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Stem cell therapy for retinal diseases
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作者 Jose Mauricio Garcia Luisa Mendonca +3 位作者 Rodrigo Brant Murilo Abud Caio Regatieri Bruno Diniz 《World Journal of Stem Cells》 2015年第1期160-164,共5页
In this review, we discuss about current knowledge about stem cell(SC) therapy in the treatment of retinal degeneration. Both human embryonic stem cell and induced pluripotent stem cell has been growth in culture for ... In this review, we discuss about current knowledge about stem cell(SC) therapy in the treatment of retinal degeneration. Both human embryonic stem cell and induced pluripotent stem cell has been growth in culture for a long time, and started to be explored in the treatment of blinding conditions. The Food and Drug Administration, recently, has granted clinical trials using SC retinal therapy to treat complex disorders, as Stargardt's dystrophy, and patients with geographic atrophy, providing good outcomes. This study 's intent is to overview the critical regeneration of the subretinal anatomy through retinal pigment epithelium transplantation, with the goal of reestablish important pathways from the retina to the occipital cortex of the brain, as well as the differentiation from pluripotent quiescent SC to adult retina, and its relationship with a primary retinal injury, different techniques of transplantation, management of immune rejection and tumorigenicity, its potential application in improving patients' vision, and, finally, approaching future directions and challenges for the treatment of several conditions. 展开更多
关键词 Macular degeneration Human embryonic stem cell Induced pluripotent stem cell Retinal pigment epithelium stargardt's disease
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少年型遗传性黄斑变化(Stargardt’s病)家系报告
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作者 哈伟基 《蚌埠医药》 1995年第2期7-7,共1页
少年型遗传性黄斑变性(Stargardt's病)又名少年型遗传性黄斑营养不良症.这病与黄色斑眼底是否是一种病?还是病程经过中的不同表现?目前尚无结论.据文献上记载,当黄色斑病未侵及黄斑部时,也就是黄斑部未出现萎缩时,视力是好的,先证... 少年型遗传性黄斑变性(Stargardt's病)又名少年型遗传性黄斑营养不良症.这病与黄色斑眼底是否是一种病?还是病程经过中的不同表现?目前尚无结论.据文献上记载,当黄色斑病未侵及黄斑部时,也就是黄斑部未出现萎缩时,视力是好的,先证者;王,男,16岁。两眼视力模糊逐渐加重七年余。 展开更多
关键词 少年型遗传性黄斑变性 stargardt's 少年型遗传性黄斑营养不良症 常染色体遗传疾病 临床表现
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