基于StaMPS-PS时序InSAR对流层延迟改正方法评估

时序分析是合成孔径雷达干涉测量(InSAR)的一项关键技术,它被广泛应用于监测广阔地区的地表缓慢形变。这种方法能够提供大范围、大面积的形变监测。其中,StaMPS PS方法凭借适用范围广、开源等优点,受到众多学者的使用。但在时序InSAR中,对流层延迟相位会导致形变监测精度的降低,因此,以合肥市为研究区域,分析了经验模型线性改正、GACOS(generic atmospheric correction online service for InSAR)改正和欧洲中期天气预报中心(ECMWF)最新发布的ERA5数据集改正,并对比这3种方法在时序InSAR反演形变速率中的改正效果。通过计算得到研究区的标准差,进行比较分析和验证。其中线性改正、ERA5和GACOS改正后的标准差分别降低了21.71%、16.14%、10.38%。对于合肥区域,这3种方法均可减弱对流层延迟的影响,且精度都有所提高,其中线性改正效果最好,适用性更高,ERA5和GACOS受天气以及地面监测点密度等影响,在该区域改正效果较差。

Prospects in the application of ultrasensitive chromosomal aneuploidy detection in precancerous lesions of gastric cancer

Gastric cancer(GC)is a prevalent malignant tumor within the digestive system,with over 40%of new cases and deaths related to GC globally occurring in China.Despite advancements in treatment modalities,such as surgery supplemented by adjuvant radiotherapy or chemotherapeutic agents,the prognosis for GC remains poor.New targeted therapies and immunotherapies are currently under invest-igation,but no significant breakthroughs have been achieved.Studies have indicated that GC is a heterogeneous disease,encompassing multiple subtypes with distinct biological characteristics and roles.Consequently,personalized treatment based on clinical features,pathologic typing,and molecular typing is crucial for the diagnosis and management of precancerous lesions of gastric cancer(PLGC).Current research has categorized GC into four subtypes:Epstein-Barr virus-positive,microsatellite instability,genome stability,and chromosome instability(CIN).Technologies such as multi-omics analysis and gene sequencing are being employed to identify more suitable novel testing methods in these areas.Among these,ultrasensitive chromosomal aneuploidy detection(UCAD)can detect CIN at a genome-wide level in subjects using low-depth whole genome sequencing technology,in conjunction with bioinformatics analysis,to achieve qualitative and quantitative detection of chromosomal stability.This editorial reviews recent research advancements in UCAD technology for the diagnosis and management of PLGC.

Microneedles for Enhanced Topical Treatment of Skin Disorders:Applications,Challenges,and Prospects

Microneedles(MNs)can be used for the topical treatment of skin disorders as they directly deliver therapeutics to the site of skin lesions,resulting in increased therapeutic efficacy while having minimum side effects.MNs are used to deliver different kinds of therapeutics(e.g.,small molecules,macromolecules,nanomedicines,living cells,bacteria,and exosomes)for treating various skin disorders,including superficial tumors,wounds,skin infections,inflammatory skin diseases,and abnormal skin appearance.The therapeutic efficacy of MNs can be improved by integrating the advantages of multiple therapeutics to perform combination therapy.Through careful designing,MNs can be further modified with biomimetic structures for the responsive drug release from internal and external stimuli and to enhance the transdermal delivery efficiency for robust therapeutic outcomes.Some studies have proposed the use of drug-free MNs as a promising mechanotherapeutic strategy to promote wound healing,scar removal,and hair regeneration via a mechanical communication pathway.Although MNs have several advantages,the practical application of MNs suffers from problems related to industrial manufacture and clinical evaluation,making it difficult for clinical translation.In this study,we summarized the various applications,emerging challenges,and developmental prospects of MNs in skin disorders to provide information on ways to advance clinical translation.

Advantages and Development Prospects of Building Information Modelling(BIM)Technology Application in Highway Engineering

Based on the advantages of the application of Building Information Modelling(BIM)technology in highway engineering,this paper analyzes the difficulties of its in-depth application,grasps the pain points of the application of BIM technology in practice,and approaches from the integration of BIM design-construction.This paper also puts forward the integration of cross-stage information based on the BIM+Geographic Information System(GIS)construction information management system to realize the BIM whole life cycle management,and provides directional support for the continuous and efficient application of BIM technology in engineering practice.

Phosphatidylserine:An overview on functionality,processing techniques,patents,and prospects

Phosphatidylserine(PS)is the part of cell structure in the body and has many beneficial functions especially in brain-related aging diseases.Although daily foods can provide PS to human body,the amount is very limited due to its poverty in most foods.To overcome the issue,numerous studies based on PS have been reported to develop PS-related supplements.In this review,PS was comprehensively and critically reviewed from the view of resources,functions,processing techniques,patents,and prospects.For resources,animal,plant,and microorganism origins were all covered with their differences in composition profiles.For functions,benefits regarding memory,cognitive enhancement,exercise performance,reducing Alzheimer’s disease,and attention-deficit hyperactivity disorder symptoms were covered as well as the functional differences among animal-,plant-,and microorganism-based PS-related supplements.For processing techniques,traditional extracting methods from animal,plant,and microorganism tissues were comparatively discussed with enzymatic synthesis based on different reaction systems.Finally,patents of PS-related supplements were evaluated as well as their applications.This review could provide scientific and valuable support for PS industry.

基于StaMPS的上海区域地表形变研究

为了及时掌握上海地区的沉降状态,更新沉降结果,本文通过获取覆盖上海市2020—2021年的哨兵1A(Sentinel-1A)影像数据,基于大气产品进行误差去除,用斯坦福永久散射体干涉(StaMPS)技术对上海地区进行时序监测。结果显示,研究区域永久散射体(PS)点平均形变速率为-10.4~6.5 mm/a,主要标准差区间在-2~2 mm/a,沉降主要发生在浦东新区和主城区的部分地区。同时,通过与小基线集技术(SBAS-InSAR)结果及相关文献对比验证,形变结果较为一致,说明该技术获取上海地区结果的正确性及适用性。最后,分析了5个典型沉降区及上海地铁14号、18号线沉降区域来说明沉降形成原因。

A review of complementary and alternative medicine used in cancer care:challenges and prospects

Cancer is a leading cause of death globally,and most patients with cancers frequently seek for complementary and alternative medicine(CAM)to ameliorate their condition.Some of the available CAM care include:acupuncture,aromatherapy,Ayurvedic medicinal drug,cannabis,chelation remedy,homeopathy,hypnotherapy,massage therapy,naturopathic medication,and conventional Chinese remedy amongst others.Despite the growing use of CAM,the evidence-base for its efficacy and safety is limited.Major challenges confronting the efficient deployment of CAM is lack of standardization and regulation;as well as the demand for more extensive studies to validate their safety and efficacy.Integrative oncology which is the combination of CAM and conventional cancer care is likewise complicated through the potential adverse interactions between CAM options and most cancers drugs.The article serves as a guide for healthcare providers and patients to determine how CAM can be safely integrated into the cancer care paradigm.Taking into account safety concerns,however,more studies need to be conducted to properly evaluate its efficacy.Ultimately,CAM can help cancer patients in achieving greater health and well-being.

Research Progress and Prospects for the Evolution Process and Treatment Technology of Urban Black and Smelly Water

Water is an important material resource for human survival,and with the increasing development of society,the amount of urban industrial wastewater and domestic sewage is gradually increasing.However,wastewater collection and treatment facilities lag behind,so that a large number of wastewater enters urban water,making urban water become gradually black and smelly.In order to provide a good living environment for human beings,a large number of scholars actively explore the treatment technology of black and smelly water.In this paper,the evolution process of black and smelly water was introduced firstly,and then the treatment technology of black and smelly water was summarized.Finally,the prospects for the development of the treatment technology were put forward.

东昆仑大格勒地区碱性岩-碳酸岩型铌矿勘查进展及找矿前景

铌广泛应用在冶金工业、原子能工业、航空航天工业、军事工业、电子工业、超导材料及医疗仪器等方面,是全球高度关注的关键矿产。碱性岩-碳酸岩型矿床赋存了世界上大部分的铌资源,而我国铌资源禀赋差,对外依存度大于90%。2021年青海省地质调查院在东昆仑大格勒地区发现了碱性岩-碳酸岩型铌矿,通过三年的勘查工作,圈定5条铌矿体,矿体延伸长160~1280 m,控制最大斜深800 m,矿体厚度4.3~115.7 m,Nb_(2)O_(5)平均品位0.092%~0.156%,伴生P_(2)O_(5)平均品位3.8%~5.6%。通过资源量估算,Nb_(2)O_(5)推断资源量超过10万吨,已达大型矿床规模。目前铌矿体在走向和倾向上延伸稳定,显示出良好的找矿前景。

郑州“7·20”地铁水淹事件STAMP致因分析

为探讨河南郑州“7·20”地铁5号线伤亡事件致因,综合运用系统理论事件模型与过程(STAMP)模型,分析5号线伤亡事件安全控制结构,据此逐级辨识事件致因;基于复杂网络理论将事件致因及其联系抽象为网络的节点和边,建立地铁水灾事件网络;计算聚类系数、度数等拓扑参数定量分析事件致因性质,确定关键致因。结果表明:地方党委政府面对汛情的应对部署不紧不实,缺少有效的组织动员和有关部门对工程建设存在失管失察是事件的深层根源;建设单位、设计单位等五方主体单位及运维单位的主体责任失职是事件的主观关键致因;应从政府及有关部门、五方主体单位和运维单位方面采取多元协同的风险防控措施。

多重防护机制下LNG动力船风险态势分析方法

为探讨多重防护机制下的液化天然气(Liquefied Natural Gas,LNG)动力船营运风险特征,提出了一种基于复杂性控制系统作用模式的风险态势分析方法。从系统控制过程视角,采用系统控制过程分析方法(System-Theoretic Process Analysis,STPA)确立LNG动力船系统安全控制的风险致因,揭示基于LNG泄漏三重防护机制的风险因子体系和风险形成机制;引入隐马尔可夫模型(Hidden Markov Model,HMM),进行无监督学习并确立模型参数,推理多重防护机制下的LNG动力船风险转移特征;结合LNG动力船营运的具体场景,对三重防护机制分别进行仿真并统计风险态势。仿真结果表明,三重防护机制在降低LNG动力船营运风险态势方面具有因子诱导的针对性,在防漏因子、止漏因子和治漏因子诱导下LNG动力船分别趋向一般风险状态、较高风险状态和高风险状态。基于复杂性控制系统作用模式的风险态势分析可为LNG动力船营运的安全控制和风险管理提供管控模式和手段。

基于系统论事故分析模型的油气智慧管道系统信息物理风险辨识

为了辨识油气智慧管道系统中存在的信息安全风险,通过基于系统论事故分析模型(systems-theoretic accident modeling and process,STAMP)的方法,对油气智慧管道系统的信息物理安全进行全面评估与分析。首先,系统综合分析了油气智慧管道涉及的设备、设施、工艺、元件,评估其安全性。其次,通过建立STAMP模型,深入分析了各层级、元件之间的反馈信息与控制动作,形成了明确的控制反馈回路,突显了元件之间的关联与控制关系。在此基础上,系统辨识出了潜在的信息风险因素,推导并构建了可能发生的系统失效场景。以天然气输气首站油气智慧管道系统为例,研究验证了基于STAMP模型的可行性和有效性。结果显示,该方法不仅直观地描述了元件之间的关联与控制关系,而且从物理层功能安全的角度全面考虑了信息风险,特别凸显了过程控制系统(process control systems,PCS)及易受攻击的操作员站。与传统方法相比,本研究所提出的方法将信息物理安全风险因素的识别率提升至80%以上,提高了40%以上,有助于避免不必要的安全措施冗余设计,提高了安全风险管控的准确性。

采用STAMP-24Model的多组织事故分析

安全生产事故往往由多组织交互、多因素耦合造成,事故原因涉及多个组织。为预防和遏制多组织生产安全事故的发生,基于系统理论事故建模与过程模型(Systems-Theory Accident Modeling and Process,STAMP)、24Model,构建一种用于多组织事故分析的方法,并以青岛石油爆炸事故为例进行事故原因分析。结果显示:STAMP-24Model可以分组织,分层次且有效、全面、详细地分析涉及多个组织的事故原因,探究多组织之间的交互关系;对事故进行动态演化分析,可得到各组织不安全动作耦合关系与形成的事故失效链及管控失效路径,进而为预防多组织事故提供思路和参考。

基于SNAP-StaMPS方法的高速公路沿线地面沉降监测

准确监测高速公路不同程度的沉降是确保高速公路正常运营以及可持续发展的基础性工作。文中以黄河三角洲高速公路及沿线为研究区,基于SNAP-StaMPS方法,采用2019年8月至2022年1月的37景Sentinel-1A数据,对该地区地面沉降监测的基础上,提取东营港疏港、东吕、荣乌3条高速公路及沿线地面沉降信息,识别出高速公路的隐患路段并对沉降原因进一步分析,为道路的维护提供基础数据支撑。研究结果显示,东营港疏港高速沉降最为严重,平均沉降速率为-74.16 mm/a;东吕高速沉降较为平缓,沉降速率为-7.9 mm/a;荣乌高速未发现明显沉降。因此证明SNAP-StaMPS方法能有效监测高速公路沿线的灾害隐患。

地理学视角下中国农业功能研究进展与展望

伴随中国城镇化、工业化、市场化的快速推进及乡村振兴战略的深入实施,中国农业发展迈入转型升级的新时期。国内学者高度重视农业发展及农业产业为全社会所提供的服务,地理学者充分发挥学科优势,逐步融合多学科理论与方法针对农业功能的概念内涵、理论基础、分类体系、测度评价、时空过程、影响因素及优化路径等开展了诸多研究。文章通过梳理中国知网平台上近10年核心期刊中关于农业功能的学术论文,选取了151篇高质量文献进行研究,得到以下几点结果:1)地理学者聚焦于农业的生产功能、经济功能、及生态功能等方面研究,更加关注农业功能空间分布、地理特征及其与环境的关系;2)人地关系地域系统理论、农业多功能理论、农业区位理论和农业功能阶段论等是农业功能研究的基础,地理学者正不断完善和丰富农业功能相关理论;3)基于GIS和RS技术以及地理数学模型,地理学者进一步研究了农业功能的空间变化与地域特征;4)地理学者科学诊断了不同地理环境下各因子的作用方式、方向与强度,并针对地区地理环境与影响因子进行功能区划与优化;5)未来地理学视角下的农业功能研究需要进一步完善理论框架体系,推动多要素、多尺度、多目标的体系研究;聚焦农业功能转型,强化多学科、大数据、新技术手段的集成研究。

超声引导下经皮注射无水乙醇联合微波消融治疗甲状腺良性囊实性肿物

目的观察超声引导下经皮注射无水乙醇(PEI)联合微波消融(MWA)治疗甲状腺良性囊实性肿物的价值。方法前瞻性纳入100例拟接受超声引导下消融治疗的甲状腺单发良性囊实性肿物患者,随机将其均分为PEI组(行PEI联合MWA序贯消融治疗)和对照组(行单纯MWA治疗),观察治疗前、后组内一般资料差异及组间疗效差异,评估序贯消融价值。结果对100个甲状腺肿物均顺利完成超声引导下消融。随访期间PEI组5例、对照组3例失访。PEI组MWA用时、MWA总能量及治疗中患者疼痛程度均低于对照组(P均<0.05)。治疗后1、3、6及12个月,PEI组肿物体积缩小率(VRR)均高于对照组(P均<0.05)。治疗后3、6及12个月,2组肿物体积与治疗前差异均有统计学意义(P均<0.05)。治疗后12个月,PEI组与对照组治疗成功率分别为95.56%(43/45)和89.36%(42/47),组间差异无统计学意义(P=0.451)。治疗后3、6及12个月,2组颈部美观评分及症状评分与治疗前差异均有统计学意义(P均<0.05)。PEI组并发症率为6.67%(3/45),对照组为14.89%(7/47),前者低于后者(P<0.05)。结论超声引导下PEI联合MWA序贯消融治疗甲状腺良性囊实性肿物效果优于单纯MWA。

四川盆地下寒武统筇竹寺组海相页岩气高产井突破与富集模式

多年来下寒武统筇竹寺组页岩气勘探开发进展缓慢,资201井获高产气流大大增加了该套页岩气规模商业化开发的信心,不同区域及层段富集规律差异及下一步勘探开发方向是筇竹寺组页岩开发面临的首要问题。以四川盆地57口钻井资料为基础,对多口重点井的古生物、沉积、储层等特征进行分析,详细剖析资201井的部署理论依据、筇竹寺组页岩气富集条件及下一步勘探开发方向。从地层研究入手,建立了筇竹寺组地层划分标准,明确筇竹寺组主体发育4套深水陆棚相的富有机质页岩(①至④号层段),其分布受裂陷槽发育控制,裂陷槽内厚度最大。分析了页岩储层发育特征,指出储层压力、孔隙度、含气饱和度从下向上、从裂陷槽外到内呈现增大趋势,储层超压对页岩孔隙保存起到重要作用;基于此结合保存条件等建立了“多层异相、超压保孔”的页岩气超压差异富集模式,指出远离散失通道的超压孔隙发育区(层段)是页岩气富集有利区(层段)。文章指出资201井及周边是未来筇竹寺组页岩气增储上产的主要区域,资源量为8.06×10^(12)m^(3);川西地区具有相当的开发潜力,资源量为0.72×10^(12)m^(3);川南长宁及黔北一带受石墨化及构造活动影响,以寻找远离风化壳及地表露头的超压孔隙发育区为主。

钛合金薄壁构件快速加热冷模热冲压成形技术进展

为了解决钛合金薄壁构件热成形效率低、成本高、组织性能控制难度大等问题,近年来钛合金冷模热冲压成形技术受到关注。在该新技术中利用室温模具对加热后的钛合金板材进行快速冲压成形和模内快速冷却,由于取消了模具加热,可以变革性地提高钛合金薄壁构件成形效率、降低成本。然而,与传统等温成形不同,在冷模热冲压成形过程中,钛合金板材温度不断下降,这对钛合金成形极限、回弹及组织性能等的控制提出了全新的挑战。分析了钛合金薄壁构件冷模热冲压成形技术特点及存在的问题,归纳了快速加热对钛合金组织性能的影响规律,综述了钛合金薄壁构件快速加热冷模热冲压成形工艺进展,最后对该技术未来的发展方向进行了展望。

基于STAMP-偏序集的非煤矿山爆炸事故系统风险评估模型

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