The epidermis, and in particular its outermost layer, the stratum corneum, contributes much of the barrier function of the skin and is a readily visible representation of skin health. Maintaining the health of the ski...The epidermis, and in particular its outermost layer, the stratum corneum, contributes much of the barrier function of the skin and is a readily visible representation of skin health. Maintaining the health of the skin barrier has arguably become more important than ever in the modern world, in which a large majority of people are exposed to environmental insults. These external factors can damage the integrity of the skin barrier and prematurely age the skin. Therefore, it has become increasingly important to maintain and protect the stratum corneum. Here, we briefly review the complex, multilayered structure of the skin and relate it to clinically translatable function, with an emphasis on the stratum corneum. In the context of epidermal structure and function, the formulation and clinical data for Phelityl® Reviving Cream will be reviewed. Phelityl Reviving Cream was shown to be associated with improvements in both immediate- and long-term parameters, including a significant positive effect on the skin barrier and immediate and long-lasting hydration.展开更多
目的:从"天人相应"的角度出发,探讨年节律对健康人皮肤屏障功能的影响。方法:选取健康志愿者50例,男女各25例。检测其在生理状态下春分、夏至、秋分、冬至四个节气的皮肤经皮水分丢失(Trans Epidermal Water Loss,TEWL)、角...目的:从"天人相应"的角度出发,探讨年节律对健康人皮肤屏障功能的影响。方法:选取健康志愿者50例,男女各25例。检测其在生理状态下春分、夏至、秋分、冬至四个节气的皮肤经皮水分丢失(Trans Epidermal Water Loss,TEWL)、角质层含水量、油脂量、p H值等指标的变化,并进行统计分析。结果:1TEWL值:冬至最大,夏至最小,二者比较差异具有统计学意义(t=17.83,P<0.05)。2角质层含水量:面颊部春分最大,冬至最小,二者比较差异具有统计学意义(t=4.89,P<0.05)。颧部夏至最大,冬至最小,二者比较差异具有统计学意义(t=3.97,P<0.05)。3油脂量:夏至最多,秋分最少,二者比较差异具有统计学意义(t=5.25,P<0.05)。4p H值:冬至最大,夏至最小,二者比较差异具有统计学意义(t=4.69,P<0.05)。结论:结果提示皮肤屏障功能随季节变化而变化,夏季较好,冬季减弱。展开更多
文摘The epidermis, and in particular its outermost layer, the stratum corneum, contributes much of the barrier function of the skin and is a readily visible representation of skin health. Maintaining the health of the skin barrier has arguably become more important than ever in the modern world, in which a large majority of people are exposed to environmental insults. These external factors can damage the integrity of the skin barrier and prematurely age the skin. Therefore, it has become increasingly important to maintain and protect the stratum corneum. Here, we briefly review the complex, multilayered structure of the skin and relate it to clinically translatable function, with an emphasis on the stratum corneum. In the context of epidermal structure and function, the formulation and clinical data for Phelityl® Reviving Cream will be reviewed. Phelityl Reviving Cream was shown to be associated with improvements in both immediate- and long-term parameters, including a significant positive effect on the skin barrier and immediate and long-lasting hydration.
文摘目的探讨果酸换肤术联合强脉冲光在中度寻常性痤疮(acne vulgaris,AC)患者中的疗效。方法方便选取2020年3月—2022年6月阳光融和医院收治的96例中度AC患者,按随机数表法分为对照组(n=48)采用果酸换肤术治疗,观察组(n=48)在对照组基础上加用强脉冲光治疗。两组患者均于治疗后持续随访12周。对比两组患者皮肤屏障功能、经表皮失水率(trans epidermal water loss,TEWL)水平、临床疗效及并发症。结果观察组治疗后角质层含水量高于对照组,皮脂水平低于对照组,差异有统计学意义(P<0.05);观察组治疗后TEWL水平低于对照组,差异有统计学意义(P<0.05);观察组临床总有效率(95.83%)高于对照组(83.33%),差异有统计学意义(χ^(2)=4.019,P<0.05);观察组并发症发生率(4.17%)低于对照组(16.67%),差异有统计学意义(P<0.05)。结论果酸换肤术联合强脉冲光能够改善中度AC患者皮肤屏障功能,降低TEWL水平,疗效显著,还可减少并发症的发生。
