Soliton molecules(SMs)of the(2+1)-dimensional generalized KonopelchenkoDubrovsky-Kaup-Kupershmidt(gKDKK)equation are found by utilizing a velocity resonance ansatz to N-soliton solutions,which can transform to asymmet...Soliton molecules(SMs)of the(2+1)-dimensional generalized KonopelchenkoDubrovsky-Kaup-Kupershmidt(gKDKK)equation are found by utilizing a velocity resonance ansatz to N-soliton solutions,which can transform to asymmetric solitons upon assigning appropriate values to some parameters.Furthermore,a double-peaked lump solution can be constructed with breather degeneration approach.By applying a mixed technique of a resonance ansatz and conjugate complexes of partial parameters to multisoliton solutions,various kinds of interactional structures are constructed;There include the soliton molecule(SM),the breather molecule(BM)and the soliton-breather molecule(SBM).Graphical investigation and theoretical analysis show that the interactions composed of SM,BM and SBM are inelastic.展开更多
The(2+1)-dimensional elliptic Toda equation is a high-dimensional generalization of the Toda lattice and a semidiscrete Kadomtsev–Petviashvili I equation.This paper focuses on investigating the resonant interactions ...The(2+1)-dimensional elliptic Toda equation is a high-dimensional generalization of the Toda lattice and a semidiscrete Kadomtsev–Petviashvili I equation.This paper focuses on investigating the resonant interactions between two breathers,a breather/lump and line solitons as well as lump molecules for the(2+1)-dimensional elliptic Toda equation.Based on the N-soliton solution,we obtain the hybrid solutions consisting of line solitons,breathers and lumps.Through the asymptotic analysis of these hybrid solutions,we derive the phase shifts of the breather,lump and line solitons before and after the interaction between a breather/lump and line solitons.By making the phase shifts infinite,we obtain the resonant solution of two breathers and the resonant solutions of a breather/lump and line solitons.Through the asymptotic analysis of these resonant solutions,we demonstrate that the resonant interactions exhibit the fusion,fission,time-localized breather and rogue lump phenomena.Utilizing the velocity resonance method,we obtain lump–soliton,lump–breather,lump–soliton–breather and lump–breather–breather molecules.The above works have not been reported in the(2+1)-dimensional discrete nonlinear wave equations.展开更多
The stromal interaction molecule(STIM)-calcium release-activated calcium channel protein(ORAI) and inositol1,4,5-trisphosphate receptors(IP_3Rs) play pivotal roles in the modulation of Ca^(2+)-regulated pathways from ...The stromal interaction molecule(STIM)-calcium release-activated calcium channel protein(ORAI) and inositol1,4,5-trisphosphate receptors(IP_3Rs) play pivotal roles in the modulation of Ca^(2+)-regulated pathways from gene transcription to cell apoptosis by driving calcium-dependent signaling processes.Increasing evidence has implicated the dysregulation of STIM-ORAI and IP_3Rs in tumorigenesis and tumor progression.By controlling the activities,structure,and/or expression levels of these Ca^(2+)-transporting proteins,malignant cancer cells can hijack them to drive essential biological functions for tumor development.However,the molecular mechanisms underlying the participation of STIM-ORAI and IP_3Rs in the biological behavior of cancer remain elusive.In this review,we summarize recent advances regarding STIM-ORAI and IP_3Rs and discuss how they promote cell proliferation,apoptosis evasion,and cell migration through temporal and spatial rearrangements in certain types of malignant cells.An understanding of the essential roles of STIM-ORAI and IP_3Rs may provide new pharmacologic targets that achieve a better therapeutic effect by inhibiting their actions in key intracellular signaling pathways.展开更多
目的:构建基于上皮间质相互作用蛋白1(epithelial-stromal interaction protein 1,EPSTI1)预后列线图预测肾透明细胞癌的预后。方法:回顾性分析2012年1月至2015年12月于福建医科大学附属第一医院221例接受手术治疗的肾透明细胞癌患者和T...目的:构建基于上皮间质相互作用蛋白1(epithelial-stromal interaction protein 1,EPSTI1)预后列线图预测肾透明细胞癌的预后。方法:回顾性分析2012年1月至2015年12月于福建医科大学附属第一医院221例接受手术治疗的肾透明细胞癌患者和TCGA数据库中533例肾透明细胞癌患者数据,对癌旁正常组织和癌组织标本进行免疫组织化学(immunohistochemistry,IHC)染色,分析EPSTI1的表达差异及与临床病理特征的相关性。对EPSTI1高表达与低表达患者的总生存期(overall survival,OS)和无病生存期(disease-free survival,DFS)进行Kaplan-Meier生存分析,采用单因素和多因素Cox比例风险模型分析OS的预后因素,进一步构建列线图模型并验证。结果:与癌旁正常肾组织比较,肾透明细胞癌组织中EPSTI1的IHC评分和m RNA表达水平均显著高于正常组织(均P<0.001),且在高T分期的癌组织中表达更高(P=0.036,P=0.006);EPSTI1蛋白表达与肿瘤最大径、TNM分期相关(P=0.002,P=0.032);EPSTI1低表达组OS、DFS均优于高表达组(P=0.046,P=0.003,P=0.001);单因素和多因素Cox回归分析结果显示,EPSTI1蛋白高表达、WHO/ISUP分级、AJCC/TNM分期是影响肾透明细胞癌患者预后不良的独立危险因素(P=0.009,P=0.039,P<0.001);基于上述变量构建的预后列线图模型对患者5年OS预测能力优于AJCC/TNM分期,校准曲线显示模型预测值与实际值间具有良好的一致性。结论:基于EPSTI1、AJCC/TNM分期和WHO/ISUP分级建立的列线图模型对肾透明细胞癌预后具有较强的预测能力。展开更多
基金Supported by the National Natural Science Foundation of China(12001424)the Natural Science Basic Research Program of Shaanxi Province(2021JZ-21)the Fundamental Research Funds for the Central Universities(2020CBLY013)。
文摘Soliton molecules(SMs)of the(2+1)-dimensional generalized KonopelchenkoDubrovsky-Kaup-Kupershmidt(gKDKK)equation are found by utilizing a velocity resonance ansatz to N-soliton solutions,which can transform to asymmetric solitons upon assigning appropriate values to some parameters.Furthermore,a double-peaked lump solution can be constructed with breather degeneration approach.By applying a mixed technique of a resonance ansatz and conjugate complexes of partial parameters to multisoliton solutions,various kinds of interactional structures are constructed;There include the soliton molecule(SM),the breather molecule(BM)and the soliton-breather molecule(SBM).Graphical investigation and theoretical analysis show that the interactions composed of SM,BM and SBM are inelastic.
基金the National Natural Science Foundation of China(Grant Nos.12061051 and 11965014)。
文摘The(2+1)-dimensional elliptic Toda equation is a high-dimensional generalization of the Toda lattice and a semidiscrete Kadomtsev–Petviashvili I equation.This paper focuses on investigating the resonant interactions between two breathers,a breather/lump and line solitons as well as lump molecules for the(2+1)-dimensional elliptic Toda equation.Based on the N-soliton solution,we obtain the hybrid solutions consisting of line solitons,breathers and lumps.Through the asymptotic analysis of these hybrid solutions,we derive the phase shifts of the breather,lump and line solitons before and after the interaction between a breather/lump and line solitons.By making the phase shifts infinite,we obtain the resonant solution of two breathers and the resonant solutions of a breather/lump and line solitons.Through the asymptotic analysis of these resonant solutions,we demonstrate that the resonant interactions exhibit the fusion,fission,time-localized breather and rogue lump phenomena.Utilizing the velocity resonance method,we obtain lump–soliton,lump–breather,lump–soliton–breather and lump–breather–breather molecules.The above works have not been reported in the(2+1)-dimensional discrete nonlinear wave equations.
文摘The stromal interaction molecule(STIM)-calcium release-activated calcium channel protein(ORAI) and inositol1,4,5-trisphosphate receptors(IP_3Rs) play pivotal roles in the modulation of Ca^(2+)-regulated pathways from gene transcription to cell apoptosis by driving calcium-dependent signaling processes.Increasing evidence has implicated the dysregulation of STIM-ORAI and IP_3Rs in tumorigenesis and tumor progression.By controlling the activities,structure,and/or expression levels of these Ca^(2+)-transporting proteins,malignant cancer cells can hijack them to drive essential biological functions for tumor development.However,the molecular mechanisms underlying the participation of STIM-ORAI and IP_3Rs in the biological behavior of cancer remain elusive.In this review,we summarize recent advances regarding STIM-ORAI and IP_3Rs and discuss how they promote cell proliferation,apoptosis evasion,and cell migration through temporal and spatial rearrangements in certain types of malignant cells.An understanding of the essential roles of STIM-ORAI and IP_3Rs may provide new pharmacologic targets that achieve a better therapeutic effect by inhibiting their actions in key intracellular signaling pathways.
