The toxicity of heavy metals (Hg2 + , Zn2 + ) and pesticides has been investigated by comparing the physiological properties in wild and tolerant strains of Synechococcus cedrorum 1191. The differential pattern of gro...The toxicity of heavy metals (Hg2 + , Zn2 + ) and pesticides has been investigated by comparing the physiological properties in wild and tolerant strains of Synechococcus cedrorum 1191. The differential pattern of growth, absorption spectra of pigments and nutrient uptake was observed in tolerant strain.展开更多
Environmental sustainability is an increasingly important issue in industry.As an environmentally friendly and sustainable way,constructing microbial cell factories to produce all kinds of valuable products has attrac...Environmental sustainability is an increasingly important issue in industry.As an environmentally friendly and sustainable way,constructing microbial cell factories to produce all kinds of valuable products has attracted more and more attention.In the process of constructing microbial cell factories,systems biology plays a crucial role.This review summarizes the recent applications of systems biology in the design and construction of microbial cell factories from four perspectives,including functional genes/enzymes discovery,bottleneck pathways identification,strains tolerance improvement and design and construction of synthetic microbial consortia.Systems biology tools can be employed to identify functional genes/enzymes involved in the biosynthetic pathways of products.These discovered genes are introduced into appropriate chassis strains to build engineering microorganisms capable of producing products.Subsequently,systems biology tools are used to identify bottleneck pathways,improve strains tolerance and guide design and construction of synthetic microbial consortia,resulting in increasing the yield of engineered strains and constructing microbial cell factories successfully.展开更多
文摘The toxicity of heavy metals (Hg2 + , Zn2 + ) and pesticides has been investigated by comparing the physiological properties in wild and tolerant strains of Synechococcus cedrorum 1191. The differential pattern of growth, absorption spectra of pigments and nutrient uptake was observed in tolerant strain.
基金by the National Key Research and Development Program of China (2019YFA0706900)National Natural Science Foundation of China (22278310).
文摘Environmental sustainability is an increasingly important issue in industry.As an environmentally friendly and sustainable way,constructing microbial cell factories to produce all kinds of valuable products has attracted more and more attention.In the process of constructing microbial cell factories,systems biology plays a crucial role.This review summarizes the recent applications of systems biology in the design and construction of microbial cell factories from four perspectives,including functional genes/enzymes discovery,bottleneck pathways identification,strains tolerance improvement and design and construction of synthetic microbial consortia.Systems biology tools can be employed to identify functional genes/enzymes involved in the biosynthetic pathways of products.These discovered genes are introduced into appropriate chassis strains to build engineering microorganisms capable of producing products.Subsequently,systems biology tools are used to identify bottleneck pathways,improve strains tolerance and guide design and construction of synthetic microbial consortia,resulting in increasing the yield of engineered strains and constructing microbial cell factories successfully.
