Objective: To further explore the mechanism of congenital pyrimidine 5'-nucleotidase I deficiency. Methods; The samples were collected from the family members of a patient with P5'N- I deficiency. The enzyme a...Objective: To further explore the mechanism of congenital pyrimidine 5'-nucleotidase I deficiency. Methods; The samples were collected from the family members of a patient with P5'N- I deficiency. The enzyme activities were measured by UMP method and the enzyme proteins were quantified by ELISA while the morphology of peripheral blood cells was observed. Results: The enzyme contents reduced as their enzyme activities decreased in the family especially in four members. There was a significant positive correlation(r =0. 955) between the activity and the content of P 5'N- I . The count of the stippling cell was varied in the family. Conclusion.- One of the reasons for congenital P5' N- I deficiency might be the deficiency in the enzyme content. The morphology of peripheral blood erythrocyte may be an assistant diagnotic index. The P5'N- I activities and contents were measured simultaneously may be a effective method in clinic diagnosis.展开更多
Poisson disk sampling is an important problem in computer graphics and has a wide variety of applications in imaging, geometry, rendering, etc. In this paper, we propose a novel Poisson disk sampling algorithm based o...Poisson disk sampling is an important problem in computer graphics and has a wide variety of applications in imaging, geometry, rendering, etc. In this paper, we propose a novel Poisson disk sampling algorithm based on disk packing. The key idea uses the observation that a relatively dense disk packing layout naturally satisfies the Poisson disk distribution property that each point is no closer to the others than a specified minimum distance, i.e., the Poisson disk radius. We use this property to propose a relaxation algorithm that achieves a good balance between the random and uniform properties needed for Poisson disk distributions. Our algorithm is easily adapted to image stippling by extending identical disk packing to unequal disks. Experimental results demonstrate the efficacy of our approaches.展开更多
文摘Objective: To further explore the mechanism of congenital pyrimidine 5'-nucleotidase I deficiency. Methods; The samples were collected from the family members of a patient with P5'N- I deficiency. The enzyme activities were measured by UMP method and the enzyme proteins were quantified by ELISA while the morphology of peripheral blood cells was observed. Results: The enzyme contents reduced as their enzyme activities decreased in the family especially in four members. There was a significant positive correlation(r =0. 955) between the activity and the content of P 5'N- I . The count of the stippling cell was varied in the family. Conclusion.- One of the reasons for congenital P5' N- I deficiency might be the deficiency in the enzyme content. The morphology of peripheral blood erythrocyte may be an assistant diagnotic index. The P5'N- I activities and contents were measured simultaneously may be a effective method in clinic diagnosis.
基金supported in part by National Natural Science Foundation of China (Nos. 61202147 and 61272243)Shandong Province Natural Science Foundation (No. ZR2012FQ026)Fundamental Research Funds for the Central Universities (No. 20720140520)
文摘Poisson disk sampling is an important problem in computer graphics and has a wide variety of applications in imaging, geometry, rendering, etc. In this paper, we propose a novel Poisson disk sampling algorithm based on disk packing. The key idea uses the observation that a relatively dense disk packing layout naturally satisfies the Poisson disk distribution property that each point is no closer to the others than a specified minimum distance, i.e., the Poisson disk radius. We use this property to propose a relaxation algorithm that achieves a good balance between the random and uniform properties needed for Poisson disk distributions. Our algorithm is easily adapted to image stippling by extending identical disk packing to unequal disks. Experimental results demonstrate the efficacy of our approaches.
