Progress in medicine requires not only innovation and development in the medical field but also the integration of the technology of other fields into the medical field. As an important technological advancement, thre...Progress in medicine requires not only innovation and development in the medical field but also the integration of the technology of other fields into the medical field. As an important technological advancement, three-dimensional (3D) reconstruction transforms traditional two-dimensional images into 3D images that are more consistent with the physiological habits of human eyes. It has been applied to the bones, heart, liver, and maxillofacial area, promoting the progress of medical technology and surgeons. This article introduces the progress of 3D reconstruction technology in the clinical application of pancreatic surgery, from the preoperative, intraoperative, and postoperative perspectives, as well as the education of young surgeons. It also puts forward new ideas for the further development of pancreatic surgery.展开更多
Progress in medicine requires not only innovation and development in the medical field but also the integration of the technology of other fields into the medical field.As an important technological advancement,three-...Progress in medicine requires not only innovation and development in the medical field but also the integration of the technology of other fields into the medical field.As an important technological advancement,three-dimensional(3D)reconstruction transforms traditional two-dimensional images into 3D images that are more consistent with the physiological habits of human eyes.It has been applied to the bones,heart,liver,and maxillofacial area,promoting the progress of medical technology and surgeons.This paper introduces the progress of 3D reconstruction technology in the clinical application of pancreatic surgery,from the preoperative,intraoperative,and postoperative perspectives,as well as the education of young surgeons.It also puts forward new ideas for the further development of pancreatic surgery.展开更多
Pancreatic cancer(PC)is an aggressive human cancer.Appropriate methods for the diagnosis and treatment of PC have not been found at the genetic level,thus making epigenetics a promising research path in studies of PC....Pancreatic cancer(PC)is an aggressive human cancer.Appropriate methods for the diagnosis and treatment of PC have not been found at the genetic level,thus making epigenetics a promising research path in studies of PC.Histone methylation is one of the most complicated types of epigenetic modifications and has proved crucial in the development of PC.Histone methylation is a reversible process regulated by readers,writers,and erasers.Some writers and erasers can be recognized as potential biomarkers and candidate therapeutic targets in PC because of their unusual expression in PC cells compared with normal pancreatic cells.Based on the impact that writers have on the development of PC,some inhibitors of writers have been developed.However,few inhibitors of erasers have been developed and put to clinical use.Meanwhile,there is not enough research on the reader domains.Therefore,the study of erasers and readers is still a promising area.This review focuses on the regulatory mechanism of histone methylation,and the diagnosis and chemotherapy of PC based on it.The future of epigenetic modification in PC research is also discussed.展开更多
Despite the development of newer oncological treatment,the survival of patients with pancreatic cancer(PC)remains poor.Recent studies have identified exosomes as essential mediators of intercellular communications and...Despite the development of newer oncological treatment,the survival of patients with pancreatic cancer(PC)remains poor.Recent studies have identified exosomes as essential mediators of intercellular communications and play a vital role in tumor initiation,metastasis and chemoresistance.Thus,the utility of liquid biopsies using exosomes in PC management can be used for early detection,diagnosis,monitoring as well as drug delivery vehicles for cancer therapy.This review summarizes the function,and clinical applications of exosomes in cancers as minimally invasive liquid biomarker in diagnostic,prognostic and therapeutic roles.展开更多
基金National Natural Science Foundation of China (No. 82001895 and 82072074)Joint Funds of Scientific and Technological Innovation Program of Fujian Province (grant number 2020Y9064) .
文摘Progress in medicine requires not only innovation and development in the medical field but also the integration of the technology of other fields into the medical field. As an important technological advancement, three-dimensional (3D) reconstruction transforms traditional two-dimensional images into 3D images that are more consistent with the physiological habits of human eyes. It has been applied to the bones, heart, liver, and maxillofacial area, promoting the progress of medical technology and surgeons. This article introduces the progress of 3D reconstruction technology in the clinical application of pancreatic surgery, from the preoperative, intraoperative, and postoperative perspectives, as well as the education of young surgeons. It also puts forward new ideas for the further development of pancreatic surgery.
基金This work was supported by grants from the National Natural Science Foundation of China(No.8200189582072074)the Joint Funds of Scientific and Technological Innovation Program of Fujian Province(grant number 2020Y9064).
文摘Progress in medicine requires not only innovation and development in the medical field but also the integration of the technology of other fields into the medical field.As an important technological advancement,three-dimensional(3D)reconstruction transforms traditional two-dimensional images into 3D images that are more consistent with the physiological habits of human eyes.It has been applied to the bones,heart,liver,and maxillofacial area,promoting the progress of medical technology and surgeons.This paper introduces the progress of 3D reconstruction technology in the clinical application of pancreatic surgery,from the preoperative,intraoperative,and postoperative perspectives,as well as the education of young surgeons.It also puts forward new ideas for the further development of pancreatic surgery.
文摘Pancreatic cancer(PC)is an aggressive human cancer.Appropriate methods for the diagnosis and treatment of PC have not been found at the genetic level,thus making epigenetics a promising research path in studies of PC.Histone methylation is one of the most complicated types of epigenetic modifications and has proved crucial in the development of PC.Histone methylation is a reversible process regulated by readers,writers,and erasers.Some writers and erasers can be recognized as potential biomarkers and candidate therapeutic targets in PC because of their unusual expression in PC cells compared with normal pancreatic cells.Based on the impact that writers have on the development of PC,some inhibitors of writers have been developed.However,few inhibitors of erasers have been developed and put to clinical use.Meanwhile,there is not enough research on the reader domains.Therefore,the study of erasers and readers is still a promising area.This review focuses on the regulatory mechanism of histone methylation,and the diagnosis and chemotherapy of PC based on it.The future of epigenetic modification in PC research is also discussed.
文摘Despite the development of newer oncological treatment,the survival of patients with pancreatic cancer(PC)remains poor.Recent studies have identified exosomes as essential mediators of intercellular communications and play a vital role in tumor initiation,metastasis and chemoresistance.Thus,the utility of liquid biopsies using exosomes in PC management can be used for early detection,diagnosis,monitoring as well as drug delivery vehicles for cancer therapy.This review summarizes the function,and clinical applications of exosomes in cancers as minimally invasive liquid biomarker in diagnostic,prognostic and therapeutic roles.
