Stellarins F and G, two new cyclopeptides from Stellaria yunnanensis

In the previous papers, we reported the structural elucidation of stellarins A-E, five new cyclopeptides from the fresh roots of Stellaria yunnanensis Franch. Further chemical study on this plant led to the isolation of two other new cyclopeptide named stellarins F(1) and G(2). By a combination of 2D-NMR, enzymatic degradation and FABMS, their structures were established to by cyclo(Gly-Ala-Gly-Ser-Pro-Trp-Phe-Pro) and cyclo(Gly-Ala-Tyr-Leu-Ala), respectively.

Two new cyclopeptides from stellaria yunnanensis

In the previous papers, we reported the isolation and structural elucidation of three new cyclopeptides, namely stellarin A, B and C, from the fresh roots of stellaria yunnanensis Franch. In a continued study on this plant, other two new cyclopeptides named stellarin D(1) and E(2) were obtained and their structures were established to be cyclo (Gly-Tyr-Leu-Phe-Pro-Ile-Pro)(1), cyclo(Gly-Ile-Pro-Tyr-Ile-Ala-Ala)(2), respectively.

千针万线草环肽A的结构修正

从云南民间药物千针万线草（Ｓｔｅｌｌａｒｉａｙｕｎｎａｎｅｎｓｉｓ）的根中分离到一新环肽ｓｔｅｌｌａｒｉｎＡ。前报主要利用快速原子轰击质谱确定其结构为ｃｙｃｌｏ（Ｇｌｙ－Ｐｒｏ－Ｐｈｅ－Ｔｙｒ－Ｇｌｙ－Ｇｌｙ－Ｐｒｏ）。最近利用最新二维核磁结合快速原子轰击质谱及酶降解重新考察了其结构，修正为ｃｙｃｌｏ（Ｇｌｙ－Ｐｒｏ－Ｐｈｅ－Ｐｒｏ－Ｇｌｙ－Ｔｙｒ－Ｇｌｙ）。

千针万线草环肽H的结构

从云南民间药物千针万线草（Ｓｔｅｌｌａｒｉａｙｕｎｎａｎｅｎｓｉｓ）的新鲜根中只得到２个环肽成分，其中１个为新环肽，命名为千针万线草环肽Ｈ（ｓｔｅｌｌａｒｉｎＨ）。经光谱技术及化学方法证明其结构为ｃｙｃｌｏ（Ｐｈｅ－Ｓｅｒ－Ｌｅｕ－Ｖａｌ－Ｌｅｕ－Ｐｒｏ－Ｐｒｏ－Ｔｙｒ－Ｓｅｒ），另一为一已知的环肽化合物（ｐｓｅｕｄｏｓｔｅｌｌａｒｉｎＡ）。