AIM: To review and assess the evidence related to cetuximab treatment in metastatic colorectal cancer(mCRC) with regard to KRAS status.METHODS: PubMed, EMBASE, Cochrane database and American Society of Clinical Oncolo...AIM: To review and assess the evidence related to cetuximab treatment in metastatic colorectal cancer(mCRC) with regard to KRAS status.METHODS: PubMed, EMBASE, Cochrane database and American Society of Clinical Oncology meeting abstracts were searched for randomized controlled trials(RCTs) reporting the effect of KRAS status on efficacy of chemotherapy regimen with or without cetuximab in mCRC. Baseline information such as sex and age was summarized from the included studies.Hazard ratios of progression-free survival(PFS) and overall survival(OS) as well as objective response based on KRAS status were extracted for analysis.RESULTS: A total of 8 RCTs with 6780 patients were included. The combined analysis showed that cetuximab failed to improve the OS and PFS in patients with mCRC.However, in subgroup analysis, the pooled data showed that addition of cetuximab to irinotecan containing chemotherapy regimen was sufficient to improve OS and PFS in wild-type KRAS mCRC patients, but not in patients with mutant-type KRAS. The addition of cetuximab increased the incidence of adverse events such as diarrhea, rash, skin toxicity/rash, and nausea and vomiting. There was no significant publication bias existing in the included studies.CONCLUSION: The clinical benefit of cetuximab was only confirmed in patients with wild-type KRAS. KRAS status could be considered a biomarker of efficacy of cetuximab.展开更多
Objective To investigate the therapeutic effects of haploidentical hematopoietic stem - cell transplantation ( Haplo - PBSCT) for acute myeloid leukemia in first relapse after complete remission by standard induction ...Objective To investigate the therapeutic effects of haploidentical hematopoietic stem - cell transplantation ( Haplo - PBSCT) for acute myeloid leukemia in first relapse after complete remission by standard induction chemotherapy. Methods Eighty - nine cases of AML in first relapse after complete remission by standard DA展开更多
Policy development on chemotherapy management has increased the demand for deeper knowledge in this field. In this way, there was a need to identify, recognize the consumption trends of chemotherapeutic and prioritize...Policy development on chemotherapy management has increased the demand for deeper knowledge in this field. In this way, there was a need to identify, recognize the consumption trends of chemotherapeutic and prioritize the interest of regulatory bodies, as well as to design programs for health education. In 1978 for the first time in Kosovo, a Hematology Department was established within the Internal Diseases Clinic by Dr. Shaban Geci. In 2013 it became a Clinic of Hematology. The Department of Clinical Hematology deals with the diagnosis of hematologic and hematopoietic diseases including erythrocytes, leukocytes, platelets as well as malignant diseases. Within the department is also the location for puncture and biopsy of the bone marrow as well as for ultrasonography. Methods: The study was prospective and was conducted at University Clinical Center of Kosova (UCCK) and is based on an anonymous survey designed specifically for this purpose. The subject of the analysis was the available space for hospitalization and administration of chemotherapeutic at UCCK, the existence or not of written protocols, and available technical equipment. Results: Respondents were asked how many nurses handle the administration of cytostatic at the clinic where they work. 48% of respondents state that 1 - 5 nurses deal with cytostatic administration, 52% of respondents say 1 - 15 nurses deal with cytostatic administration, while alternatives 6 - 10 nurses and 16 and more nurses were not selected by no respondents.展开更多
Three-dimensional(3D)printing technology,as a novel technical method,can convert conventional computed tomography(CT)or magnetic resonance imaging(MRI)scans to computer-aided design files and develop a 2D spatial stru...Three-dimensional(3D)printing technology,as a novel technical method,can convert conventional computed tomography(CT)or magnetic resonance imaging(MRI)scans to computer-aided design files and develop a 2D spatial structure into a 3D imaging structure.In recent years,the technology has been widely used in numerous areas,including head and neck surgery,orthopedics,and bio-medicinal research.This article uses examples of 3D printed tumor models to develop Response Evaluation Criteria In Solid Tumors(RECIST)standards to evaluate the changes in tumors.RECIST standard is currently recognized as the standard for assessment of chemotherapy.Under the RECIST standard,changes occurring in tumors before and after the surgery,are evaluated.The assessment depends upon a CT evaluation of the changes in the lesions with the largest diameters.In addition,the disease progression and stability of remission is also assessed.Three-dimensional printing technology is more intuitive in the evaluation of changes to human tumors following chemotherapy and targeted therapy.However,a few reports are available.展开更多
文摘AIM: To review and assess the evidence related to cetuximab treatment in metastatic colorectal cancer(mCRC) with regard to KRAS status.METHODS: PubMed, EMBASE, Cochrane database and American Society of Clinical Oncology meeting abstracts were searched for randomized controlled trials(RCTs) reporting the effect of KRAS status on efficacy of chemotherapy regimen with or without cetuximab in mCRC. Baseline information such as sex and age was summarized from the included studies.Hazard ratios of progression-free survival(PFS) and overall survival(OS) as well as objective response based on KRAS status were extracted for analysis.RESULTS: A total of 8 RCTs with 6780 patients were included. The combined analysis showed that cetuximab failed to improve the OS and PFS in patients with mCRC.However, in subgroup analysis, the pooled data showed that addition of cetuximab to irinotecan containing chemotherapy regimen was sufficient to improve OS and PFS in wild-type KRAS mCRC patients, but not in patients with mutant-type KRAS. The addition of cetuximab increased the incidence of adverse events such as diarrhea, rash, skin toxicity/rash, and nausea and vomiting. There was no significant publication bias existing in the included studies.CONCLUSION: The clinical benefit of cetuximab was only confirmed in patients with wild-type KRAS. KRAS status could be considered a biomarker of efficacy of cetuximab.
文摘Objective To investigate the therapeutic effects of haploidentical hematopoietic stem - cell transplantation ( Haplo - PBSCT) for acute myeloid leukemia in first relapse after complete remission by standard induction chemotherapy. Methods Eighty - nine cases of AML in first relapse after complete remission by standard DA
文摘Policy development on chemotherapy management has increased the demand for deeper knowledge in this field. In this way, there was a need to identify, recognize the consumption trends of chemotherapeutic and prioritize the interest of regulatory bodies, as well as to design programs for health education. In 1978 for the first time in Kosovo, a Hematology Department was established within the Internal Diseases Clinic by Dr. Shaban Geci. In 2013 it became a Clinic of Hematology. The Department of Clinical Hematology deals with the diagnosis of hematologic and hematopoietic diseases including erythrocytes, leukocytes, platelets as well as malignant diseases. Within the department is also the location for puncture and biopsy of the bone marrow as well as for ultrasonography. Methods: The study was prospective and was conducted at University Clinical Center of Kosova (UCCK) and is based on an anonymous survey designed specifically for this purpose. The subject of the analysis was the available space for hospitalization and administration of chemotherapeutic at UCCK, the existence or not of written protocols, and available technical equipment. Results: Respondents were asked how many nurses handle the administration of cytostatic at the clinic where they work. 48% of respondents state that 1 - 5 nurses deal with cytostatic administration, 52% of respondents say 1 - 15 nurses deal with cytostatic administration, while alternatives 6 - 10 nurses and 16 and more nurses were not selected by no respondents.
基金Supported by a grant from the National Natural Science Foundation of China(No.81702622)。
文摘Three-dimensional(3D)printing technology,as a novel technical method,can convert conventional computed tomography(CT)or magnetic resonance imaging(MRI)scans to computer-aided design files and develop a 2D spatial structure into a 3D imaging structure.In recent years,the technology has been widely used in numerous areas,including head and neck surgery,orthopedics,and bio-medicinal research.This article uses examples of 3D printed tumor models to develop Response Evaluation Criteria In Solid Tumors(RECIST)standards to evaluate the changes in tumors.RECIST standard is currently recognized as the standard for assessment of chemotherapy.Under the RECIST standard,changes occurring in tumors before and after the surgery,are evaluated.The assessment depends upon a CT evaluation of the changes in the lesions with the largest diameters.In addition,the disease progression and stability of remission is also assessed.Three-dimensional printing technology is more intuitive in the evaluation of changes to human tumors following chemotherapy and targeted therapy.However,a few reports are available.
