR3,before and after menstruation,RID changes are different between PD patients and healthy female undergraduates,which needs a further study in the future.
