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ANTITUMOR PRINCIPLES OF STELLERA CHAMAEJASME L. 被引量:3
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作者 冯威健 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1997年第2期89-95,共7页
Methanol extract of Stellera chamaejasme L wasassessed for antitumor activity by an antitumor activebioassay against murine leukemia P388 in vivo. Thebioassay-directed separation of the extract furnishedseven diterpen... Methanol extract of Stellera chamaejasme L wasassessed for antitumor activity by an antitumor activebioassay against murine leukemia P388 in vivo. Thebioassay-directed separation of the extract furnishedseven diterpene compounds (stellerarin, stelleramacrin,gnidimacrin, pimelea factor P2, subtoxin, huratoxin,simplexin ) and two biflavanone compounds (neochemae-jasmin A and B). Among them, gnidimacrin, stellerarinand stelleramacrin (a novel compound) were found tohave high antitumor and cytotoxic activities against P388,L1210 and K562 in vivo and in vitro. The results suggestedthat the diterpene compounds were the potent anti-tumor principles of Stellera chamaejame L 展开更多
关键词 Antitumor agents stellerarin Stelleramacrin Gnidimacrin Pimelea factor P_2 Subtoxin Huratoxin Simplexin Neochemaejasmin A Neochemaejasmin B.Plant Stellera chamaejasme L
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