Background: Pseudoepitheliomatous hyperplasia (PEH), a histological mimic of squamous cell carcinoma, is an exuberant reactive epithelial proliferation that may be induced by a variety of infectious, traumatic, inflam...Background: Pseudoepitheliomatous hyperplasia (PEH), a histological mimic of squamous cell carcinoma, is an exuberant reactive epithelial proliferation that may be induced by a variety of infectious, traumatic, inflammatory and neoplastic conditions of the skin and mucous membranes. PEH has been described in association with Spitz nevi and intramucosal nevi but not with oral malignant melanoma. Methods and results: A case of PEH in malignant melanoma of the palate in a 46-year-old female patient has been described. A search of the English literature did not disclose any previously reported case of such event. Conclusions: PEH associated with oral malignant melanoma is apparently very rare and most likely originates from the surface epithelium. This is in contrast with PEH in cutaneous melanoma where follicular or eccrine units have been suggested to be the origin.展开更多
Background: CD117, the receptor for kit-ligand, which is a growth factor for melanocyte migration and proliferation, has shown differential staining in various benign and malignant melanocytic lesions. The purpose of ...Background: CD117, the receptor for kit-ligand, which is a growth factor for melanocyte migration and proliferation, has shown differential staining in various benign and malignant melanocytic lesions. The purpose of this study is to compare CD117 immunohistological staining in Spitz nevus versus malignant melanoma, to determine whether CD117 can aid in the diagnosis of these two lesions. Methods: CD-117 immunohistological staining was performed in 22 clinically and pathologically diagnosed pigmented lesions including 9 cases of Spitz nevus, 10 cases of primary MM and 3 cases of metastatic melanoma. Results: There was no significant difference in CD117 staining in either epidermis or dermis between Spitz nevi and primary melanomas. However staining of metastatic melanomas is less than dermal staining of primary MM and Spitz nevus. Conclusions: CD117 is unlikely a useful diagnostic tool in differentiating Spitz nevus from primaryMM. On the other hand, CD 117 may be useful in differentiating metastatic melanoma from primary melanoma in patients who had a history of melanoma and who present with new dermal lesions.展开更多
Follicular malignant melanoma can be regarded as a rare and unique presentation ofmelanoma. It is characterized by a deepseated follicular structure in which atypicalmelanocytes extend downward along the follicular ep...Follicular malignant melanoma can be regarded as a rare and unique presentation ofmelanoma. It is characterized by a deepseated follicular structure in which atypicalmelanocytes extend downward along the follicular epitheliumand permeate parts of the follicle as well as the adjacent dermis. The clinical diagnosis of follicular malignant melanoma may be difficult because the tumor mostly resembles a comedo or a pigmented cyst. We studied five cases of follicular malignant melanoma in which the patients were between 61 and 82 years old. Three lesions were localized on the nose, one on the cheek, and one on the back of the neck. Clinically, all five cases measured distinctly less than 0.5 cm in size. While lentigo maligna is traditionally known as a pigmented macule in actinically damaged skin that gradually evolves in a slow process before invasive growth, three follicular malignant melanomas had developed in relatively short timeframes of 9 months to 1 1/2 years. In all five cases the inconspicuous clinical appearance did not herald a malignant melanoma with invasive growth. Follicular malignant melanoma underlines the importance of a correct excision technique with subsequent histologic workup and diagnosis. Superficial shave excision or even laser treatment in these specific cases may lead to a fatal prognosis for the patient.展开更多
患者女，63岁，因尿道口流血1月余入院。查体：在截石位6~8点处可见一息肉样肿物，红肿，无明显出血。临床以“尿道肉阜”于2013年4月4日行尿道口肉阜电灼术。术中见尿道外口6点处见一直径约0.6 cm 的鲜红色息肉样物，触之易出血，予以...患者女，63岁，因尿道口流血1月余入院。查体：在截石位6~8点处可见一息肉样肿物，红肿，无明显出血。临床以“尿道肉阜”于2013年4月4日行尿道口肉阜电灼术。术中见尿道外口6点处见一直径约0.6 cm 的鲜红色息肉样物，触之易出血，予以电切。电凝止血，留置尿管，标本送病理。病理检查：灰红碎组织三块0.8 cm＆#215;0.6 cm＆#215;0.6 cm。病理组织学特点：瘤细胞主由上皮样细胞、梭形细胞及小色素细胞混杂组成，瘤细胞呈团及巢状分布，瘤细胞大小不等，核大，深染，核仁明显，部分瘤细胞胞质内见黑色素颗粒，间质血管丰富。免疫组织化学染色 S-100、HMB45、CD56、CD68阳性。肌酸激酶（CK）、EMA、CD34、F8、MAC387、Desmin、Myoglobin 阴性。病理诊断：原发性女性尿道恶性黑色素瘤。展开更多
文摘Background: Pseudoepitheliomatous hyperplasia (PEH), a histological mimic of squamous cell carcinoma, is an exuberant reactive epithelial proliferation that may be induced by a variety of infectious, traumatic, inflammatory and neoplastic conditions of the skin and mucous membranes. PEH has been described in association with Spitz nevi and intramucosal nevi but not with oral malignant melanoma. Methods and results: A case of PEH in malignant melanoma of the palate in a 46-year-old female patient has been described. A search of the English literature did not disclose any previously reported case of such event. Conclusions: PEH associated with oral malignant melanoma is apparently very rare and most likely originates from the surface epithelium. This is in contrast with PEH in cutaneous melanoma where follicular or eccrine units have been suggested to be the origin.
文摘Background: CD117, the receptor for kit-ligand, which is a growth factor for melanocyte migration and proliferation, has shown differential staining in various benign and malignant melanocytic lesions. The purpose of this study is to compare CD117 immunohistological staining in Spitz nevus versus malignant melanoma, to determine whether CD117 can aid in the diagnosis of these two lesions. Methods: CD-117 immunohistological staining was performed in 22 clinically and pathologically diagnosed pigmented lesions including 9 cases of Spitz nevus, 10 cases of primary MM and 3 cases of metastatic melanoma. Results: There was no significant difference in CD117 staining in either epidermis or dermis between Spitz nevi and primary melanomas. However staining of metastatic melanomas is less than dermal staining of primary MM and Spitz nevus. Conclusions: CD117 is unlikely a useful diagnostic tool in differentiating Spitz nevus from primaryMM. On the other hand, CD 117 may be useful in differentiating metastatic melanoma from primary melanoma in patients who had a history of melanoma and who present with new dermal lesions.
文摘Follicular malignant melanoma can be regarded as a rare and unique presentation ofmelanoma. It is characterized by a deepseated follicular structure in which atypicalmelanocytes extend downward along the follicular epitheliumand permeate parts of the follicle as well as the adjacent dermis. The clinical diagnosis of follicular malignant melanoma may be difficult because the tumor mostly resembles a comedo or a pigmented cyst. We studied five cases of follicular malignant melanoma in which the patients were between 61 and 82 years old. Three lesions were localized on the nose, one on the cheek, and one on the back of the neck. Clinically, all five cases measured distinctly less than 0.5 cm in size. While lentigo maligna is traditionally known as a pigmented macule in actinically damaged skin that gradually evolves in a slow process before invasive growth, three follicular malignant melanomas had developed in relatively short timeframes of 9 months to 1 1/2 years. In all five cases the inconspicuous clinical appearance did not herald a malignant melanoma with invasive growth. Follicular malignant melanoma underlines the importance of a correct excision technique with subsequent histologic workup and diagnosis. Superficial shave excision or even laser treatment in these specific cases may lead to a fatal prognosis for the patient.
