Does the addition of Braun anastomosis to Billroth Ⅱ reconstruction on laparoscopic-assisted distal gastrectomy benefit patients?

BACKGROUND Operation is the primary therapeutic option for patients with distal gastrectomy.Braun anastomosis is usually performed after Billroth Ⅱ reconstruction,which is wildly applied on distal gastrectomy because it is believed to benefit patients.However,studies are needed to confirm that.AIM To identify whether the addition of Braun anastomosis to Billroth Ⅱ reconstruction on laparoscopy-assisted distal gastrectomy benefits patients.METHODS A total of 143 patients with gastric cancer underwent laparoscopy-assisted distal gastrectomy at Centre 1 of PLA general hospital between January 2015 and December 2019.Clinical data of the patients were collected,and 93 of the 143 patients were followed up.These 93 patients were divided into two groups:Group 1(Billroth Ⅱ reconstruction,33 patients);and Group 2(Billroth Ⅱ reconstruction combined with Braun anastomosis,60 patients).Postoperative complication follow-up data and relevant clinical data were compared between the two groups.RESULTS There were no significant differences between Group 1 and Group 2 in postoperative complications(6.1%vs 6.7%,P=0.679),anal exhaust time or blood loss.The follow-up prevalence of reflux gastritis indicated no significant difference between Group 1 and Group 2(68.2%vs 51.7%,P=0.109).The followup European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 scores revealed no evident difference between Group 1 and Group 2 as well.Group 1 had a shorter operating time than Group 2 on average(234.6 min vs 262.0 min,P=0.017).CONCLUSION Combined with Billroth Ⅱ reconstruction,Braun anastomosis has been applied due to its ability to reduce the prevalence of reflux gastritis.Whereas in this study,the prevalence of reflux gastritis showed no significant difference,leading to a conclusion that under the circumstance of Braun anastomosis costing more time and more money,simple Billroth Ⅱ reconstruction should be widely applied.

Restoration,Strengthening and Planning in Italian and German Reconstruction after World War Ⅱ:Essay in Three Steps

Post WWⅡ reconstruction took place at a time of fundamental importance for our understanding of the divide,theoretical and technical,between consolidation,reconstruction and restoration.Indeed,this period represents the moment in which the earliest stages of this rift emerged.In this essay,we shall attempt to provide an account of this phenomenon by citing case studies considered important within the Italian and German context:post-WWⅡ reconstruction work in the Veneto region(at key sites such as the Basilica Palladiana in Vicenza,the Palazzo dei Trecento in Treviso and the Church of the Eremitani in Padua),reconstruction of the Alte Pinakothek in Munich,and reconstruction and work for new use of the hospital,Ospedale Maggiore,in Milan,as a seat for the Università Statale.Considering these instances provides us with an opportunity to reconsider the transition,theoretical and technical,between conservation of ruins and reconstruction of memory.

Prognostic and predictive significance of MSI in stages Ⅱ/Ⅲ colon cancer

In colon cancer,classic disease staging remains the key prognosis and treatment determinant.Although adjuvant chemotherapy has an established role in stageⅢcolon cancer patients,in stageⅡit is still a subject of controversy due to its restriction to a small subgroup of patients with high-risk histopathologic features.Patients with stageⅡtumors form a highly heterogeneous group,with five-year relative overall survival rates ranging from 87.5%(ⅡA)to 58.4%(ⅡC).Identifying those for whom adjuvant chemotherapy would be appropriate and necessary has been challenging,and prognostic markers which could serve in the selection of patients more likely to recur or benefit from adjuvant chemotherapy are eagerly needed.The stronger candidate in this category seems to be microsatellite instability(MSI).The recently reported European Society for Medical Oncology guidelines suggest that MSI should be evaluated in stageⅡcolorectal cancer patients in order to contribute in treatment decisionmaking regarding chemotherapy administration.Thehypothetical predictive role of MSI regarding its response to 5-fluorouracil-based adjuvant chemotherapy has proven a much more difficult issue to address.Almost every possible relation between MSI and chemotherapy outcome has been described in the adjuvant colon cancer setting in the international literature,and the matter is far from being settled.In this current report we critically evaluate the prognostic and predictive impact of MSI status in patients with stageⅡand stageⅢcolon cancer patients.

Impact of lymphatic and/or blood vessel invasion in stage Ⅱ gastric cancer

AIM： To determine the prognostic value of lymphatic and/or blood vessel invasion （LBVI） in patients with stage 11 gastric cancer. METHODS： From January 2001 to December 2006, 487 patients with histologically confirmed primary gas- tric adenocarcinoma were diagnosed with stage 11 gas- tric cancer according to the new 7th edition American Joint Committee on Cancer stage classification at the Department of Gastric Cancer and Soft Tissue Surgery, Fudan University Shanghai Cancer Center. All patients underwent curative gastrectomy with standard lymph node （LN） dissection. Fifty-one patients who died in the postoperative period, due to various complications or other conditions, were excluded. Clinicopathologicalfindings and clinical outcomes were analyzed. Patients were subdivided into four groups according to the status of LBVI and LN metastases. These four patient groups were characterized with regard to age, sex, tumor site, pT category, tumor grading and surgical procedure （subtotal resection vs total resection）, and compared for 5-year overall survival by univariate and multivariate analysis. RESULTS： The study was composed of 320 men and 116 women aged 58.9 ± 11.5 years （range： 23-88 years）. The 5-year overall survival rates were 50.7% and the median survival time was 62 too. Stage Ⅱ a cancer was observed in 334 patients, including 268 T3N0, 63 T2N1, and three TIN2, and stage Ⅱb was observed in 102 patients, including 49 patients T3N1, 51 T2N2, one TIN3, and one T4aN0. The incidence of LBVI was 28.0% in stage II gastric cancer with 19.0% （51/269） and 42.5% （71/167） in LN-negative and LN- positive patients, respectively. In 218 patients （50.0%）, there was neither a histopathologically detectable LBVI nor LN metastases （LBVI-/LN-, group I）; in 51 patients （11.7%）, LBVI with no evidence of LN me- tastases was detected （LBVILN-, group 11）. In 167 patients （38.3%）, LN metastases were found. Among those patients, LBVI was not determined in 96 patients （22.0%） （LBVI-γLN, group Ⅲ）, and was determined in 71 patients （16.3%） （LBVI＋LN＋, group Ⅳ）. Correla- tion analysis showed that N category and the number of positive LNs were significantly associated with the presence of LBVI （P 〈 0.001）. The overall 5-year sur- vival was significantly longer in LN-negative patients compared with LN-positive patients （56.1% vs 42.3%, P = 0.015）. There was a significant difference in the overall 5-year survival between LBVI-positive and LBVI- negative tumors （39.6% vs 54.8%, P = 0.006）. Overall 5-year survival rates in each group were 58.8% （ Ⅰ）, 45.8% （Ⅱ）, 45.7% （Ⅲ） and 36.9% （Ⅳ）, and there was a significant difference in overall survival between the four groups （P=-0.009）. Multivariate analysis in stage 11 gastric cancer patients revealed that LBVI in- dependently affected patient prognosis in LN-negativepatients （P = 0.018） but not in LN-positive patients （P = 0.508）. CONCLUSION： In LN-negative stage 11 gastric cancer patients, LBVI is an additional independent prognostic markeF, and may provide useful information to identify patients with poorer prognosis.

Prognostic values of chromosome 18q microsatellite alterations in stage Ⅱ colonic carcinoma

AIM: To investigate the prognostic value of chromosome 18q microsatellite alterations (MA) in stage Ⅱ colon cancer. METHODS: One hundred and six patients with sporadic stage Ⅱ colon cancer were enrolled in this study. DNA was extracted from formalin-fixed, paraffin-embedded tumor and adjacent normal mucosal tissue samples. MA, including loss of heterozygosity (LOH) and microsatellite instability (MSI), was analyzed by polymerase chain reaction, polyacrylamide gel-electrophoresis and DNA sequencing at 5 microsatellite loci on chromosome 18q (D18S474, D18S55, D18S58, D18S61 and D18S64).RESULTS: Among the 102 patients eligible for MA information, the overall frequencies of LOH, high and low frequency MSI/microsatellite stable were 49.0%, 17.6% and 82.4%, respectively. The high frequency of 18q-LOH was signif icantly associated with the poor 5-year overall survival (OS) (P=0.008) and disease free survival (P=0.006). High levels of MSI were significantly associated with a longer 5-year OS (P=0.045) while the higher frequency of 18q-LOH at the loci of D18S474 and D18S61 was significantly associated with a poorer 5-year OS (P=0.010 and 0.005, respectively). But multivariate analysis showed that only the frequency of 18q-LOH was significantly associated with the prognosis of the disease. CONCLUSION: High frequency of 18q-LOH is an independent prognostic factor indicating poor prognosis of the patients with stage Ⅱ colon cancer.

Different strategies of treatment for uterine cervical carcinoma stage ⅠB2-ⅡB

Uterine cervical cancer is the second most common gynecological malignancy. It is estimated that over 35% of tumors are diagnosed at locally advanced disease, stage ⅠB2-ⅡB with an estimated 5-year overall survival of 60%. During the last decades, the initial treatment for these women has been debated and largely varies through different countries. Thus, radical concurrent chemoradiation is the standard of care in United Sated and Canada, and neoadjuvant chemotherapy followed by radical surgery is the first line of treatment in some institutions of Europe, Asia and Latin America. Until today, there is no evidence of which strategy is better over the other. This article describe the evidence as well as the advantages and disadvantages of the main strategies of treatment for women affected by uterine cervical cancer stage ⅠB2-ⅡB.

Macroscopic appearance of TypeⅣand giant Type Ⅲ is a high risk for a poor prognosis in pathological stage Ⅱ/Ⅲ advanced gastric cancer with postoperative adjuvant chemotherapy

AIM To evaluate whether a high risk macroscopic appearance(Type Ⅳ and giant Type Ⅲ) is associated with a dismal prognosis after curative surgery, because its prognostic relevance remains elusive in pathological stage Ⅱ/Ⅲ(p Stage Ⅱ/Ⅲ) gastric cancer.METHODS One hundred and seventy-two advanced gastric cancer(defined as pT2 or beyond) patients with p Stage Ⅱ/Ⅲ who underwent curative surgery plus adjuvant S1 chemotherapy were evaluated, and the prognostic relevance of a high-risk macroscopic appearance was examined. RESULTS Advanced gastric cancers with a high-risk macroscopic appearance were retrospectively identified by preoperative recorded images. A high-risk macroscopic appearance showed a significantly worse relapse free survival(RFS)(35.7%) and overall survival(OS)(34%) than an average risk appearance(P = 0.0003 and P < 0.0001, respectively). A high-risk macroscopic appearance was significantly associated with the 13^(th) Japanese Gastric Cancer Association(JGCA) pT(P = 0.01), but not with the 13^(th) JGCA pN. On univariate analysis for RFS and OS, prognostic factors included 13^(th) JGCA p Stage(P < 0.0001)and other clinicopathological factors including macroscopic appearance. A multivariate Cox proportional hazards model for univariate prognostic factors identified highrisk macroscopic appearance(P = 0.036, HR = 2.29 for RFS and P = 0.021, HR = 2.74 for OS) as an independent prognostic indicator. CONCLUSION A high-risk macroscopic appearance was associated with a poor prognosis, and it could be a prognostic factor independent of 13^(th) JGCA stage in p Stage Ⅱ/Ⅲ advanced gastric cancer.

Effect of hepatic artery resection and reconstruction on the prognosis of patients with advanced hilar cholangiocarcinoma

BACKGROUND Hilar cholangiocarcinoma(HC)is a good adaptation certificate of hepatic arterectomy,and hepatic arterectomy is conductive to the radical resection of cholangiocarcinoma,which simplifies the operation and helps with a combined resection of the peripheral portal tissue.With continuous development of surgical techniques,especially microsurgical technique,vascular invasion is no longer a contraindication to surgery in the past 10 years.However,hepatic artery reconstruction after hepatic arterectomy has been performed to treat liver tumor in many centers with better results,but it is rarely applied in advanced HC.AIM To determine the prognosis of patients with advanced HC after hepatic artery resection and reconstruction.METHODS A total of 98 patients with HC who underwent radical operation in our hospital were selected for this retrospective analysis.According to whether the patients underwent hepatic artery resection and reconstruction or not,they were divided into reconstruction(n=40)and control(n=58)groups.The traumatic indices,surgical resection margin,liver function tests before and after the operation,and surgical complications were compared between the two groups.RESULTS Operation time,blood loss,hospital stay,and gastrointestinal function recovery time were higher in the reconstruction group than in the control group(P<0.05);The R0 resection rates were 90.00%and 72.41%in the reconstruction and control groups,respectively(P<0.05).Serum alanine aminotransferase was lower in the reconstruction group on day one and three postoperatively,whereas serum aspartate aminotransferase was lower on the third day(P<0.05).Preoperatively,the Karnofsky performance status scores were similar between the groups(P>0.05),but was higher in the reconstruction group(P<0.05)two weeks postoperatively.There was no difference in the complication rate between the two groups(27.50%vs 32.67%,P>0.05).Two-year survival rate(42.50%vs 39.66%)and two-year survival time(22.0 mo vs 23.0 mo)were similar between the groups(P>0.05).CONCLUSION Radical surgery combined with reconstruction after hepatic artery resection improves R0 resection rate and reduces postoperative liver injury in advanced HC.However,the operation is difficult and the effect on survival time is not clear.

Successful Treatment of Postpeak Stage Patients with ClassⅡ Division 1 Malocclusion Using Non-extraction and Multiloop Edgewise Archwire Therapy: A Report on 16 Cases

Aim To determine cephalometrically the mechanism of the treatment effects of non-extraction and multiloop edgewise archwire （MEAW） technique on postpeak Class Ⅱ Division 1 patients. Methodology In this retrospective study, 16 postpeak Class Ⅱ Division 1 patients successfully corrected using a non-extraction and MEAW technique were cephalometrically evaluated and compared with 16 matched control subjects treated using an extraction technique. Using CorelDRAW software, standardized digital cephalograms preand post-active treatments were traced and a reference grid was set up. The superimpositions were based on the cranial base, the mandibular and the maxilla regions,and skeletal and dental changes were measured. Changes following treatment were evaluated using the paired-sample t-test. Student＇s t-test for unpaired samples was used to assess the differences in changes between the MEAW and the extraction control groups. Results The correction of the molar relationships comprised 54% skeletal change （mainly the advancement of the mandible） and 46% dental change. Correction of the anterior teeth relationships comprised 30% skeletal change and 70% dental change. Conclusion The MEAW technique can produce the desired vertical and sagittal movement of the tooth segment and then effectively stimulate mandibular advancement by utilizing the residual growth potential of the condyle.

Utility of endoscopic retrograde cholangiopancreatography on biliopancreatic diseases in patients with Billroth Ⅱ-reconstructed stomach

AIM To examine the utility of endoscopic retrograde cholangiopancreatography(ERCP) on biliopancreatic diseases in the patients with Billroth II-reconstructed stomach.METHODS For 26 cases of biliopancreatic diseases in patients with Billroth Ⅱ-reconstructed stomach,ERCP was conducted using a straight-view scope or a retrograde obliqueviewing endoscope.All the cases were patients aiming at selective insertion into the bile duct.One patient aimed at diagnosis,and 25 patients aimed at treatment.The cases in which the endoscope reached the duodenal papilla and anastomosis,and insertion into the bile duct became possible,were considered successful.RESULTS The rate of reaching the duodenal papilla and anastomosis was 84.7%(22/26 patients).Among the cases without reaching the duodenal papilla and anastomosis,there were 2 in which the endoscope did not pass due to tumor-induced duodenal infiltration.In 1 case,the fiber did not reach the duodenal papilla due to long afferent loop.The success rate of insertion into the bile duct in patients in which the endoscope reached the duodenal papilla and anastomosis was 90.9%(20/22 patients),and the success rate of procedures including treatment was 86.3%(19/22 patients).After treatment,mild cholangitis was observed in 1 patient(4.5%,1/22 patients) but relieved conservatively.No other accidental symptom was observed.CONCLUSION It was considered that the ERCP for biliopancreatic diseases in patients with Billroth II-reconstructed stomach will become a less invasive,safe and useful examination and treatment approach.

Pattern of Refractive Correction and Timing of Stage Ⅱ IOL Implantation after Congenital Cataract Extraction

Congenital cataract occurs during infancy when the axial length and corneal and visual function are in the sensitive stages of rapid development..Inappropriate surgical intervention not only fails to restore visual function,.but also causes irreversible serious influences upon eyeball development in children diagnosed with congenital cataract. At present, the uncertainty of selection of intraocular lens(IOL) degrees during the eyeball development period is averted by using a main treatment of congenital cataract that includes two-stage surgery:.stage I cataract extraction and stage II IOL implantation. However, the accurate selection of a refractive correction method and the timing of IOL implantation during stage II surgery for aphakic eyes remains controversial following stage I cataract extraction..This review retrospectively summarizes the current progress and existing problems indicated by related recent studies focusing on refractive correction pattern and IOL implantation timing.

Construction of TGP StageⅡWorks

In the construction of Three Gorges Project, the total amount of concrete is about 28 Mm\+3 , and the total amount of metal works and reinforcement is approximately 0.72 Mt . The TGP is constructed in 3 stages . The preparation period together with the first stage is 5 years , the second stage and third stage are both 6 years .In the second stage construction of 6 years (1998～2003) , there are 18.46 Mm\+3 of concrete to be placed and 0.192 Mt of metal works and embedded parts for mechanical and electric equipment to be installed . In 1999, a world record of annual concrete placement of 4.585 Mm\+3 was set . In 2000, it is planned to place 5.4 Mm\+3 of concrete and to install 38 000 t of metal works . Construction equipments and layout of construction site , concrete production and its temperature control, metal works, mechanical and electric equipments in the second stage construction are presented.

The path toward prognostication and prediction in stage Ⅱ colon cancer

Currently,there are several newer biomarkers that may be clinically useful in colon cancer. This paper focuses on a few of these biomarkers,namely microsatellite instability,loss of heterozygosity at chromosome 18q(LOH18q) and multi-gene assays,and discusses the clinical evidence behind their predictive or prognostic abilities. The results show that although there have been several newer prognostic factors identified,such as LOH18 q and multi-gene assays,none of these factors can predict benefit from treatment. Therefore,ongoing prospective clinical trials are still needed to further assess the role and optimal use of these tests.

基于NSGA-Ⅱ算法选择光谱反射率重建样本的研究

为解决光谱反射率重建过程中训练样本数目庞大导致工作量大,重建精度不高等问题,提出一种基于NSGA-Ⅱ算法的光谱反射率重建样本选择方法。近日Liang等提出了一种从大量样本数据中选取具有代表性样本的新方法,定义光谱重建误差为均方根误差与拟合优度系数的乘积,以这一标准选择光谱重建误差最小的样本作为代表性样本进行光谱反射率重建。受Liang等人工作的启发结合NSGA-Ⅱ算法选择代表性样本,先对全体训练样本使用多项式回归算法和伪逆法进行光谱反射率重建,再使用NSGA-Ⅱ算法,设定两个目标函数,一个是所需代表性样本个数的光谱均方根误差的和,另一个是拟合优度系数倒数的和,令两个目标函数值最小。将经过NSGA-Ⅱ算法挑选出的Pareto等级为1的全部样本按照样本出现次数由高至低排序,以此顺序从高到低依次选为代表性样本,直至达到所需代表性样本个数。若从Pareto等级为1的样本集合中挑选的代表性样本数不足所需要的个数则选择下一等级出现次数最多且没有被选择过的样本直至代表性样本数达到需求。将1269块无光泽Munsell标准色卡按照样本下标划分为偶数色卡、奇数色卡,第一组实验用Munsell奇数色卡为全体训练样本,从Munsell偶数色卡中随机选择20个色块为测试样本。第二组实验选用Munsell偶数色卡为全体训练样本,从Munsell奇数色卡中随机选取20个色块为测试样本。第三组实验训练样本与第一组相同,RC24色卡为测试样本。将该方法与Mohammadi、Cao、Liang等提出的三种样本选择方法进行对比。通过实验得到使用NSGA-Ⅱ算法结合多项式回归与伪逆法选择的代表性样本重建的光谱反射率在均方根误差和色差两个指标上均优于现有的样本选择方法,并且该方法不限于特定系统,具有通用性。

金匮肾气丸辅治Ⅱ-Ⅲ期糖尿病肾病疗效观察

目的:观察金匮肾气丸辅治Ⅱ-Ⅲ期糖尿病肾病的临床疗效。方法:74例按照随机数字表法分为对照组与研究组各37例,两组均用达格列净和贝那普利治疗,研究组加用金匮肾气丸。结果:研究组总有效率与估算肾小球滤过率(eGFR)水平高于对照组(P<0.05),中医证候积分、血肌酐(SCR)、血尿素氮(BUN)、24h尿总量蛋白(TUP)和尿微量白蛋白/尿肌酐(UMA/UCR)以及空腹血糖(FBG)水平均低于对照组(P<0.05)。结论:金匮肾气丸辅治Ⅱ-Ⅲ期糖尿病肾病可提高疗效。

产妇泌乳Ⅱ期启动延迟发生率及影响因素分析

目的分析住院期间产妇泌乳Ⅱ期启动延迟的发生率和影响因素,指导母乳科学喂养。方法采用便利抽样法选取医院产科2023年4月至7月收治的分娩产妇121例,按是否发生泌乳Ⅱ期启动延迟分为延迟组(41例)和非延迟组(80例)。收集产妇一般人口学特征,分析疾病史、生育史、母乳喂养教育等因素对产妇泌乳Ⅱ期启动延迟发生的影响。结果产妇泌乳Ⅱ期启动延迟发生率为33.88%。多因素Logistic回归分析结果显示,年龄不低于35岁[OR=3.576,95%CI(1.081,11.833),P=0.037],产次为初产[OR=4.082,95%CI(1.282,12.997),P=0.017],分娩方式为剖宫产[OR=4.648,95%CI(1.347,16.041),P=0.015],妊娠期糖尿病[OR=10.893,95%CI(2.612,45.432),P=0.001],母乳喂养指导[OR=5.399,95%CI(1.458,19.988),P=0.012],母婴30 min内未早期接触[OR=4.200,95%CI(1.316,13.404),P=0.015],新生儿24 h内有效吮吸次数不超过8次[OR=3.845,95%CI(1.141,12.954),P=0.030]均为发生泌乳Ⅱ期启动延迟的影响因素。结论该院产妇泌乳Ⅱ期启动延迟发生率较高,年龄≥35岁、初产、剖宫产、妊娠期糖尿病、未接受母乳喂养指导、母婴30 min内未早期接触、新生儿24 h内有效吮吸次数≤8次均为发生泌乳Ⅱ期启动延迟的危险因素。

443例Ⅱ期结直肠癌患者预后分析及辅助化疗的必要性

背景与目的:Ⅱ期结直肠癌患者的预后差异较大,且术后辅助化疗的必要性尚无定论,本研究旨在分析Ⅱ期结直肠癌患者术后的预后影响因素并探讨术后辅助化疗的必要性。方法:对2000年1月至2005年1月在中山大学肿瘤防治中心行结直肠癌根治术的443例Ⅱ期结直肠癌患者的临床资料进行统计,用Kaplan-Meier法计算生存率、绘制生存曲线,对可能影响患者生存时间的因素进行单因素和Cox多因素模型分析。对具有2008NCCN指南所述的预后不良因素(肠梗阻或穿孔、组织学分化差、送检淋巴结少于9枚、T4分期)的结肠癌患者亚组,再按照有无术后辅助化疗(XELOX或FOLFOX方案)进行分类,同样用Kaplan-Meier法和log-rank法进行计算和检验。结果:443例患者的中位随访时间为59个月,总的3年、5年生存率分别为88.4%、82.5%。Cox单因素和多因素分析显示,术前有无肠梗阻或穿孔、有无糖尿病、大体标本切缘与肿瘤的距离、送检淋巴结是否大于9枚是Ⅱ期结直肠癌最重要的预后因素。术前有肠梗阻或穿孔、送检淋巴结少于9枚的Ⅱ期结癌患者经辅助化疗后,5年生存率(分别为80%、86%)高于未化疗组(分别为67%、64%)。结论:术前伴有梗阻或穿孔、2型糖尿病、淋巴结检出数目少于9枚和切缘小于1cm的Ⅱ期结直肠癌患者预后较差;具有肠梗阻或穿孔、淋巴结送检数目少于9枚的Ⅱ期结肠癌患者可能从辅助化疗中获益。

健脾消积口服液结合西药治疗Ⅱ、Ⅲ期肝癌40例的临床观察

目的:探讨健脾消积口服液结合西药治疗Ⅱ、Ⅲ期肝癌的临床疗效。方法:将75例Ⅱ、Ⅲ期肝癌患者按数字表法随机分为治疗组(40例)与对照组(35例),两组患者均采用相同的西药疗法,治疗组同时加用健脾消积口服液治疗。观察近期疗效、生存质量、中医证候变化、免疫学等指标变化。结果:治疗组与对照组完全缓解率分别为5％、0,稳定分别为62.5％、37.1％;生存质量:总改善率分别为47.5％、25.7％;证候改善率分别为80.0％、54.3％,两组间比较,差异均有显著性(P<0.01)。两组治疗前T淋巴细胞亚群比较差异无显著性,治疗组治疗后与治疗前比较,除CD_8外,CD_3、C_3D和CD_4。/CD_8比值改善,差异均有显著性(P<0.05或P<0.01),且优于对照组治疗后(P<0.05或P<0.01)。结论:健脾消积口服液可提高Ⅱ、Ⅲ期肝癌患者的生存质量,延长生存时间,并有提高细胞免疫功能的作用。

Ⅱ-32A育性光温反应及敏感生育期的研究

利用人工气候箱研究了广东湛江和福建提纯的Ⅱ 32A育性对温度和光长的反应以及育性的温度敏感生育期。结果表明 2 6℃以上温度可引起Ⅱ 32A育性的部分恢复 ,温度越高 ,育性恢复越大。福建提纯的Ⅱ 32A育性恢复还受短光长促进 ,并存在光温互作效应。Ⅱ 32A育性的温度敏感生育期出现得特别早 ,为第 1苞分化期至花粉母细胞形成期与减数分裂期之间 ,最敏感生育期为二次枝梗原基和颖花原基分化期至雌雄蕊原基形成期之间。因此 ,Ⅱ

Ⅰ、Ⅱ期乳腺癌保乳根治术加放疗的临床分析

目的比较Ⅰ、Ⅱ期乳腺癌保乳根治术加放疗与改良根治术的临床疗效。方法回顾性分析我院2002年1月～2006年12月实施保乳手术加放疗(保乳组)的106例及改良根治术(对照组)的131例Ⅰ、Ⅱ期乳腺癌患者的临床资料,比较两组的疗效。结果与对照组比较,保乳组术后拔管时间短、并发症发生率低,并且美容效果评价的优良率明显高于对照组;两组的5年生存率及无病生存率相似,差异无统计学意义(P>0.05)。结论保乳手术加放疗可达到与改良根治术相似的生存率,且手术并发症发生率低,美容效果好,是Ⅰ、Ⅱ期乳腺癌治疗的首选方式。