BACKGROUND Alterations in health-related quality of life(HRQoL)and neuropsychological disorders were described in the hepatitis C virus(HCV)patients.Although several studies investigated the modifications of HRQoL aft...BACKGROUND Alterations in health-related quality of life(HRQoL)and neuropsychological disorders were described in the hepatitis C virus(HCV)patients.Although several studies investigated the modifications of HRQoL after HCV eradication,no data exists on the modifications of neuropsychological symptoms.AIM To investigate the effect of directly acting antivirals(DAAs)treatment on HRQoL and neuropsychological symptoms.METHODS Thirty nine patients with HCV infection underwent a neuropsychological assessment,including Zung-Self Depression-Rating-Scale,Spielberg State-Trait Anxiety Inventory Y1-Y2 and the Toronto-Alexithymia Scale-20 items before and after DAAs treatment.HRQoL was detected by Short-Form-36(SF-36).RESULTS All HRQoL domains,but role limitation physical and bodily pain,significantly improved after treatment.Interestingly,after DAAs treatment,all domains of HRQoL returned similar to those of controls.Each neuropsychological test significantly improved after HCV eradication.A significant correlation was observed among each psychological test and the summary components of SF-36.At multiple linear regression analysis including each psychological test as possible covariates,Zung-Self Depression Rating Scale(Zung-SDS)score was independently and significantly related to summary components of the SF-36 in the basal state and the difference between Zung-SDS score before and after treatment was the only variable significantly and independently related to the modification of HRQoL induced by the treatment.CONCLUSION Neuropsychological symptoms strongly influenced HRQoL in HCV patients and there was a significant improvement of neuropsychological tests and HRQoL after DAAs treatment.展开更多
The necessary and sufficient condition of the stability of linear nonautonomous system under the frequently-acting perturbation has been given and proved on the basis of[1] and [2], and the theorem of the equivalence ...The necessary and sufficient condition of the stability of linear nonautonomous system under the frequently-acting perturbation has been given and proved on the basis of[1] and [2], and the theorem of the equivalence on the uniform and asymptotical stability in the sense of Liapunov ami the stability under the frequently-acting perturbation of linear nonautonomous system has been given in this paper. Besides, the analysis of the dynamic stabilitv of robot has been presented by applying the theorem in this paper, which is closer to reality展开更多
In this paper the stability of nonlinear nonautonomous systems under the frequently-acting perturbation is studied. This study is a forward development of the study of the stability in the Liapunov sense; furthermore,...In this paper the stability of nonlinear nonautonomous systems under the frequently-acting perturbation is studied. This study is a forward development of the study of the stability in the Liapunov sense; furthermore, it is of significance in practice since perturbations are often not single in the time domain. Malkin proved a general theorem about thesubject. To apply the theorem, however, the user has to construct a Liapunov function which satisfies specified conditions and it is difficult to find such a function for nonlinear nonautonomous systems. In the light of the principle of Liapunov's indirect method, which is an effective method to decide the stability of nonlinear systems in the Liapunov sense, the authors have achieved several important conclusions expressed in the form of theorems to determine the stability of nonlinear nonautonomous systems under the frequently-acting perturbation.展开更多
文摘BACKGROUND Alterations in health-related quality of life(HRQoL)and neuropsychological disorders were described in the hepatitis C virus(HCV)patients.Although several studies investigated the modifications of HRQoL after HCV eradication,no data exists on the modifications of neuropsychological symptoms.AIM To investigate the effect of directly acting antivirals(DAAs)treatment on HRQoL and neuropsychological symptoms.METHODS Thirty nine patients with HCV infection underwent a neuropsychological assessment,including Zung-Self Depression-Rating-Scale,Spielberg State-Trait Anxiety Inventory Y1-Y2 and the Toronto-Alexithymia Scale-20 items before and after DAAs treatment.HRQoL was detected by Short-Form-36(SF-36).RESULTS All HRQoL domains,but role limitation physical and bodily pain,significantly improved after treatment.Interestingly,after DAAs treatment,all domains of HRQoL returned similar to those of controls.Each neuropsychological test significantly improved after HCV eradication.A significant correlation was observed among each psychological test and the summary components of SF-36.At multiple linear regression analysis including each psychological test as possible covariates,Zung-Self Depression Rating Scale(Zung-SDS)score was independently and significantly related to summary components of the SF-36 in the basal state and the difference between Zung-SDS score before and after treatment was the only variable significantly and independently related to the modification of HRQoL induced by the treatment.CONCLUSION Neuropsychological symptoms strongly influenced HRQoL in HCV patients and there was a significant improvement of neuropsychological tests and HRQoL after DAAs treatment.
文摘The necessary and sufficient condition of the stability of linear nonautonomous system under the frequently-acting perturbation has been given and proved on the basis of[1] and [2], and the theorem of the equivalence on the uniform and asymptotical stability in the sense of Liapunov ami the stability under the frequently-acting perturbation of linear nonautonomous system has been given in this paper. Besides, the analysis of the dynamic stabilitv of robot has been presented by applying the theorem in this paper, which is closer to reality
文摘In this paper the stability of nonlinear nonautonomous systems under the frequently-acting perturbation is studied. This study is a forward development of the study of the stability in the Liapunov sense; furthermore, it is of significance in practice since perturbations are often not single in the time domain. Malkin proved a general theorem about thesubject. To apply the theorem, however, the user has to construct a Liapunov function which satisfies specified conditions and it is difficult to find such a function for nonlinear nonautonomous systems. In the light of the principle of Liapunov's indirect method, which is an effective method to decide the stability of nonlinear systems in the Liapunov sense, the authors have achieved several important conclusions expressed in the form of theorems to determine the stability of nonlinear nonautonomous systems under the frequently-acting perturbation.
