Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial spectrum.However,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct target.In addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon exposure.To investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with kanamycin.We found that the mice exhibited auditory deficits following the acute loss of outer hair cells.Spiral ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over time.Transcriptomic profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 inflammasome.Activation of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory cytokines.Pharmacological intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury model.These findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron degeneration.Inhibition of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

Structural Research on Embedment of a Bare Deflated Spiral Case

Complete bearing spiral case has not been applied to large power stations in China so far. The proposal of applying complete bearing spiral case necessitates an analysis of the reliability of the spiral case structure and the security of units under various working conditions. In combination with practice of a project, this paper presents a three-dimensional nonlinear finite element static analysis of the concrete using a concrete smeared crack model by means of the well-known finite element method （FEM） software ABAQUS. The stress distribution of the spiral case and reinforcing bars, the range of damages in surrounding concrete, and the displacement of structure are quantified. The computational results indicate that the embedment method ensures the structure＇s safety in strength. At the same time, the result shows that this embedment is a kind of preponderant method for embedment in aspects of economy and technique of construction, and the application of this embedment method to the hydropower station is feasible provided that some proper engineering measures are taken to constrain the width of the concrete in accord with the code＇s requirements. The paper proves the security and reliability of the structural design of spiral case in hydropower station accordingly.

The bar and spiral arms in the Milky Way: structure and kinematics

The Milky Way is a spiral galaxy with the Schechter characteristic luminosity L*,thus an important anchor point of the Hubble sequence of all spiral galaxies.Yet the true appearance of the Milky Way has remained elusive for centuries.We review the current best understanding of the structure and kinematics of our home galaxy,and present an updated scientifically accurate visualization of the Milky Way structure with almost all components of the spiral arms,along with the COBE image in the solar perspective.The Milky Way contains a strong bar,four major spiral arms,and an additional arm segment(the Local arm)that may be longer than previously thought.The Galactic boxy bulge that we observe is mostly the peanut-shaped central bar viewed nearly end-on with a bar angle of^25°-30°from the SunGalactic center line.The bar transitions smoothly from a central peanut-shaped structure to an extended thin part that ends around R^5 kpc.The Galactic bulge/bar contains^30%-40%of the total stellar mass in the Galaxy.Dynamical modelling of both the stellar and gas kinematics yields a bar pattern rotation speed of^35-40 km s-1 kpc-1,corresponding to a bar rotation period of^160-180 Myr.From a galaxy formation point of view,our Milky Way is probably a pure-disk galaxy with little room for a significant merger-made,"classical"spheroidal bulge,and we give a number of reasons why this is the case.

Performance analysis of single-focus phase singularity based on elliptical reflective annulus quadrangle-element coded spiral zone plates

Optical vortices generated by the conventional vortex lens are usually disturbed by the undesired higher-order foci,which may lead to additional artifacts and thus degrade the contrast sensitivity. In this work, we propose an efficient methodology to combine the merit of elliptical reflective zone plates(ERZPs) and the advantage of spiral zone plates(SZPs) in establishing a specific single optical element, termed elliptical reflective annulus quadrangle-element coded spiral zone plates(ERAQSZPs) to generate single-focus phase singularity. Differing from the abrupt reflectance of the ERZPs, a series of randomly distributed nanometer apertures are adopted to realize the sinusoidal reflectance. Typically, according to our physical design, the ERAQSZPs are fabricated on a bulk substrate;therefore, the new idea can significantly reduce the difficulty in the fabrication process. Based on the Kirchhoff diffraction theory and convolution theorem, the focusing performance of ERAQSZPs is calculated. The results reveal that apart from the capability of generating optical vortices,ERAQSZPs can also integrate the function of focusing, energy selection, higher-order foci elimination, as well as high spectral resolution together. In addition, the focusing properties can be further improved by appropriately adjusting the parameters, such as zone number and the size of the consisted primitives. These findings are expected to direct a new direction toward improving the performance of optical capture, x-ray fluorescence spectra, and forbidden transition.

Terahertz quasi-perfect vortex beam with integer-order and fractional-order generated by spiral spherical harmonic axicon

We propose a new method to generate terahertz perfect vortex beam with integer-order and fractional-order. A new optical diffractive element composed of the phase combination of a spherical harmonic axicon and a spiral phase plate is designed and called spiral spherical harmonic axicon. A terahertz Gaussian beam passes through the spiral spherical harmonic axicon to generate a terahertz vortex beam. When only the topological charge number carried by spiral spherical harmonic axicon increases, the ring radius of terahertz vortex beam increases slightly, so the beam is shaped into a terahertz quasi-perfect vortex beam. Importantly, the terahertz quasi-perfect vortex beam can carry not only integer-order topological charge number but also fractional-order topological charge number. This is the first time that vortex beam and quasi-perfect vortex beam with fractional-order have been successfully realized in terahertz domain and experiment.

Device-assisted enteroscopy: Are we ready to dismiss the spiral?

Motorized spiral enteroscopy(MSE)is the latest advance in device-assisted enteroscopy.Adverse events related to MSE were discussed in a recent large systematic review and meta-analysis and were directly compared with those of balloon enteroscopy in a case-matched study and a randomized controlled trial.Following the real-life application of MSE,an unexpected safety issue emerged regarding esophageal injury and the technique has been withdrawn from the global market,despite encouraging results in terms of diagnostic and therapeutic yield.We conducted an Italian multicenter real-life prospective study,which was prematurely terminated after the withdrawal of MSE from the market.The primary goals were the evaluation of MSE performance(both diagnostic and therapeutic)and its safety in routine endoscopic practice,particularly in the early phase of introduction in the endoscopic unit.A subanalysis,which involved patients who underwent MSE after unsuccessful balloon enteroscopy,demonstrated,for the first time,the promising performance of MSE as a rescue procedure.Given its remarkable performance in clinical practice and its potential role as a backup technique following a previously failed enteroscopy,it may be more appropriate to refine and enhance MSE in the future rather than completely abandoning it.

Fusion of Spiral Convolution-LSTM for Intrusion Detection Modeling

Aiming at the problems of low accuracy and slow convergence speed of current intrusion detection models,SpiralConvolution is combined with Long Short-Term Memory Network to construct a new intrusion detection model.The dataset is first preprocessed using solo thermal encoding and normalization functions.Then the spiral convolution-Long Short-Term Memory Network model is constructed,which consists of spiral convolution,a two-layer long short-term memory network,and a classifier.It is shown through experiments that the model is characterized by high accuracy,small model computation,and fast convergence speed relative to previous deep learning models.The model uses a new neural network to achieve fast and accurate network traffic intrusion detection.The model in this paper achieves 0.9706 and 0.8432 accuracy rates on the NSL-KDD dataset and the UNSWNB-15 dataset under five classifications and ten classes,respectively.

Study on the Relationship between Structural Aspects and Aerodynamic Characteristics of Archimedes Spiral Wind Turbines

A combined experimental and numerical research study is conducted to investigate the complex relationship between the structure and the aerodynamic performances of an Archimedes spiral wind turbine(ASWT).Two ASWTs are considered,a prototypical version and an improved version.It is shown that the latter achieves the best aerodynamic performance when the spread angles at the three sets of blades areα_(1)=30°,α_(2)=55°,α3=60°,respectively and the blade thickness is 4 mm.For a velocity V=10 m/s,a tip speed ratio(TSR)=1.58 and 2,the maximum CP values are 0.223 and 0.263 for the prototypical ASWT and improved ASWT,respectively,and the maximum C_(P) enhancement is 17.93%.For V=10 m/s and TSR=2,the CP values of the prototypical ASWT and improved ASWT are 0.225 and 0.263,respectively,with an aerodynamic performance enhancement of 16.88%.Through mutual verification of the test outcomes and numerical results,it is concluded that the proposed approach can effectively lead to aerodynamic performance improvement.

Motorized spiral enteroscopy:A cautious step forward in technological innovation

With the continuous advancement in medical technology,endoscopy has gained significant attention as a crucial diagnostic tool.The introduction of motorized spiral enteroscopy(MSE)represents a significant advancement in the diagnosis and treatment of small bowel diseases.While there are safety concerns and a high reliance on the operator’s skills,MSE should not be disregarded entirely.Instead,it should be considered as a supplementary endoscopic technique,particularly in situations where conventional endoscopy proves ineffective.Through continuous research and technical optimization,MSE has the potential to become an im-portant addition to the endoscopy toolbox in the future.We call on colleagues in the industry to work together to promote the improvement of MSE technology through continuous research and practice,with the aim to bring out its unique value in endoscopy while ensuring patient safety.

Effectiveness of magnetic resonance imaging and spiral computed tomography in the staging and treatment prognosis of colorectal cancer

BACKGROUND Colorectal cancer(CRC)is a prevalent cancer type in clinical settings;its early signs can be difficult to detect,which often results in late-stage diagnoses in many patients.The early detection and diagnosis of CRC are crucial for improving treatment success and patient survival rates.Recently,imaging techniques have been hypothesized to be essential in managing CRC,with magnetic resonance imaging(MRI)and spiral computed tomography(SCT)playing a significant role in enhancing diagnostic and treatment approaches.AIM To explore the effectiveness of MRI and SCT in the preoperative staging of CRC and the prognosis of laparoscopic treatment.METHODS Ninety-five individuals admitted to Zhongshan Hospital Xiamen University underwent MRI and SCT and were diagnosed with CRC.The precision of MRI and SCT for the presurgical classification of CRC was assessed,and pathological staging was used as a reference.Receiver operating characteristic curves were used to evaluate the diagnostic efficacy of blood volume,blood flow,time to peak,permeability surface,blood reflux constant,volume transfer constant,and extracellular extravascular space volume fraction on the prognosis of patients with CRC.RESULTS Pathological biopsies confirmed the following CRC stages:23,23,32,and 17 at T1,T2,T3,and T4,respectively.There were 39 cases at the N0 stage,22 at N1,34 at N2,44 at M0 stage,and 51 at M1.Using pathological findings as the benchmark,the combined use of MRI and SCT for preoperative TNM staging in patients with CRC demonstrated superior sensitivity,specificity,and accuracy compared with either modality alone,with a statistically significant difference in accuracy(P<0.05).Receiver operating characteristic curve analysis revealed the predictive values for laparoscopic treatment prognosis,as indicated by the areas under the curve for blood volume,blood flow,time to peak,and permeability surface,blood reflux constant,volume transfer constant,and extracellular extravascular space volume fraction were 0.750,0.683,0.772,0.761,0.709,0.719,and 0.910,respectively.The corresponding sensitivity and specificity values were also obtained(P<0.05).CONCLUSION MRI with SCT is effective in the clinical diagnosis of patients with CRC and is worthy of clinical promotion.

Time-Varying Mesh Stiffness Calculation and Dynamic Modeling of Spiral Bevel Gear with Spalling Defects

Time-varying mesh stiffness(TVMS)is a vital internal excitation source for the spiral bevel gear(SBG)transmission system.Spalling defect often causes decrease in gear mesh stiffness and changes the dynamic characteristics of the gear system,which further increases noise and vibration.This paper aims to calculate the TVMS and establish dynamic model of SBG with spalling defect.In this study,a novel analytical model based on slice method is proposed to calculate the TVMS of SBG considering spalling defect.Subsequently,the influence of spalling defect on the TVMS is studied through a numerical simulation,and the proposed analytical model is verified by a finite element model.Besides,an 8-degrees-of-freedom dynamic model is established for SBG transmission system.Incorporating the spalling defect into TVMS,the dynamic responses of spalled SBG are analyzed.The numerical results indicate that spalling defect would cause periodic impact in time domain.Finally,an experiment is designed to verify the proposed dynamic model.The experimental results show that the spalling defect makes the response characterized by periodic impact with the rotating frequency of spalled pinion.

Dark Matter Density Profiles of Selected Spiral Galaxies

Understanding the dark matter distribution throughout a galaxy can provide insight into its elusive nature. Numerous density profiles, such as the Navarro, Frenk and White model, have been created in an attempt to study this distribution through analyzing orbital velocities of luminous matter and modeling dark matter distributions to explain these observations. However, we are interested in a simple model to consider the significant fluctuations in rotation curves at larger radii. Therefore, our model is much simpler compared to those previously mentioned. Our model used all the observational data available for four selected galactic rotation curves. These data present a significant variation in the orbital velocity of matter at the same distances. By running real observational data through our model, we show that the density of the dark matter within them shows real complex structure, which is not suggested by other computational models. Our aim of this paper is to model this structure and then speculate as to the cause and implications of these density fluctuations.

The Origin of the Flat Rotation Curves in Spiral Galaxies: The Hidden Roles of Glitching SMDEOs and Emission of Gravitational Waves

Supermassive DEOs (SMDEOs) are cosmologically evolved objects made of irreducible incompressible supranuclear dense superfluids: The state we consider to govern the matter inside the cores of massive neutron stars. These cores are practically trapped in false vacua, rendering their detection by outside observers impossible. Based on massive parallel computations and theoretical investigations, we show that SMDEOs at the centres of spiral galaxies that are surrounded by massive rotating torii of normal matter may serve as powerful sources for gravitational waves carrying away roughly 1042 erg/s. Due to the extensive cooling by GWs, the SMDEO-Torus systems undergo glitching, through which both rotational and gravitational energies are abruptly ejected into the ambient media, during which the topologies of the embedding spacetimes change from curved into flatter ones, thereby triggering a burst gravitational energy of order 1059 erg. Also, the effects of glitches found to alter the force balance of objects in the Lagrangian-L1 region between the central SMDEO-Torus system and the bulge, enforcing the enclosed objects to develop violent motions, that may explain the origin of the rotational curve irregularities observed in the innermost part of spiral galaxies. Our study shows that the generated GWs at the centres of galaxies, which traverse billions of objects during their outward propagations throughout the entire galaxy, lose energy due to repeatedly squeezing and stretching the objects. Here, we find that these interactions may serve as damping processes that give rise to the formation of collective forces f∝m(r)/r, that point outward, endowing the objects with the observed flat rotation curves. Our approach predicts a correlation between the baryonic mass and the rotation velocities in galaxies, which is in line with the Tully-Fisher relation. The here-presented self-consistent approach explains nicely the observed rotation curves without invoking dark matter or modifying Newtonian gravitation in the low-field approximation.

Design of Pinion Machine Tool-settings for Spiral Bevel Gears by Controlling Contact Path and Transmission Errors

This paper proposes a new approach to design pinion machine tool-settings for spiral bevel gears by controlling contact path and transmission errors. It is based on the satisfaction of contact condition of three given control points on the tooth surface. The three meshing points are controlled to be on a predesigned straight contact path that meets the pre-designed parabolic function of transmission errors. Designed separately, the magnitude of transmission errors and the orientation of the contact path are subjected to precise control. In addition, in order to meet the manufacturing requirements, we suggest to modify the values of blank offset, one of the pinion machine tool-settings, and redesign pinion ma- chine tool-settings to ensure that the magnitude and the geometry of transmission errors should not be influenced apart from minor effects on the predesigned straight contact path. The proposed approach together with its ideas has been proven by a numerical example and the manufacturing practice of a pair of spiral bevel gears.

Influence of spiral crystal selector on crystal orientation of single crystal superalloy

To increase efficiency and improve performance, reducing cost and emissions, advanced single crystal Ni-based superalloys are required in aerospace propulsion and power generating gas turbines. With the development of alloy, significant improvements in casting techniques have been achieved by introducing the directionally solidified （DS） casting process followed by single crystal （SX） technique. The deviation of preferred orientation of single crystal superalloys is one of the most important defects in casting. In directional solidification equipment with high temperature gradient, single crystal specimens of DZ417G alloy were prepared successfully by the modified Bridgeman method with spiral grain selector. The orientation was investigated by means of X-ray diffraction （XRD） and electron backscattered diffraction （EBSD）.The results show that the crystal selector with a smaller angle can effectively reduce the deviation of preferred orientation.

Three-dimensional Imaging of Multi-slice Spiral CT in Bronchial Artery Correlative Study on Blood Supply of Central Lung Cancer and Its Clinical Significance

Objective: To evaluate three-dimensional bronchial artery imaging charactersin central lung cancer and applied values with multi-slice spiral CT (MSCT) to provide theoreticalevidence on blood supply and intervention therapy. Methods: Eighteen patients with central lungcancer underwent MSCT with real time helical thin-slice CT scanning. Three-dimensional bronchialartery reconstruction was done at the console work-station. The space anatomical characters ofbronchial artery were observed through different rotations. Results: For 6 cases, thethree-dimensional images of bronchial artery (33.33%) could exactly show the origins, the routes(lung inner segment and mediatism segment) and the diameters of bronchial arteries. Vision rate ofbronchial arteries was the highest in pulmonary artery stricture and truncation groups, and thevessels' diameter became larger apparently. These characters demonstrated blood supply of this kindof central lung cancer come from bronchial artery. Volume rendering images were the best ones amongthree-dimensional images. Conclusion: Three-dimensional imaging with MSCT in bronchial artery canreveal the anatomical characters of bronchial artery and provide theoretical evidence on bloodsupply and intervention therapy of central lung cancer.

Spiral CT三维重建图像在复杂性颌面部骨折诊断中的应用

目的:探讨Spiral CT三维图像重建系统在复杂性颌面部骨折诊断中的意义。方法:对48例颌面部复杂性骨折患者行颌面部CT三维重建,多方位、多视角观察Spiral CT三维重建的效果。结果:Spiral CT三维重建图像清晰,直观立体的反映骨折的部位、类型、骨折断段移位的方向和距离以及周围组织空间位置关系。结论:Spiral CT三维重建对颌面部多发性、复杂性骨折具有独特的诊断价值。

Performance Analysis of RF Spiral Inductor with Gradually Changed Metal Width and Space

To decrease the metal losses of RF spiral inductor,a novel layout structure with gradually reduced metal line width and space from outside to inside is presented. This gradual changed inductor has less eddy-current effect than the conventional inductor of fixed metal width and space. So the series resistance can be reduced and the quality （Q） factor of the inductor relating to metal losses is increased. The obtained experimental results corroborate the validity of the proposed method. For a 6nH inductor on high-resistivity silicon at 2.46GHz,Q factor of 14.25 is 11.3% higher than the conventional inductor with the same layout size. This inductor can be integrated with radio frequency integrated circuits to gain better performance in RF front end of a wireless communication system.

Spiral刺绣针法的路径生成算法

Spiral刺绣针法是一种重要的刺绣针法.首先将待刺绣的区域划分成若干能够生成连续螺旋线的环状子区域,然后将这些子区域组织成一个二叉树结构,采用一个递归过程来连接各个子区域内的螺旋线,最终形成Spiral针法路径.文中算法生成的路径能够由内向外以等距的螺旋线填充任意形状多边形的连通域,并且螺旋线的形状与区域的边界相似.实验结果表明,该算法能获得较好的刺绣效果.

GEOMETRIC MODELING OF GENERATING-MANUFACTURED SPIRAL BEVEL GEARS BASED ON CUTTING SIMULATION

A geometric modeling method for generating-manufactured spiral bevel gears（SBGs） is proposed. It consists of two steps： （1） creating a reference model by simulating the process of cutting spiral bevel gear,（2） reconstructing the final solid model by collecting data points from the reference model and fitting these points into NURBS surfaces. In this method,cutting simulation avoids abstruse mathematical theories and complex methods,thus making it convenient to obtain data points on the complex tooth surface before the gear is manufactured and efficient to increase the accuracy of the solid model. Also,the representations of tooth surfaces of the final model is unified as a NURBS surface function. The NURBS surface is continuous and smooth,thus it is available for wide applications in CAD/CAE. The experiment proves that the method can be used to establish an accurate pair of SBG models,thus providing a feasible and effective way for CAD/CAE modeling.