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Orchard Sports Injury and Illness Classification System (OSIICS) Version 15
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作者 John W.Orchard Ebonie Rio +2 位作者 Kay M.Crossley Jessica J.Orchard Margo Mountjoy 《Journal of Sport and Health Science》 SCIE CAS CSCD 2024年第4期599-604,共6页
Background:Sports medicine(injury and illnesses)requires distinct coding systems because the International Classification of Diseases is insuf-ficient for sports medicine coding.The Orchard Sports Injury and Illness C... Background:Sports medicine(injury and illnesses)requires distinct coding systems because the International Classification of Diseases is insuf-ficient for sports medicine coding.The Orchard Sports Injury and Illness Classification System(OSIICS)is one of two sports medicine coding systems recommended by the International Olympic Committee.Regular updates of coding systems are required.Methods:For Version 15,updates for mental health conditions in athletes,sports cardiology,concussion sub-types,infectious diseases,and skin and eye conditions were considered particularly important.Results:Recommended codes were added from a recent International Olympic Committee consensus statement on mental health conditions in athletes.Two landmark sports cardiology papers were used to update a more comprehensive list of sports cardiology codes.Rugby union protocols on head injury assessment were used to create additional concussion codes.Conclusion:It is planned that OSIICS Version 15 will be translated into multiple new languages in a timely fashion to facilitate international accessibility.The large number of recently published sport-specific and discipline-specific consensus statements on athlete surveillance warrant regular updating of OSIICS. 展开更多
关键词 sports cardiology DERMATOLOGY Eye injuries CONCUSSION Infectious diseases sports injury classification
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A marathon,not a sprint:Increasing population physical activity as a legacy of sports mega-events
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作者 Fiona C.Bull Paul J.Simpson 《Journal of Sport and Health Science》 SCIE CAS CSCD 2024年第6期732-735,共4页
1.Legacy matters The withdrawal of Australia as hosts for the Commonwealth Games in 2026 demonstrates that large international sporting events are more than just sporting mastery,medals,and memories.Money also matters... 1.Legacy matters The withdrawal of Australia as hosts for the Commonwealth Games in 2026 demonstrates that large international sporting events are more than just sporting mastery,medals,and memories.Money also matters.1 The cost of hosting a major international tournament is eye-wateringly high.Host governments need to show that the billions of dollars of investment deliver a return beyond sporting glory to justify the resources that are spent. 展开更多
关键词 RETURN DOLLAR sport
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Orientation and Decision-Making for Soccer Based on Sports Analytics and AI:A Systematic Review
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作者 Zhiqiang Pu Yi Pan +4 位作者 Shijie Wang Boyin Liu Min Chen Hao Ma Yixiong Cui 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第1期37-57,共21页
Due to ever-growing soccer data collection approaches and progressing artificial intelligence(AI) methods, soccer analysis, evaluation, and decision-making have received increasing interest from not only the professio... Due to ever-growing soccer data collection approaches and progressing artificial intelligence(AI) methods, soccer analysis, evaluation, and decision-making have received increasing interest from not only the professional sports analytics realm but also the academic AI research community. AI brings gamechanging approaches for soccer analytics where soccer has been a typical benchmark for AI research. The combination has been an emerging topic. In this paper, soccer match analytics are taken as a complete observation-orientation-decision-action(OODA) loop.In addition, as in AI frameworks such as that for reinforcement learning, interacting with a virtual environment enables an evolving model. Therefore, both soccer analytics in the real world and virtual domains are discussed. With the intersection of the OODA loop and the real-virtual domains, available soccer data, including event and tracking data, and diverse orientation and decisionmaking models for both real-world and virtual soccer matches are comprehensively reviewed. Finally, some promising directions in this interdisciplinary area are pointed out. It is claimed that paradigms for both professional sports analytics and AI research could be combined. Moreover, it is quite promising to bridge the gap between the real and virtual domains for soccer match analysis and decision-making. 展开更多
关键词 Artificial intelligence(AI) DECISION-MAKING FOOTBALL review SOCCER sports analytics
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An integrated spatial planning of the mountainous landscapes for ski sports in a case area at the eastern Türkiye
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作者 SATIR Onur TOSUN Busra +2 位作者 COSKUN OZYOL Funda OZDEMIR Omer Faruk BERBEROGLU Suha 《Journal of Mountain Science》 SCIE CSCD 2024年第3期754-767,共14页
Mountainous regions have disadvantages in economic development because of harsh physical and climatic conditions.However,winter tourism activities are one of the key components for supporting economic development in t... Mountainous regions have disadvantages in economic development because of harsh physical and climatic conditions.However,winter tourism activities are one of the key components for supporting economic development in the highlands.Establishing a ski resort area supports direct and indirect employment in a region,and it stops immigration from mountainous regions to other places.This research aimed to assess the potential ski areas using a multi criteria evaluation technique in the Van region which is located in the eastern part of Türkiye.In this context,snow cover duration,sun effect,slope,slope length,elevation,population density,distance from main roads and lake visibility were used as input factors in the decision making process.Each factor was standardized using a fuzzy technique based on existing well-known ski centers in Türkiye.The weight of inputs was defined by applying a survey to the professional skiers.The most important factors were detected as transportation opportunities and snow covers whereas,the least important factors were elevation and population density.Additionally,lake visibility was very important to make a difference from other existing facilities in the region.Therefore,it was included as constraints and lake visible areas were extracted at the final stage of the research.Potential ski areas were mapped in three levels as professional,intermediate and beginner skiers.One of the suitable areas was selected as a sample projection and for the 3D simulation of the ski investment area.Potential costs and benefits were discussed.It was found that a ski tourism area investment can be amortized in 3 years in the region. 展开更多
关键词 Winter sports and tourism Decision making 3D simulation and modelling Landscape planning GIS
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Eight of ten patients return to daily activities, work, and sports after total knee arthroplasty
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作者 Maud Cornelia Wilhelmina Maria Peters Yvette Pronk Justus-Martijn Brinkman 《World Journal of Orthopedics》 2024年第7期608-617,共10页
BACKGROUND Besides return to work(RTW)and return to sports(RTS),patients also prefer to return to daily activities(RTA)such as walking,sleeping,grocery shopping,and domestic work following total knee arthroplasty(TKA)... BACKGROUND Besides return to work(RTW)and return to sports(RTS),patients also prefer to return to daily activities(RTA)such as walking,sleeping,grocery shopping,and domestic work following total knee arthroplasty(TKA).However,evidence on the timelines and probability of patients’RTA is sparse.AIM To assess the percentage of patients able to RTA,RTW,and RTS after TKA,as well as the timeframe and influencing factors of this return.METHODS A retrospective cohort study with prospectively collected data was conducted at a medium-sized Dutch orthopedic hospital.Assessments of RTA,RTW,and RTS were performed at 3 mo and/or 6 mo following TKA.Investigated factors en-compassed patient characteristics,surgical characteristics,and preoperative patient-reported outcomes.RESULTS TKA patients[n=2063;66 years old(interquartile range[IQR]:7 years);47%male;28 kg/m2(IQR:4 kg/m2)]showed RTA ranging from 28%for kneeling to 94%for grocery shopping,with 20 d(IQR:27 d)spent for putting on shoes to 74 d(IQR:57 d)for kneeling.RTW rates varied from 62%for medium-impact work to 87%for low-impact work,taking 33 d(IQR:29 d)to 78 d(IQR:55 d).RTS ranged from 48%for medium-impact sports to 90%for low-impact sports,occurring within 43 d(IQR:24 d)to 90 d(IQR:60 d).One or more of the investigated factors influenced the return to each of the 14 activities examined,with R²values ranging from 0.013 to 0.127.CONCLUSION Approximately 80%of patients can RTA,RTW,and RTS within 6 mo after TKA.Return is not consistently in-fluenced by predictive factors.Results help set realistic pre-and postoperative expectations. 展开更多
关键词 KNEE ARTHROPLASTY Replacement Return to work Return to daily activities Return to sports
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Research on Sports Public Service Supply in the Chengdu-Chongqing Twin-City Economic Circle under the Background of Regional Economic Development
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作者 Yiming Yang Yun Liu Yu Huang 《Proceedings of Business and Economic Studies》 2024年第2期106-113,共8页
Using literature,questionnaires,interviews,and mathematical statistics to investigate the current situation of sports public services in the Chengdu-Chongqing Twin-city Economic Circle.The results show that there are ... Using literature,questionnaires,interviews,and mathematical statistics to investigate the current situation of sports public services in the Chengdu-Chongqing Twin-city Economic Circle.The results show that there are some problems in Chengdu-Chongqing sports public services,such as big difference in the development level of supply between urban and rural areas,low supply level,low efficiency,supply mechanism defect,lack of social sports instructors,an outstanding contradiction between the quality of sports public service and residents’demand.To address the problems,government departments should accelerate the transformation of government functions,improve the relevant regulations and systems,increase the investment in sports public services,improve the quality of supply,cultivate the backbone team,integrate resources,and combine the national characteristics with regional characteristics,take into account the personalized needs of the residents,combine the sports public services with intelligence,and build the service system of“Internet+Fitness.” 展开更多
关键词 Regional economy Chengdu-Chongqing Twin-city Economic Circle sports demand sports public service Current supply situation
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THE 6^(th) SPORTS GAMES OF THE BUDDHIST ACADEMY OF XIZANG HELD IN LHASA
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作者 Jiahuajia(Text/Photos) Degyi Drolma(Text/Photos) 《China's Tibet》 2024年第3期F0002-F0002,共1页
On May 8th,the 6th sportsgames of the Buddhist Academy of Xizang was held in Lhasa.The sports games featured field events,track events,and fun sports events,including 100 metres,standing long jump,shot put,400m relay,... On May 8th,the 6th sportsgames of the Buddhist Academy of Xizang was held in Lhasa.The sports games featured field events,track events,and fun sports events,including 100 metres,standing long jump,shot put,400m relay,two-person running with legs tied up,and sandbag carrying-a traditional Tibetan sport.The teachers and students of the academy actively participated in and enjoyed the sports.Let's share their passion forsports together! 展开更多
关键词 TIBETAN sports games
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Strategies for Boxing Teaching in Competitive Sports Schools
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作者 Yu Huang 《Journal of Contemporary Educational Research》 2024年第7期258-263,共6页
To improve the quality of boxing teaching in competitive sports schools,it is necessary to first analyze the strengths and weaknesses of boxing teaching in competitive sports schools,and then optimize the teaching str... To improve the quality of boxing teaching in competitive sports schools,it is necessary to first analyze the strengths and weaknesses of boxing teaching in competitive sports schools,and then optimize the teaching strategy.The strategies include innovating the boxing curriculum system and content,building learning communities inside and outside the classroom,personalizing the teaching forms and methods,using multimedia to broaden the teaching path,focusing on the integration of boxing teaching leagues,and diversifying the teaching incentives and evaluations. 展开更多
关键词 Competitive sports schools BOXING Teaching strategies
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Analysis of China’s Sports Diplomacy Path from the Perspective of Soft Power
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作者 Ying Ye 《Journal of Contemporary Educational Research》 2024年第7期246-251,共6页
“When a country prospers,sports thrive.”Building a strong sports country is an important connotation of realizing the great rejuvenation of the Chinese nation and building a moderately prosperous society in all resp... “When a country prospers,sports thrive.”Building a strong sports country is an important connotation of realizing the great rejuvenation of the Chinese nation and building a moderately prosperous society in all respects.Actively engaging in sports diplomacy from the perspective of soft power can expand a country’s international influence,promote friendly cooperation between nations,and enhance the overall image of the country.This article analyzes the concepts of soft power and sports diplomacy and explores the path of China’s sports diplomacy from four aspects:promoting diverse subjects,expanding propaganda channels,optimizing underlying design,and actively participating in competitions. 展开更多
关键词 Soft power sports diplomacy Implementation path
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Extreme Sports
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作者 KANG CHENYI ATHIEI AJUONG 《ChinAfrica》 2024年第8期58-59,共2页
The Double Take column looks at a single topic from an African and Chinese perspective.This month we discuss whether it is worthwhile to engage in extreme sports.
关键词 EXTREME EXTREME sports
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The Influence of Swimming Athletes’ Burnout on Their Sports Participation Motivation in Hunan, China
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作者 Lejia Ou 《Journal of Contemporary Educational Research》 2024年第3期179-186,共8页
Objective:This study aims to explore the effect of swimming athletes’burnout on their sports motivation in Hunan University,China.It seeks to understand how burnout influences various motivational factors,providing i... Objective:This study aims to explore the effect of swimming athletes’burnout on their sports motivation in Hunan University,China.It seeks to understand how burnout influences various motivational factors,providing insights for optimizing swimming sports courses and enhancing student participation.Method:Employing random sampling,the study surveyed 260 swimming athletes from Hunan University.The research utilized a questionnaire divided into three parts:demographic information,the Athlete Burnout Questionnaire(ABQ),and the Intrinsic Motivation Inventory(IMI).Pearson’s r correlation analysis was conducted using SPSS to examine the relationships between burnout dimensions and motivational factors.Results:The study found significant correlations between a reduced sense of accomplishment and various motivational dimensions,including“interest/enjoyment,”“perceived competence,”“perceived choice,”and particularly“perceived tension.”Physical exhaustion showed a significant correlation only with“perceived tension,”indicating a strong link between psychological stress and physical fatigue.Sports devaluation was significantly correlated with“perceived tension,”suggesting that psychological stress impacts athletes’valuation of their sport.Conclusion:The findings highlight the complex interplay between burnout and motivation in swimming athletes.Psychological stress,as indicated by“perceived tension,”emerges as a key factor influencing both the physical and emotional aspects of burnout.The study underscores the need for holistic training approaches that balance physical training with psychological well-being,personalized coaching,and supportive environments to enhance intrinsic motivation and manage stress effectively. 展开更多
关键词 Swimmer sports participation motivation Athletes’burnout
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The Impact of Sports Games on the Psychological Health of Middle School Students
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作者 Zhuozhuo Xin Seong Pek Lim Haojun Zhao 《Journal of Contemporary Educational Research》 2024年第3期95-100,共6页
This study conducted a 16-week comparative experiment with 160 students from Jinan No.5 Middle School in Shandong Province as the experimental subjects.During the implementation of the experiment,the subjects were div... This study conducted a 16-week comparative experiment with 160 students from Jinan No.5 Middle School in Shandong Province as the experimental subjects.During the implementation of the experiment,the subjects were divided into two groups:an experimental group and a control group.The experimental group was subjected to physical exercise interventions using sports game teaching methods during physical education class,while the control group followed traditional physical education teaching methods.The results showed that the psychological health status of the students in the experimental group was significantly better than that of the control group after the experiment.The application of sports games helps to improve the psychological health of middle school students in the course of physical education,promoting a positive and forward direction in student psychology and is an effective means to enhance the psychological health level of middle school students. 展开更多
关键词 sports games Physical education Middle school students Psychological health
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Engaging in sports via the metaverse? An examination through analysis of metaverse research trends in sports
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作者 Ahyun Kim Sang-Soo Kim 《Data Science and Management》 2024年第3期181-188,共8页
In sports, virtual spaces are sometimes utilized to enhance performance or user experience. In this study, we conducted a frequency analysis, semantic network analysis, and topic modeling using 134 abstracts obtained ... In sports, virtual spaces are sometimes utilized to enhance performance or user experience. In this study, we conducted a frequency analysis, semantic network analysis, and topic modeling using 134 abstracts obtained through keyword searches focusing on “sport(s)” in combination with “metaverse”, “augmented reality”, “virtual reality”, “lifelogging”, and “mixed reality”. First, the top 20 words were extracted through frequency analysis, and then each type of extracted word was retained to select seven words. The analysis revealed the emergence of key themes such as “user(s)”, “game(s)”, “technolog(y/ies)”, “experience(d)”, “physical”, “training”, and “video”, with variations in intensity depending on the type of metaverse. Second, the relationships between the words were reconfirmed using semantic networks based on the seven selected words. Finally, topic modeling analysis was conducted to uncover themes specific to each type of metaverse. We also found that “performance/scoring” was a prominent word across all types of metaverses. This suggests that in addition to providing enjoyment through sports, there is a high possibility that all users (both general users and athletes) utilize the metaverse to achieve positive outcomes and success. The importance of “performance/scoring” in sports may seem obvious;however, it also provides significant insights for practitioners when combined with metaverse-related keywords. Ultimately, this study has managerial implications for enhancing the performance of specialized users in the sports industry. 展开更多
关键词 sport Metaverse Frequency analysis Topic modeling Semantic network analysis
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Development of a Sports Safety Promotion Framework Based on KABP Theory and 4M Management
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作者 Duoyang Hu Di Mu 《Journal of Contemporary Educational Research》 2024年第7期331-334,共4页
This study explores the significance,current research landscape,and conceptualization of sports safety promotion.Safety in sports is fundamental to youth physical activities,and an excessive focus on or neglect of saf... This study explores the significance,current research landscape,and conceptualization of sports safety promotion.Safety in sports is fundamental to youth physical activities,and an excessive focus on or neglect of safety is unwarranted.Globally,numerous countries have extensively researched sports safety promotion and implemented diverse strategies.Drawing from KABP(Knowledge,Attitude,Behavior,Practice)theory and 4M(Man,Machine,Medium,Management)management,this paper presents a conceptual framework for sports safety promotion.It integrates these theories to devise a comprehensive accident prevention model within a sports safety promotion system.The framework prioritizes enhancing students’safety literacy and underscores the practical application of safety knowledge and skills in simulated sports settings following structured safety education.It aims to enhance students’competency and proficiency in averting sports-related injuries. 展开更多
关键词 Knowledge Attitude Behavior Practice theory Man Machine Medium Management management sports safety promotion Youth sports safety
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Analysis of the Application of Sports Medicine Ultrasound in the Rehabilitation of Anterior Talofibular Ligament Injury
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作者 Ling Dong Yanyan Chu 《Proceedings of Anticancer Research》 2024年第3期144-149,共6页
Objective: To explore the application effect of sports medicine ultrasound in the rehabilitation treatment of anterior talofibular ligament injury. Methods: 36 patients who visited our hospital from January 2020 to Se... Objective: To explore the application effect of sports medicine ultrasound in the rehabilitation treatment of anterior talofibular ligament injury. Methods: 36 patients who visited our hospital from January 2020 to September 2023 were selected as research subjects and randomly divided into the study group (18 cases) and the control group (18 cases). The control group adopted routine examination and rehabilitation training, and the study group adopted sports medicine ultrasound and rehabilitation training. The ankle function scores and daily living ability of the two groups were compared before treatment and 9 weeks after treatment. Results: There was no statistically significant difference between the study group and the control group in terms of ankle function scores and ability to perform activities of daily living before treatment (P > 0.05), but the difference was statistically significant after treatment (P < 0.05). Conclusion: Ultrasound can be used as a supplement to magnetic resonance imaging (MRI) of the ankle joint for diagnosing anterior talofibular ligament injury;ultrasound can show the location, distance, and degree of tear of the anterior talofibular ligament rupture and accurately predict muscle atrophy around the ankle joint;ultrasound combined with computed tomography (CT) can better determine the type of intra-articular fracture of the talar subtalar joint, and guide the choice of surgical timing. In addition, ultrasound can be used to determine the severity of peroneal muscle atrophy, assess the progress of early postoperative functional exercise, and guide personalized rehabilitation programs. 展开更多
关键词 sports medicine ultrasound Anterior talofibular ligament injury REHABILITATION
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草根·职业·梦想:中国sportsmanship之时代特征探析——以“矣进宏CBA首秀”为例
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作者 燕阳 李斌 《体育科研》 2024年第5期38-47,共10页
平凡草根书写逐梦华章,是中国体育精神(sportsmanship)的独特浪漫。通过自然语言处理模型BERTopic,以及媒介框架与“诠释包裹”理论,挖掘“矣进宏CBA首秀”的媒介框架设置以及舆情主题特征,进而以小见大剖析中国sportsmanship的时代特... 平凡草根书写逐梦华章,是中国体育精神(sportsmanship)的独特浪漫。通过自然语言处理模型BERTopic,以及媒介框架与“诠释包裹”理论,挖掘“矣进宏CBA首秀”的媒介框架设置以及舆情主题特征,进而以小见大剖析中国sportsmanship的时代特征。认为:“矣进宏CBA首秀”拥有“感恩与回馈”“拼搏与追梦”“助力与团结”“错愕与反思”“小梦与大梦”五个框架,舆情网络围绕草根与职业的身份对立展开,进而呈现出以“草根精神—敢梦敢当”的希望传递、“团结互惠—爱之道德”的国家赓续、“人格尊重—超越规则”的公平竞争为主要时代特征的sportsmanship。 展开更多
关键词 体育精神 CBA 草根精神 互惠道德 篮球 体育新闻 BERTopic
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Development Strategy of Sichuan Sports Museum under the Background of Cultural and Tourism Integration
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作者 Junxian Feng 《Proceedings of Business and Economic Studies》 2024年第3期173-178,共6页
Through conducting a SWOT analysis of the Chengdu Sports Institute Museum,and utilizing the 4M management,5W display,and 4P marketing theoretical models,this study explores effective strategies suitable for Sichuan sp... Through conducting a SWOT analysis of the Chengdu Sports Institute Museum,and utilizing the 4M management,5W display,and 4P marketing theoretical models,this study explores effective strategies suitable for Sichuan sports museums in terms of functionality,display,and marketing. 展开更多
关键词 Integration of culture and tourism sports museum Development strategy
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Exploration of The Construction Path of Sports Injury and First Aid Course Systems for College Students
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作者 Xiaobo Zhan Haiyan Liu Dan Tan 《Journal of Clinical and Nursing Research》 2024年第4期105-109,共5页
By the requirements of the Ministry of Education on life safety education, colleges, and universities have set up a course on Sports Injury and First Aid to organize relevant knowledge and increase the student’s awar... By the requirements of the Ministry of Education on life safety education, colleges, and universities have set up a course on Sports Injury and First Aid to organize relevant knowledge and increase the student’s awareness of first aid knowledge so that they can use reasonable methods to address sport-related injuries. At the same time, they can cope with first-aid situations and assist rescuers in completing resuscitation activities. This paper is based on the study of three colleges in Chongqing. This paper selected students from 3 universities in Chongqing and evaluated the mastery of first aid knowledge of college students, pointing out the value of implementing the “Sports Injury and First Aid” course in colleges and universities. This can provide opportunities to improve the theoretical content of the discipline, actively carry out practical activities, reasonably set the assessment method, and provide basic protection to ensure that the “Sports Injury and First Aid” course can be carried out normally to improve the mastery level of students’ first aid knowledge. 展开更多
关键词 College students sports injury and first aid course INFRASTRUCTURE Faculty strength
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Advances in self-powered sports monitoring sensors based on triboelectric nanogenerators 被引量:2
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作者 Fengxin Sun Yongsheng Zhu +3 位作者 Changjun Jia Tianming Zhao Liang Chu Yupeng Mao 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第4期477-488,共12页
The new era of the internet of things brings great opportunities to the field of intelligent sports.The collection and analysis of sports data are becoming more intelligent driven by the widely-distributed sensing net... The new era of the internet of things brings great opportunities to the field of intelligent sports.The collection and analysis of sports data are becoming more intelligent driven by the widely-distributed sensing network system.Triboelectric nanogenerators(TENGs)can collect and convert energy as selfpowered sensors,overcoming the limitations of external power supply,frequent power replacement and high-cost maintenance.Herein,we introduce the working modes and principles of TENGs,and then summarize the recent advances in self-powered sports monitoring sensors driven by TENGs in sports equipment facilities,wearable equipment and competitive sports specialities.We discuss the existing issues,i.e.,device stability,material sustainability,device design rationality,textile TENG cleanability,sports sensors safety,kinds and manufacturing of sports sensors,and data collection comprehensiveness,and finally,propose the countermeasures.This work has practical significance to the current TENG applications in sports monitoring,and TENG-based sensing technology will have a broad prospect in the field of intelligent sports in the future. 展开更多
关键词 Triboelectric nanogenerator Wearable energy sensors sport monitoring
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Refinement of saliva microRNA biomarkers for sports-related concussion 被引量:1
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作者 Steven D.Hicks Cayce Onks +17 位作者 Raymond Y.Kim Kevin J.Zhen Jayson Loeffert Andrea C.Loeffert Robert P.Olympia Gregory Fedorchak Samantha DeVita Zofia Gagnon Callan McLoughlin Miguel M.Madeira Scott L.Zuckerman Timothy Lee Matthew Heller Chuck Monteith Thomas R.Campbell Christopher Neville Elise Fengler Michael N.Dretsch 《Journal of Sport and Health Science》 SCIE CSCD 2023年第3期369-378,共10页
Background:Recognizing sport-related concussion(SRC)is challenging and relies heavily on subjective symptom reports.An objective,biological marker could improve recognition and understanding of SRC.There is emerging e... Background:Recognizing sport-related concussion(SRC)is challenging and relies heavily on subjective symptom reports.An objective,biological marker could improve recognition and understanding of SRC.There is emerging evidence that salivary micro-ribonucleic acids(miRNAs)may serve as biomarkers of concussion;however,it remains unclear whether concussion-related miRNAs are impacted by exercise.We sought to determine whether40 miRNAs previously implicated in concussion pathophysiology were affected by participation in a variety of contact and non-contact sports.Our goal was to refine a miRNA-based tool capable of identifying athletes with SRC without the confounding effects of exercise.Methods:This case-control study harmonized data from concussed and non-concussed athletes recruited across 10 sites.Levels of salivary miRNAs within 455 samples from 314 individuals were measured with RNA sequencing.Within-subjects testing was used to identify and exclude miRNAs that changed with either(a)a single episode of exercise(166 samples from 83 individuals)or(b)season-long participation in contact sports(212 samples from 106 individuals).The miRNAs that were not impacted by exercise were interrogated for SRC diagnostic utility using logistic regression(172 samples from 75 concussed and 97 non-concussed individuals).Results:Two miRNAs(miR-532-5p and miR-182-5p)decreased(adjusted p<0.05)after a single episode of exercise,and 1 miRNA(miR-4510)increased only after contact sports participation.Twenty-three miRNAs changed at the end of a contact sports season.Two of these miRNAs(miR-26b-3p and miR-29c-3p)were associated(R>0.50;adjusted p<0.05)with the number of head impacts sustained in a single football practice.Among the 15 miRNAs not confounded by exercise or season-long contact sports participation,11 demonstrated a significant difference(adjusted p<0.05)between concussed and non-concussed participants,and 6 displayed moderate ability(area under curve>0.70)to identify concussion.A single ratio(miR-27a-5p/miR-30a-3p)displayed the highest accuracy(AUC=0.810,sensitivity=82.4%,specificity=73.3%)for differentiating concussed and non-concussed participants.Accuracy did not differ between participants with SRC and non-SRC(z=0.5,p=0.60).Conclusion:Salivary miRNA levels may accurately identify SRC when not confounded by exercise.Refinement of this approach in a large cohort of athletes could eventually lead to a non-invasive,sideline adjunct for SRC assessment. 展开更多
关键词 BIOMARKER Contact sports FOOTBALL RNA Traumatic brain injury
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