Development of a new cerebral ischemia reperfusion model of Mongolian gerbils and standardized evaluation system

Background:The Mongolian gerbil is an excellent laboratory animal for preparing the cerebral ischemia model due to its inherent deficiency in the circle of Willis.However,the low incidence and unpredictability of symptoms are caused by numerous complex variant types of the circle.Additionally,the lack of an evaluation system for the cer-ebral ischemia/reperfusion(I/R)model of gerbils has shackled the application of this model.Methods:We created a symptom-oriented principle and detailed neurobehavioral scoring criteria.At different time points of reperfusion,we analyzed the alteration in locomotion by rotarod test and grip force score,infarct volume by triphenyltetrazo-lium chloride(TTC)staining,neuron loss using Nissl staining,and histological charac-teristics using hematoxylin-eosin(H&E)straining.Results:With a successful model rate of 56%,32 of the 57 gerbils operated by our method harbored typical features of cerebral I/R injury,and the mortality rate in the male gerbils was significantly higher than that in the female gerbils.The suc-cessfully prepared I/R gerbils demonstrated a significant reduction in motility and grip strength at 1 day after reperfusion;formed obvious infarction;exhibited typi-cal pathological features,such as tissue edema,neuronal atrophy and death,and vacuolated structures;and were partially recovered with the extension of reperfu-sion time.Conclusion:This study developed a new method for the unilateral common carotid artery ligation I/R model of gerbil and established a standardized evaluation system for this model,which could provide a new cerebral I/R model of gerbils with more practical applications.

Calculation of Particle Decay Times in the Standard Model

We present here a two-step method of classification and calculation for decay rates in the Standard Model. The first step is a phenomenological classification method, which is an extended and improved schematic experimental formula for decay width originally introduced by Chang. This schematic formula separates decays into seven classes. Furthermore, from it is derived a process-specific interaction energy mX. The second step is a numerical calculation method, which calculates this interaction energy mX numerically by minimization of action from the Lagrangian of the process, from which follows the decay width via the phenomenological formula. The Lagrangian is based on an extension of the Standard Model, the extended SU(4)-preon-model. A comparison of numerically calculated and observed decay widths for a large selection of decays shows a good agreement.

Calculation of the Standard Model Parameters and Particles Based on a SU(4) Preon Model

This paper describes an extension and a new foundation of the Standard Model of particle physics based on a SU(4)-force called hyper-color, and on preon subparticles. The hyper-color force is a generalization of the SU(2)-based weak interaction and the SU(1)-based right-chiral self-interaction, in which the W-and the Z-bosons are Yukawa residual-field-carriers of the hyper-color force, in the same sense as the pions are the residual-field-carriers of the color SU(3) interaction. Using the method of numerical minimization of the SU(4)-action based on this model, the masses and the inner structure of leptons, quarks and weak bosons are calculated: the mass results are very close to the experimental values. We calculate also precisely the value of the Cabibbo angle, so the mixing matrices of the Standard model, CKM matrix for quarks and PMNS matrix for neutrinos can also be calculated. In total, we reduce the 29 parameters of the Standard Model to a total of 7 parameters.

Non-Uniform Pion Tetrahedron Aether and Electron Tetrahedron Model

We propose that the QCD vacuum pion tetrahedron condensate density vary in space and drops to extremely low values in the Kennan, Barger and Cowie (KBC) void in analogy to earth’s atmospheric density drop with elevation from earth. We propose a formula for the gravitation acceleration based on the non-uniform pion tetrahedron condensate. Gravity may be due to the underlying microscopic attraction between quarks and antiquarks, which are part of the vacuum pion tetrahedron condensate. We propose an electron tetrahedron model, where electrons are comprised of tetraquark tetrahedrons, and . The quarks determine the negative electron charge and the or quarks determine the electron two spin states. The electron tetrahedron may perform a high frequency quark exchange reactions with the pion tetrahedron condensate by tunneling through the condensation gap creating a delocalized electron cloud with a fixed spin. The pion tetrahedron may act as a QCD glue bonding electron pairs in atoms and molecules and protons to neutrons in the nuclei. Conservation of valence quarks and antiquarks is proposed.

The Standard Model Theory [May Be] a Wrong Theory

The Standard Model is the theory of Physics that describes the elementary particles of matter and the strong, weak and electromagnetic interactions, between them. The theory of the Standard Model does not include the description of the gravitational interactions. It is a very well founded theory that has predicted many experimental results, such as the existence of many particles and has withstood many experimental tests. The key missing piece of the theory to fill in was the Higgs boson, whose existence was reasonably suspected and confirmed by CERN’s ATLAS and CMS experiments in 2012. The current synthesis of the theory was completed in the mid-1970s, after the experimental confirmation of the existence of the quarks, and then confirmed, with the discovery of the Higgs boson, in 2012. All these, are according to the established views of science. But according to the opinions of many scientists, opinions with which I as the author of this paper agree, the theory of the Standard Model is a wrong theory because, while it makes some successful predictions, it does not answer to a number of many other questions that it should answer for its final establishment. Specifically and according to established views, the theory cannot explain the existence of dark matter and dark energy, the behavior of neutrinos and the existence of particles with very different masses. It is also questionable whether the Higgs boson, discovered in the ATLAS experiment is actually the particle that contributes to the creation of the mass of the elementary particles of matter, and whether the Higgs mechanism is theoretically a correct mechanism. There is doubt if the interactions, actually be created by the exchange of bosons? If bosons are really exist? And not any convincing explanation is given by the theory, for the case that, the bosons exist as particles, where were they found? And how do they work? For replace, or fill the void will be left by the theory of the Standard Model, which I believe sooner or later will be renewed or retired, I propose a New Model that more convincingly describes the elementary components of matter and the interactions between them. The New Model also addresses all the weak points of the theory of the Standard Model, including the interaction of gravity. But the main feature of the New Model, which will surprise you! Is its reliability, correctness, logic and simplicity. But this is something you will judge after studying the New Model.

Theory of 3F4D Universe (Beyond Standard Model of Particle Physics)

In this theory, “mass is equivalent to length of imaginary straight line segment” and “direction to imaginary line segment is intrinsic property of that particle which is Equivalent to its intrinsic spin”. With this concept, all fundamental particles, fermions and bosons are described as quanta imaginary string particles with a definite direction. For e.g. unidirectional imaginary straight line with fixed length are massive spin 1/2 fermions;while unidirectional imaginary quanta curved lines are massless spin 1 bosons. Thus, it gives co-relation between massless (curved imaginary line) and spin = 1 properties of boson as proved in QED theory. All fundamental particles of standard model and beyond standard model are arranged in one simple diagram in 3 folds (bottom fold, middle upper and lower folds and top fold) and are projected in 4th Imaginary Dimension in order of decreased in Mass from TeV to approx. 0 eV. This theory is beyond standard model because it predicts new fundamental particles viz. dark matter (spin = 0 massive boson) along with gravitons (spin = 2, massless bosons);4th pair of neutrinos, vertical massless boson (VMB) particles and tri-axis massive boson (spin = 0) particle. The discovery of these new particles will act as solid proof to this theory. With this 3F4D representation of the universe at an atomic and sub-atomic level, it solves lots of current problems of SM of particle physics like matter-antimatter asymmetry, origin of mass of hadrons like protons, origin of mass and L.H. nature for neutrinos, wave-particle duality of particles, etc. giving true insight of fundamental particles. With proving that, dark matter is not a quanta particle, rather it is a single entity and spreads/expands throughout the universe in the form of “web of spider”, it shows space-time is not empty, but it is filled with Continuous lines of Dark Matter and we, materialistic massive objects are floating/sailing w.r.t. current of this vast ocean. Correlation of its continuity with time gives new a definition to time: “Time is neither Illusion nor 4th Dimension, but, it represents Continuous Flow of Single Entity, Dark Matter”. Space-time is not Empty and is filled with massive dark matter, hence, we have to add more terms to newtonian gravitational equation to account for gravitational strength of mass of surrounding dark matter which represents curvature of space-time in terms of Increase in its mass-density w.r.t. to mass-density of flat universe. Finally, using an empirical formula (h = k*c*Q;k = boltzmann’s constant = mass in TeV range) and inverse relation of mass-density of DM with age of the universe (H2 = Constant•G•Mass-Density of DM);Unification of Gravity at TeV is achieved without consideration of “Gravitational Constant, G”, hence, Planck’s Scale is not required.

Attribute-Based Re-Encryption Scheme in the Standard Model

In this paper, we propose a new attribute-based proxy re-encryption scheme, where a semi-trusted proxy, with some additional information, can transform a ciphertext under a set of attributes into a new ciphertext under another set of attributes on the same message, but not vice versa, furthermore, its security was proved in the standard model based on decisional bilinear Diffie-Hellman assumption. This scheme can be used to realize fine-grained selectively sharing of encrypted data, but the general proxy rencryption scheme severely can not do it, so the proposed schemecan be thought as an improvement of general traditional proxy re-encryption scheme.

Cryptanalysis and Improvement of a New Certificateless Signature Scheme in the Standard Model

Digital signature,as an important cryptographic primitive,has been widely used in many application scenarios,such as e-commerce,authentication,cloud computing,and so on.Certificateless Public Key Cryptography(PKC)can get rid of the certificate management problem in the traditional Public Key Infrastructure(PKI)and eliminate the key-escrow problem in the identity-based PKC.Lately,a new Certificateless Signature(CLS)scheme has been proposed by Kyung-Ah Shim(IEEE SYSTEMS JOURNAL,2018,13(2)),which claimed to achieve provable security in the standard model.Unfortunately,we present a concrete attack to demonstrate that the scheme cannot defend against the Type I adversary.In this type of attack,the adversary can replace the public key of the signer,and then he plays the role of the signer to forge a legal certificateless signature on any message.Furthermore,we give an improved CLS scheme to resist such an attack.In terms of the efficiency and the signature length,the improved CLS is preferable to the original scheme and some recently proposed CLS schemes in the case of precomputation.

Particles Composition and Interactions Using the Nuon Model

The Standard Model in Particle Physics has been able to make many predictions confirmed later with a flow of experimental results. With the discovery of the Higgs boson at the LHC, one is full of admiration for the people contributing to this model fifty years ago and its predictions that have been confirmed gradually. The original particle quark constituent model has evolved with the deep inelastic experiments to a quark and gluons system, then to a more general system with virtual quarks. This work is the result of observations while working at CERN in Geneva with many different experiments at the ISR, SPS, LEP, LHC colliders. A new model based on nuons is introduced, that allows accurate evaluations of the particle masses (mesons and baryons) and magnetic moment, computes very accurately the kinematics distributions for particles and jets observed in the p-p collisions at the LHC (elastic and inelastic) and at lower energy machines. This new model looks at a first glance in contradiction with the quark model because it can build the elementary particles with nuons only, i.e. electrons and neutrinos. However, all the existing physics involved in electron, positron and neutrino interactions may be used to explain interactions between composite particles such as protons or heavy ions.

The Complex Field Theory and Mass Formation—An Alternative Model to Higgs Mechanism

The electromagnetic force, strong nuclear force, weak nuclear force, and gravitational force are the four fundamental forces of nature. The Standard Model (SM) succeeded in combining the first three forces to describe the most basic building blocks of matter and govern the universe. Despite the model’s great success in resolving many issues in particle physics but still has several setbacks and limitations. The model failed to incorporate the fourth force of gravity. It infers that all fermions and bosons are massless contrary to experimental facts. In addition, the model addresses neither the 95% of the universe’s energy of Dark Matter (DM) and Dark Energy (DE) nor the universe’s expansion. The Complex Field Theory (CFT) identifies DM and DE as complex fields of complex masses and charges that encompasses the whole universe, and pervade all matter. This presumption resolves the issue of failing to detect DM and DE for the last five decades. The theory also presents a model for the universe’s expansion and presumes that every material object carries a fraction of this complex field proportional to its mass. These premises clearly explain the physical nature of the gravitational force and its complex field and pave the way for gravity into the SM. On the other hand, to solve the issue of massless bosons and fermions in the SM, Higgs mechanism introduces a pure and abstractive theoretical model of unimaginable four potentials to generate fictitious bosons as mass donors to fermions and W± and Z bosons. The CFT in this paper introduces, for the first time, a physical explanation to the mystery of the mass formation of particles rather than Higgs’ pure mathematical derivations. The analyses lead to uncovering the mystery of electron-positron production near heavy nuclei and never in a vacuum. In addition, it puts a constraint on Einstein’s mass-energy equation that energy can never be converted to mass without the presence of dense dark matter and cannot be true in a vacuum. Furthermore, CFT provides different perspectives and resolves real-world physics concepts such as the nuclear force, Casimir force, Lamb’s shift, and the anomalous magnetic moment to be published elsewhere.

Stability analysis of discrete-time BAM neural networks based on standard neural network models

To facilitate stability analysis of discrete-time bidirectional associative memory (BAM) neural networks, they were converted into novel neural network models, termed standard neural network models (SNNMs), which interconnect linear dynamic systems and bounded static nonlinear operators. By combining a number of different Lyapunov functionals with S-procedure, some useful criteria of global asymptotic stability and global exponential stability of the equilibrium points of SNNMs were derived. These stability conditions were formulated as linear matrix inequalities (LMIs). So global stability of the discrete-time BAM neural networks could be analyzed by using the stability results of the SNNMs. Compared to the existing stability analysis methods, the proposed approach is easy to implement, less conservative, and is applicable to other recurrent neural networks.

Semi-Harmonic Scaling Enables Calculation of Masses of Elementary Particles of the Standard Model

The underlying rules for a natural system describing cellular automata are simple, but produce highly complex behavior. A mathematical basis for the spectra of discrete coherent and non-coherent electromagnetic (EM) frequencies was derived, in which the algorithm exhibits an information distribution according to ratios of 2:3 in 1:2 at a semi-harmonic manner. This generalized music (GM) model shows that energy both in elementary particles and animate systems is semi-harmonic, quantized and discrete. A support for an ontological basis of the Standard Model was found, and indicates that the GM-model underlies the quantum field theory of subatomic particles. The present theory combines quantum mechanics and classical periodic systems, obeys to locality and solves the “hidden variable theory of Bohm”. The discovered pattern of electromagnetic field eigenvalues, within a broad range of discrete frequencies, points at a de Broglie/Bohm type of causal interpretation of quantum mechanics, implying an integral resonant pilot-wave/particle modality. The model has been substantiated by a meta-analysis of measured discrete energies of: 37 different Elementary Particles, 45 different EPR-measurements, zero-point energies of elements and about 450 electromagnetic wave frequencies of cells with a mean accuracy of 0.58%. It has been shown that the GM-scale is frequency-locked with zero-point oscillations, and thereby evidently implies involvement of entanglement.

Spatiotemporal patterns and drivers of cultivated land conversion in Inner Mongolia Autonomous Region,northern China

Protection and optimization of cultivated land resources are of great significance to national food security.Cultivated land conversion in northern China has increased in recent years due to the industrialization and urbanization of society.However,the assessment of cultivated land conversion in this area is insufficient,posing a potential risk to cultivated land resources.This study evaluated the evolution and spatiotemporal patterns of cultivated land conversion in Inner Mongolia Autonomous Region,China,and the driving factors to improve rational utilization and to protect cultivated land resources.The spatiotemporal patterns of cultivated land conversion in Inner Mongolia were analyzed using the cultivated land conversion index,kernel density analysis,a standard deviation ellipse model,and a geographic detector.Results showed that from 2000 to 2020,the trends in cultivated land conversion area and rate in Inner Mongolia exhibited fluctuating growth,with the total area of cultivated land conversion reaching 7307.59 km^(2) at a rate of 6.69%.Spatial distribution of cultivated land conversion was primarily concentrated in the Hetao Plain,Nengjiang Plain,Liaohe Plain,and the Hohhot-Baotou-Ordos urban agglomeration.Moreover,the standard deviational ellipse of cultivated land conversion in Inner Mongolia exhibited a directional southwest-northeast-southwest-northeast distribution,with the northeast-southwest direction identified as the main driving force of spatial change in cultivated land conversion.Meanwhile,cultivated land conversion exhibited an increase-decrease-increase change process,indicating that spatial distribution of cultivated land conversion in Inner Mongolia became gradually apparent within the study period.The geographic detector results further revealed that the main driving factors of cultivated land conversion in Inner Mongolia were the share of secondary and tertiary industries and per-unit area yield of grain,with explanatory rates of 57.00%,55.00%,and 51.00%,respectively.Additionally,improved agricultural production efficiency and the coordinated development of population urbanization and industry resulted in cultivated land conversion.Collectively,the findings of this study indicated that,from 2000 to 2020,the cultivated land conversion in Inner Mongolia was significant and fluctuated in time,and had strong spatial heterogeneity.The primary drivers of these events included the effects of agriculture,population,and social economy.

Structural Foundation and Geometry of the Material Singularity (and Its Quantum Entanglement)

In this paper we develop and study, as the second part of one more general development, the energy transmutation equation for the material singularity, previously obtained through the symmetrisation of a wave packet, that is, we develop the correlation between the terms of this equation, which accounts for the formation of matter from a previous vibrational state, and the different possible energy species. These energetic species are ascribed, in a simplified form, to the equation E¯ω=E¯k+E¯f, which allows us, through its associated phase factor, to gain an insight into the wave character of the kinetic energy and thus to attain the basis of the matter-wave, and all sorts of related phenomenologies, including that concerning quantum entanglement. The formation of the matter was previously identified as an energetic process, analogous to the kinetic one, in which finally the inertial mass is consolidated as a mass in a different phase, now, in addition, the mass of the material singularity is identified as a volumetric density of waves of toroidal geometry created in the process of singularisation or energy transfer between species, which makes it possible to establish the real relation or correspondence between the corpuscular and photonic energy equation (E=mc2=hν), i.e. to explain through m the intimate sense of the first equivalence, which explains what νis in the second one.

Quantum Mechanics and General Relativity Identify Standard Model Particles as Black Holes

The Standard Model of particle physics does not account for charged fermion mass values and neutrino mass, or explain why only three particles are in each charge state 0, -e/3, 2e/3, and -e. These issues are addressed by treating Standard Model particles with mass m as spheres with diameter equal to their Compton wavelength l =ħ/mc, where ħis Planck’s constant and c the speed of light, and any charge in diametrically opposed pairs ±ne/6 with n = 1, 2, or 3 at the axis of rotation on the sphere surface. Particles are ground state solutions of quantized Friedmann equations from general relativity, with differing internal gravitational constants. Energy distribution within particles identifies Standard Model particles with spheres containing central black holes with mass m, and particle spin resulting from black hole angular momentum. In each charge state, energy distribution within particles satisfies a cubic equation in l, allowing only three particles in the charge state and requiring neutrino mass. Cosmic vacuum energy density is a lower limit on energy density of systems in the universe, and setting electron neutrino average energy density equal to cosmic vacuum energy density predicts neutrino masses consistent with experiment. Relations between charged fermion wavelength solutions to cubic equations in different charge states determine charged fermion masses relative to electron mass as a consequence of charge neutrality of the universe. An appendix shows assigning charge ±e/6 to bits of information on the event horizon available for holographic description of physics in the observable universe accounts for dominance of matter over anti-matter. The analysis explains why only three Standard Models are in each charge state and predicts neutrino masses based on cosmic vacuum energy density as a lower bound on neutrino energy density.

Estimate Totel Number of the Earth Atmospheric Particle with Standard Atmosphere model

The total number of atmospheric particle (AP) is an important datum for planetary science and geoscience. Estimating entire AP number is also a familiar question in general physics. With standard atmosphere model, considering the number difference of AP caused by rough and uneven in the earth surface below, the sum of dry clean atmosphere particle is . So the whole number of AP including water vapor is . The rough estimation for the total number of AP on other planets (or satellites) in condensed state is also discussed on the base of it.

Neutral Higgs Boson Pair Production in Standard Model with the Fourth GenerationQuarks at LHC

We investigated the neutral Higgs boson pair production at the CERN Large Hadron Collider (LHC) in the SM with four families. We found that the gluon-gluon fusion mode is the most dominant one in producing neutral Higgs boson pair at the LHC, and it can be used to probe the trilinear Higgs coupling. If the heavy quarks of the fourth generation really exist within the SM, they can manifest their effect on the cross section of the Higgs pair production process at the LHC. Our numerical results show that there will be neutral Higgs boson pair production events per year if the next generation heavy quarks really exist, while there will be only events produced per year if there are only three families in the SM.

On the Possible Structures of Electron and Proton

In this work, the possible structures of electron and proton have been explored. Based on the potential expressions of electron and proton, we found that the electron and proton share the similar structure inside re and rn. And within re and rn, the conventional charge concept stops working, the same charge repelling force doesn’t exist anymore and as a result, the requirement of charge conservation is automatically removed. Whereas beyond re and rn, the potential expressions of electron and proton obey the point charge potentials as we normally understand. Therefore, the conventional charge concept can be applied and the requirement of charge conservation takes effect. Furthermore, a possible mechanism for the creations of electric monopole and magnetic monopole is discussed. In addition, to compare the particle size in micro-world, the balloon criterion is proposed. By this balloon criterion, the proton is determined about 10 times bigger than electron. From the physical picture about electron and proton described above, the stabilities of electron and proton can be explained quite well.

Estimates of the Charges and Size of the Three Types of Neutrinos

It is the current belief of the Physics Community that neutrinos are bereft of Charge because of Conservation of Charge in decay processes such as Beta Decay and are point particles with no physical size or shape. It is the purpose of this paper to calculate the charges and the size of the electron neutrino, the muon neutrino, and the tau neutrino based on data available of their rest masses using the charges and rest masses of the electron, muon, and tau leptons from the Standard Model of Particle Physics Table. We base our calculations on the premise that Energy can create both Mass and Charge. Charge by itself is not conserved in any process that produces neutrinos. Only Total Energy is conserved.

R-Parity Violation Effects on b_1 → bχ_1~0 in Minimal SupersymmetricStandard Model

We investigate in detail the effects of R-parity lepton number violation onthe decay b_1 → bχ_1~0 in the R-parity violating minimal supersymmetric standard model (R_p-MSSM)under the present experimental constraints on R_p parameters. In our numerical calculations weconsider two cases of input parameters of the squark and slepton sectors, M_(squark) 【 M_(slepton)and M_(squark) 】 M_(slepton), for comparison. The results show that the relative R-parity violatingcorrection is not very sensitive to the mass of the lightest neutralino bχ_1~0 the degenerateR-parity violating coupling parameter λ′_2 but strongly depends on M_(squark), M_(slepton) tan βand tie degenerate R-parity violating coupling parameter λ′_1. The relative correction is about -4～ 3% and can exceed -6% in some region of parameter space. Therefore, precise experiment analyseson the decay b_1 → bχ_1~0 may provide a probe of the R-parity violation.