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Cerebral perfusion in patients with unilateral internal carotid artery occlusion by dual post-labeling delays arterial spin labeling imaging
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作者 Gui-Rong Zhang Yan-Yan Zhang +1 位作者 Wen-Bin Liang Dun Ding 《World Journal of Radiology》 2024年第9期429-438,共10页
BACKGROUND Global and regional cerebral blood flow(CBF)changes in patients with unilateral internal carotid artery occlusion(ICAO)are unclear when the dual post-labeling delays(PLD)arterial spin labeling(ASL)magnetic ... BACKGROUND Global and regional cerebral blood flow(CBF)changes in patients with unilateral internal carotid artery occlusion(ICAO)are unclear when the dual post-labeling delays(PLD)arterial spin labeling(ASL)magnetic resonance imaging(MRI)technique is used.Manual delineation of regions of interest for CBF measurement is time-consuming and laborious.AIM To assess global and regional CBF changes in patients with unilateral ICAO with the ASL-MRI perfusion technique.METHODS Twenty hospitalized patients with ICAO and sex-and age-matched controls were included in the study.Regional CBF was measured by Dr.Brain's ASL software.The present study evaluated differences in global,middle cerebral artery(MCA)territory,anterior cerebral artery territory,and Alberta Stroke Program Early Computed Tomography Score(ASPECTS)regions(including the caudate nucleus,lentiform nucleus,insula ribbon,internal capsule,and M1-M6)and brain lobes(including frontal,parietal,temporal,and insular lobes)between ICAO patients and controls at PLD 1.5 s and PLD 2.5 s.RESULTS When comparing CBF between ICAO patients and controls,the global CBF in ICAO patients was lower at both PLD 1.5 s and PLD 2.5 s;the CBF on the occluded side was lower in 15 brain regions at PLD 1.5 s,and it was lower in 9 brain regions at PLD 2.5 s;the CBF in the contralateral hemisphere was lower in the caudate nucleus and internal capsule at PLD 1.5 s and in M6 at PLD 2.5 s.The global CBF in ICAO patients was lower at PLD 1.5 s than at PLD 2.5 s.The ipsilateral CBF at PLD 1.5 s was lower than that at PLD 2.5 s in 15 regions,whereas the contralateral CBF was lower at PLD 1.5 s than at PLD 2.5 s in 12 regions.The ipsilateral CBF was lower than the contralateral CBF in 15 regions at PLD 1.5 s,and in M6 at PLD 2.5 s.CONCLUSION Unilateral ICAO results in hypoperfusion in the global and MCA territories,especially in the ASPECTS area.Dual PLD settings prove more suitable for accurate CBF quantification in ICAO. 展开更多
关键词 Arterial spin labeling Internal carotid artery occlusion Ischemic stroke Cerebral blood flow HEMODYNAMIC
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The Antioxidization Effects of TP-5, Thy(1[Lys23] and Their Spin Labeled Derivatives
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作者 王勤 王芳 +2 位作者 孟雪琴 胡晓愚 杨金波 《Journal of Chinese Pharmaceutical Sciences》 CAS 2000年第4期182-184,共3页
TP-5 and Thy(1, synthesized by solid phase synthesis, have the effect to restrain the formation of superoxide anion in xanthine oxidase system in vitro. The formations of lipid peroxide in several organs (such as live... TP-5 and Thy(1, synthesized by solid phase synthesis, have the effect to restrain the formation of superoxide anion in xanthine oxidase system in vitro. The formations of lipid peroxide in several organs (such as liver, brain and thymus) of the mice treated with TP-5, TP-5(R, active fragment of Thy(1 and active fragment of Thy(1(R of 10 (g(kg(d-1 for 10 d were decreased. That means these peptides possess the capability of antioxidezation. 展开更多
关键词 TP-5 Thy(1[Lys23](23~27)OH spin labeled derivative Antioxidization Malonaldehyde (MDA) ESR atlas
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Pulsed arterial spin labeling effectively and dynamically observes changes in cerebral blood flow after mild traumatic brain injury 被引量:3
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作者 Shu-ping Peng Yi-ning Li +5 位作者 Jun Liu Zhi-yuan Wang Zi-shu Zhang Shun-ke Zhou Fang-xu Tao Zhi-xue Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第2期257-261,共5页
Cerebral blood flow is strongly associated with brain function, and is the main symptom and diagnostic basis for a variety of encephalopathies. However, changes in cerebral blood flow after mild traumatic brain injury... Cerebral blood flow is strongly associated with brain function, and is the main symptom and diagnostic basis for a variety of encephalopathies. However, changes in cerebral blood flow after mild traumatic brain injury remain poorly understood. This study sought to observe changes in cerebral blood flow in different regions after mild traumatic brain injury using pulsed arterial spin labeling. Our results demonstrate maximal cerebral blood flow in gray matter and minimal in the white matter of patients with mild traumatic brain injury. At the acute and subacute stages, cerebral blood flow was reduced in the occipital lobe, parietal lobe, central region, subcutaneous region, and frontal lobe. Cerebral blood flow was restored at the chronic stage. At the acute, subacute, and chronic stages, changes in cerebral blood flow were not apparent in the insula. Cerebral blood flow in the temporal lobe and limbic lobe diminished at the acute and subacute stages, but was restored at the chronic stage. These findings suggest that pulsed arterial spin labeling can precisely measure cerebral blood flow in various brain regions, and may play a reference role in evaluating a patient's condition and judging prognosis after traumatic brain injury. 展开更多
关键词 nerve regeneration MRI pulsed arterial spin labeling technique cerebral blood flow mild traumatic brain injury GlasgowComa Scale white matter gray matter CT neural regeneration
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Three-dimensional-arterial spin labeling perfusion correlation with diabetes-associated cognitive dysfunction and vascular endothelial growth factor in type 2 diabetes mellitus rat 被引量:5
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作者 Ju-Wei Shao Jin-De Wang +6 位作者 Qian He Ying Yang Ying-Ying Zou Wei Su Shu-Tian Xiang Jian-Bo Li Jing Fang 《World Journal of Diabetes》 SCIE 2021年第4期499-513,共15页
BACKGROUND Type 2 diabetes mellitus(T2DM) has been strongly associated with an increased risk of developing cognitive dysfunction and dementia.The mechanisms of diabetes-associated cognitive dysfunction(DACD) have not... BACKGROUND Type 2 diabetes mellitus(T2DM) has been strongly associated with an increased risk of developing cognitive dysfunction and dementia.The mechanisms of diabetes-associated cognitive dysfunction(DACD) have not been fully elucidated to date.Some studies proved lower cerebral blood flow(CBF) in the hippocampus was associated with poor executive function and memory in T2DM.Increasing evidence showed that diabetes leads to abnormal vascular endothelial growth factor(VEGF) expression and CBF changes in humans and animal models.In this study,we hypothesized that DACD was correlated with CBF alteration as measured by three-dimensional(3D) arterial spin labeling(3D-ASL) and VEGF expression in the hippocampus.AIM To assess the correlation between CBF(measured by 3D-ASL and VEGF expression) and DACD in a rat model of T2DM.METHODS Forty Sprague-Dawley male rats were divided into control and T2DM groups.The T2DM group was established by feeding rats a high-fat diet and glucose to induce impaired glucose tolerance and then injecting them with streptozotocin to induce T2DM.Cognitive function was assessed using the Morris water maze experiment.The CBF changes were measured by 3D-ASL magnetic resonance imaging.VEGF expression was determined using immunofluorescence.RESULTS The escape latency time significantly reduced 15 wk after streptozotocin injection in the T2DM group.The total distance traveled was longer in the T2DM group;also,the platform was crossed fewer times.The percentage of distance in the target zone significantly decreased.CBF decreased in the bilateral hippocampus in the T2DM group.No difference was found between the right CBF value and the left CBF value in the T2DM group.The VEGF expression level in the hippocampus was lower in the T2DM group and correlated with the CBF value.The escape latency negatively correlated with the CBF value.The number of rats crossing the platform positively correlated with the CBF value.CONCLUSION Low CBF in the hippocampus and decreased VEGF expression might be crucial in DACD.CBF measured by 3D-ASL might serve as a noninvasive imaging biomarker for cognitive impairment associated with T2DM. 展开更多
关键词 Diabetes-associated cognitive dysfunction Diabetes mellitus Type 2 Perfusion imaging Receptors Vascular endothelial growth factor Hippocampus Three-dimensional pseudo-continuous arterial spin labeling
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Three-dimensional arterial spin labeling and diffusion kurtosis imaging in evaluating perfusion and infarct area size in acute cerebral ischemia 被引量:3
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作者 Yan-Yan Jiang Zhi-Lin Zhong Min Zuo 《World Journal of Clinical Cases》 SCIE 2022年第17期5586-5594,共9页
BACKGROUND Early thrombolytic therapy is crucial to treat acute cerebral infarction,especially since the onset of thrombolytic therapy takes 1-6 h.Therefore,early diagnosis and evaluation of cerebral infarction is imp... BACKGROUND Early thrombolytic therapy is crucial to treat acute cerebral infarction,especially since the onset of thrombolytic therapy takes 1-6 h.Therefore,early diagnosis and evaluation of cerebral infarction is important.AIM To investigate the diagnostic value of magnetic resonance multi-delay threedimensional arterial spin labeling(3DASL)and diffusion kurtosis imaging(DKI)in evaluating the perfusion and infarct area size in patients with acute cerebral ischemia.METHODS Eighty-four patients who experienced acute cerebral ischemia from March 2019 to February 2021 were included.All patients in the acute stage underwent magnetic resonance-based examination,and the data were processed by the system’s own software.The apparent diffusion coefficient(ADC),average diffusion coefficient(MD),axial diffusion(AD),radial diffusion(RD),average kurtosis(MK),radial kurtosis(fairly RK),axial kurtosis(AK),and perfusion parameters post-labeling delays(PLD)in the focal area and its corresponding area were compared.The correlation between the lesion area of cerebral infarction under MK and MD and T2-weighted imaging(T2WI)was analyzed.RESULTS The DKI parameters of focal and control areas in the study subjects were compared.The ADC,MD,AD,and RD values in the lesion area were significantly lower than those in the control area.The MK,RK,and AK values in the lesion area were significantly higher than those in the control area.The MK/MD value in the infarct lesions was used to determine the matching situation.MK/MD<5 mm was considered matching and MK/MD≥5 mm was considered mismatching.PLD1.5s and PLD2.5s perfusion parameters in the central,peripheral,and control areas of the infarct lesions in MK/MD-matched and-unmatched patients were not significantly different.PLD1.5s and PLD2.5s perfusion parameter values in the central area of the infarct lesions in MK/MD-matched and-unmatched patients were significantly lower than those in peripheral and control areas.The MK and MD maps showed a lesion area of 20.08±5.74 cm^(2) and 22.09±5.58 cm^(2),respectively.T2WI showed a lesion area of 19.76±5.02 cm^(2).There were no significant differences in the cerebral infarction lesion areas measured using the three methods.MK,MD,and T2WI showed a good correlation.CONCLUSION DKI parameters showed significant difference between the focal and control areas in patients with acute ischemic cerebral infarction.3DASL can effectively determine the changes in perfusion levels in the lesion area.There was a high correlation between the area of the infarct lesions diagnosed by DKI and T2WI. 展开更多
关键词 Magnetic resonance Multi-delay 3D arterial spin labeling Diffusion kurtosis imaging Acute ischemic cerebral infarction PERFUSION Nerve function
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Hyperperfusion of Multiple Sclerosis Plaques Characterized by 3D FSE Arterial Spin Labelling 被引量:2
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作者 Zhi-ye Chen Lin Ma 《Chinese Medical Sciences Journal》 CAS CSCD 2014年第3期194-196,共3页
MULTIPLE sclerosis (MS) is a common inflammatory demyelinating disorder of central nervous system, and the disease burder could be well evaluated by conven-tional magnetic resonance imaging (MRI),1 including T2-we... MULTIPLE sclerosis (MS) is a common inflammatory demyelinating disorder of central nervous system, and the disease burder could be well evaluated by conven-tional magnetic resonance imaging (MRI),1 including T2-weighted, fluid-attenuatd inversion recovery, and postcontrast Tl-weighted sequences. 2 We investigated the perfusion state of MS plaques using brain perfusion imaging in a 12-year-old boy with MS. 展开更多
关键词 multiple sclerosis arterial spin labelling PERFUSION magnetic resonance imaging
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Study on the synthesis of spin labeled poly(styrene-co-maleic acid)s and their segmental motion 被引量:1
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作者 Kaleem-Ur-Rahman Naveed Li Wang +9 位作者 Haojie Yu Qian Zhang Wei Xiong Raja Summe Ullah Ahsan Nazir Muhammad Usman Shah Fahad Amin Khan Md Alim Uddin Di Shen 《Magnetic Resonance Letters》 2022年第2期80-90,I0002,共12页
Study of the segmental mobility of polymer chains is important when the polymer is used as drag reduction agents of crude oil.Electron spin resonance(ESR)spectroscopy can provide important information about segmental ... Study of the segmental mobility of polymer chains is important when the polymer is used as drag reduction agents of crude oil.Electron spin resonance(ESR)spectroscopy can provide important information about segmental dynamics of polymer chains,which is related to their microenvironment.In this article,we employed an amphiphilic polymer to study the effect of hydrophilic/hydrophobic balance of the polymers on the segmental motion of polymer chains.Poly(styrene-co-maleic acid)(PSMA)was spin labeled with 4-amino TEMPO radicals by increasing the concentration of radical moiety on the polymer chains.The PSMA and spin labeled-PSMAs(SL-PSMAs)were characterized by nuclear magnetic resonance(NMR),Fourier transform infrared(FT-IR)spectroscopy,Cyclic voltammetry(CV)and ESR techniques.Inter-polymer complexes(IPCs)of SL-PSMA-2 were prepared by employing polyethylene glycols(PEGs)of varying molecular weights.The results showed that the increased hydrophobic interactions of nitroxide radicals on the SLPSMAs’chains reduced the rotational mobility of spin labels and the random coil-toglobular transition of polymer chains occurred at higher pH value for SL-PSMAs,which showed a slow motion component in the ESR spectra of SL-PSMAs.Further,by increasing the molecular weight of PEGs in IPCs the complexation was increased,which also reduced the rotational motion of spin labels due to interpolymer hydrogen bonding causing a slow motion component in the ESR spectra.©2021 The Authors. 展开更多
关键词 Electron spin resonance(ESR) spin labeling Nitroxide radicals poly(styrene-co-maleic acid)s Segmental motion
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Reliability of Three Dimentional Pseudo-continuous Arterial Spin Labeling:A Volumetric Cerebral Perfusion Imaging with Different Post-labeling Time and Functional State in Health Adults
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作者 刘梦琦 陈志晔 马林 《Chinese Medical Sciences Journal》 CAS CSCD 2018年第1期38-44,共7页
Objective To evaluate the reliability of three dimensional spiral fast spin echo pseudo-continuous arterial spin labeling(3 D pc-ASL) in measuring cerebral blood flow(CBF) with different post-labeling delay time(PLD) ... Objective To evaluate the reliability of three dimensional spiral fast spin echo pseudo-continuous arterial spin labeling(3 D pc-ASL) in measuring cerebral blood flow(CBF) with different post-labeling delay time(PLD) in the resting state and the right finger taping state.Methods 3 D pc-ASL and three dimensional T1-weighted fast spoiled gradient recalled echo(3 D T1-FSPGR) sequence were applied to eight healthy subjects twice at the same time each day for one week interval. ASL data acquisition was performed with post-labeling delay time(PLD) 1.5 seconds and 2.0 seconds in the resting state and the right finger taping state respectively. CBF mapping was calculated and CBF value of both the gray matter(GM) and white matter(WM) was automatically extracted. The reliability was evaluated using the intraclass correlation coefficient(ICC) and Bland and Altman plot.Results ICC of the GM(0.84) and WM(0.92) was lower at PLD 1.5 seconds than that(GM, 0.88; WM, 0.94) at PLD 2.0 seconds in the resting state, and ICC of GM(0.88) was higher in the right finger taping state than that in the resting state at PLD 1.5 seconds. ICC of the GM and WM was 0.71 and 0.78 for PLD 1.5 seconds and PLD 2.0 seconds in the resting state at the first scan, and ICC of the GM and WM was 0.83 and 0.79 at the second scan, respectively.Conclusion This work demonstrated that 3 D pc-ASL might be a reliable imaging technique to measure CBF over the whole brain at different PLD in the resting state or controlled state. 展开更多
关键词 pseudo-continuous ARTERIAL spin labelING magnetic resonance imaging intraclass correlation coefficient RELIABILITY
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Synthesis of Novel Spin Labeled Daunomycin Derivatives
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作者 Shu Jia ZHANG Yan Guang WANG Ju Biao LI 《Chinese Chemical Letters》 SCIE CAS CSCD 2001年第6期483-484,共2页
Three spin labeled daunomycin derivatives 2-4 were synthesized and their biological activities were tested against mouse leukemia L1210 and human liver cancer BEL-7402 cells in vitro.
关键词 spin labeled daunomycin derivatives antitumor activity SYNTHESIS
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Neural plasticity secondary to carpal tunnel syndrome: a pseudo-continuous arterial spin labeling study
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作者 Xue Deng Phoebe Lai-Heung Chau +3 位作者 Suk-Yee Chiu Kwok-Pui Leung Yong Hu Wing-Yuk Ip 《Neural Regeneration Research》 SCIE CAS CSCD 2021年第1期158-165,共8页
Conventional neuroimaging techniques cannot truly reflect the change of regional cerebral blood flow in patients with carpal tunnel syndrome.Pseudo-continuous arterial spinning labeling(pCASL)as an efficient non-invas... Conventional neuroimaging techniques cannot truly reflect the change of regional cerebral blood flow in patients with carpal tunnel syndrome.Pseudo-continuous arterial spinning labeling(pCASL)as an efficient non-invasive neuroimaging technique can be applied to directly quantify the neuronal activities of individual brain regions that show the persistent symptoms owing to its better spatial resolution and increased signal-to-noise ratio.Therefore,this prospective observational study was conducted in 27 eligible female carpal tunnel syndrome,aged 57.7±6.51 years.Psychometric tests,nerve conduction studies and pCASL neuroimaging assessment were performed.The results showed that the relevant activated brain regions in the cortical,subcrotical,and cerebral regions were correlated with numbness,pain,functionality,median nerve status and motor amplitude of median nerve(K=21–2849,r=–0.77–0.76,P<0.05).There was a tendency of pain processing which shifted from the nociceptive circuitry to the emotional and cognitive one during the process of chronic pain caused by carpal tunnel syndrome.It suggests the necessity of addressing the ignored cognitive or emotional state when managing patients with carpal tunnel syndrome.Approval for this study was obtained from the Institutional Review Board of The University of Hong Kong/Hospital Authority Hong Kong West,China(HKU/HA HKW IRB,approval No.UW17-129)on April 11,2017.This study was registered in Clinical Trial Registry of The University of Hong Kong,China(registration number:HKUCTR-2220)on April 24,2017. 展开更多
关键词 Boston carpal tunnel questionnaire carpal tunnel syndrome COGNITIVE nerve conduction studies PAIN principal component analysis pseudo-continuous arterial spin labeling
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Synthesis of Several Spin Labeled Ureas
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《厦门大学学报(自然科学版)》 CAS CSCD 北大核心 1999年第S1期482-482,共1页
关键词 spin Synthesis of Several spin labeled Ureas
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Advances in arterial spin labeled cerebral perfusion imaging in cerebrovascular diseases
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作者 Xiaodong Wang Gang Yang Fengfan Bai 《Journal of Translational Neuroscience》 2020年第4期20-25,共6页
Cerebrovascular disease is a disease with high morbidity,disability and mortality rates,which seri-ously affects the daily life of patients and is a heavy burden on families and society.Arterial spin labeling(ASL)is a... Cerebrovascular disease is a disease with high morbidity,disability and mortality rates,which seri-ously affects the daily life of patients and is a heavy burden on families and society.Arterial spin labeling(ASL)is a magnetic resonance imaging(MRI)technology that uses the magnetic labeling of hydrogen atoms in arterial blood as tracers to noninvasively evaluate brain blood flow.ASL does not require injection of an exogenous contrast agent,and has the advantages of no radiation,simplicity and low cost.In cerebrovascular diseases,ASL can evaluate the collateral cerebrovascular circulation and abnormal perfusion of brain tissue,which can provide a reliable basis for early diagnosis and clinical decision-making.This study reviewed ASL and its application in the diagnosis,treatment and prognosis of cerebrovascular diseases. 展开更多
关键词 cerebrovascular disease arterial spin labeling(ASL) cerebral perfusion imaging technique
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Arterial spin labeling in neuroimaging 被引量:23
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作者 Sasitorn Petcharunpaisan Joana Ramalho Mauricio Castillo 《World Journal of Radiology》 CAS 2010年第10期384-398,共15页
Arterial spin labeling(ASL) is a magnetic resonance imaging technique for measuring tissue perfusion using a freely diffusible intrinsic tracer.As compared with other perfusion techniques,ASL offers several advantages... Arterial spin labeling(ASL) is a magnetic resonance imaging technique for measuring tissue perfusion using a freely diffusible intrinsic tracer.As compared with other perfusion techniques,ASL offers several advantages and is now available for routine clinical practice in many institutions.Its noninvasive nature and ability to quantitatively measure tissue perfusion make ASL ideal for research and clinical studies.Recent technical advances have increased its sensitivity and also extended its potential applications.This review focuses on some basic knowledge of ASL perfusion,emerging techniques and clinical applications in neuroimaging. 展开更多
关键词 ARTERIAL spin labelING Continuous ARTERIAL spin labelING Pulsed ARTERIAL spin labelING Pseudocontinuous ARTERIAL spin labelING Velocity-selective ARTERIAL spin labelING TERRITORIAL ARTERIAL spin labelING ARTERIAL spin labelING at multiple inversion times Perfusion-based functional magnetic resonance imaging
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Intracranial Dural Arteriovenous Fistula: Preliminary Report of Arterial Spin Labeling
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作者 Kyo Noguchi Hideto Kawabe Hikaru Seto 《Open Journal of Medical Imaging》 2013年第1期1-6,共6页
Purpose: We report the results of applying arterial spin labeling (ASL) to intracranial dural arteriovenous fistula (DAVF). Methods: Sixteen patients with angiographically confirmed DAVF underwent ASL on a clinical 1.... Purpose: We report the results of applying arterial spin labeling (ASL) to intracranial dural arteriovenous fistula (DAVF). Methods: Sixteen patients with angiographically confirmed DAVF underwent ASL on a clinical 1.5 T or 3 T MR system. ASL was performed by Q2TIPS (second version of quantitative imaging of perfusion by using a single subtraction MRI pulse sequence with thin-slice TI1 periodic saturation) with echo-planar imaging. Draining veins such as dural venous sinus and cortical veins were evaluated on ASL. Results: ASL clearly depicted draining dural venous sinus in all patients with DAVF Borden type I (6/6, 100%) and type II (4/4, 100%). ASL depicted cortical venous reflux in only one patient with DAVF Borden type II (1/4, 25%). ASL depicted drainage directly into cortical veins in all patients with Borden type III (6/6, 100%). Conclusion: Our preliminary study suggests that ASL can depict draining veins in patients with DAVF. 展开更多
关键词 DURAL ARTERIOVENOUS FISTULA ARTERIAL spin labeling ASL
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Arterial spin labeling perfusion MRI applications in drug‑resistant epilepsy and epileptic emergency
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作者 Yingchun Xu Ge Tan +3 位作者 Deng Chen Jiao Liu Zixian Zhou Ling Liu 《Acta Epileptologica》 2023年第3期139-147,共9页
Epilepsy affects all age groups and is one of the most common and disabling neurological disorders worldwide.Drug-resistant epilepsy(DRE),status epilepticus(SE),and sudden unexpected death in epilepsy(SUDEP),which are... Epilepsy affects all age groups and is one of the most common and disabling neurological disorders worldwide.Drug-resistant epilepsy(DRE),status epilepticus(SE),and sudden unexpected death in epilepsy(SUDEP),which are associated with considerable healthcare costs and mortality,have always been difficult to address and become the focus of clinical research.The rapid identification of seizure onset and accurate localization of epileptic foci are crucial for the treatment and prognosis of people with DRE,SE,or near-SUDEP.However,most of the conventional neuroimaging techniques for assessing cerebral blood flow of people with epilepsy are restricted by time consumption,limited resolution,and ionizing radiation.Arterial spin labeling(ASL)is a newly powerful non-contrast magnetic resonance imaging technique that enables the quantitative evaluation of brain perfusion,characterized by its unique advantages of reproducibility and easy accessibility.Recent studies have demonstrated the potential advantages of ASL for the diagnosis and evaluation of epilepsy.Therefore,in this review,we discussed the complementary value of ASL in evaluating and characterizing the basic substrates underlying refractory epilepsy and epileptic emergencies. 展开更多
关键词 Arterial spin labeling Cerebral blood flow Drug-resistant epilepsy Epileptic emergency Status epilepticus SUDEP
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Quantitative assessment of acute kidney injury by noninvasive arterial spin labeling perfusion MRI:a pilot study 被引量:10
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作者 DONG Jian YANG Li +5 位作者 SU Tao YANG XueDong CHEN Bin ZHANG Jue WANG XiaoYing JIANG XueXiang 《Science China(Life Sciences)》 SCIE CAS 2013年第8期745-750,共6页
The kidneys are essential for maintaining homeostasis,are responsible for the reabsorption of water,glucose and amino acids,and filter the blood by removing waste.Acute kidney injury(AKI) is a syndrome characterized b... The kidneys are essential for maintaining homeostasis,are responsible for the reabsorption of water,glucose and amino acids,and filter the blood by removing waste.Acute kidney injury(AKI) is a syndrome characterized by the rapid loss of renal excretory function and the accumulation of end metabolic products of urea and creatinine.AKI is associated with the later development of chronic kidney disease and end-stage kidney disease,and may eventually be fatal.Early diagnosis of AKI and assessments of the effects of treatment,however,are challenging.The pathophysiological mechanism of AKI is thought to be the imbalance between oxygen supply and demand in the kidneys.We have assessed the ability of arterial spin labeling(ASL) perfusion magnetic resonance imaging(MRI),without the administration of contrast media,to quantify renal blood flow(RBF) non-invasively.We found that RBF was significantly lower in AKI patients than in healthy volunteers.These results suggest that ASL perfusion MRI,a noninvasive measurement of RBF,may be useful in the early diagnosis of AKI. 展开更多
关键词 arterial spin labeling (ASL) acute kidney injury (AKI) renal blood flow (RBF) magnetic resonance imaging (MRI)
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Structural characteristics of the hydrophobic patch of azurin and its interaction with p53: a site-directed spin labeling study 被引量:1
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作者 XU Chao YIN JunJie ZHAO BaoLu 《Science China(Life Sciences)》 SCIE CAS 2010年第10期1181-1188,共8页
Site-directed spin labeling (SDSL) is a powerful tool for monitoring protein structure, dynamics and conformational changes. In this study, the domain-specific properties of azurin and its interaction with p53 were st... Site-directed spin labeling (SDSL) is a powerful tool for monitoring protein structure, dynamics and conformational changes. In this study, the domain-specific properties of azurin and its interaction with p53 were studied using this technique. Mutations of six residues, that are located in the hydrophobic patch of azurin, were prepared and spin labeled. Spectra of the six azurin mutants in solution showed that spin labeled residues 45 and 63 are in a very restricted environment, residues 59 and 65 are in a spacious environment and have free movement, and residues 49 and 51 are located in a relatively closed pocket. Polarity experiments confirmed these results. The changes observed in the spectra of spin labeled azurin upon interaction with p53 indicate that the hydrophobic patch is involved in this interaction. Our results provide valuable insight into the topographic structure of the hydrophobic domain of azurin, as well as direct evidence of its interaction with p53 in solution via the hydrophobic patch. Cytotoxicity studies of azurin mutants showed that residues along the hydrophobic patch are important for its cytotoxicity. 展开更多
关键词 AZURIN P53 spin label protein-protein interaction ANTICANCER ESR
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The synthesis, bioactivity and paramagnetic resonance of angiotensin Ⅱ and its spin labelled derivative 被引量:2
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作者 WANG Rui, LI Xiaoxu, HU Xiaoyu, NI Jingman, LI Changling and LU Jingfen1. Department of Biology, State Key Laboratory of Applied Organic Chemistry, Lanzhou 730000, China 2. Department of Chemistry, Lanzhou University, Lanzhou 730000 3. State Key Laboratory of Natural and Biomimetic Drugs, Beijing Medical U-niversity, Beijing 100083, China. 《Chinese Science Bulletin》 SCIE EI CAS 1997年第21期1843-1846,共4页
ANGIOTENSIN Ⅱ(Ang Ⅱ) is an important constituent in renin-angiotension system (RAS).The amino acid sequence of Ang Ⅱ is DRVYIHPF. Ang Ⅱ plays an important role both inmaintenance of normal blood pressure and in oc... ANGIOTENSIN Ⅱ(Ang Ⅱ) is an important constituent in renin-angiotension system (RAS).The amino acid sequence of Ang Ⅱ is DRVYIHPF. Ang Ⅱ plays an important role both inmaintenance of normal blood pressure and in occurrence of hypertension. Ang Ⅱ binding re-ceptor can induce many kinds of physiological effects. Spin labeling is an effective method thatgreatly deepened the knowledge in structure, movement and interaction of biologicalmolecules. For example, it has been used in studying interaction of antigen and antibody suc- 展开更多
关键词 spin labelLED ANGIOTENSIN solid phase PEPTIDE SYNTHESIS bioactivity electron spin resonance.
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Protective Effects of Metallothionein on Cardiac Myocytes Against Hydroxyl Radicals by ESR Spin Label Method 被引量:1
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作者 华玥 程时 +1 位作者 卢景芬 杨正红 《Chinese Science Bulletin》 SCIE EI CAS 1993年第8期670-673,共4页
关键词 METALLOTHIONEIN CARDIAC MYOCYTES ESR spin label
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Spin-Labelled 1-Ethyl-1-Nitrosourea Prevents Doxorubicin and Bleomycin-Induced Oxidative Stress in Lungs, Hearts and Kidneys of Tumour-Bearing Mice
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作者 Veselina G. Gadjeva Galina D. Nikolova +3 位作者 Boncho G. Grigorov Antoaneta M. Zheleva Anna N. Tolekova Maya I. Vasileva 《Advances in Biological Chemistry》 2014年第5期291-300,共10页
This study was carried out to determine the possible protective effect of 1-ethyl-3-[4-(2, 2, 6, 6-tetramethylpiperidine-1-oxyl)]-1-nitrosourea (SLENU), recently synthesised in our laboratory on doxorubicin and bleomy... This study was carried out to determine the possible protective effect of 1-ethyl-3-[4-(2, 2, 6, 6-tetramethylpiperidine-1-oxyl)]-1-nitrosourea (SLENU), recently synthesised in our laboratory on doxorubicin and bleomycin-induced oxidative toxicity in C57 black tumour-bearing mice. Specifically, alterations in some biomarkers of oxidative stress, such as lipid peroxidation products measured as malondialdehyde (MDA) levels and activities of the antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT), were studied in lung, heart and kidney homogenates isolated from C57 black tumor-bearing mice after i.p. treatment with solutions of DOX (60 mg/kg) and BLM (60 mg/kg). The same biomarkers were also measured after i.p. pretreatment of mice with SLENU (100 mg/kg). After treatment with doxorubicin, heart and kidney homogenates of mice had significantly higher productions of lipid peroxidation compared to lung homogenates. It was accompanied by increased activity of the antioxidant defence enzyme superoxide dismutase and decreased activity of catalase. Bleomycin-induced oxidative stress was confirmed by significantly higher production of lipid peroxidation in lungs compared to heart homogenates, elevation of the anti-oxidant activity of superoxide dismutase and decreased activity of catalase enzymes. After pre-treatment of the mice with SLENU, the levels of all studied oxidative stress biomarkers were significantly improved in comparison with those of the mice treated alone with either bleomycin, or doxorubicin. The present results and those from a previously demonstrated superoxide scavenging activities (SSA) of the nitrosourea SLENU have enabled us to explain the protective effect of the spin-labelled nitrosourea on doxorubicin and bleomycin-induced oxidative stress by scavenging of??O2- and increased NO release. 展开更多
关键词 DOXORUBICIN BLEOMYCIN spin-labelled Superoxide DISMUTASE Catalase Lipid Peroxidation
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