倾斜的海浪由放在多步底部地形学上的垂直多孔的结构抑制在线性水波浪理论的帮助下被学习。倾斜的波浪的某部分，多孔的结构上的事件，变得被多步底部反映了，多孔的结构，和剩余的宣传进跟随多孔的结构的水媒介。二个盒子被考虑：在跟...倾斜的海浪由放在多步底部地形学上的垂直多孔的结构抑制在线性水波浪理论的帮助下被学习。倾斜的波浪的某部分，多孔的结构上的事件，变得被多步底部反映了，多孔的结构，和剩余的宣传进跟随多孔的结构的水媒介。二个盒子被考虑：在跟随多孔的结构然后跟随多孔的结构的无界的水媒介的一种特殊情况的水媒介从多孔的结构在有限距离放的第一面一稳固的垂直的墙。在两个盒子中，边界价值问题在三不同媒介被建立，是的第一媒介水，是的第二媒介由 p 组成的多孔的结构在每个步骤上面的垂直区域一个和是的第三媒介水再。由沿着 virtualvertical 边界使用匹配的条件，线性方程的一个系统被推出。思考系数和播送进步波浪的无尺寸的振幅的行为由于不同相关参数被学习。由于倾斜的水的繁殖，通过多孔的结构的波浪也是的精力损失执行了。各种各样的参数的效果例如迅速凋落的模式的数字，孔，磨擦因素，结构宽度，步骤和入射角的数字，在思考以后，系数和播送波浪的无尺寸的振幅为两个盒子图形地被学习。迅速凋落的模式的数字仅仅影响散布现象。但是孔表演的更高的价值相对为更低的孔比那降低思考。在思考系数的摆动为磨擦因素的更低的价值被观察，但是它随磨擦因素的价值的增加消失。播送进步波浪的振幅独立于结构的孔。但是磨擦因素的更低的价值引起更高的传动。调查然后为第二个盒子被执行，即，当墙是不在的时。这里考虑的二个盒子之间的重要差别是思考由于薄多孔的结构很高稳固的墙什么时候作为与盒子相比存在没有墙什么时候是在场的。精力损失也由于不同的孔，磨擦因素，结构宽度和入射角被检验。我们的模型的有效性被与可得到的匹配它查明。展开更多
The ideal treatment strategy for Crohn’s disease (CD) remains uncertain, as does the optimal endpoint of therapy. Top-down versus step-up describes two different approaches: early use of immunomodulators and biologic...The ideal treatment strategy for Crohn’s disease (CD) remains uncertain, as does the optimal endpoint of therapy. Top-down versus step-up describes two different approaches: early use of immunomodulators and biological agents in the former versus initial treatment with steroids in the latter, with escalation to immunomodulators or biological drugs in patients proven to be steroid refractory or steroid dependent. Top-down therapy has been associated with higher rates of mucosal healing. If mucosal healing proves to be associated with better long-term outcomes, such as a decreased need for hospitalization and surgery, top-down therapy may be the better approach for many patients. The main concern with the top-down approach is the toxicity of the immunomodulators and biological agents, which have been linked with infectious complications as well as an increased risk of lymphoma. It is unlikely that one strategy will be best for all patients given the underlying heterogeneity of CD presentation and severity. Ultimately, we must weigh the safety and efficacy of the therapies with the risks of the disease itself. Unfortunately our ability to risk stratify patients at diagnosis remains rudimentary. The purpose of this paper is to review the data that supports or refutes the differing treatment paradigms in CD, and to provide a rationale for an approach, termed the "accelerated step-up" approach, which attempts to balance the risks and benefits of our currently available therapies with the risk of disease related complications as we understand them in 2008.展开更多
Four weeks of uncertain stress was used to establish an animal model of chronic stress. Basic fibroblast growth factor was injected daily for 15 days following stress induction. Cell morphology in the hippocampal CA3 ...Four weeks of uncertain stress was used to establish an animal model of chronic stress. Basic fibroblast growth factor was injected daily for 15 days following stress induction. Cell morphology in the hippocampal CA3 region of chronic stress mice revealed cell damage. Nitric oxide content and calcium concentration were significantly increased in the hippocampus, and learning and memory functions were significantly decreased. After basic fibroblast growth factor intervention, Ca2~ overload was decreased and neuronal damage was relieved in hippocampal neurons, which improved learning and memory functions in chronic stress mice. Latency was prolonged and the number of errors was decreased in a passive avoidance test.展开更多
文摘倾斜的海浪由放在多步底部地形学上的垂直多孔的结构抑制在线性水波浪理论的帮助下被学习。倾斜的波浪的某部分，多孔的结构上的事件，变得被多步底部反映了，多孔的结构，和剩余的宣传进跟随多孔的结构的水媒介。二个盒子被考虑：在跟随多孔的结构然后跟随多孔的结构的无界的水媒介的一种特殊情况的水媒介从多孔的结构在有限距离放的第一面一稳固的垂直的墙。在两个盒子中，边界价值问题在三不同媒介被建立，是的第一媒介水，是的第二媒介由 p 组成的多孔的结构在每个步骤上面的垂直区域一个和是的第三媒介水再。由沿着 virtualvertical 边界使用匹配的条件，线性方程的一个系统被推出。思考系数和播送进步波浪的无尺寸的振幅的行为由于不同相关参数被学习。由于倾斜的水的繁殖，通过多孔的结构的波浪也是的精力损失执行了。各种各样的参数的效果例如迅速凋落的模式的数字，孔，磨擦因素，结构宽度，步骤和入射角的数字，在思考以后，系数和播送波浪的无尺寸的振幅为两个盒子图形地被学习。迅速凋落的模式的数字仅仅影响散布现象。但是孔表演的更高的价值相对为更低的孔比那降低思考。在思考系数的摆动为磨擦因素的更低的价值被观察，但是它随磨擦因素的价值的增加消失。播送进步波浪的振幅独立于结构的孔。但是磨擦因素的更低的价值引起更高的传动。调查然后为第二个盒子被执行，即，当墙是不在的时。这里考虑的二个盒子之间的重要差别是思考由于薄多孔的结构很高稳固的墙什么时候作为与盒子相比存在没有墙什么时候是在场的。精力损失也由于不同的孔，磨擦因素，结构宽度和入射角被检验。我们的模型的有效性被与可得到的匹配它查明。
文摘The ideal treatment strategy for Crohn’s disease (CD) remains uncertain, as does the optimal endpoint of therapy. Top-down versus step-up describes two different approaches: early use of immunomodulators and biological agents in the former versus initial treatment with steroids in the latter, with escalation to immunomodulators or biological drugs in patients proven to be steroid refractory or steroid dependent. Top-down therapy has been associated with higher rates of mucosal healing. If mucosal healing proves to be associated with better long-term outcomes, such as a decreased need for hospitalization and surgery, top-down therapy may be the better approach for many patients. The main concern with the top-down approach is the toxicity of the immunomodulators and biological agents, which have been linked with infectious complications as well as an increased risk of lymphoma. It is unlikely that one strategy will be best for all patients given the underlying heterogeneity of CD presentation and severity. Ultimately, we must weigh the safety and efficacy of the therapies with the risks of the disease itself. Unfortunately our ability to risk stratify patients at diagnosis remains rudimentary. The purpose of this paper is to review the data that supports or refutes the differing treatment paradigms in CD, and to provide a rationale for an approach, termed the "accelerated step-up" approach, which attempts to balance the risks and benefits of our currently available therapies with the risk of disease related complications as we understand them in 2008.
基金the "Eleventh Five-Year" Scientific and Technological Research Projects of the Education Department of Jilin Province, No. [2008]137
文摘Four weeks of uncertain stress was used to establish an animal model of chronic stress. Basic fibroblast growth factor was injected daily for 15 days following stress induction. Cell morphology in the hippocampal CA3 region of chronic stress mice revealed cell damage. Nitric oxide content and calcium concentration were significantly increased in the hippocampus, and learning and memory functions were significantly decreased. After basic fibroblast growth factor intervention, Ca2~ overload was decreased and neuronal damage was relieved in hippocampal neurons, which improved learning and memory functions in chronic stress mice. Latency was prolonged and the number of errors was decreased in a passive avoidance test.
