Creatinine(Cr)is a biochemical waste molecule generated from muscle metabolism and primarily cleared from the bloodstream by the kidneys.If kidney function declines,Cr levels in the blood tend to increase.Therefore,Cr...Creatinine(Cr)is a biochemical waste molecule generated from muscle metabolism and primarily cleared from the bloodstream by the kidneys.If kidney function declines,Cr levels in the blood tend to increase.Therefore,Cr serves as an indicator of kidney function.In this work,we present a simple method for the rapid screening for impaired renal function based on the subject's Cr concentration.In our setup,broadband white light is delivered to a finger clamp through a fiber-optic cable to illuminate the patient's finger.The light is transmitted through the finger and collected by a second optical fiber coupled to a visible-near-infrared(VisNIR)spectrometer which covers the spectral range from 400nm to 1100nm.During the calibration process,the transmitted spectra acquired from 60 patients were measured.An average was calculated using the peak level of the transmitted,diffused intensity at three different wavelengths to create a"Cr intensity index".Patients were divided into five groups according to their Cr concentration levels,ranging from 1 mg/dL to 13 mg/dL.Our observations indicated that each group featured a unique spectral fingerprint.Next,we tested the index on 20 patients not included in the cali-bration procedure(unknown samples).We were able to classify patients into groups according to their Cr level with moderate prediction accuracy(R^(2)=0.55)and mean screening error of up to 16%.Future efforts will evaluate the accuracy of this approach with larger patient populations representing a broad range of Cr concentration.Still,this preliminary work is an essential step toward developing this useful noninvasive Cr screening platform using NIR light spectroscopy.展开更多
In this work two different fluorochromes (Alexa 594 and Alexa 680) are conjugated to the same monoclonal antibody (Cetuximab) for obtaining a characteristic M-shaped dual-peak spectrum. Dual-labeling of Cetuximab ...In this work two different fluorochromes (Alexa 594 and Alexa 680) are conjugated to the same monoclonal antibody (Cetuximab) for obtaining a characteristic M-shaped dual-peak spectrum. Dual-labeling of Cetuximab by mixing both fluorochromes before the conjugation step gives spectral results similar to those of mixing of fluorochrome-labeled Cetuximab after the conjugation step (P 〉 0.05). In conclusion, both methods may be used equivalently for producing a dual-labeled single-antibody probe. Future studies may test whether the M-shaped spectrum may increase the diagnostic confidence in tumor-targeted multispectral optical imaging.展开更多
High peak-to-average-power ratio(PAPR) and spectral leakage are two main drawbacks of multicarrier systems, such as in orthogonal frequency division multiplexing(OFDM), in future 5G wireless communications. For genera...High peak-to-average-power ratio(PAPR) and spectral leakage are two main drawbacks of multicarrier systems, such as in orthogonal frequency division multiplexing(OFDM), in future 5G wireless communications. For generating optimized wave forms for 5G communications, this paper proposes an iterative scheme combining time-domain N-continuous OFDM(TD-NC-OFDM) and serial peak cancellation(SPC). Based on the theory of projection onto convex sets(POCS), the effectiveness of the proposed scheme is proved, and the optimized time-frequency domain multicarrier waveforms are analyzed in terms of a balanced tradeoff between out-of-band spectral leakage and PAPR. Both theoretical analysis and simulation results show that the proposed scheme can jointly optimize both the PAPR and out-ofband radiation, with moderate computational complexity.展开更多
基岩面埋深是公路工程建设中的重要参考依据。本文通过福建地区两个探测实例,研究了微动H/V谱比法探测基岩面埋深的方法技术,介绍了微动H/V(Horizontal to Vertical)谱比法提取基岩面埋深的方法原理。首先对微动单个三分量检波器采集地...基岩面埋深是公路工程建设中的重要参考依据。本文通过福建地区两个探测实例,研究了微动H/V谱比法探测基岩面埋深的方法技术,介绍了微动H/V(Horizontal to Vertical)谱比法提取基岩面埋深的方法原理。首先对微动单个三分量检波器采集地震记录进行处理和分析,获取了测点的峰值频率F 0。在钻孔较多的情况下,可根据钻孔的中风化岩深度与峰值频率F 0的幂函数拟合,得到了该区的经验参数a和b,从而可以计算整个测区每个测点的中风化岩深度三维分布。在钻孔较少的情况下,可根据测区内部分钻孔的孔内剪切波值计算该区的覆盖层平均横波速度,进而根据经验公式计算覆盖层厚度和基岩面三维埋深分布。两个探测实例研究结果表明:微动H/V谱比法是一种快速获取公路工程三维基岩面的方法,在一定条件下,相对误差能够控制在5%左右,能够满足工程勘察的需求。微动谱比法具有简便性和易操作性,点位可随机布置,几乎不受场地条件限制,能够取得较好的地质效果,可推广应用。展开更多
针对传统密度峰值聚类在波段选择时缺乏信息论角度的相似性度量以及波段数目确定问题,提出基于光谱角-光谱信息散度的自适应密度峰值波段选择方法(SSDPC:Spectral angle mapping and Spectral information divergence Density Peaks Clu...针对传统密度峰值聚类在波段选择时缺乏信息论角度的相似性度量以及波段数目确定问题,提出基于光谱角-光谱信息散度的自适应密度峰值波段选择方法(SSDPC:Spectral angle mapping and Spectral information divergence Density Peaks Cluster)。该方法将光谱信息散度和光谱角用于高光谱图像密度峰值聚类进行波段选择,取代传统的欧氏距离构建波段相似矩阵。通过构建波段评分策略,有效自动选择出重要的光谱波段子集。在3组高光谱数据集上调用RX(Reed-Xiaoli)算法进行异常检测,在SSDPC的相似性度量方法下,异常检测精度较欧氏距离度量方法分别平均提高1.16%、1.18%和0.07%;在自适应的SSDPC波段选择方法下,异常检测精度相较原始RX算法分别提升6.49%、2.71%和0.05%。结果表明,该算法具有良好的鲁棒性,能提升高光谱图像异常检测的性能并降低其虚警率。展开更多
This study evaluates the capability of the Simulating WAves Nearshore(SWAN)wave model(version 41.01)in predicting significant wave height and spectral peak energy content for swell waves in very shallow water of surf ...This study evaluates the capability of the Simulating WAves Nearshore(SWAN)wave model(version 41.01)in predicting significant wave height and spectral peak energy content for swell waves in very shallow water of surf zone during depth-induced wave breaking and dissipation.The model results were compared with field measurements at five nearshore stations.The results demonstrated that some breaker index formulations were successful for significant wave height prediction in surf zones.However,an incorrect shape of the energy spectrum and overestimated near spectral peak energy content at shallow water stations were obtained using all of the embedded depth-induced wave breaking formulations in SWAN.The dependent breaker index on relative depth(Kpd)formulation,which was successful in predicting near spectral peak energy content,resulted in an average error of 30%.Finally,this formulation was modified to enhance the model performance in reproducing the spectral peak energy content.展开更多
为了解决变换域通信系统(transformed domain communication system, TDCS)信号检测及参数估计问题,通过对TDCS信号自相关函数的推导分析,提出了一种基于二次自相关的TDCS信号检测及基函数估计的方法。分析发现,TDCS信号的自相关函数会...为了解决变换域通信系统(transformed domain communication system, TDCS)信号检测及参数估计问题,通过对TDCS信号自相关函数的推导分析,提出了一种基于二次自相关的TDCS信号检测及基函数估计的方法。分析发现,TDCS信号的自相关函数会出现周期性谱峰,且峰峰间距为基函数周期的二分之一,故以谱峰间隔是否呈现周期性作为TDCS信号的存在性判据,并根据峰峰距离进一步估计TDCS信号的基函数周期。但单次自相关处理得到的局部谱峰受信道噪声影响大,为此提出了二次自相关法,该方法使得局部峰值特征进一步加强,相较于单次自相关,二次自相关可在更低的信噪比下实现TDCS信号检测并对基函数周期进行有效估计。展开更多
In order to study the differences in vertical component between onshore and offshore motions,the vertical-to-horizontal peak ground acceleration ratio(V/H PGA ratio) and vertical-to-horizontal response spectral ratio(...In order to study the differences in vertical component between onshore and offshore motions,the vertical-to-horizontal peak ground acceleration ratio(V/H PGA ratio) and vertical-to-horizontal response spectral ratio(V/H) were investigated using the ground motion recordings from the K-NET network and the seafloor earthquake measuring system(SEMS).The results indicate that the vertical component of offshore motions is lower than that of onshore motions.The V/H PGA ratio of acceleration time histories at offshore stations is about 50%of the ratio at onshore stations.The V/H for offshore ground motions is lower than that for onshore motions,especially for periods less than 0.8 s.Furthermore,based on the results in statistical analysis for offshore recordings in the K-NET,the simplified V/H design equations for offshore motions in minor and moderate earthquakes are proposed for seismic analysis of offshore structures.展开更多
针对变换域通信系统(Transform Domain Communication System,TDCS)信号难以检测的问题,设计了基于功率谱二次处理的检测方法。通过数学建模,理论推导了TDCS信号的自相关函数,并由此推出了TDCS信号的两次功率谱函数,证明了TDCS信号的二...针对变换域通信系统(Transform Domain Communication System,TDCS)信号难以检测的问题,设计了基于功率谱二次处理的检测方法。通过数学建模,理论推导了TDCS信号的自相关函数,并由此推出了TDCS信号的两次功率谱函数,证明了TDCS信号的二次功率谱存在周期性谱峰的特征,并给出了谱峰周期与基函数周期的数学关系。据此设计了一种TDCS信号检测算法,该算法能够检测TDCS信号并对基函数周期给予估计。理论分析了高斯白噪声对检测算法的影响,通过计算机仿真,验证了该算法在低信噪比下的性能,对比了二次功率谱法与时域相关法的检测性能,验证了采样数据长度对检测性能的影响。仿真结果表明在低信噪比条件下,本文算法对基函数周期估计仍有效,且算法性能相较于自相关法提高了约1.5 dB,增加采样数据长度可进一步提高二次功率谱算法的准确性。展开更多
文摘Creatinine(Cr)is a biochemical waste molecule generated from muscle metabolism and primarily cleared from the bloodstream by the kidneys.If kidney function declines,Cr levels in the blood tend to increase.Therefore,Cr serves as an indicator of kidney function.In this work,we present a simple method for the rapid screening for impaired renal function based on the subject's Cr concentration.In our setup,broadband white light is delivered to a finger clamp through a fiber-optic cable to illuminate the patient's finger.The light is transmitted through the finger and collected by a second optical fiber coupled to a visible-near-infrared(VisNIR)spectrometer which covers the spectral range from 400nm to 1100nm.During the calibration process,the transmitted spectra acquired from 60 patients were measured.An average was calculated using the peak level of the transmitted,diffused intensity at three different wavelengths to create a"Cr intensity index".Patients were divided into five groups according to their Cr concentration levels,ranging from 1 mg/dL to 13 mg/dL.Our observations indicated that each group featured a unique spectral fingerprint.Next,we tested the index on 20 patients not included in the cali-bration procedure(unknown samples).We were able to classify patients into groups according to their Cr level with moderate prediction accuracy(R^(2)=0.55)and mean screening error of up to 16%.Future efforts will evaluate the accuracy of this approach with larger patient populations representing a broad range of Cr concentration.Still,this preliminary work is an essential step toward developing this useful noninvasive Cr screening platform using NIR light spectroscopy.
文摘In this work two different fluorochromes (Alexa 594 and Alexa 680) are conjugated to the same monoclonal antibody (Cetuximab) for obtaining a characteristic M-shaped dual-peak spectrum. Dual-labeling of Cetuximab by mixing both fluorochromes before the conjugation step gives spectral results similar to those of mixing of fluorochrome-labeled Cetuximab after the conjugation step (P 〉 0.05). In conclusion, both methods may be used equivalently for producing a dual-labeled single-antibody probe. Future studies may test whether the M-shaped spectrum may increase the diagnostic confidence in tumor-targeted multispectral optical imaging.
基金supported in part by the National Science Foundation of China under Grant number 61471090the National HighTech R&D Program of China under Grant number 2014AA01A707+1 种基金the Fundamental Research Funds for the Central Universities(No.ZYGX2013J112)the Foundation Project of National Key Laboratory of Science and Technology on Communications under Grant 9140C020108140C02005
文摘High peak-to-average-power ratio(PAPR) and spectral leakage are two main drawbacks of multicarrier systems, such as in orthogonal frequency division multiplexing(OFDM), in future 5G wireless communications. For generating optimized wave forms for 5G communications, this paper proposes an iterative scheme combining time-domain N-continuous OFDM(TD-NC-OFDM) and serial peak cancellation(SPC). Based on the theory of projection onto convex sets(POCS), the effectiveness of the proposed scheme is proved, and the optimized time-frequency domain multicarrier waveforms are analyzed in terms of a balanced tradeoff between out-of-band spectral leakage and PAPR. Both theoretical analysis and simulation results show that the proposed scheme can jointly optimize both the PAPR and out-ofband radiation, with moderate computational complexity.
文摘基岩面埋深是公路工程建设中的重要参考依据。本文通过福建地区两个探测实例,研究了微动H/V谱比法探测基岩面埋深的方法技术,介绍了微动H/V(Horizontal to Vertical)谱比法提取基岩面埋深的方法原理。首先对微动单个三分量检波器采集地震记录进行处理和分析,获取了测点的峰值频率F 0。在钻孔较多的情况下,可根据钻孔的中风化岩深度与峰值频率F 0的幂函数拟合,得到了该区的经验参数a和b,从而可以计算整个测区每个测点的中风化岩深度三维分布。在钻孔较少的情况下,可根据测区内部分钻孔的孔内剪切波值计算该区的覆盖层平均横波速度,进而根据经验公式计算覆盖层厚度和基岩面三维埋深分布。两个探测实例研究结果表明:微动H/V谱比法是一种快速获取公路工程三维基岩面的方法,在一定条件下,相对误差能够控制在5%左右,能够满足工程勘察的需求。微动谱比法具有简便性和易操作性,点位可随机布置,几乎不受场地条件限制,能够取得较好的地质效果,可推广应用。
文摘针对传统密度峰值聚类在波段选择时缺乏信息论角度的相似性度量以及波段数目确定问题,提出基于光谱角-光谱信息散度的自适应密度峰值波段选择方法(SSDPC:Spectral angle mapping and Spectral information divergence Density Peaks Cluster)。该方法将光谱信息散度和光谱角用于高光谱图像密度峰值聚类进行波段选择,取代传统的欧氏距离构建波段相似矩阵。通过构建波段评分策略,有效自动选择出重要的光谱波段子集。在3组高光谱数据集上调用RX(Reed-Xiaoli)算法进行异常检测,在SSDPC的相似性度量方法下,异常检测精度较欧氏距离度量方法分别平均提高1.16%、1.18%和0.07%;在自适应的SSDPC波段选择方法下,异常检测精度相较原始RX算法分别提升6.49%、2.71%和0.05%。结果表明,该算法具有良好的鲁棒性,能提升高光谱图像异常检测的性能并降低其虚警率。
基金supported by Iranian National Institute for Oceanography and Atmospheric Science
文摘This study evaluates the capability of the Simulating WAves Nearshore(SWAN)wave model(version 41.01)in predicting significant wave height and spectral peak energy content for swell waves in very shallow water of surf zone during depth-induced wave breaking and dissipation.The model results were compared with field measurements at five nearshore stations.The results demonstrated that some breaker index formulations were successful for significant wave height prediction in surf zones.However,an incorrect shape of the energy spectrum and overestimated near spectral peak energy content at shallow water stations were obtained using all of the embedded depth-induced wave breaking formulations in SWAN.The dependent breaker index on relative depth(Kpd)formulation,which was successful in predicting near spectral peak energy content,resulted in an average error of 30%.Finally,this formulation was modified to enhance the model performance in reproducing the spectral peak energy content.
文摘为了解决变换域通信系统(transformed domain communication system, TDCS)信号检测及参数估计问题,通过对TDCS信号自相关函数的推导分析,提出了一种基于二次自相关的TDCS信号检测及基函数估计的方法。分析发现,TDCS信号的自相关函数会出现周期性谱峰,且峰峰间距为基函数周期的二分之一,故以谱峰间隔是否呈现周期性作为TDCS信号的存在性判据,并根据峰峰距离进一步估计TDCS信号的基函数周期。但单次自相关处理得到的局部谱峰受信道噪声影响大,为此提出了二次自相关法,该方法使得局部峰值特征进一步加强,相较于单次自相关,二次自相关可在更低的信噪比下实现TDCS信号检测并对基函数周期进行有效估计。
基金Project(2011CB013605)supported by the National Basic Research Development Program of China(973 Program)Projects(51178071,51008041)supported by the National Natural Science Foundation of ChinaProject(NCET-12-0751)supported by the New Century Excellent Talents Program in University of Ministry of Education of China
文摘In order to study the differences in vertical component between onshore and offshore motions,the vertical-to-horizontal peak ground acceleration ratio(V/H PGA ratio) and vertical-to-horizontal response spectral ratio(V/H) were investigated using the ground motion recordings from the K-NET network and the seafloor earthquake measuring system(SEMS).The results indicate that the vertical component of offshore motions is lower than that of onshore motions.The V/H PGA ratio of acceleration time histories at offshore stations is about 50%of the ratio at onshore stations.The V/H for offshore ground motions is lower than that for onshore motions,especially for periods less than 0.8 s.Furthermore,based on the results in statistical analysis for offshore recordings in the K-NET,the simplified V/H design equations for offshore motions in minor and moderate earthquakes are proposed for seismic analysis of offshore structures.
文摘针对变换域通信系统(Transform Domain Communication System,TDCS)信号难以检测的问题,设计了基于功率谱二次处理的检测方法。通过数学建模,理论推导了TDCS信号的自相关函数,并由此推出了TDCS信号的两次功率谱函数,证明了TDCS信号的二次功率谱存在周期性谱峰的特征,并给出了谱峰周期与基函数周期的数学关系。据此设计了一种TDCS信号检测算法,该算法能够检测TDCS信号并对基函数周期给予估计。理论分析了高斯白噪声对检测算法的影响,通过计算机仿真,验证了该算法在低信噪比下的性能,对比了二次功率谱法与时域相关法的检测性能,验证了采样数据长度对检测性能的影响。仿真结果表明在低信噪比条件下,本文算法对基函数周期估计仍有效,且算法性能相较于自相关法提高了约1.5 dB,增加采样数据长度可进一步提高二次功率谱算法的准确性。