This paper generalizes the definition and its scope of large scale activity based on its current practice and supervision system in China, makes risk analysis during activities, and puts forward proposals on carrying ...This paper generalizes the definition and its scope of large scale activity based on its current practice and supervision system in China, makes risk analysis during activities, and puts forward proposals on carrying out relevant standardization works after discussions about the actuality and prospect of social security on large scale activities in China.展开更多
Objective： Diffuse large B-cell lymphoma （DLBCL） is a heterogeneous disease. The prognostic factor currently used is not accurate enough to predict the outcomes of patients with DLBCL. The prognostic significance o...Objective： Diffuse large B-cell lymphoma （DLBCL） is a heterogeneous disease. The prognostic factor currently used is not accurate enough to predict the outcomes of patients with DLBCL. The prognostic significance of interim PET/CT in DLBCL remains controversial. The aim of this study is to determine the predictive value of interim 18F-FDG PET/CT after first-line treatment in patients with DLBCL. Methods： Thirty-two patients with DLBCL underwent baseline, interim and post-treatment lSF-FDG PET/CT scans. Imaging results were analyzed for the survival of patients via software SPSS 13.0, retrospectively. Results： Thirty-one of the 32 patients were treated with R-CHOP regimen, and interim 18F-FDG PET/CT of 24 patients was performed after 2 cycles of treatment. After a median follow-up period of 16.7 months, the 2-year progression-free survival （PFS） rates were significantly different between the groups above and below SUVmax CUt-Off value of 2.5 （P=0.039）. No significant differences were found in the 2-year PFS rates if SUVm, cut-offvalues were set as 2.0 and 3.0, respectively （P=0.360; P=0.113）. Conclusions： Interim PET/CT could predict the prognosis of DLBCL patients with the SUVmax cut-off value of 2.5, but more clinical data should be concluded to confirm this conclusion.展开更多
In the context of constructing Global Energy Interconnection(GEI), energy storage technology, as one of the important basic supporting technologies in power system, will play an important role in the energy configurat...In the context of constructing Global Energy Interconnection(GEI), energy storage technology, as one of the important basic supporting technologies in power system, will play an important role in the energy configuration and optimization. Based on the most promising battery energy storage technology, this paper introduces the current status of the grid technology, the application of large-scale energy storage technology and the supporting role of battery energy storage for GEI. Based on several key technologies of large-scale battery energy storage system, preliminary analysis of the standard system construction of energy storage system is made, and the future prospect is put forward.展开更多
To detect the prognostic significance of interim F-FDG PET/CT SUV(standard uptake value) reduction(△SUV_(max)) associated with Ki67 in patients with diffuse large B cell lymphoma(DLBCL).47 DLBCL patients underwent PE...To detect the prognostic significance of interim F-FDG PET/CT SUV(standard uptake value) reduction(△SUV_(max)) associated with Ki67 in patients with diffuse large B cell lymphoma(DLBCL).47 DLBCL patients underwent PET/CT before initiation and after 2-4 cycles of chemotherapy were included.The SUV_(max)of the dominant lesions were calculated.Ki67 positive indices were provided by enzyme-labeled immunohistochemistry.SPSS17.0 was used for statistical analysis.ASUV_(max) of different groups were compared by t test.Receiver-operator characteristic analysis was performed to determine the optimal cutoff values.KaplanMeier analyses of PFS(Progression-free survival) were compared using log-rank test.The average of △SUV_(max)and △SUV_(max)%were 11.53 and 69.10%,respectively.The optimal cutoff values of △SUV_(max)x and △SUV_(max)%were 11.45 and 82.92%,respectively.Higher △SUV_(max) and △SUV_(max)%indicated longer PFS(p < 0.001).The optimal cutoff value of Ki67 was 55%.Ki67>55%was revealed to be an indicator of shorter PFS(p = 0.019).Either △SUV_(max)≤11.45 or Ki67>55%was defined as an indicator to poor outcome and scored 1 point.The PFS rate was 100%in patients scored 0 point,yet 0%in patients scored 2 points.PFS tended to be shorter along with the score getting higher(p = 0.006).△SUV_(max) and Ki67 positive index were both of significance in DLBCL prognosis.The prognostic value may be confirmed when △SUV_(max) was accordant with Ki67.展开更多
The purchasement and development as well as the benefit of utilization for the large equipment in universities of China are analyzed in this paper, the paper in dicates that in utilization of large equipment the contr...The purchasement and development as well as the benefit of utilization for the large equipment in universities of China are analyzed in this paper, the paper in dicates that in utilization of large equipment the contradictions such as urgency and necessity for the purchasement and development of large equipment and serious waste in resources since inadequacy of annual utilization rate of large equipment are existed, it also raises that the key step of giving full play to the benefit of large equipment is to strengthen management and development after the equipment are purchased, the paper regards through stressing standardized management and maintenance、opening the laboratory、improving the functions of equipment、renovating technology、fully examining and scientifically deciding before purchasement, the investment benefit for the large equipment can be raised effectively.展开更多
Nanoparticles provide great advantages but also great risks. Risks associating with nanoparticles are the problem of all technologies, but they increase in many times in nanotechnologies. Adequate methods of outgoing ...Nanoparticles provide great advantages but also great risks. Risks associating with nanoparticles are the problem of all technologies, but they increase in many times in nanotechnologies. Adequate methods of outgoing production inspection are necessary to solve the problem of risks, and the inspection must be based on the safety standard. Existing safety standard results from a principle of “maximum permissible concentrations or MPC”. This principle is not applicable to nanoparticles, but a safety standard reflecting risks inherent in nanoparticles doesn’t exist. Essence of the risks is illustrated by the example from pharmacology, since its safety assurance is conceptually based on MPC and it has already come against this problem. Possible formula of safety standard for nanoparticles is reflected in many publications, but conventional inspection methods cannot provide its realization, and this gap is an obstacle to assumption of similar formulas. Therefore the development of nanoparticle industry as a whole (also development of the pharmacology in particular) is impossible without the creation of an adequate inspection method. There are suggested new inspection methods founded on the new physical principle and satisfying to the adequate safety standard for nanoparticles. These methods demonstrate that creation of the adequate safety standard and the outgoing production inspection in a large-scale manufacturing of nanoparticles are the solvable problems. However there is a great distance between the physical principle and its hardware realization, and a transition from the principle to the hardware demands great intellectual and material costs. Therefore it is desirable to call attention of the public at large to the necessity of urgent expansions of investigations associated with outgoing inspections in nanoparticles technologies. It is necessary also to attract attention, first, of representatives of state structures controlling approvals of the adequate safety standard to this problem, since it is impossible to compel producers providing the safety without the similar standard, and, second, of leaders of pharmacological industry, since their industry already entered into the nanotechnology era, and they have taken an interest in a forthcoming development of inspection methods.展开更多
文摘This paper generalizes the definition and its scope of large scale activity based on its current practice and supervision system in China, makes risk analysis during activities, and puts forward proposals on carrying out relevant standardization works after discussions about the actuality and prospect of social security on large scale activities in China.
文摘Objective： Diffuse large B-cell lymphoma （DLBCL） is a heterogeneous disease. The prognostic factor currently used is not accurate enough to predict the outcomes of patients with DLBCL. The prognostic significance of interim PET/CT in DLBCL remains controversial. The aim of this study is to determine the predictive value of interim 18F-FDG PET/CT after first-line treatment in patients with DLBCL. Methods： Thirty-two patients with DLBCL underwent baseline, interim and post-treatment lSF-FDG PET/CT scans. Imaging results were analyzed for the survival of patients via software SPSS 13.0, retrospectively. Results： Thirty-one of the 32 patients were treated with R-CHOP regimen, and interim 18F-FDG PET/CT of 24 patients was performed after 2 cycles of treatment. After a median follow-up period of 16.7 months, the 2-year progression-free survival （PFS） rates were significantly different between the groups above and below SUVmax CUt-Off value of 2.5 （P=0.039）. No significant differences were found in the 2-year PFS rates if SUVm, cut-offvalues were set as 2.0 and 3.0, respectively （P=0.360; P=0.113）. Conclusions： Interim PET/CT could predict the prognosis of DLBCL patients with the SUVmax cut-off value of 2.5, but more clinical data should be concluded to confirm this conclusion.
基金supported by National Key R&D Program of China(2017YFB0903504)
文摘In the context of constructing Global Energy Interconnection(GEI), energy storage technology, as one of the important basic supporting technologies in power system, will play an important role in the energy configuration and optimization. Based on the most promising battery energy storage technology, this paper introduces the current status of the grid technology, the application of large-scale energy storage technology and the supporting role of battery energy storage for GEI. Based on several key technologies of large-scale battery energy storage system, preliminary analysis of the standard system construction of energy storage system is made, and the future prospect is put forward.
文摘To detect the prognostic significance of interim F-FDG PET/CT SUV(standard uptake value) reduction(△SUV_(max)) associated with Ki67 in patients with diffuse large B cell lymphoma(DLBCL).47 DLBCL patients underwent PET/CT before initiation and after 2-4 cycles of chemotherapy were included.The SUV_(max)of the dominant lesions were calculated.Ki67 positive indices were provided by enzyme-labeled immunohistochemistry.SPSS17.0 was used for statistical analysis.ASUV_(max) of different groups were compared by t test.Receiver-operator characteristic analysis was performed to determine the optimal cutoff values.KaplanMeier analyses of PFS(Progression-free survival) were compared using log-rank test.The average of △SUV_(max)and △SUV_(max)%were 11.53 and 69.10%,respectively.The optimal cutoff values of △SUV_(max)x and △SUV_(max)%were 11.45 and 82.92%,respectively.Higher △SUV_(max) and △SUV_(max)%indicated longer PFS(p < 0.001).The optimal cutoff value of Ki67 was 55%.Ki67>55%was revealed to be an indicator of shorter PFS(p = 0.019).Either △SUV_(max)≤11.45 or Ki67>55%was defined as an indicator to poor outcome and scored 1 point.The PFS rate was 100%in patients scored 0 point,yet 0%in patients scored 2 points.PFS tended to be shorter along with the score getting higher(p = 0.006).△SUV_(max) and Ki67 positive index were both of significance in DLBCL prognosis.The prognostic value may be confirmed when △SUV_(max) was accordant with Ki67.
文摘The purchasement and development as well as the benefit of utilization for the large equipment in universities of China are analyzed in this paper, the paper in dicates that in utilization of large equipment the contradictions such as urgency and necessity for the purchasement and development of large equipment and serious waste in resources since inadequacy of annual utilization rate of large equipment are existed, it also raises that the key step of giving full play to the benefit of large equipment is to strengthen management and development after the equipment are purchased, the paper regards through stressing standardized management and maintenance、opening the laboratory、improving the functions of equipment、renovating technology、fully examining and scientifically deciding before purchasement, the investment benefit for the large equipment can be raised effectively.
文摘Nanoparticles provide great advantages but also great risks. Risks associating with nanoparticles are the problem of all technologies, but they increase in many times in nanotechnologies. Adequate methods of outgoing production inspection are necessary to solve the problem of risks, and the inspection must be based on the safety standard. Existing safety standard results from a principle of “maximum permissible concentrations or MPC”. This principle is not applicable to nanoparticles, but a safety standard reflecting risks inherent in nanoparticles doesn’t exist. Essence of the risks is illustrated by the example from pharmacology, since its safety assurance is conceptually based on MPC and it has already come against this problem. Possible formula of safety standard for nanoparticles is reflected in many publications, but conventional inspection methods cannot provide its realization, and this gap is an obstacle to assumption of similar formulas. Therefore the development of nanoparticle industry as a whole (also development of the pharmacology in particular) is impossible without the creation of an adequate inspection method. There are suggested new inspection methods founded on the new physical principle and satisfying to the adequate safety standard for nanoparticles. These methods demonstrate that creation of the adequate safety standard and the outgoing production inspection in a large-scale manufacturing of nanoparticles are the solvable problems. However there is a great distance between the physical principle and its hardware realization, and a transition from the principle to the hardware demands great intellectual and material costs. Therefore it is desirable to call attention of the public at large to the necessity of urgent expansions of investigations associated with outgoing inspections in nanoparticles technologies. It is necessary also to attract attention, first, of representatives of state structures controlling approvals of the adequate safety standard to this problem, since it is impossible to compel producers providing the safety without the similar standard, and, second, of leaders of pharmacological industry, since their industry already entered into the nanotechnology era, and they have taken an interest in a forthcoming development of inspection methods.
