Objective: To report a mathematical function that characterizes the double-pass line spread function (LSF) of the human eye. Determining analytical functions that represent the double-pass LSF is important because it ...Objective: To report a mathematical function that characterizes the double-pass line spread function (LSF) of the human eye. Determining analytical functions that represent the double-pass LSF is important because it allows modeling the optical performance of the eye. Methods: Optical section retinal images, generated in normal human eyes using a modified slit-lamp biomicroscope, were analyzed to derive the double-pass LSF by plotting the intensity distribution of laser light reflected/ scattered from the vitreoretinal interface. Three mathematical functions (Lorentzian, Gaussian, exponential) were fitted to the double-pass LSF and the root mean square error (RMSE) was calculated to provide a measure of the goodness of fit. Results: The Lorentzian function provided the best representation of the double-pass LSF of normal human eyes. The full width at half maximum (FWHM) of the Lorentzian fitted curve was positively correlated with age, indicating that the double-pass LSF broadens with age. Furthermore, the goodness of fit of the Lorentzian function was significantly better in younger subjects as compared with older subjects, suggesting that the fitted function to the double-pass LSF may vary according to age. Conclusion: The results demonstrate an age-related change in the double-pass LSF width and the goodness of fit of the Lorentzian function.展开更多
For the first lime, the pressure and flow pulse wave propagation phenomenon is studied in this paper on the basis of he cardiovascular dynamic coupling. E(t)-R model is adopted for left ventricle and T-Y tube model fo...For the first lime, the pressure and flow pulse wave propagation phenomenon is studied in this paper on the basis of he cardiovascular dynamic coupling. E(t)-R model is adopted for left ventricle and T-Y tube model for systemic arteries. Furthermore, impulse response method and Fourier analysis method are employed After reasonable cardiovascular parameters and their value have been selected, the pressure and flow waveforms ape obtained at any poing along the systemic arteries. The results fit measured data well. In addition, the influences of cardiovascular parameters on pulse wave propagation are studied. The work is useful in practice.展开更多
基金supported by the National Eye Institute, Bethesda, MD (Nos. EY14275 and EY1792)Department of Veteran Affairs, and the Research to Prevent Blindness, UIC Eye Center, New York, NY, USA
文摘Objective: To report a mathematical function that characterizes the double-pass line spread function (LSF) of the human eye. Determining analytical functions that represent the double-pass LSF is important because it allows modeling the optical performance of the eye. Methods: Optical section retinal images, generated in normal human eyes using a modified slit-lamp biomicroscope, were analyzed to derive the double-pass LSF by plotting the intensity distribution of laser light reflected/ scattered from the vitreoretinal interface. Three mathematical functions (Lorentzian, Gaussian, exponential) were fitted to the double-pass LSF and the root mean square error (RMSE) was calculated to provide a measure of the goodness of fit. Results: The Lorentzian function provided the best representation of the double-pass LSF of normal human eyes. The full width at half maximum (FWHM) of the Lorentzian fitted curve was positively correlated with age, indicating that the double-pass LSF broadens with age. Furthermore, the goodness of fit of the Lorentzian function was significantly better in younger subjects as compared with older subjects, suggesting that the fitted function to the double-pass LSF may vary according to age. Conclusion: The results demonstrate an age-related change in the double-pass LSF width and the goodness of fit of the Lorentzian function.
文摘For the first lime, the pressure and flow pulse wave propagation phenomenon is studied in this paper on the basis of he cardiovascular dynamic coupling. E(t)-R model is adopted for left ventricle and T-Y tube model for systemic arteries. Furthermore, impulse response method and Fourier analysis method are employed After reasonable cardiovascular parameters and their value have been selected, the pressure and flow waveforms ape obtained at any poing along the systemic arteries. The results fit measured data well. In addition, the influences of cardiovascular parameters on pulse wave propagation are studied. The work is useful in practice.
